Darren Roblyer, PhD
Associate Professor
Boston University College of Engineering
Dept of Biomedical Engineering

PhD, Rice University



Darren Roblyer is an associate professor of Biomedical Engineering and Electrical and Computer Engineering at Boston University. His research focuses on translational diffuse optical imaging and spectroscopy. His group develops both wearables and frequency-domain near-infrared spectroscopy techniques to address unmet clinical needs in cancer, cardiovascular disease, and kidney disease.

Prof. Roblyer received a B.S. in Biomedical Engineering from Johns Hopkins University in 2004, and received his Ph.D. in Bioengineering at Rice University in 2009. He was a Department of Defense Postdoctoral Fellow at the Beckman Laser Institute at the University of California, Irvine studying under Professor Bruce Tromberg prior to joining the faculty at Boston University in 2012.


Early breast cancer treatment response monitoring with real-time diffuse optical imaging
09/01/2021 - 08/31/2024 (PI)
Department of Defense/Army Medical Research Acquisition Activity


Frequency domain shortwave infrared spectroscopy (FD-SWIRS) for volume status monitoring during hemodialysis in end stage kidney disease
03/01/2022 - 01/31/2024 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
1R21DK132784-01

A wearable probe for deep tissue imaging of hemodynamics in breast tumors
01/01/2022 - 06/30/2023 (PI)
American Cancer Society, Inc.


Frequency domain diffuse optical spectroscopy and diffuse correlation spectroscopy for assessing inspiratory muscle metabolism in mechanically ventilated patients
09/15/2021 - 06/30/2023 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
1R21EB031250-01

Label-free measurement of blood lipids with hyperspectral short-wave infrared spatial frequency domain imaging to improve cardiovascular disease risk prediction and treatment monitoring
07/01/2020 - 03/31/2023 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
5R21EB030197-03

EFRI CEE: Optically Controlled Localized Epigenetic Chromatin Remodeling with Photoactivatable CRISPR-dCas9
09/01/2018 - 08/31/2022 (Subcontract PI)
Beth Israel Deaconess Medical Center, Inc National Science Fdn
EFMA-1830878

Estimating blood pressure changes using laser speckle contrast measurements on the wrist and hand
12/07/2021 - 07/31/2022 (PI)
Facebook Technologies, LLC


Development of less toxic treatment strategies for metastatic and drug resistant breast cancer using noninvasive optical monitoring
09/01/2015 - 08/31/2021 (PI)
Department of Defense/Army Medical Research Acquisition Activity


A wearable probe for deep tissue imaging of hemodynamics in breast tumors
07/01/2018 - 12/31/2020 (PI)
American Cancer Society, Inc.


CardioptOx Pilot
11/01/2018 - 05/31/2020 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NHLBI
5U54HL119145-07

Showing 10 of 15 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Pilvar A, Plutzky J, Pierce M, Roblyer D. Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties. J Biomed Opt. 2022 Jun; 27(6). PMID: 35715883; PMCID: PMC9204261; DOI: 10.1117/1.JBO.27.6.066003;
     
  2. Tank A, Vergato C, Waxman DJ, Roblyer D. Spatial frequency domain imaging for monitoring immune-mediated chemotherapy treatment response and resistance in a murine breast cancer model. Sci Rep. 2022 Apr 07; 12(1):5864.View Related Profiles. PMID: 35393476; PMCID: PMC8989878; DOI: 10.1038/s41598-022-09671-2;
     
  3. Vergato C, DOshi K, Roblyer D, Waxman DJ. Type-I Interferon Signaling Is Essential for Robust Metronomic Chemo-Immunogenic Tumor Regression in Murine Breast Cancer. 2022. View Publication
  4. Applegate MB, Amelard R, Gomez CA, Roblyer D. Real-Time Handheld Probe Tracking and Image Formation Using Digital Frequency-Domain Diffuse Optical Spectroscopy. IEEE Trans Biomed Eng. 2021 11; 68(11):3399-3409. PMID: 33835913; PMCID: PMC8612633; DOI: 10.1109/TBME.2021.3072036;
     
  5. Jawde SB, Karrobi K, Roblyer D, Vicario F, Herrmann J, Casey D, Lutchen KR, Stamenovic D, Bates JHT, Suki B. Inflation instability in the lung: an analytical model of a thick-walled alveolus with wavy fibres under large deformations. J R Soc Interface. 2021 10; 18(183):20210594.View Related Profiles. PMID: 34637644; PMCID: PMC8510704; DOI: 10.1098/rsif.2021.0594;
     
  6. Kang W, Ferruzzi J, Spatarelu CP, Han YL, Sharma Y, Koehler SA, Mitchel JA, Khan A, Butler JP, Roblyer D, Zaman MH, Park JA, Guo M, Chen Z, Pegoraro AF, Fredberg JJ. A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation. iScience. 2021 Nov 19; 24(11):103252.View Related Profiles. PMID: 34755092; PMCID: PMC8564056; DOI: 10.1016/j.isci.2021.103252;
     
  7. Istfan R, Gómez CA, Applegate M, Rozenberg D, Reid WD, Roblyer D. Hemodynamics of the sternocleidomastoid measured with frequency domain near-infrared spectroscopy towards non-invasive monitoring during mechanical ventilation. Biomed Opt Express. 2021 Jul 01; 12(7):4147-4162. PMID: 34457405; PMCID: PMC8367268; DOI: 10.1364/BOE.430423;
     
  8. Spink S, Teng F, Pera V, Peterson H, Cormier T, Sauer-Budge A, Chargin D, Brookfield S, Eggebrecht A, Ko NY, Roblyer D. High optode-density wearable diffuse optical probe for monitoring paced breathing hemodynamics in breast tissue. J Biomed Opt. 2021 06; 26(6). PMID: 34080400; PMCID: PMC8170390; DOI: 10.1117/1.JBO.26.6.062708;
     
  9. Applegate M, Gómez C, Roblyer D. Modulation frequency selection and efficient look-up table inversion for frequency domain diffuse optical spectroscopy. J Biomed Opt. 2021 03; 26(3). PMID: 33768742; PMCID: PMC7992233; DOI: 10.1117/1.JBO.26.3.036007;
     
  10. Tabassum S, Tank A, Wang F, Karrobi K, Vergato C, Bigio IJ, Waxman DJ, Roblyer D. Optical scattering as an early marker of apoptosis during chemotherapy and antiangiogenic therapy in murine models of prostate and breast cancer. Neoplasia. 2021 03; 23(3):294-303.View Related Profiles. PMID: 33578267; PMCID: PMC7881266; DOI: 10.1016/j.neo.2021.01.005;
     
Showing 10 of 64 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 63 publications over 16 distinct years, with a maximum of 8 publications in 2018 and 2020

YearPublications
20072
20082
20092
20105
20112
20123
20132
20144
20152
20164
20176
20188
20193
20208
20217
20223
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44 Cummington St
Boston MA 02215
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