Darren Roblyer, PhD
Associate Professor
Boston University College of Engineering
Biomedical Engineering

PhD, Rice University
BS, Johns Hopkins University

Darren Roblyer is an associate professor of Biomedical Engineering and Electrical and Computer Engineering at Boston University. His research focuses on translational diffuse optical imaging and spectroscopy. His group develops both wearables and frequency-domain near-infrared spectroscopy techniques to address unmet clinical needs in cancer, cardiovascular disease, and kidney disease.

Prof. Roblyer received a B.S. in Biomedical Engineering from Johns Hopkins University in 2004, and received his Ph.D. in Bioengineering at Rice University in 2009. He was a Department of Defense Postdoctoral Fellow at the Beckman Laser Institute at the University of California, Irvine studying under Professor Bruce Tromberg prior to joining the faculty at Boston University in 2012.

Early breast cancer treatment response monitoring with real-time diffuse optical imaging
09/01/2021 - 08/31/2024 (PI)
Department of Defense/Army Medical Research Acquisition Activity

Frequency domain diffuse optical spectroscopy and diffuse correlation spectroscopy for assessing inspiratory muscle metabolism in mechanically ventilated patients
09/15/2021 - 06/30/2024 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering

Label-free measurement of blood lipids with hyperspectral short-wave infrared spatial frequency domain imaging to improve cardiovascular disease risk prediction and treatment monitoring
07/01/2020 - 03/31/2024 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering

Frequency domain shortwave infrared spectroscopy (FD-SWIRS) for volume status monitoring during hemodialysis in end stage kidney disease
03/01/2022 - 01/31/2024 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases

Estimating blood pressure changes using laser speckle contrast measurements on the wrist and hand
12/07/2021 - 10/31/2023 (PI)
Facebook Technologies, LLC

EFRI CEE: Optically Controlled Localized Epigenetic Chromatin Remodeling with Photoactivatable CRISPR-dCas9
09/01/2018 - 08/31/2023 (Subcontract PI)
Beth Israel Deaconess Medical Center, Inc National Science Fdn

Multiplexed Imaging in the Near Infrared with Indium Phosphide Quantum Shells
08/01/2022 - 07/31/2023 (Subcontract PI)
Northeastern University NIH NIGMS

A wearable probe for deep tissue imaging of hemodynamics in breast tumors
01/01/2022 - 06/30/2023 (PI)
American Cancer Society, Inc.

Development of less toxic treatment strategies for metastatic and drug resistant breast cancer using noninvasive optical monitoring
09/01/2015 - 08/31/2021 (PI)
Department of Defense/Army Medical Research Acquisition Activity

A wearable probe for deep tissue imaging of hemodynamics in breast tumors
07/01/2018 - 12/31/2020 (PI)
American Cancer Society, Inc.

Showing 10 of 16 results. Show All Results


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Garrett A, Kim B, Sie EJ, Gurel NZ, Marsili F, Boas DA, Roblyer D. Simultaneous photoplethysmography and blood flow measurements towards the estimation of blood pressure using speckle contrast optical spectroscopy. Biomed Opt Express. 2023 Apr 01; 14(4):1594-1607.View Related Profiles. PMID: 37078049; PMCID: PMC10110303; DOI: 10.1364/BOE.482740;
  2. Karrobi K, Tank A, Fuzail MA, Kalidoss M, Tilbury K, Zaman M, Ferruzzi J, Roblyer D. Fluorescence Lifetime Imaging Microscopy (FLIM) reveals spatial-metabolic changes in 3D breast cancer spheroids. Sci Rep. 2023 Mar 03; 13(1):3624.View Related Profiles. PMID: 36869092; PMCID: PMC9984376; DOI: 10.1038/s41598-023-30403-7;
  3. Pilvar A, Plutzky J, Pierce M, Roblyer D. Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties. J Biomed Opt. 2022 Jun; 27(6). PMID: 35715883; PMCID: PMC9204261; DOI: 10.1117/1.JBO.27.6.066003;
  4. Vergato C, Doshi KA, Roblyer D, Waxman DJ. Type-I interferon signaling is essential for robust metronomic chemo-immunogenic tumor regression in murine breast cancer. Cancer Res Commun. 2022 Apr; 2(4):246-257.View Related Profiles. PMID: 36187936; PMCID: PMC9524291; DOI: 10.1158/2767-9764.crc-21-0148;
  5. Tank A, Vergato C, Waxman DJ, Roblyer D. Spatial frequency domain imaging for monitoring immune-mediated chemotherapy treatment response and resistance in a murine breast cancer model. Sci Rep. 2022 Apr 07; 12(1):5864.View Related Profiles. PMID: 35393476; PMCID: PMC8989878; DOI: 10.1038/s41598-022-09671-2;
  6. Vergato C, DOshi K, Roblyer D, Waxman DJ. Type-I Interferon Signaling Is Essential for Robust Metronomic Chemo-Immunogenic Tumor Regression in Murine Breast Cancer. 2022. View Publication
  7. Applegate MB, Amelard R, Gomez CA, Roblyer D. Real-Time Handheld Probe Tracking and Image Formation Using Digital Frequency-Domain Diffuse Optical Spectroscopy. IEEE Trans Biomed Eng. 2021 11; 68(11):3399-3409. PMID: 33835913; PMCID: PMC8612633; DOI: 10.1109/TBME.2021.3072036;
  8. Jawde SB, Karrobi K, Roblyer D, Vicario F, Herrmann J, Casey D, Lutchen KR, Stamenovic D, Bates JHT, Suki B. Inflation instability in the lung: an analytical model of a thick-walled alveolus with wavy fibres under large deformations. J R Soc Interface. 2021 10; 18(183):20210594.View Related Profiles. PMID: 34637644; PMCID: PMC8510704; DOI: 10.1098/rsif.2021.0594;
  9. Kang W, Ferruzzi J, Spatarelu CP, Han YL, Sharma Y, Koehler SA, Mitchel JA, Khan A, Butler JP, Roblyer D, Zaman MH, Park JA, Guo M, Chen Z, Pegoraro AF, Fredberg JJ. A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation. iScience. 2021 Nov 19; 24(11):103252.View Related Profiles. PMID: 34755092; PMCID: PMC8564056; DOI: 10.1016/j.isci.2021.103252;
  10. Istfan R, Gómez CA, Applegate M, Rozenberg D, Reid WD, Roblyer D. Hemodynamics of the sternocleidomastoid measured with frequency domain near-infrared spectroscopy towards non-invasive monitoring during mechanical ventilation. Biomed Opt Express. 2021 Jul 01; 12(7):4147-4162. PMID: 34457405; PMCID: PMC8367268; DOI: 10.1364/BOE.430423;
Showing 10 of 67 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 66 publications over 17 distinct years, with a maximum of 8 publications in 2018 and 2020

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44 Cummington St
Boston MA 02215
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