Darren Roblyer | Profiles RNS

Darren Roblyer, PhD

Professor

Boston University College of Engineering

Biomedical Engineering

PhD, Rice University
BS, Johns Hopkins University

Websites

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ORCID : 0000-0002-5301-4364

Darren Roblyer is a professor of Biomedical Engineering and Electrical and Computer Engineering at Boston University. His research focuses on translational diffuse optical imaging and spectroscopy. His group develops both wearables and frequency-domain near-infrared spectroscopy techniques to address unmet clinical needs in cancer, cardiovascular disease, and kidney disease.

Prof. Roblyer received a B.S. in Biomedical Engineering from Johns Hopkins University in 2004, and received his Ph.D. in Bioengineering at Rice University in 2009. He was a Department of Defense Postdoctoral Fellow at the Beckman Laser Institute at the University of California, Irvine studying under Professor Bruce Tromberg prior to joining the faculty at Boston University in 2012.

BU Research

A Relaxin-loaded Hydrogel for the Treatment of Hypertrophic Scars
07/01/2024 - 06/30/2029 (Multi-PI)
PI: Darren Roblyer, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR083161-02

Handheld Spatial Frequency Domain Imaging using Spiral Illumination for Skin Imaging
08/01/2025 - 04/30/2029 (Multi-PI)
PI: Darren Roblyer, PhD
NIH/National Institute of Biomedical Imaging & Bioengineering
1R01EB037660-01

Assessing spatial frequency domain imaging as an objective quantification of longitudinal skin changes in scleroderma
04/02/2025 - 03/31/2029 (Co-Investigator)
PI: Andreea M. Bujor, MD, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
1R01AR085317-01

Handheld Spatial Frequency Domain Imaging (SFDI) to measure skin involvement in Scleroderma
08/01/2025 - 07/31/2028 (Key Person / Mentor)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
1F31AR085975-01

REU Site: Translational Biophotonics
04/01/2025 - 03/31/2028 (Multi-PI)
PI: Darren Roblyer, PhD
National Science Foundation
EEC-2447191

Remote Patient Monitoring of Breast Cancer Treatment Using at-home Optical Imaging
01/01/2025 - 12/31/2026 (PI)
American Cancer Society, Inc.

Early breast cancer treatment response monitoring with real-time diffuse optical imaging
09/01/2021 - 08/31/2025 (PI)
Department of Defense/Army Medical Research Acquisition Activity

Northeast AFRL Regional Research Convergence Hub (NE Hub)
08/01/2024 - 07/31/2025 (Subcontract PI)
Cornell University DOD Air Force Mat C

Multiplexed Imaging in the Near Infrared with Indium Phosphide Quantum Shells
08/01/2022 - 07/31/2025 (Subcontract PI)
Northeastern University NIH NIGMS
7R01GM129437-04

Frequency domain shortwave infrared spectroscopy (FD-SWIRS) for volume status monitoring during hemodialysis in end stage kidney disease
03/01/2022 - 01/31/2025 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R21DK132784-02

Showing 10 of 23 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Matsumura U, Rodrigues A, Mori T, Rassam P, Van Hollebeke M, Rozenberg D, Brochard L, Goligher EC, Roblyer D, Reid WD. Timing of activation of different inspiratory muscles during incremental inspiratory loading in healthy adults: A cross-sectional study. Can J Respir Ther. 2025; 61:191-205. PMID: 40822663; PMCID: PMC12357601; DOI: 10.29390/001c.143022;

Garrett A, Kim B, Gurel NZ, Sie EJ, Wilson BK, Marsili F, Forman JP, Hamburg NM, Boas DA, Roblyer D. Speckle contrast optical spectroscopy for cuffless blood pressure estimation based on microvascular blood flow and volume oscillations. Biomed Opt Express. 2025 Aug 01; 16(8):3004-3016.View Related Profiles.

Roblyer, Darren
Boas, David
Forman, John
Hamburg, Naomi

PMID: 40809974; PMCID: PMC12339296; DOI: 10.1364/BOE.560022;

Parsanasab M, Mehendale AM, Karrobi K, Roblyer D, Venugopalan V. Structured light imaging mesoscopy: detection of embedded morphological changes in superficial tissues. J Biomed Opt. 2025 Jun; 30(6):065001. PMID: 40534904; PMCID: PMC12175002; DOI: 10.1117/1.JBO.30.6.065001;

Suciu D, Pham T, Wei LL, Guruprasad S, Roblyer D. Frequency domain broadband short-wave infrared spectroscopy for measurement of tissue optical properties from 685 to 1300 nm. J Biomed Opt. 2025 Apr; 30(4):045001. PMID: 40292022; PMCID: PMC12022801; DOI: 10.1117/1.JBO.30.4.045001;

Pham T, Wei LL, Roblyer D. Cross-wavelength calibrating method for real-time imaging of tissue optical properties using frequency-domain diffuse optical spectroscopy. Biomed Opt Express. 2024 Aug 01; 15(8):4963-4979. PMID: 39346994; PMCID: PMC11427195; DOI: 10.1364/BOE.529551;

Rodrigues A, Shingai K, Gómez CA, Rassam P, Rozenberg D, Goligher E, Brochard L, Roblyer D, Reid WD. Continuous measurements of respiratory muscle blood flow and oxygen consumption using noninvasive frequency-domain near-infrared spectroscopy and diffuse correlation spectroscopy. J Appl Physiol (1985). 2024 Aug 01; 137(2):382-393. PMID: 38867669; PMCID: PMC11424177; DOI: 10.1152/japplphysiol.00871.2023;

Tao R, Gröhl J, Hacker L, Pifferi A, Roblyer D, Bohndiek SE. Tutorial on methods for estimation of optical absorption and scattering properties of tissue. J Biomed Opt. 2024 Jun; 29(6):060801. PMID: 38864093; PMCID: PMC11166171; DOI: 10.1117/1.JBO.29.6.060801;

Gómez CA, Brochard L, Goligher EC, Rozenberg D, Reid WD, Roblyer D. Combined frequency domain near-infrared spectroscopy and diffuse correlation spectroscopy system for comprehensive metabolic monitoring of inspiratory muscles during loading. J Biomed Opt. 2024 Mar; 29(3):035002. PMID: 38532926; PMCID: PMC10965138; DOI: 10.1117/1.JBO.29.3.035002;

Gómez CA, Brochard L, Goligher EC, Rozenberg D, Reid WD, Roblyer D. A combined frequency domain near infrared spectroscopy and diffuse correlation spectroscopy system for comprehensive metabolic monitoring of inspiratory muscles during loading. bioRxiv. 2023 Dec 01. PMID: 38076980; PMCID: PMC10705398; DOI: 10.1101/2023.11.30.569133;

Fried D, Pierce M, Roblyer D. Special Section Guest Editorial: Short Wave Infrared Techniques and Applications in Biomedical Optics. J Biomed Opt. 2023 Sep; 28(9):094800. PMID: 37692561; PMCID: PMC10492591; DOI: 10.1117/1.JBO.28.9.094800;

Showing 10 of 81 results. Show More

Zhang S, Grifno G, Passaro R, Regan K, Zheng S, Hadzipasic M, Banerji R, O'Connor L, Chu V, Kim SY, Yang J, Shi L, Karrobi K, Roblyer D, Grinstaff MW, Nia HT. Intravital measurements of solid stresses in tumours reveal length-scale and microenvironmentally dependent force transmission. Nat Biomed Eng. 2023 Nov; 7(11):1473-1492.View Related Profiles.

Roblyer, Darren
Nia, Hadi
Grinstaff, Mark

PMID: 37640900; PMCID: PMC10836235; DOI: 10.1038/s41551-023-01080-8;

Spink SS, Pilvar A, Wei LL, Frias J, Anders K, Franco ST, Rose OC, Freeman M, Bag G, Huang H, Roblyer D. Shortwave infrared diffuse optical wearable probe for quantification of water and lipid content in emulsion phantoms using deep learning. J Biomed Opt. 2023 Sep; 28(9):094808. PMID: 37313427; PMCID: PMC10258729; DOI: 10.1117/1.JBO.28.9.094808;

Pilvar A, Smith DW, Plutzky J, Roblyer D. Feasibility of postprandial optical scattering of lipoproteins in blood as an optical marker of cardiovascular disease risk: modeling and experimental validation. J Biomed Opt. 2023 Jun; 28(6):065002. PMID: 37305780; PMCID: PMC10249051; DOI: 10.1117/1.JBO.28.6.065002;

Pilvar A, Mehendale AM, Karrobi K, El-Adili F, Bujor A, Roblyer D. Spatial frequency domain imaging for the assessment of scleroderma skin involvement. Biomed Opt Express. 2023 Jun 01; 14(6):2955-2968.View Related Profiles.

Bujor, Andreea
Roblyer, Darren

PMID: 37342706; PMCID: PMC10278615; DOI: 10.1364/BOE.489609;

Garrett A, Kim B, Sie EJ, Gurel NZ, Marsili F, Boas DA, Roblyer D. Simultaneous photoplethysmography and blood flow measurements towards the estimation of blood pressure using speckle contrast optical spectroscopy. Biomed Opt Express. 2023 Apr 01; 14(4):1594-1607.View Related Profiles.

Roblyer, Darren
Boas, David

PMID: 37078049; PMCID: PMC10110303; DOI: 10.1364/BOE.482740;

Karrobi K, Tank A, Fuzail MA, Kalidoss M, Tilbury K, Zaman M, Ferruzzi J, Roblyer D. Fluorescence Lifetime Imaging Microscopy (FLIM) reveals spatial-metabolic changes in 3D breast cancer spheroids. Sci Rep. 2023 Mar 03; 13(1):3624.View Related Profiles.

Roblyer, Darren
Zaman, Muhammad

PMID: 36869092; PMCID: PMC9984376; DOI: 10.1038/s41598-023-30403-7;

Pilvar A, Plutzky J, Pierce M, Roblyer D. Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties. J Biomed Opt. 2022 Jun; 27(6). PMID: 35715883; PMCID: PMC9204261; DOI: 10.1117/1.JBO.27.6.066003;

Vergato C, Doshi KA, Roblyer D, Waxman DJ. Type-I interferon signaling is essential for robust metronomic chemo-immunogenic tumor regression in murine breast cancer. Cancer Res Commun. 2022 Apr; 2(4):246-257.View Related Profiles.

Roblyer, Darren
Waxman, David

PMID: 36187936; PMCID: PMC9524291; DOI: 10.1158/2767-9764.crc-21-0148;

Tank A, Vergato C, Waxman DJ, Roblyer D. Spatial frequency domain imaging for monitoring immune-mediated chemotherapy treatment response and resistance in a murine breast cancer model. Sci Rep. 2022 Apr 07; 12(1):5864.View Related Profiles.

Roblyer, Darren
Waxman, David

PMID: 35393476; PMCID: PMC8989878; DOI: 10.1038/s41598-022-09671-2;

Vergato C, DOshi K, Roblyer D, Waxman DJ. Type-I Interferon Signaling Is Essential for Robust Metronomic Chemo-Immunogenic Tumor Regression in Murine Breast Cancer. 2022. View Publication

Applegate MB, Amelard R, Gomez CA, Roblyer D. Real-Time Handheld Probe Tracking and Image Formation Using Digital Frequency-Domain Diffuse Optical Spectroscopy. IEEE Trans Biomed Eng. 2021 11; 68(11):3399-3409. PMID: 33835913; PMCID: PMC8612633; DOI: 10.1109/TBME.2021.3072036;

Jawde SB, Karrobi K, Roblyer D, Vicario F, Herrmann J, Casey D, Lutchen KR, Stamenovic D, Bates JHT, Suki B. Inflation instability in the lung: an analytical model of a thick-walled alveolus with wavy fibres under large deformations. J R Soc Interface. 2021 10; 18(183):20210594.View Related Profiles.

Suki, Bela
Roblyer, Darren
Stamenovic, Dimitrije
Lutchen, Kenneth

PMID: 34637644; PMCID: PMC8510704; DOI: 10.1098/rsif.2021.0594;

Kang W, Ferruzzi J, Spatarelu CP, Han YL, Sharma Y, Koehler SA, Mitchel JA, Khan A, Butler JP, Roblyer D, Zaman MH, Park JA, Guo M, Chen Z, Pegoraro AF, Fredberg JJ. A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation. iScience. 2021 Nov 19; 24(11):103252.View Related Profiles.

Roblyer, Darren
Zaman, Muhammad

PMID: 34755092; PMCID: PMC8564056; DOI: 10.1016/j.isci.2021.103252;

Istfan R, Gómez CA, Applegate M, Rozenberg D, Reid WD, Roblyer D. Hemodynamics of the sternocleidomastoid measured with frequency domain near-infrared spectroscopy towards non-invasive monitoring during mechanical ventilation. Biomed Opt Express. 2021 Jul 01; 12(7):4147-4162. PMID: 34457405; PMCID: PMC8367268; DOI: 10.1364/BOE.430423;

Spink S, Teng F, Pera V, Peterson H, Cormier T, Sauer-Budge A, Chargin D, Brookfield S, Eggebrecht A, Ko NY, Roblyer D. High optode-density wearable diffuse optical probe for monitoring paced breathing hemodynamics in breast tissue. J Biomed Opt. 2021 06; 26(6).View Related Profiles.

Roblyer, Darren
Ko, Naomi

PMID: 34080400; PMCID: PMC8170390; DOI: 10.1117/1.JBO.26.6.062708;

Applegate M, Gómez C, Roblyer D. Modulation frequency selection and efficient look-up table inversion for frequency domain diffuse optical spectroscopy. J Biomed Opt. 2021 03; 26(3). PMID: 33768742; PMCID: PMC7992233; DOI: 10.1117/1.JBO.26.3.036007;

Tabassum S, Tank A, Wang F, Karrobi K, Vergato C, Bigio IJ, Waxman DJ, Roblyer D. Optical scattering as an early marker of apoptosis during chemotherapy and antiangiogenic therapy in murine models of prostate and breast cancer. Neoplasia. 2021 03; 23(3):294-303.View Related Profiles.

Roblyer, Darren
Waxman, David
Bigio, Irving

PMID: 33578267; PMCID: PMC7881266; DOI: 10.1016/j.neo.2021.01.005;

Applegate MB, Spink SS, Roblyer D. Dual-DMD hyperspectral spatial frequency domain imaging (SFDI) using dispersed broadband illumination with a demonstration of blood stain spectral monitoring. Biomed Opt Express. 2021 Jan 01; 12(1):676-688. PMID: 33520393; PMCID: PMC7818964; DOI: 10.1364/BOE.411976;

Sunil S, Evren Erdener S, Cheng X, Kura S, Tang J, Jiang J, Karrobi K, Kiliç K, Roblyer D, Boas DA. Stroke core revealed by tissue scattering using spatial frequency domain imaging. Neuroimage Clin. 2021; 29:102539.View Related Profiles.

Roblyer, Darren
Boas, David

PMID: 33385882; PMCID: PMC7779322; DOI: 10.1016/j.nicl.2020.102539;

DeCamp SJ, Tsuda VMK, Ferruzzi J, Koehler SA, Giblin JT, Roblyer D, Zaman MH, Weiss ST, Kiliç A, De Marzio M, Park CY, Ogassavara NC, Mitchel JA, Butler JP, Fredberg JJ. Epithelial layer unjamming shifts energy metabolism toward glycolysis. Sci Rep. 2020 10 27; 10(1):18302.View Related Profiles.

Roblyer, Darren
Zaman, Muhammad

PMID: 33110128; PMCID: PMC7591531; DOI: 10.1038/s41598-020-74992-z;

Zhao Y, Pilvar A, Tank A, Peterson H, Jiang J, Aster JC, Dumas JP, Pierce MC, Roblyer D. Shortwave-infrared meso-patterned imaging enables label-free mapping of tissue water and lipid content. Nat Commun. 2020 10 23; 11(1):5355. PMID: 33097705; PMCID: PMC7585425; DOI: 10.1038/s41467-020-19128-7;

Roblyer D. Perspective on the increasing role of optical wearables and remote patient monitoring in the COVID-19 era and beyond. J Biomed Opt. 2020 10; 25(10). PMID: 33089674; PMCID: PMC7575829; DOI: 10.1117/1.JBO.25.10.102703;

Peterson HM, Tank A, Geller DS, Yang R, Gorlick R, Hoang BH, Roblyer D. Characterization of bony anatomic regions in pediatric and adult healthy volunteers using diffuse optical spectroscopic imaging. J Biomed Opt. 2020 08; 25(8):1-17. PMID: 32790252; PMCID: PMC7422854; DOI: 10.1117/1.JBO.25.8.086002;

Tank A, Peterson HM, Pera V, Tabassum S, Leproux A, O'Sullivan T, Jones E, Cabral H, Ko N, Mehta RS, Tromberg BJ, Roblyer D. Diffuse optical spectroscopic imaging reveals distinct early breast tumor hemodynamic responses to metronomic and maximum tolerated dose regimens. Breast Cancer Res. 2020 03 13; 22(1):29.View Related Profiles.

Roblyer, Darren
Cabral, Howard
Ko, Naomi

PMID: 32169100; PMCID: PMC7071774; DOI: 10.1186/s13058-020-01262-1;

Applegate M, Karrobi K, Angelo J, Austin W, Tabassum S, Aguénounon E, Tilbury K, Saager R, Gioux S, Roblyer D. OpenSFDI: an open-source guide for constructing a spatial frequency domain imaging system. J Biomed Opt. 2020 01; 25(1):1-13. PMID: 31925946; PMCID: PMC7008504; DOI: 10.1117/1.JBO.25.1.016002;

Ferruzzi J, Sun M, Gkousioudi A, Pilvar A, Roblyer D, Zhang Y, Zaman MH. Compressive Remodeling Alters Fluid Transport Properties of Collagen Networks - Implications for Tumor Growth. Sci Rep. 2019 11 20; 9(1):17151.View Related Profiles.

Roblyer, Darren
Zaman, Muhammad

PMID: 31748563; PMCID: PMC6868165; DOI: 10.1038/s41598-019-50268-z;

Karrobi K, Tank A, Tabassum S, Pera V, Roblyer D. Diffuse and nonlinear imaging of multiscale vascular parameters for in vivo monitoring of preclinical mammary tumors. J Biophotonics. 2019 06; 12(6):e201800379. PMID: 30706695; DOI: 10.1002/jbio.201800379;

Bungart B, Cao Y, Yang-Tran T, Gorsky S, Lan L, Roblyer D, Koch MO, Cheng L, Masterson T, Cheng JX. Cylindrical illumination with angular coupling for whole-prostate photoacoustic tomography. Biomed Opt Express. 2019 Mar 01; 10(3):1405-1419.View Related Profiles.

Roblyer, Darren
Cheng, Ji-Xin

PMID: 30891355; PMCID: PMC6420282; DOI: 10.1364/BOE.10.001405;

Zhao Y, Deng Y, Bao F, Peterson H, Istfan R, Roblyer D. Deep learning model for ultrafast multifrequency optical property extractions for spatial frequency domain imaging. Opt Lett. 2018 Nov 15; 43(22):5669-5672. PMID: 30439924; DOI: 10.1364/OL.43.005669;

Zhao Y, Applegate MB, Istfan R, Pande A, Roblyer D. Quantitative real-time pulse oximetry with ultrafast frequency-domain diffuse optics and deep neural network processing. Biomed Opt Express. 2018 Dec 01; 9(12):5997-6008. PMID: 31065408; PMCID: PMC6491012; DOI: 10.1364/BOE.9.005997;

Cochran JM, Busch DR, Leproux A, Zhang Z, O'Sullivan TD, Cerussi AE, Carpenter PM, Mehta RS, Roblyer D, Yang W, Paulsen KD, Pogue B, Jiang S, Kaufman PA, Chung SH, Schnall M, Snyder BS, Hylton N, Carp SA, Isakoff SJ, Mankoff D, Tromberg BJ, Yodh AG. Tissue oxygen saturation predicts response to breast cancer neoadjuvant chemotherapy within 10 days of treatment. J Biomed Opt. 2018 10; 24(2):1-11. PMID: 30338678; PMCID: PMC6194199; DOI: 10.1117/1.JBO.24.2.021202;

Hayakawa CK, Karrobi K, Pera V, Roblyer D, Venugopalan V. Optical sampling depth in the spatial frequency domain. J Biomed Opt. 2018 09; 24(7):1-14. PMID: 30218504; PMCID: PMC6675966; DOI: 10.1117/1.JBO.24.7.071603;

Hayakawa CK, Karrobi K, Pera V, Roblyer D, Venugopalan V. Optical sampling depth in the spatial frequency domain. J Biomed Opt. 2018 08; 23(8):1-14. PMID: 30141285; DOI: 10.1117/1.JBO.24.7.071603;

Tabassum S, Pera V, Greening G, Muldoon TJ, Roblyer D. Two-layer inverse model for improved longitudinal preclinical tumor imaging in the spatial frequency domain. J Biomed Opt. 2018 07; 23(7):1-12. PMID: 30054994; DOI: 10.1117/1.JBO.23.7.076011;

Applegate MB, Roblyer D. Multi-distance diffuse optical spectroscopy with a single optode via hypotrochoidal scanning. Opt Lett. 2018 Feb 15; 43(4):747-750. PMID: 29444068; DOI: 10.1364/OL.43.000747;

Pera V, Karrobi K, Tabassum S, Teng F, Roblyer D. Optical property uncertainty estimates for spatial frequency domain imaging. Biomed Opt Express. 2018 Feb 01; 9(2):661-678. PMID: 29552403; PMCID: PMC5854069; DOI: 10.1364/BOE.9.000661;

Aguirre AD, Apiou-Sbirlea G, Roblyer D, Tromberg BJ. Special Section Guest Editorial: Translational Biophotonics. J Biomed Opt. 2017 12; 22(12):1-2. PMID: 29282907; DOI: 10.1117/1.JBO.22.12.121601;

Peterson HM, Hoang BH, Geller D, Yang R, Gorlick R, Berger J, Tingling J, Roth M, Gill J, Roblyer D. In vivo, noninvasive functional measurements of bone sarcoma using diffuse optical spectroscopic imaging. J Biomed Opt. 2017 Dec; 22(12):1-9. PMID: 29264893; DOI: 10.1117/1.JBO.22.12.121612;

Leproux, O'Sullivan TD, Cerussi A, Durkin A, Hill B, Hylton N, Yodh AG, Carp SA, Boas D, Jiang S, Paulsen KD, Pogue B, Roblyer D, Yang W, Tromberg BJ. Performance assessment of diffuse optical spectroscopic imaging instruments in a 2-year multicenter breast cancer trial J Biomed Opt. 2017 12 01; 22(12):121604.View Related Profiles.

Roblyer, Darren
Boas, David

PMID: 29389104; PMCID: PMC5995138; DOI: 10.1117/1.JBO.22.12.121604;

Applegate MB, Roblyer D. High-speed spatial frequency domain imaging with temporally modulated light. J Biomed Opt. 2017 07 01; 22(7):76019. PMID: 28759675; DOI: 10.1117/1.JBO.22.7.076019;

Torjesen A, Istfan R, Roblyer D. Ultrafast wavelength multiplexed broad bandwidth digital diffuse optical spectroscopy for in vivo extraction of tissue optical properties. J Biomed Opt. 2017 03 01; 22(3):36009. PMID: 28280840; DOI: 10.1117/1.JBO.22.3.036009;

Teng F, Cormier T, Sauer-Budge A, Chaudhury R, Pera V, Istfan R, Chargin D, Brookfield S, Ko NY, Roblyer DM. Wearable near-infrared optical probe for continuous monitoring during breast cancer neoadjuvant chemotherapy infusions. J Biomed Opt. 2017 01 01; 22(1):14001.View Related Profiles.

Roblyer, Darren
Ko, Naomi

PMID: 28114449; PMCID: PMC5289133; DOI: 10.1117/1.JBO.22.1.014001;

Tabassum S, Zhao Y, Istfan R, Wu J, Waxman DJ, Roblyer D. Feasibility of spatial frequency domain imaging (SFDI) for optically characterizing a preclinical oncology model. Biomed Opt Express. 2016 Oct 01; 7(10):4154-4170.View Related Profiles.

Roblyer, Darren
Waxman, David

PMID: 27867722; PMCID: PMC5102554; DOI: 10.1364/BOE.7.004154;

Tromberg BJ, Zhang Z, Leproux A, O'Sullivan TD, Cerussi AE, Carpenter PM, Mehta RS, Roblyer D, Yang W, Paulsen KD, Pogue BW, Jiang S, Kaufman PA, Yodh AG, Chung SH, Schnall M, Snyder BS, Hylton N, Boas DA, Carp SA, Isakoff SJ, Mankoff D. Predicting Responses to Neoadjuvant Chemotherapy in Breast Cancer: ACRIN 6691 Trial of Diffuse Optical Spectroscopic Imaging. Cancer Res. 2016 10 15; 76(20):5933-5944.View Related Profiles.

Roblyer, Darren
Boas, David

PMID: 27527559; PMCID: PMC5148152; DOI: 10.1158/0008-5472.CAN-16-0346;

Zhao Y, Tabassum S, Piracha S, Nandhu MS, Viapiano M, Roblyer D. Angle correction for small animal tumor imaging with spatial frequency domain imaging (SFDI). Biomed Opt Express. 2016 Jun 01; 7(6):2373-84. PMID: 27375952; PMCID: PMC4918590; DOI: 10.1364/BOE.7.002373;

Roblyer D, Schwarz RA, Richards-Kortum RR. Fluorescence spectroscopy. 2016.

Diep P, Pannem S, Sweer J, Lo J, Snyder M, Stueber G, Zhao Y, Tabassum S, Istfan R, Wu J, Erramilli S, Roblyer D. Three-dimensional printed optical phantoms with customized absorption and scattering properties. Biomed Opt Express. 2015 Nov 01; 6(11):4212-20. PMID: 26600987; PMCID: PMC4646531; DOI: 10.1364/BOE.6.004212;

Zhao Y, Roblyer D. Spatial mapping of fluorophore quantum yield in diffusive media. J Biomed Opt. 2015 Aug; 20(8):86013. PMID: 26308165; DOI: 10.1117/1.JBO.20.8.086013;

Singh-Moon RP, Roblyer DM, Bigio IJ, Joshi S. Spatial mapping of drug delivery to brain tissue using hyperspectral spatial frequency-domain imaging. J Biomed Opt. 2014 Sep; 19(9):96003.View Related Profiles.

Roblyer, Darren
Bigio, Irving

PMID: 25199058; PMCID: PMC4157604; DOI: 10.1117/1.JBO.19.9.096003;

Jung J, Istfan R, Roblyer D. Note: A simple broad bandwidth undersampling frequency-domain digital diffuse optical spectroscopy system. Rev Sci Instrum. 2014 Jul; 85(7):076108. PMID: 25085193; PMCID: PMC4119194; DOI: 10.1063/1.4890669;

Jung J, Istfan R, Roblyer D. Effect of modulation frequency bandwidth on measurement accuracy and precision for digital Diffuse Optical Spectroscopy (dDOS). Proceedings of SPIE - The International Society for Optical Engineering. 2014; 8936. View Publication

Greening GJ, Istfan R, Higgins LM, Balachandran K, Roblyer D, Pierce MC, Muldoon TJ. Characterization of thin poly(dimethylsiloxane)-based tissue-simulating phantoms with tunable reduced scattering and absorption coefficients at visible and near-infrared wavelengths. J Biomed Opt. 2014; 19(11):115002. PMID: 25387084; PMCID: PMC4227531; DOI: 10.1117/1.JBO.19.11.115002;

Roblyer D, O'Sullivan TD, Warren RV, Tromberg B. Feasibility of Direct Digital Sampling for Diffuse Optical Frequency Domain Spectroscopy in Tissue. Meas Sci Technol. 2013 Apr 01; 24(4):045501. PMID: 24678143; PMCID: PMC3963501; DOI: 10.1088/0957-0233/24/4/045501;

O'Sullivan TD, Leproux A, Chen JH, Bahri S, Matlock A, Roblyer D, McLaren CE, Chen WP, Cerussi AE, Su MY, Tromberg BJ. Optical imaging correlates with magnetic resonance imaging breast density and reveals composition changes during neoadjuvant chemotherapy. Breast Cancer Res. 2013 Feb 22; 15(1):R14. PMID: 23433249; PMCID: PMC3672664; DOI: 10.1186/bcr3389;

Ueda S, Roblyer D, Cerussi A, Durkin A, Leproux A, Santoro Y, Xu S, O'Sullivan TD, Hsiang D, Mehta R, Butler J, Tromberg BJ. Baseline tumor oxygen saturation correlates with a pathologic complete response in breast cancer patients undergoing neoadjuvant chemotherapy. Cancer Res. 2012 Sep 01; 72(17):4318-28. PMID: 22777823; PMCID: PMC3609716; DOI: 10.1158/0008-5472.CAN-12-0056;

Cerussi AE, Warren R, Hill B, Roblyer D, Leproux A, Durkin AF, O'Sullivan TD, Keene S, Haghany H, Quang T, Mantulin WM, Tromberg BJ. Tissue phantoms in multicenter clinical trials for diffuse optical technologies. Biomed Opt Express. 2012 May 01; 3(5):966-71. PMID: 22567589; PMCID: PMC3342201; DOI: 10.1364/BOE.3.000966;

Roblyer D, Ueda S, Cerussi AE, Durkin AJ. Functional Measurements of Tumor Response during Neoadjuvant Chemotherapy Infusion and Early during Treatment Using Diffuse Optical Spectroscopic Imaging. Cancer Research. 2012; 71(24 Suppl.):P2-09-15.

Roblyer D, Ueda S, Cerussi A, Tanamai W, Durkin A, Mehta R, Hsiang D, Butler JA, McLaren C, Chen WP, Tromberg B. Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment. Proc Natl Acad Sci U S A. 2011 Aug 30; 108(35):14626-31. PMID: 21852577; PMCID: PMC3167535; DOI: 10.1073/pnas.1013103108;

Muldoon TJ, Roblyer D, Williams MD, Stepanek VM, Richards-Kortum R, Gillenwater AM. Noninvasive imaging of oral neoplasia with a high-resolution fiber-optic microendoscope. Head Neck. 2012 Mar; 34(3):305-12. PMID: 21413101; PMCID: PMC3078517; DOI: 10.1002/hed.21735;

Roblyer D, Kurachi C, Stepanek V, Schwarz RA, Williams MD, El-Naggar AK, Lee JJ, Gillenwater AM, Richards-Kortum R. Comparison of multispectral wide-field optical imaging modalities to maximize image contrast for objective discrimination of oral neoplasia. J Biomed Opt. 2010 Nov-Dec; 15(6):066017. PMID: 21198191; PMCID: PMC3013151; DOI: 10.1117/1.3516593;

Pierce MC, Rosback K, Roblyer D, Muldoon T, Williams MD, el-Naggar AK, Gillen A, Kortum R. Wide-field and high-resolution optical imaging for early detection of oral neoplasia. Head & Neck Oncology. 2010; 2(Suppl. 1). View Publication

Rahman MS, Ingole N, Roblyer D, Stepanek V, Richards-Kortum R, Gillenwater A, Shastri S, Chaturvedi P. Evaluation of a low-cost, portable imaging system for early detection of oral cancer. Head Neck Oncol. 2010 Apr 22; 2:10. PMID: 20409347; PMCID: PMC2867772; DOI: 10.1186/1758-3284-2-10;

Muldoon TJ, Thekkek N, Roblyer D, Maru D, Harpaz N, Potack J, Anandasabapathy S, Richards-Kortum R. Evaluation of quantitative image analysis criteria for the high-resolution microendoscopic detection of neoplasia in Barrett's esophagus. J Biomed Opt. 2010 Mar-Apr; 15(2):026027. PMID: 20459272; PMCID: PMC2874050; DOI: 10.1117/1.3406386;

Roblyer D, Kortum RR. Optical diagnostics for early detection of oral cancer. 2010.

Roblyer D, Kurachi C, Stepanek V, Williams MD, El-Naggar AK, Lee JJ, Gillenwater AM, Richards-Kortum R. Objective detection and delineation of oral neoplasia using autofluorescence imaging. Cancer Prev Res (Phila). 2009 May; 2(5):423-31. PMID: 19401530; PMCID: PMC2719708; DOI: 10.1158/1940-6207.CAPR-08-0229;

Roblyer D, Kurachi C, Gillenwater A, Kortum R. In Vivo Fluorescence Hyperspectral Imaging of Oral Neoplasia. Proceedings of SPIE - The International Society for Optical Engineering. 2009; 7169. View Publication

Javier DJ, Nitin N, Roblyer DM, Richards-Kortum R. Metal-based nanorods as molecule-specific contrast agents for reflectance imaging in 3D tissues. J Nanophotonics. 2008 Apr 23; 2(1):23506. PMID: 19066632; PMCID: PMC2597016; DOI: 10.1117/1.2927370;

Roblyer D, Richards-Kortum R, Sokolov K, El-Naggar AK, Williams MD, Kurachi C, Gillenwater AM. Multispectral optical imaging device for in vivo detection of oral neoplasia. J Biomed Opt. 2008 Mar-Apr; 13(2):024019. PMID: 18465982; PMCID: PMC3970814; DOI: 10.1117/1.2904658;

Roblyer D, Richards-Kortum R, Park SY, Adewole I, Follen M. Objective screening for cervical cancer in developing nations: lessons from Nigeria. Gynecol Oncol. 2007 Oct; 107(1 Suppl 1):S94-7. PMID: 17825396; DOI: 10.1016/j.ygyno.2007.07.042;

Nitin N, Javier DJ, Roblyer DM, Richards-Kortum R. Widefield and high-resolution reflectance imaging of gold and silver nanospheres. J Biomed Opt. 2007 Sep-Oct; 12(5):051505. PMID: 17994869; DOI: 10.1117/1.2800314;

Wall M, Heaster T, Tilbury K, Choi WJ, Roblyer D, Wang R, Skala M, Liu JTC. Imaging and Metabolism. Metabolic Imaging Approaches: Optical Imaging. 99-126. View Publication

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 80 publications over 19 distinct years, with a maximum of 8 publications in 2018 and 2020 and 2023

Bar chart showing 80 publications over 19 distinct years, with a maximum of 8 publications in 2018 and 2020 and 2023

Year	Publications
2007	2
2008	2
2009	2
2010	5
2011	2
2012	3
2013	2
2014	4
2015	2
2016	4
2017	6
2018	8
2019	3
2020	8
2021	7
2022	4
2023	8
2024	4
2025	4

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