Christopher W. Akey, PhD
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Cornell University

We are studying the structure and function of macromolecular machines and chaperones. In our work, we use biochemistry and molecular biology coupled with structural electron microscopy, X-ray crystallography and molecular modeling. This hybrid approach allows us to create snapshots of these large assemblies and thus, to infer function from form.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

The Structural Basis of Protein Biogenesis
09/01/2015 - 06/30/2019 (PI)
NIH/National Institute of General Medical Sciences

HMS Salary support for Dr. Guettler
10/01/2017 - 09/30/2018 (PI)
President & Fellows of Harvard College on behalf of Harvard Medical School

Apoptosomes Structure and Procaspase Activation
04/01/2012 - 12/31/2015 (PI)
NIH/National Institute of General Medical Sciences

The Structural Basis of Protein Biogenesis
01/01/1991 - 07/31/2014 (PI)
NIH/National Institute of General Medical Sciences

Structural and Cell Biology in Cardiovascular Systems
07/01/1977 - 08/31/2008 (PI)
NIH/National Heart, Lung, and Blood Institute
5 T32 HL07291 25

Structure and Function of Histone Chaperones
03/05/2004 - 02/29/2008 (PI)
NIH/National Institute of General Medical Sciences
5 R01 GM60537 08

New Tools for Exploring the Dynamic Interactome
08/01/2006 - 07/31/2007 (PI)
The Rockefeller University NIH NCRR

Nucleoplasmin & N1: Co-Chaperones in Nucleosome Assembly
01/01/2000 - 12/31/2003 (PI)
NIH/National Institute of General Medical Sciences
5 R01 GM60537 04

An IVEM for High Resolution Electron Cryo-Microscopy
04/01/2000 - 03/31/2001 (PI)
NIH/National Center for Health Research Resources
1 S10 RR14700 01

Yr Title Project-Sub Proj Pubs
2017 The Structural basis of Protein Biogenesis 5R01GM045377-22 6
2016 The Structural basis of Protein Biogenesis 5R01GM045377-21 6
2016 The Structural basis of Protein Biogenesis 3R01GM045377-21S1 6
2015 Apoptosomes Structure and Procaspase Activation 5R01GM063834-12 7
2015 The Structural basis of Protein Biogenesis 2R01GM045377-20 6
2014 Apoptosomes Structure and Procaspase Activation 5R01GM063834-11 7
2013 Apoptosomes Structure and Procaspase Activation 5R01GM063834-10 7
2012 Apoptosomes Structure and Procaspase Activation 2R01GM063834-09A1 7
2012 The Structural Basis of Protein Biogenesis 5R01GM045377-19 6
2011 RIBOSOME SECY PROTEIN 5P41RR002250-26-5270 187
Showing 10 of 67 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Dorstyn L, Akey CW, Kumar S. New insights into apoptosome structure and function. Cell Death Differ. 2018 Jul; 25(7):1194-1208. PMID: 29765111.
  2. Kim SJ, Fernandez-Martinez J, Nudelman I, Shi Y, Zhang W, Raveh B, Herricks T, Slaughter BD, Hogan JA, Upla P, Chemmama IE, Pellarin R, Echeverria I, Shivaraju M, Chaudhury AS, Wang J, Williams R, Unruh JR, Greenberg CH, Jacobs EY, Yu Z, de la Cruz MJ, Mironska R, Stokes DL, Aitchison JD, Jarrold MF, Gerton JL, Ludtke SJ, Akey CW, Chait BT, Sali A, Rout MP. Integrative structure and functional anatomy of a nuclear pore complex. Nature. 2018 Mar 22; 555(7697):475-482. PMID: 29539637.
  3. Mendez DL, Akey IV, Akey CW, Kranz RG. Oxidized or Reduced Cytochrome c and Axial Ligand Variants All Form the Apoptosome in Vitro. Biochemistry. 2017 Jun 06; 56(22):2766-2769. PMID: 28510448.
  4. Cheng TC, Akey IV, Yuan S, Yu Z, Ludtke SJ, Akey CW. A Near-Atomic Structure of the Dark Apoptosome Provides Insight into Assembly and Activation. Structure. 2017 Jan 03; 25(1):40-52.View Related Profiles. PMID: 27916517; DOI: 10.1016/j.str.2016.11.002;.
  5. Cheng TC, Hong C, Akey IV, Yuan S, Akey CW. A near atomic structure of the active human apoptosome. Elife. 2016 Oct 04; 5.View Related Profiles. PMID: 27697150; DOI: 10.7554/eLife.17755;.
  6. Park E, Ménétret JF, Gumbart JC, Ludtke SJ, Li W, Whynot A, Rapoport TA, Akey CW. Structure of the SecY channel during initiation of protein translocation. Nature. 2014 Feb 6; 506(7486):102-6. PMID: 24153188; PMCID: PMC3948209; DOI: 10.1038/nature12720;.
  7. D'Brot A, Chen P, Vaishnav M, Yuan S, Akey CW, Abrams JM. Tango7 directs cellular remodeling by the Drosophila apoptosome. Genes Dev. 2013 Aug 1; 27(15):1650-5.View Related Profiles. PMID: 23913920; PMCID: PMC3744723; DOI: 10.1101/gad.219287.113;.
  8. Farelli JD, Gumbart JC, Akey IV, Hempstead A, Amyot W, Head JF, McKnight CJ, Isberg RR, Akey CW. IcmQ in the Type 4b secretion system contains an NAD+ binding domain. Structure. 2013 Aug 6; 21(8):1361-73.View Related Profiles. PMID: 23850453; PMCID: PMC3816012; DOI: 10.1016/j.str.2013.05.017;.
  9. Yuan S, Akey CW. Apoptosome structure, assembly, and procaspase activation. Structure. 2013 Apr 2; 21(4):501-15.View Related Profiles. PMID: 23561633; PMCID: PMC3644875; DOI: 10.1016/j.str.2013.02.024;.
  10. Yuan S, Topf M, Reubold TF, Eschenburg S, Akey CW. Changes in Apaf-1 conformation that drive apoptosome assembly. Biochemistry. 2013 Apr 2; 52(13):2319-27.View Related Profiles. PMID: 23521171; PMCID: PMC3645920; DOI: 10.1021/bi301721g;.
Showing 10 of 52 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 51 publications over 29 distinct years, with a maximum of 5 publications in 2013

Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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