Allen A. Mitchell, MD
Boston University School of Public Health
Dept of Epidemiology

MD, Tufts University

Allen A. Mitchell is Professor of Epidemiology Pediatrics at the Boston University Schools of Public Health and Medicine. He is also Director Emeritus of the Slone Epidemiology Center at Boston University, having served as Director from 1998-2015.

Dr. Mitchell obtained his BA degree from Washington University in St. Louis in 1966 and his M.D. from Tufts University School of Medicine in Boston in 1970. After pediatric residency training at the Boston Floating Hospital for Infants and Children (Tufts-New England Medical Center), he joined the Boston Collaborative Drug Surveillance Program where, among other activities, he worked with Drs. Slone, Shapiro, and Heinonen in the analysis of Collaborative Perinatal Project data on birth defects and drugs in pregnancy.

In 1973-75 he was a fellow in pediatric clinical pharmacology at Children's Hospital in Boston (jointly with the Center for the Evaluation of Clinical Procedures at the Harvard School of Public Health), during which time he established the Pediatric Drug Surveillance ("PeDS") Program, an intensive drug surveillance effort focused on the frequency of medication use and adverse effects among hospitalized children. In 1975 he joined Drs. Slone and Shapiro at the newly-created Drug Epidemiology Unit (now Slone Epidemiology Center--SEC) at Boston University, where he continued to direct the PeDS Program.

Following his interest in both pharmacoepidemiology and birth defects, Dr. Mitchell in 1975 applied the concept of case-control surveillance to the study of teratogenesis, and initiated the SEC Birth Defects Study (BDS) which continued uninterrupted data collection until November, 2015. During that time, the BDS collected data on prenatal exposures for over 50,000 malformed infants (and controls) identified at over 90 hospitals and state birth defects registries in the regions surrounding Boston, Philadelphia, Toronto, San Diego, New York State, and Nashville. The BDS was one of two data collection components collaborating with the American Academy of Allergy, Asthma, and Immunology in a national systematic surveillance effort (Vaccines and Medication in Pregnancy Safety Surveillance—“VAMPSS”) designed to evaluate the risks and safety of the wide range of medications taken by pregnant women.

Dr. Mitchell designed and directed a practitioner-based trial of 84,000 children to assess the safety of pediatric ibuprofen, and in the process created a network that continued to conduct clinically-relevant office-based research. He also developed and directed epidemiologic efforts to evaluate pregnancy prevention efforts as part of risk management programs associated with isotretinoin (Accutane and others) and thalidomide (Thalomid), and designed the Slone Survey, a random sample of the U.S. population designed to identify the broad range of medications used in the week prior to interview.

Dr. Mitchell is the author of numerous publications in the fields of pediatric and birth defects pharmacoepidemiology and serves on many editorial boards and advisory committees.

Boston University School of Medicine
General Pediatrics

2012 Ntional Birth Defects Prevention Network: Godfrey P. Oakley, Jr., Award for significant contributions to the field of birth defects

Massachusetts Center for Birth Defects Research and Prevention
07/01/2014 - 06/30/2019 (PI)
Comm. of Mass./Department of Public Health HHS CDC

Exploring Modifiable Factors for Folic Acid Resistant Spina Bifida
09/01/2015 - 04/30/2019 (Co-PI)
PI: Martha Werler, DSc
HHS/CDC/National Center for Birth Defects and Developmental Disabilities
6 U01DD001184-03-02

Analysis of the Association between Infections, Vaccinations, and Medications during Pregnancy and Possible Birth Defects Outcomes, and Creation of an Archived Database
09/23/2016 - 03/22/2019 (PI)
HHS/National Vaccine Program Office

Protocol Development for Pregnancy Surveillance for Mepolizumab (VAMPSS)
01/11/2016 - 01/10/2017 (PI)
Educational Research Trust (AAAAI) GlaxoSmithKline, Inc

Postmarking Surveillance of Afluria Influenza Vaccine Safety in Pregnancy
08/01/2013 - 11/30/2015 (PI)
American Academy of Allergy, Asthma, and Immunology

09/30/2009 - 07/31/2015 (PI)
HHS/Agency for Healthcare Research and Quality

Case Control Safety Surveillance Study of Influenza in Pregnant Women and their Infants
07/07/2010 - 07/06/2015 (PI)
HHS/PHS (Public Health Contracts) DHHS

Hirschsprung Disease, Birth Defects and Intestinal Motility Disorders
07/01/2014 - 06/30/2015 (PI)
The Children's Hospital of Philadelphia Burroughs Wellcome

Postmarking Surveillence of Duloxetine Safety in Pregnancy
02/28/2014 - 06/30/2015 (PI)
American Academy of Allergy, Asthma, and Immunology Eli Lilly and Co

Genetic and Non Genetic Risk for Hirschsprung Disease
07/01/2010 - 06/30/2015 (PI)
The Washington University Other Fdns/Societies

Showing 10 of 24 results. Show All Results

Yr Title Project-Sub Proj Pubs
2018 BD-STEPS II (Birth Defects Study To Evaluate Pregnancy exposureS) - Core 1U01DD001224-01
2018 BD-STEPS II (Birth Defects Study To Evaluate Pregnancy exposureS) - Core 6U01DD001224-01M002
2015 Massachusetts Stillbirth Risk Factor Pilot Project 3U01DD001037-03S1 4
2015 Massachusetts Center for Birth Defects Research and Prevention 5U01DD001037-03 4
2014 Massachusetts Center for Birth Defects Research and Prevention 5U01DD001037-02 4
2013 Massachusetts Center for Birth Defects Research and Prevention 1U01DD001037-01 4
2013 Specific birth defects and asthma medications in pregnancy: Demonstration project 5R18HS018463-05 2
2013 Massachusetts Center for Birth Defects Research and Prevention 5U01DD000493-05 8
2012 Specific birth defects and asthma medications in pregnancy: Demonstration project 5R18HS018463-04 2
2012 Phthalates in Drugs and Male Genital Malformation 5R01HD059861-04 5
Showing 10 of 67 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Petersen JM, Parker SE, Crider KS, Tinker SC, Mitchell AA, Werler MM. One-Carbon Cofactor Intake and Risk of Neural Tube Defects Among Women Who Meet Folic Acid Recommendations: A Multicenter Case-Control Study. Am J Epidemiol. 2019 Jun 01; 188(6):1136-1143.View Related Profiles. PMID: 30976786.
  2. Tinker SC, Reefhuis J, Bitsko RH, Gilboa SM, Mitchell AA, Tran EL, Werler MM, Broussard CS. Use of benzodiazepine medications during pregnancy and potential risk for birth defects, National Birth Defects Prevention Study, 1997-2011. Birth Defects Res. 2019 Jun 01; 111(10):613-620.View Related Profiles. PMID: 30891943.
  3. Kerr SM, Van Bennekom CM, Mitchell AA. Risk factors for congenital microcephaly in the pre-Zika era. Birth Defects Res. 2019 Jan 15; 111(2):96-118. PMID: 30584689.
  4. Petersen JM, Mitchell AA, Van Bennekom C, Werler MM. Validity of maternal recall of gestational age and weight at birth: Comparison of structured interview and medical records. Pharmacoepidemiol Drug Saf. 2019 Feb; 28(2):269-273.View Related Profiles. PMID: 30488571.
  5. Weber KA, Yang W, Carmichael SL, Lupo PJ, Dukhovny S, Yazdy MM, Lin AE, Van Bennekom CM, Mitchell AA, Shaw GM. An application of data mining to identify potential risk factors for anophthalmia and microphthalmia. Paediatr Perinat Epidemiol. 2018 11; 32(6):545-555.View Related Profiles. PMID: 30300919.
  6. Ephross SA, Mitchell AA, Sacks S, Straus W, Stürmer T. Principles and considerations for effective academia-industry collaboration in pharmacoepidemiology. Pharmacoepidemiol Drug Saf. 2018 11; 27(11):1153-1156. PMID: 30232825.
  7. Parker SE, Van Bennekom C, Anderka M, Mitchell AA. Ondansetron for Treatment of Nausea and Vomiting of Pregnancy and the Risk of Specific Birth Defects. Obstet Gynecol. 2018 Aug; 132(2):385-394.View Related Profiles. PMID: 29995744.
  8. Dukhovny S, Van Bennekom CM, Gagnon DR, Hernandez Diaz S, Parker SE, Anderka M, Werler MM, Mitchell AA. Metformin in the first trimester and risks for specific birth defects in the National Birth Defects Prevention Study. Birth Defects Res. 2018 04 17; 110(7):579-586.View Related Profiles. PMID: 29388358.
  9. Kerr SM, Parker SE, Mitchell AA, Tinker SC, Werler MM. Periconceptional maternal fever, folic acid intake, and the risk for neural tube defects. Ann Epidemiol. 2017 Dec; 27(12):777-782.e1.View Related Profiles. PMID: 29133009.
  10. Kerr S, Van Bennekom CM, Liang JL, Mitchell AA. Tdap Vaccination Coverage During Pregnancy - Selected Sites, United States, 2006-2015. MMWR Morb Mortal Wkly Rep. 2017 Oct 20; 66(41):1105-1108. PMID: 29049273.
Showing 10 of 218 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 209 publications over 39 distinct years, with a maximum of 13 publications in 2013

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72 E. Concord St Instructional (L)
Boston MA 02118
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