Alla Grishok, PhD
Associate Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, University of Massachusetts Medical School

Gene regulation by RNA and chromatin

Research in the Grishok laboratory utilizes the nematode Caenorhabditis elegans and focuses on new mechanisms of gene regulation by short RNAs and chromatin-modifying complexes. Model organisms, such as C. elegans, are best suited for basic science. Importantly, discoveries made in basic research have the potential to affect translational science and the biotech industry in often-unpredictable ways.

Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

The role of DOT1L methyltransferase in controlling the noncoding transcriptome
08/01/2020 - 07/31/2024 (PI)
NIH/National Institute of General Medical Sciences

Regulation of RNA Processing and Transcription by Endogenous RNAi
04/01/2016 - 03/31/2018 (PI)
NIH/National Institute of General Medical Sciences


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Lascarez-Lagunas LI, Herruzo E, Grishok A, San-Segundo PA, Colaiácovo MP. DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans. PLoS Genet. 2020 10; 16(10):e1009171. PMID: 33104701; PMCID: PMC7644094; DOI: 10.1371/journal.pgen.1009171;
  2. Esse R, Grishok A. Caenorhabditis elegans Deficient in DOT-1.1 Exhibit Increases in H3K9me2 at Enhancer and Certain RNAi-Regulated Regions. Cells. 2020 08 06; 9(8). PMID: 32781660; PMCID: PMC7464606; DOI: 10.3390/cells9081846;
  3. Esse R, Gushchanskaia ES, Lord A, Grishok A. DOT1L complex suppresses transcription from enhancer elements and ectopic RNAi in Caenorhabditis elegans. RNA. 2019 10; 25(10):1259-1273.View Related Profiles. PMID: 31300558; PMCID: PMC6800474; DOI: 10.1261/rna.070292.119;
  4. Zaarur N, Desevin K, Mackenzie J, Lord A, Grishok A, Kandror KV. ATGL-1 mediates the effect of dietary restriction and the insulin/IGF-1 signaling pathway on longevity in C. elegans. Mol Metab. 2019 09; 27:75-82.View Related Profiles. PMID: 31311719; PMCID: PMC6717769; DOI: 10.1016/j.molmet.2019.07.001;
  5. Gushchanskaia ES, Esse R, Ma Q, Lau NC, Grishok A. Interplay between small RNA pathways shapes chromatin landscapes in C. elegans. Nucleic Acids Res. 2019 06 20; 47(11):5603-5616.View Related Profiles. PMID: 31216042; PMCID: PMC6582410; DOI: 10.1093/nar/gkz275;
  6. Cecere G, Grishok A. RNA Chromatin Immunoprecipitation (RNA-ChIP) in Caenorhabditis elegans. Bio Protoc. 2014 Dec 20; 4(24). PMID: 29170745; PMCID: PMC5697774; DOI: 10.21769/BioProtoc.1358;
  7. Cecere G, Hoersch S, O'Keeffe S, Sachidanandam R, Grishok A. Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape. Nat Struct Mol Biol. 2014 Apr; 21(4):358-65. PMID: 24681887; PMCID: PMC4068146; DOI: 10.1038/nsmb.2801;
  8. Kennedy LM, Grishok A. Neuronal migration is regulated by endogenous RNAi and chromatin-binding factor ZFP-1/AF10 in Caenorhabditis elegans. Genetics. 2014 May; 197(1):207-20. PMID: 24558261; PMCID: PMC4012481; DOI: 10.1534/genetics.114.162917;
  9. Cecere G, Grishok A. A nuclear perspective on RNAi pathways in metazoans. Biochim Biophys Acta. 2014 Mar; 1839(3):223-33. PMID: 24361586; PMCID: PMC3951611; DOI: 10.1016/j.bbagrm.2013.11.009;
  10. Kennedy LM, Pham SC, Grishok A. Nonautonomous regulation of neuronal migration by insulin signaling, DAF-16/FOXO, and PAK-1. Cell Rep. 2013 Sep 12; 4(5):996-1009. PMID: 23994474; PMCID: PMC3800683; DOI: 10.1016/j.celrep.2013.07.045;
Showing 10 of 24 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 24 publications over 11 distinct years, with a maximum of 4 publications in 2012 and 2013


Contact for Mentoring:

72 E. Concord St Silvio Conte (K)
Boston MA 02118
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