Alla Grishok, PhD
Associate Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, University of Massachusetts Amherst

Gene regulation by RNA and chromatin

Research in the Grishok laboratory utilizes the nematode Caenorhabditis elegans and focuses on new mechanisms of gene regulation by short RNAs and chromatin-modifying complexes. Model organisms, such as C. elegans, are best suited for basic science. Importantly, discoveries made in basic research have the potential to affect translational science and the biotech industry in often-unpredictable ways.

Regulation of RNA Processing and Transcription by Endogenous RNAi
04/01/2016 - 03/31/2018 (PI)
NIH/National Institute of General Medical Sciences

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Esse R, Gushchanskaia ES, Lord A, Grishok A. DOT1L complex suppresses transcription from enhancer elements and ectopic RNAi in Caenorhabditis elegans. RNA. 2019 Jul 12. PMID: 31300558.
  2. Gushchanskaia ES, Esse R, Ma Q, Lau NC, Grishok A. Interplay between small RNA pathways shapes chromatin landscapes in C. elegans. Nucleic Acids Res. 2019 Jun 20; 47(11):5603-5616.View Related Profiles. PMID: 31216042.
  3. Cecere G, Grishok A. RNA Chromatin Immunoprecipitation (RNA-ChIP) in Caenorhabditis elegans. Bio Protoc. 2014 Dec 20; 4(24). PMID: 29170745.
  4. Cecere G, Hoersch S, O'Keeffe S, Sachidanandam R, Grishok A. Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape. Nat Struct Mol Biol. 2014 Apr; 21(4):358-65. PMID: 24681887; PMCID: PMC4068146; DOI: 10.1038/nsmb.2801;.
  5. Kennedy LM, Grishok A. Neuronal migration is regulated by endogenous RNAi and chromatin-binding factor ZFP-1/AF10 in Caenorhabditis elegans. Genetics. 2014 May; 197(1):207-20. PMID: 24558261; PMCID: PMC4012481; DOI: 10.1534/genetics.114.162917;.
  6. Cecere G, Grishok A. A nuclear perspective on RNAi pathways in metazoans. Biochim Biophys Acta. 2014 Mar; 1839(3):223-33. PMID: 24361586; PMCID: PMC3951611; DOI: 10.1016/j.bbagrm.2013.11.009;.
  7. Kennedy LM, Pham SC, Grishok A. Nonautonomous regulation of neuronal migration by insulin signaling, DAF-16/FOXO, and PAK-1. Cell Rep. 2013 Sep 12; 4(5):996-1009. PMID: 23994474; PMCID: PMC3800683; DOI: 10.1016/j.celrep.2013.07.045;.
  8. Cecere G, Hoersch S, Jensen MB, Dixit S, Grishok A. The ZFP-1(AF10)/DOT-1 complex opposes H2B ubiquitination to reduce Pol II transcription. Mol Cell. 2013 Jun 27; 50(6):894-907. PMID: 23806335; PMCID: PMC3784254; DOI: 10.1016/j.molcel.2013.06.002;.
  9. Grishok A. Biology and Mechanisms of Short RNAs in Caenorhabditis elegans. Adv Genet. 2013; 83:1-69. PMID: 23890211; DOI: 10.1016/B978-0-12-407675-4.00001-8;.
  10. Avgousti DC, Cecere G, Grishok A. The conserved PHD1-PHD2 domain of ZFP-1/AF10 is a discrete functional module essential for viability in Caenorhabditis elegans. Mol Cell Biol. 2013 Mar; 33(5):999-1015. PMID: 23263989; PMCID: PMC3623080; DOI: 10.1128/MCB.01462-12;.
Showing 10 of 25 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 25 publications over 13 distinct years, with a maximum of 4 publications in 2012 and 2013

Contact for Mentoring:

72 E. Concord St Silvio Conte (K)
Boston MA 02118
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