Vladimir Botchkarev | Profiles RNS

Vladimir A Botchkarev, MD, PhD

Professor

Boston University Chobanian & Avedisian School of Medicine

Dermatology

Dermatology (excluding Mohs Surgery)

MD, Chuvash State University
PhD, Peoples' Friendship University of Russia

Websites

	Dermatology Faculty
	Harvard Catalyst
	HSTalks
	Epigenesys Profile
	LinkedIn

ORCID : 0000-0002-5212-5353

Vladimir Botchkarev, MD, PhD is Research Associate Professor in the Department of Dermatology. He received his medical training at Chuvash State University in Cheboksary, Russian and his doctoral training at People’s Friendship University in Moscow, Russia. He was a recipient of the Research Career Development Award from the Dermatology Foundation and Independent Scientist Award from the National Institutes of Health. He is also a recipient of the research grants from the NIAMS and NCI. His name was included in the books 2000 Outstanding Scientists of the 21st Century, Great Minds of the 21st Century and Who is Who in Medicine. His primary research interests are the molecular mechanisms of hair growth and pathobiology of different forms of hair loss.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Adjunct Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

BU Research
NIH RePORTER Research

Targeting Senescence to Improve Wound Healing in Aging
09/01/2023 - 05/31/2028 (Key Person / Mentor)
PI: Daniel S. Roh, MD, PhD
NIH/National Institute on Aging
5K76AG083300-02

Transposable elements in the keratinocyte genome and their regulation during skin development and epidermal differentiation
03/16/2021 - 01/31/2026 (Multi-PI)
PI: Vladimir A Botchkarev, MD, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR078306-04

The skin of naked mole rats as a model for scar-free wound healing
09/01/2023 - 08/31/2025 (Multi-PI)
PI: Vladimir A Botchkarev, MD, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
4R33AR078093-03

Mechanisms of skin cancer resistance in Naked mole-rats
07/01/2023 - 06/30/2024 (Key Person / Mentor)
PI: Iqra Fatima
Dermatology Foundation

DNA hydroxymethylation and Tet-enzymes in the control of the skin development and hair growth
08/01/2019 - 06/30/2024 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR075776-05

The skin of naked mole rats as a model for scar-free wound healing
09/01/2020 - 08/31/2023 (Multi-PI)
PI: Vladimir A Botchkarev, MD, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R61AR078093-02

Chromatin architectural protein CTCF and regulation of skin development and tumorigenesis
02/15/2017 - 04/30/2023 (Multi-PI)
PI: Vladimir A Botchkarev, MD, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR071727-05

Epigenetic regulation of skin development and keratinocyte differentiation
09/01/2014 - 08/31/2020 (Multi-PI)
PI: Vladimir A Botchkarev, MD, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR064580-05

BMP Signaling in the Control of Skin Development, Hair Growth and Tumorogenesis
07/01/2010 - 06/30/2016 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR049778-11

Modulation of Chemotherapy-Induced Hair Loss
06/01/2012 - 04/30/2013 (PI)
Edimer Pharmaceuticals, Inc

Showing 10 of 23 results. Show All Results

Title

Yr	Title	Project-Sub Proj
2024	Transposable elements in the keratinocyte genome and their regulation during skin development and epidermal differentiation	5R01AR078306-04
2024	Genome transposable elements as drivers of inflammation in understudied skin types	3R01AR078306-04S1
2023	Transposable elements in the keratinocyte genome and their regulation during skin development and epidermal differentiation	5R01AR078306-03
2023	The skin of naked mole rats as a model for scar-free wound healing	4R33AR078093-03
2023	DNA hydroxymethylation and Tet-enzymes in the control of the skin development and hair growth	5R01AR075776-05
2022	Transposable elements in the keratinocyte genome and their regulation during skin development and epidermal differentiation	5R01AR078306-02
2022	DNA hydroxymethylation and Tet-enzymes in the control of the skin development and hair growth	5R01AR075776-04
2021	Transposable elements in the keratinocyte genome and their regulation during skin development and epidermal differentiation	1R01AR078306-01
2021	The skin of naked mole rats as a model for scar-free wound healing	5R61AR078093-02
2021	DNA hydroxymethylation and Tet-enzymes in the control of the skin development and hair growth	5R01AR075776-03

Showing 10 of 45 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Botchkarev VA, Fessing MY, Sharov AA. Deciphering a Message from the Nucleus: How Transcription Factors and Spatial Chromatin Interactions Orchestrate Epidermal Differentiation. J Invest Dermatol. 2023 Jul; 143(7):1117-1120. PMID: 37045617; PMCID: PMC10715816; DOI: 10.1016/j.jid.2023.02.013;

Chen GD, Fatima I, Xu Q, Rozhkova E, Fessing MY, Mardaryev AN, Sharov AA, Xu GL, Botchkarev VA. DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation. Sci Adv. 2023 Jan 13; 9(2):eabo7605.View Related Profiles.

Rozhkova, Elena
Fatima, Iqra
Botchkarev, Vladimir

PMID: 36630508; PMCID: PMC9833667; DOI: 10.1126/sciadv.abo7605;

Fatima I, Chen G, Botchkareva NV, Sharov AA, Thornton D, Wilkinson HN, Hardman MJ, Grutzkau A, Pedro de Magalhaes J, Seluanov A, Smith ESJ, Gorbunova V, Mardaryev AN, Faulkes CG, Botchkarev VA. Skin Aging in Long-Lived Naked Mole-Rats Is Accompanied by Increased Expression of Longevity-Associated and Tumor Suppressor Genes. J Invest Dermatol. 2022 Nov; 142(11):2853-2863.e4.View Related Profiles.

Fatima, Iqra
Botchkarev, Vladimir

PMID: 35691364; PMCID: PMC9613526; DOI: 10.1016/j.jid.2022.04.028;

Crouch J, Shvedova M, Thanapaul RJRS, Botchkarev V, Roh D. Epigenetic Regulation of Cellular Senescence. Cells. 2022 02 15; 11(4).View Related Profiles.

Roh, Daniel
Shvedova, Maria
Botchkarev, Vladimir

PMID: 35203320; PMCID: PMC8870565; DOI: 10.3390/cells11040672;

Botchkarev VA, Sharov AA. Histone Deacetylases in the Control of Epidermal Homeostasis: From Chromatin Biology toward Therapy. J Invest Dermatol. 2022 01; 142(1):12-14. PMID: 34565558; PMCID: PMC8734647; DOI: 10.1016/j.jid.2021.06.021;

Ahmed MI, Pickup ME, Rimmer AG, Alam M, Mardaryev AN, Poterlowicz K, Botchkareva NV, Botchkarev VA. Interplay of MicroRNA-21 and SATB1 in Epidermal Keratinocytes during Skin Aging. J Invest Dermatol. 2019 12; 139(12):2538-2542.e2. PMID: 31255698; PMCID: PMC7754164; DOI: 10.1016/j.jid.2019.04.022;

Castellano-Pellicena I, Uzunbajakava NE, Mignon C, Raafs B, Botchkarev VA, Thornton MJ. Does blue light restore human epidermal barrier function via activation of Opsin during cutaneous wound healing? Lasers Surg Med. 2019 04; 51(4):370-382. PMID: 30168605

Poterlowicz K, Yarker JL, Malashchuk I, Lajoie BR, Mardaryev AN, Gdula MR, Sharov AA, Kohwi-Shigematsu T, Botchkarev VA, Fessing MY. 5C analysis of the Epidermal Differentiation Complex locus reveals distinct chromatin interaction networks between gene-rich and gene-poor TADs in skin epithelial cells. PLoS Genet. 2017 Sep; 13(9):e1006966.View Related Profiles.

Gdula, Michal
Botchkarev, Vladimir

PMID: 28863138; PMCID: PMC5599062; DOI: 10.1371/journal.pgen.1006966;

Rapisarda V, Malashchuk I, Asamaowei IE, Poterlowicz K, Fessing MY, Sharov AA, Karakesisoglou I, Botchkarev VA, Mardaryev A. p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes. J Invest Dermatol. 2017 Oct; 137(10):2157-2167. PMID: 28595999; PMCID: PMC5610935; DOI: 10.1016/j.jid.2017.05.013;

Botchkarev VA. Second International Symposium-Epigenetic Regulation of Skin Regeneration and Aging: From Chromatin Biology towards the Understanding of Epigenetic Basis of Skin Diseases. J Invest Dermatol. 2017 08; 137(8):1604-1608. PMID: 28583676

Showing 10 of 107 results. Show More

Botchkarev VA. The Molecular Revolution in Cutaneous Biology: Chromosomal Territories, Higher-Order Chromatin Remodeling, and the Control of Gene Expression in Keratinocytes. J Invest Dermatol. 2017 May; 137(5):e93-e99. PMID: 28411854; PMCID: PMC5567742; DOI: 10.1016/j.jid.2016.04.040;

Botchkarev VA, Mardaryev AN. Repressing the Keratinocyte Genome: How the Polycomb Complex Subunits Operate in Concert to Control Skin and Hair Follicle Development. J Invest Dermatol. 2016 08; 136(8):1538-40. PMID: 27450498; PMCID: PMC5567744; DOI: 10.1016/j.jid.2016.04.026;

Botchkarev VA, Sharov AA. Modeling Chemotherapy-Induced Hair Loss: From Experimental Propositions toward Clinical Reality. J Invest Dermatol. 2016 Mar; 136(3):557-9. PMID: 26902124; DOI: 10.1016/j.jid.2015.10.068;

Mardaryev AN, Liu B, Rapisarda V, Poterlowicz K, Malashchuk I, Rudolf J, Sharov AA, Jahoda CA, Fessing MY, Benitah SA, Xu GL, Botchkarev VA. Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. J Cell Biol. 2016 Jan 4; 212(1):77-89. PMID: 26711500; PMCID: PMC4700479; DOI: 10.1083/jcb.201506065;

Botchkarev VA. Integration of the Transcription Factor-Regulated and Epigenetic Mechanisms in the Control of Keratinocyte Differentiation. J Investig Dermatol Symp Proc. 2015 Nov; 17(2):30-2. PMID: 26551942; PMCID: PMC5080658; DOI: 10.1038/jidsymp.2015.37;

Botchkarev VA. Epigenetic Regulation of Epidermal Development and Keratinocyte Differentiation. J Investig Dermatol Symp Proc. 2015 Jul; 17(1):18-9. PMID: 26067308; PMCID: PMC7745084; DOI: 10.1038/jidsymp.2015.15;

Mardaryev AN, Gdula MR, Yarker JL, Emelianov VU, Poterlowicz K, Sharov AA, Sharova TY, Scarpa JA, Joffe B, Solovei I, Chambon P, Botchkarev VA, Fessing MY. p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells. Development. 2014 Sep; 141(17):3437.View Related Profiles.

Gdula, Michal
Sharova, Tatyana
Botchkarev, Vladimir

PMID: 25139860; DOI: 10.1242/dev.115725;

Botchkarev VA, Flores ER. p53/p63/p73 in the epidermis in health and disease. Cold Spring Harb Perspect Med. 2014 Aug; 4(8). PMID: 25085956; PMCID: PMC4109579; DOI: 10.1101/cshperspect.a015248;

Sharova TY, Poterlowicz K, Botchkareva NV, Kondratiev NA, Aziz A, Spiegel JH, Botchkarev VA, Sharov AA. Complex changes in the apoptotic and cell differentiation programs during initiation of the hair follicle response to chemotherapy. J Invest Dermatol. 2014 Dec; 134(12):2873-82.View Related Profiles.

Spiegel, Jeffrey
Sharova, Tatyana
Botchkarev, Vladimir

PMID: 24999588; PMCID: PMC4227948; DOI: 10.1038/jid.2014.267;

Lewis CJ, Mardaryev AN, Sharov AA, Fessing MY, Botchkarev VA. The Epigenetic Regulation of Wound Healing. Adv Wound Care (New Rochelle). 2014 Jul 01; 3(7):468-475. PMID: 25032066; PMCID: PMC4085819; DOI: 10.1089/wound.2014.0522;

Mardaryev AN, Gdula MR, Yarker JL, Emelianov VU, Emelianov VN, Poterlowicz K, Sharov AA, Sharova TY, Scarpa JA, Joffe B, Solovei I, Chambon P, Botchkarev VA, Fessing MY. p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells. Development. 2014 Jan; 141(1):101-11.View Related Profiles.

Gdula, Michal
Sharova, Tatyana
Botchkarev, Vladimir

PMID: 24346698; PMCID: PMC3865752; DOI: 10.1242/dev.103200;

Botchkarev VA, Fessing MY, Botchkareva NV, Westgate G, Tobin DJ. First International Symposium "Epigenetic Control of Skin Development and Regeneration": how chromatin regulators orchestrate skin functions. J Invest Dermatol. 2013 Aug; 133(8):1918-21. PMID: 23856928; DOI: 10.1038/jid.2013.126;

Gdula MR, Poterlowicz K, Mardaryev AN, Sharov AA, Peng Y, Fessing MY, Botchkarev VA. Remodeling of three-dimensional organization of the nucleus during terminal keratinocyte differentiation in the epidermis. J Invest Dermatol. 2013 Sep; 133(9):2191-201.View Related Profiles.

Gdula, Michal
Botchkarev, Vladimir

PMID: 23407401; PMCID: PMC4135477; DOI: 10.1038/jid.2013.66;

Liu B, Liu YF, Du YR, Mardaryev AN, Yang W, Chen H, Xu ZM, Xu CQ, Zhang XR, Botchkarev VA, Zhang Y, Xu GL. Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development. 2013 Feb; 140(4):780-8. PMID: 23362346; PMCID: PMC3557775; DOI: 10.1242/dev.085035;

Paus R, Haslam IS, Sharov AA, Botchkarev VA. Pathobiology of chemotherapy-induced hair loss. Lancet Oncol. 2013 Feb; 14(2):e50-9. PMID: 23369683; DOI: 10.1016/S1470-2045(12)70553-3;

Botchkarev VA, Gdula MR, Mardaryev AN, Sharov AA, Fessing MY. Epigenetic regulation of gene expression in keratinocytes. J Invest Dermatol. 2012 Nov; 132(11):2505-21.View Related Profiles.

Sharov, Andrei
Gdula, Michal
Botchkarev, Vladimir

PMID: 22763788; PMCID: PMC3650472; DOI: 10.1038/jid.2012.182;

Kohwi-Shigematsu T, Poterlowicz K, Ordinario E, Han HJ, Botchkarev VA, Kohwi Y. Genome organizing function of SATB1 in tumor progression. Semin Cancer Biol. 2013 Apr; 23(2):72-9. PMID: 22771615; PMCID: PMC4048061; DOI: 10.1016/j.semcancer.2012.06.009;

Mardaryev AN, Meier N, Poterlowicz K, Sharov AA, Sharova TY, Ahmed MI, Rapisarda V, Lewis C, Fessing MY, Ruenger TM, Bhawan J, Werner S, Paus R, Botchkarev VA. Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury. Development. 2011 Nov; 138(22):4843-52.View Related Profiles.

Bhawan, Jag
Sharova, Tatyana
Botchkarev, Vladimir

PMID: 22028024; PMCID: PMC4067271; DOI: 10.1242/dev.070284;

Fessing MY, Mardaryev AN, Gdula MR, Sharov AA, Sharova TY, Rapisarda V, Gordon KB, Smorodchenko AD, Poterlowicz K, Ferone G, Kohwi Y, Missero C, Kohwi-Shigematsu T, Botchkarev VA. p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis. J Cell Biol. 2011 Sep 19; 194(6):825-39.View Related Profiles.

Gdula, Michal
Sharova, Tatyana
Botchkarev, Vladimir

PMID: 21930775; PMCID: PMC3207288; DOI: 10.1083/jcb.201101148;

Peters EM, Liezmann C, Spatz K, Daniltchenko M, Joachim R, Gimenez-Rivera A, Hendrix S, Botchkarev VA, Brandner JM, Klapp BF. Nerve growth factor partially recovers inflamed skin from stress-induced worsening in allergic inflammation. J Invest Dermatol. 2011 Mar; 131(3):735-43. PMID: 21085186; DOI: 10.1038/jid.2010.317;

Sharov AA, Schroeder M, Sharova TY, Mardaryev AN, Peters EM, Tobin DJ, Botchkarev VA. Matrix metalloproteinase-9 is involved in the regulation of hair canal formation. J Invest Dermatol. 2011 Jan; 131(1):257-60.View Related Profiles.

Sharova, Tatyana
Botchkarev, Vladimir

PMID: 20882038; PMCID: PMC3138469; DOI: 10.1038/jid.2010.279;

Lyubimova A, Garber JJ, Upadhyay G, Sharov A, Anastasoaie F, Yajnik V, Cotsarelis G, Dotto GP, Botchkarev V, Snapper SB. Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice. J Clin Invest. 2010 Feb; 120(2):446-56. PMID: 20071778; PMCID: PMC2810069; DOI: 10.1172/JCI36478;

Fessing MY, Atoyan R, Shander B, Mardaryev AN, Botchkarev VV, Poterlowicz K, Peng Y, Efimova T, Botchkarev VA. BMP signaling induces cell-type-specific changes in gene expression programs of human keratinocytes and fibroblasts. J Invest Dermatol. 2010 Feb; 130(2):398-404. PMID: 19710687; PMCID: PMC3138418; DOI: 10.1038/jid.2009.259;

Sharov AA, Mardaryev AN, Sharova TY, Grachtchouk M, Atoyan R, Byers HR, Seykora JT, Overbeek P, Dlugosz A, Botchkarev VA. Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways. Am J Pathol. 2009 Sep; 175(3):1303-14.View Related Profiles.

Sharova, Tatyana
Botchkarev, Vladimir

PMID: 19700758; PMCID: PMC2731148; DOI: 10.2353/ajpath.2009.090163;

Atoyan RY, Sharov AA, Eller MS, Sargsyan A, Botchkarev VA, Gilchrest BA. Oligonucleotide treatment increases eumelanogenesis, hair pigmentation and melanocortin-1 receptor expression in the hair follicle. Exp Dermatol. 2007 Aug; 16(8):671-7.View Related Profiles.

Gilchrest, Barbara
Botchkarev, Vladimir

PMID: 17620094

Siebenhaar F, Sharov AA, Peters EM, Sharova TY, Syska W, Mardaryev AN, Freyschmidt-Paul P, Sundberg JP, Maurer M, Botchkarev VA. Substance P as an immunomodulatory neuropeptide in a mouse model for autoimmune hair loss (alopecia areata). J Invest Dermatol. 2007 Jun; 127(6):1489-97.View Related Profiles.

Sharova, Tatyana
Botchkarev, Vladimir

PMID: 17273166

Fessing MY, Sharova TY, Sharov AA, Atoyan R, Botchkarev VA. Involvement of the Edar signaling in the control of hair follicle involution (catagen). Am J Pathol. 2006 Dec; 169(6):2075-84.View Related Profiles.

Sharova, Tatyana
Botchkarev, Vladimir

PMID: 17148670; PMCID: PMC1762472; DOI: 10.2353/ajpath.2006.060227;

Sharov AA, Sharova TY, Mardaryev AN, Tommasi di Vignano A, Atoyan R, Weiner L, Yang S, Brissette JL, Dotto GP, Botchkarev VA. Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes. Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48):18166-71.View Related Profiles.

Yang, Shi
Sharova, Tatyana
Botchkarev, Vladimir

PMID: 17114283; PMCID: PMC1838724; DOI: 10.1073/pnas.0608899103;

Botchkarev VA, Yaar M, Peters EM, Raychaudhuri SP, Botchkareva NV, Marconi A, Raychaudhuri SK, Paus R, Pincelli C. Neurotrophins in skin biology and pathology. J Invest Dermatol. 2006 Aug; 126(8):1719-27.View Related Profiles.

Yaar, Mina
Botchkarev, Vladimir

PMID: 16845411

Palkina TN, Sharov AA, Sharov TY, Botchkarev VA. Neurotrophins in autoimmune diseases: possible implications for alopecia areata. J Investig Dermatol Symp Proc. 2005 Dec; 10(3):282. PMID: 16402482

Botchkarev VA, Fessing MY. Edar signaling in the control of hair follicle development. J Investig Dermatol Symp Proc. 2005 Dec; 10(3):247-51. PMID: 16382675

Sharov A, Tobin DJ, Sharova TY, Atoyan R, Botchkarev VA. Changes in different melanocyte populations during hair follicle involution (catagen). J Invest Dermatol. 2005 Dec; 125(6):1259-67.View Related Profiles.

Sharova, Tatyana
Botchkarev, Vladimir

PMID: 16354197

Mammucari C, Tommasi di Vignano A, Sharov AA, Neilson J, Havrda MC, Roop DR, Botchkarev VA, Crabtree GR, Dotto GP. Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Dev Cell. 2005 May; 8(5):665-76. PMID: 15866158

Sharov AA, Fessing M, Atoyan R, Sharova TY, Haskell-Luevano C, Weiner L, Funa K, Brissette JL, Gilchrest BA, Botchkarev VA. Bone morphogenetic protein (BMP) signaling controls hair pigmentation by means of cross-talk with the melanocortin receptor-1 pathway. Proc Natl Acad Sci U S A. 2005 Jan 4; 102(1):93-8.View Related Profiles.

Gilchrest, Barbara
Sharova, Tatyana
Botchkarev, Vladimir

PMID: 15618398; PMCID: PMC544050

Botchkarev VA, Sharov AA. BMP signaling in the control of skin development and hair follicle growth. Differentiation. 2004 Dec; 72(9-10):512-26.View Related Profiles.

Sharov, Andrei
Botchkarev, Vladimir

PMID: 15617562

Sharov AA, Siebenhaar F, Sharova TY, Botchkareva NV, Gilchrest BA, Botchkarev VA. Fas signaling is involved in the control of hair follicle response to chemotherapy. Cancer Res. 2004 Sep 1; 64(17):6266-70.View Related Profiles.

Sharov, Andrei
Gilchrest, Barbara
Sharova, Tatyana
Botchkarev, Vladimir

PMID: 15342414

Metz M, Botchkarev VA, Botchkareva NV, Welker P, Tobin DJ, Knop J, Maurer M, Paus R. Neurotrophin-3 regulates mast cell functions in neonatal mouse skin. Exp Dermatol. 2004 May; 13(5):273-81. PMID: 15140017

Herz U, Botchkarev VA, Paus R, Renz H. Increased airway responsiveness, allergy-type-I skin responses and systemic anaphylaxis in a humanized-severe combined immuno-deficiency mouse model. Clin Exp Allergy. 2004 Mar; 34(3):478-87. PMID: 15005744

Botchkarev VA, Botchkareva NV, Peters EM, Paus R. Epithelial growth control by neurotrophins: leads and lessons from the hair follicle. Prog Brain Res. 2004; 146:493-513. PMID: 14699982

Peters EM, Maurer M, Botchkarev VA, Jensen Kd, Welker P, Scott GA, Paus R. Kit is expressed by epithelial cells in vivo. J Invest Dermatol. 2003 Nov; 121(5):976-84. PMID: 14708595

Botchkarev VA. Neurotrophins and their role in pathogenesis of alopecia areata. J Investig Dermatol Symp Proc. 2003 Oct; 8(2):195-8. PMID: 14582672

Botchkarev VA, Paus R. Molecular biology of hair morphogenesis: development and cycling. J Exp Zool B Mol Dev Evol. 2003 Aug 15; 298(1):164-80. PMID: 12949776

Stefanato CM, Yaar M, Bhawan J, Phillips TJ, Kosmadaki MG, Botchkarev V, Gilchrest BA. Modulations of nerve growth factor and Bcl-2 in ultraviolet-irradiated human epidermis. J Cutan Pathol. 2003 Jul; 30(6):351-7.View Related Profiles.

Gilchrest, Barbara
Bhawan, Jag
Yaar, Mina
Phillips, Tania
Botchkarev, Vladimir

PMID: 12834482

Sharov AA, Weiner L, Sharova TY, Siebenhaar F, Atoyan R, Reginato AM, McNamara CA, Funa K, Gilchrest BA, Brissette JL, Botchkarev VA. Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation. EMBO J. 2003 Jun 16; 22(12):2992-3003.View Related Profiles.

Sharov, Andrei
Gilchrest, Barbara
Sharova, Tatyana
Botchkarev, Vladimir

PMID: 12805214; PMCID: PMC162143

Botchkarev VA, Kishimoto J. Molecular control of epithelial-mesenchymal interactions during hair follicle cycling. J Investig Dermatol Symp Proc. 2003 Jun; 8(1):46-55. PMID: 12894994

Botchkarev VA. Molecular mechanisms of chemotherapy-induced hair loss. J Investig Dermatol Symp Proc. 2003 Jun; 8(1):72-5. PMID: 12894998

Botchkareva NV, Botchkarev VA, Gilchrest BA. Fate of melanocytes during development of the hair follicle pigmentary unit. J Investig Dermatol Symp Proc. 2003 Jun; 8(1):76-9.View Related Profiles.

Gilchrest, Barbara
Botchkarev, Vladimir

PMID: 12894999

Freyschmidt-Paul P, McElwee KJ, Botchkarev V, Kissling S, Wenzel E, Sundberg JP, Happle R, Hoffmann R. Fas-deficient C3.MRL-Tnfrsf6(lpr) mice and Fas ligand-deficient C3H/HeJ-Tnfsf6(gld) mice are relatively resistant to the induction of alopecia areata by grafting of alopecia areata-affected skin from C3H/HeJ mice. J Investig Dermatol Symp Proc. 2003 Jun; 8(1):104-8. PMID: 12895005

Botchkarev VA. Stress and the hair follicle: exploring the connections. Am J Pathol. 2003 Mar; 162(3):709-12. PMID: 12598304; PMCID: PMC1868107

Botchkarev VA, Yaar M, Gilchrest BA, Paus R. p75 Neurotrophin receptor antagonist retards apoptosis-driven hair follicle involution (catagen). J Invest Dermatol. 2003 Jan; 120(1):168-9.View Related Profiles.

Gilchrest, Barbara
Yaar, Mina
Botchkarev, Vladimir

PMID: 12535214

Botchkarev VA. Bone morphogenetic proteins and their antagonists in skin and hair follicle biology. J Invest Dermatol. 2003 Jan; 120(1):36-47. PMID: 12535196

Sharov AA, Li GZ, Palkina TN, Sharova TY, Gilchrest BA, Botchkarev VA. Fas and c-kit are involved in the control of hair follicle melanocyte apoptosis and migration in chemotherapy-induced hair loss. J Invest Dermatol. 2003 Jan; 120(1):27-35.View Related Profiles.

Sharov, Andrei
Gilchrest, Barbara
Li, Guangmu
Sharova, Tatyana
Botchkarev, Vladimir

PMID: 12535195

Peters EM, Botchkarev VA, Müller-Röver S, Moll I, Rice FL, Paus R. Developmental timing of hair follicle and dorsal skin innervation in mice. J Comp Neurol. 2002 Jun 17; 448(1):28-52. PMID: 12012374

Tobin DJ, Foitzik K, Reinheckel T, Mecklenburg L, Botchkarev VA, Peters C, Paus R. The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling. Am J Pathol. 2002 May; 160(5):1807-21. PMID: 12000732; PMCID: PMC1850854

Botchkarev VA, Botchkareva NV, Sharov AA, Funa K, Huber O, Gilchrest BA. Modulation of BMP signaling by noggin is required for induction of the secondary (nontylotrich) hair follicles. J Invest Dermatol. 2002 Jan; 118(1):3-10.View Related Profiles.

Sharov, Andrei
Gilchrest, Barbara
Botchkarev, Vladimir

PMID: 11851869

Botchkarev VA, Botchkareva NV, Nakamura M, Huber O, Funa K, Lauster R, Paus R, Gilchrest BA. Noggin is required for induction of the hair follicle growth phase in postnatal skin. FASEB J. 2001 Oct; 15(12):2205-14.View Related Profiles.

Gilchrest, Barbara
Botchkarev, Vladimir

PMID: 11641247

Botchkarev VA, Komarova EA, Siebenhaar F, Botchkareva NV, Sharov AA, Komarov PG, Maurer M, Gudkov AV, Gilchrest BA. p53 Involvement in the control of murine hair follicle regression. Am J Pathol. 2001 Jun; 158(6):1913-9.View Related Profiles.

Gilchrest, Barbara
Botchkarev, Vladimir

PMID: 11395365; PMCID: PMC1891974

Botchkareva NV, Khlgatian M, Longley BJ, Botchkarev VA, Gilchrest BA. SCF/c-kit signaling is required for cyclic regeneration of the hair pigmentation unit. FASEB J. 2001 Mar; 15(3):645-58.View Related Profiles.

Gilchrest, Barbara
Botchkarev, Vladimir

PMID: 11259383

Peters EM, Botchkarev VA, Botchkareva NV, Tobin DJ, Paus R. Hair-cycle-associated remodeling of the peptidergic innervation of murine skin, and hair growth modulation by neuropeptides. J Invest Dermatol. 2001 Feb; 116(2):236-45. PMID: 11179999

Roth W, Deussing J, Botchkarev VA, Pauly-Evers M, Saftig P, Hafner A, Schmidt P, Schmahl W, Scherer J, Anton-Lamprecht I, Von Figura K, Paus R, Peters C. Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling. FASEB J. 2000 Oct; 14(13):2075-86. PMID: 11023992

Botchkarev VA, Botchkareva NV, Albers KM, Chen LH, Welker P, Paus R. A role for p75 neurotrophin receptor in the control of apoptosis-driven hair follicle regression. FASEB J. 2000 Oct; 14(13):1931-42. PMID: 11023977

Botchkarev VA, Komarova EA, Siebenhaar F, Botchkareva NV, Komarov PG, Maurer M, Gilchrest BA, Gudkov AV. p53 is essential for chemotherapy-induced hair loss. Cancer Res. 2000 Sep 15; 60(18):5002-6.View Related Profiles.

Gilchrest, Barbara
Botchkarev, Vladimir

PMID: 11016618

Müller-Röver S, Bulfone-Paus S, Handjiski B, Welker P, Sundberg JP, McKay IA, Botchkarev VA, Paus R. Intercellular adhesion molecule-1 and hair follicle regression. J Histochem Cytochem. 2000 Apr; 48(4):557-68. PMID: 10727297

Foitzik K, Lindner G, Mueller-Roever S, Maurer M, Botchkareva N, Botchkarev V, Handjiski B, Metz M, Hibino T, Soma T, Dotto GP, Paus R. Control of murine hair follicle regression (catagen) by TGF-beta1 in vivo. FASEB J. 2000 Apr; 14(5):752-60. PMID: 10744631

Botchkareva NV, Botchkarev VA, Welker P, Airaksinen M, Roth W, Suvanto P, Müller-Röver S, Hadshiew IM, Peters C, Paus R. New roles for glial cell line-derived neurotrophic factor and neurturin: involvement in hair cycle control. Am J Pathol. 2000 Mar; 156(3):1041-53. PMID: 10702420; PMCID: PMC1876831

Botchkareva NV, Botchkarev VA, Albers KM, Metz M, Paus R. Distinct roles for nerve growth factor and brain-derived neurotrophic factor in controlling the rate of hair follicle morphogenesis. J Invest Dermatol. 2000 Feb; 114(2):314-20. PMID: 10651992

Botchkarev VA, Peters EM, Botchkareva NV, Maurer M, Paus R. Hair cycle-dependent changes in adrenergic skin innervation, and hair growth modulation by adrenergic drugs. J Invest Dermatol. 1999 Dec; 113(6):878-87. PMID: 10594725

Botchkareva NV, Botchkarev VA, Chen LH, Lindner G, Paus R. A role for p75 neurotrophin receptor in the control of hair follicle morphogenesis. Dev Biol. 1999 Dec 1; 216(1):135-53. PMID: 10588868

Tobin DJ, Slominski A, Botchkarev V, Paus R. The fate of hair follicle melanocytes during the hair growth cycle. J Investig Dermatol Symp Proc. 1999 Dec; 4(3):323-32. PMID: 10674391

Paus R, Müller-Röver S, Botchkarev VA. Chronobiology of the hair follicle: hunting the " hair cycle clock". J Investig Dermatol Symp Proc. 1999 Dec; 4(3):338-45. PMID: 10674393

Slominski AT, Botchkarev V, Choudhry M, Fazal N, Fechner K, Furkert J, Krause E, Roloff B, Sayeed M, Wei E, Zbytek B, Zipper J, Wortsman J, Paus R. Cutaneous expression of CRH and CRH-R. Is there a "skin stress response system?". Ann N Y Acad Sci. 1999 Oct 20; 885:287-311. PMID: 10816662

Paus R, Botchkarev VA, Botchkareva NV, Mecklenburg L, Luger T, Slominski A. The skin POMC system (SPS). Leads and lessons from the hair follicle. Ann N Y Acad Sci. 1999 Oct 20; 885:350-63. PMID: 10816666

Botchkarev VA, Botchkareva NV, Slominski A, Roloff B, Luger T, Paus R. Developmentally regulated expression of alpha-MSH and MC-1 receptor in C57BL/6 mouse skin suggests functions beyond pigmentation. Ann N Y Acad Sci. 1999 Oct 20; 885:433-9. PMID: 10816682

Slominski A, Botchkareva NV, Botchkarev VA, Chakraborty A, Luger T, Uenalan M, Paus R. ACTH production in C57BL/6 mouse skin. Ann N Y Acad Sci. 1999 Oct 20; 885:448-50. PMID: 10816685

Botchkarev VA, Kief S, Paus R, Moll I. Overexpression of brain-derived neurotrophic factor increases Merkel cell number in murine skin. J Invest Dermatol. 1999 Oct; 113(4):691-2. PMID: 10504460

Lommatzsch M, Braun A, Mannsfeldt A, Botchkarev VA, Botchkareva NV, Paus R, Fischer A, Lewin GR, Renz H. Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Implications for paracrine and target-derived Neurotrophic functions. Am J Pathol. 1999 Oct; 155(4):1183-93. PMID: 10514401; PMCID: PMC1867012

Botchkareva NV, Botchkarev VA, Metz M, Silos-Santiago I, Paus R. Retardation of hair follicle development by the deletion of TrkC, high-affinity neurotrophin-3 receptor. J Invest Dermatol. 1999 Sep; 113(3):425-7. PMID: 10469347

Peters EM, Maurer M, Botchkarev VA, Gordon DS, Paus R. Hair growth-modulation by adrenergic drugs. Exp Dermatol. 1999 Aug; 8(4):274-81. PMID: 10439225

Botchkarev VA, Botchkareva NV, Roth W, Nakamura M, Chen LH, Herzog W, Lindner G, McMahon JA, Peters C, Lauster R, McMahon AP, Paus R. Noggin is a mesenchymally derived stimulator of hair-follicle induction. Nat Cell Biol. 1999 Jul; 1(3):158-64. PMID: 10559902

Botchkarev VA, Metz M, Botchkareva NV, Welker P, Lommatzsch M, Renz H, Paus R. Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 act as "epitheliotrophins" in murine skin. Lab Invest. 1999 May; 79(5):557-72. PMID: 10334567

Botchkarev VA, Botchkareva NV, Welker P, Metz M, Lewin GR, Subramaniam A, Bulfone-Paus S, Hagen E, Braun A, Lommatzsch M, Renz H, Paus AR. A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control. FASEB J. 1999 Feb; 13(2):395-410. PMID: 9973328

Tobin DJ, Hagen E, Botchkarev VA, Paus R. Do hair bulb melanocytes undergo apoptosis during hair follicle regression (catagen)? J Invest Dermatol. 1998 Dec; 111(6):941-7. PMID: 9856800

Müller-Röver S, Peters EJ, Botchkarev VA, Panteleyev A, Paus R. Distinct patterns of NCAM expression are associated with defined stages of murine hair follicle morphogenesis and regression. J Histochem Cytochem. 1998 Dec; 46(12):1401-10. PMID: 9815282

Slominski A, Botchkareva NV, Botchkarev VA, Chakraborty A, Luger T, Uenalan M, Paus R. Hair cycle-dependent production of ACTH in mouse skin. Biochim Biophys Acta. 1998 Nov 19; 1448(1):147-52. PMID: 9824688

Maurer M, Peters EM, Botchkarev VA, Paus R. Intact hair follicle innervation is not essential for anagen induction and development. Arch Dermatol Res. 1998 Oct; 290(10):574-8. PMID: 9836509

Braun A, Appel E, Baruch R, Herz U, Botchkarev V, Paus R, Brodie C, Renz H. Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma. Eur J Immunol. 1998 Oct; 28(10):3240-51. PMID: 9808193

Botchkarev VA, Botchkareva NV, Lommatzsch M, Peters EM, Lewin GR, Subramaniam A, Braun A, Renz H, Paus R. BDNF overexpression induces differential increases among subsets of sympathetic innervation in murine back skin. Eur J Neurosci. 1998 Oct; 10(10):3276-83. PMID: 9786221

St-Jacques B, Dassule HR, Karavanova I, Botchkarev VA, Li J, Danielian PS, McMahon JA, Lewis PM, Paus R, McMahon AP. Sonic hedgehog signaling is essential for hair development. Curr Biol. 1998 Sep 24; 8(19):1058-68. PMID: 9768360

Botchkarev VA, Welker P, Albers KM, Botchkareva NV, Metz M, Lewin GR, Bulfone-Paus S, Peters EM, Lindner G, Paus R. A new role for neurotrophin-3: involvement in the regulation of hair follicle regression (catagen). Am J Pathol. 1998 Sep; 153(3):785-99. PMID: 9736028; PMCID: PMC1853006

Botchkarev VA, Botchkarev NV, Albers KM, van der Veen C, Lewin GR, Paus R. Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis. J Invest Dermatol. 1998 Aug; 111(2):279-85. PMID: 9699730

Roloff B, Fechner K, Slominski A, Furkert J, Botchkarev VA, Bulfone-Paus S, Zipper J, Krause E, Paus R. Hair cycle-dependent expression of corticotropin-releasing factor (CRF) and CRF receptors in murine skin. FASEB J. 1998 Mar; 12(3):287-97. PMID: 9506472

Lindner G, Botchkarev VA, Botchkareva NV, Ling G, van der Veen C, Paus R. Analysis of apoptosis during hair follicle regression (catagen) Am J Pathol. 1997 Dec; 151(6):1601-17. PMID: 9403711; PMCID: PMC1858357

Botchkarev VA, Eichmüller S, Johansson O, Paus R. Hair cycle-dependent plasticity of skin and hair follicle innervation in normal murine skin. J Comp Neurol. 1997 Sep 29; 386(3):379-95. PMID: 9303424

Paus R, Peters EM, Eichmüller S, Botchkarev VA. Neural mechanisms of hair growth control. J Investig Dermatol Symp Proc. 1997 Aug; 2(1):61-8. PMID: 9487018

Botchkarev VA, Eichmüller S, Peters EM, Pietsch P, Johansson O, Maurer M, Paus R. A simple immunofluorescence technique for simultaneous visualization of mast cells and nerve fibers reveals selectivity and hair cycle--dependent changes in mast cell--nerve fiber contacts in murine skin. Arch Dermatol Res. 1997 Apr; 289(5):292-302. PMID: 9164640

Warbrick EV, Taylor AM, Botchkarev VA, Coleman JW. Rat connective tissue-type mast cells express MHC class II: up-regulation by IFN-gamma. Cell Immunol. 1995 Jul; 163(2):222-8. PMID: 7606795

Botchkarev VA, Paus R, Czarnetzki BM, Kupriyanov VS, Gordon DS, Johansson O. Hair cycle-dependent changes in mast cell histochemistry in murine skin. Arch Dermatol Res. 1995; 287(7):683-6. PMID: 8534134

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 107 publications over 26 distinct years, with a maximum of 15 publications in 1999

Bar chart showing 107 publications over 26 distinct years, with a maximum of 15 publications in 1999

Year	Publications
1995	2
1997	4
1998	10
1999	15
2000	7
2001	4
2002	3
2003	13
2004	6
2005	4
2006	3
2007	2
2009	2
2010	3
2011	2
2012	2
2013	4
2014	5
2015	3
2016	2
2017	4
2018	1
2019	1
2021	1
2022	2
2023	2

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