Daniel Roh | Profiles RNS

Daniel S. Roh, MD, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Surgery

MD, University of Pittsburgh School of Medicine
PhD, University of Pittsburgh School of Medicine
BA, Duke University
BS, Duke University

Websites

	Boston Medical Center
	Harvard Catalyst
	Google Scholar
	LinkedIn

ORCID : 0000-0002-5288-2805

I am a Plastic & Reconstructive surgeon at Chobanian and Avedisian School of Medicine. Currently, I am an Assistant Professor of Surgery, Division of Plastic & Reconstructive Surgery. My overall research interests are in acute and chronic wound healing processes and pathologic cutaneous scarring such as hypertrophic scars and keloids. My current research goals are to investigate the role of senescence in delayed wound healing of aging, acute wound healing processes, chronic wounds such as venous ulcers, pressure ulcers and diabetic ulcers, and pathologic cutaneous scarring. As a reconstructive surgeon, my clinical practice mirrors my research interests as I see many patients affected by wounds and scars. My ultimate goal is to improve upon my patients’ care through translational biomedical research.

Deputy Chief
Boston University Chobanian & Avedisian School of Medicine
Surgery
Plastic & Reconstructive Surgery

Medical Director
Boston Medical Center
Surgery
Clinical Ambulatory Operations

Targeting Senescence to Improve Wound Healing in Aging
09/01/2023 - 05/31/2028 (PI)
NIH/National Institute on Aging
5K76AG083300-02

Targeting extracellular matrix-senescence crosstalk as a novel approach to improve tissue repair in aging
04/01/2024 - 03/31/2028 (Multi-PI)
PI: Daniel S. Roh, MD, PhD
Hevolution Foundation

Targeting Senescence to Improve Wound Healing in Aging
12/31/2022 - 08/31/2023 (Subcontract PI)
American Federation for Aging Research Hevolution Fdn

Delineation of beneficial and detrimental roles of senescent cells in impaired wound healing of aging
07/01/2022 - 08/31/2023 (PI)
American Federation for Aging Research

Role of Senescence on the Impaired Wound Healing of Aging
08/15/2021 - 06/30/2023 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIA
2P30AG031679-11

Role of Senescence in the Impaired Wound Healing of Aging
09/15/2020 - 05/31/2023 (PI)
NIH/National Institute on Aging
5R03AG067983-02

Role of Senescence on the Impaired Wound Healing of Aging
07/01/2020 - 06/30/2021 (Subcontract PI)
The Brigham and Women's Hospital, Inc. NIH NIA
3P30AG031679-10S3

Title

A Relaxin-loaded Hydrogel for the Treatment of Hypertrophic Scars
07/01/2024 - 06/30/2029 (Co-Investigator)
PI: Mark Grinstaff, PhD
National Institute of Arthritis & Musculoskeletal & Skin Diseases NIH
1R01AR083161-01A1

Targeting Senescence to Improve Wound Healing in Aging
12/31/2022 - 12/31/2025 (PI)
American Federation for Aging Research

Yr	Title	Project-Sub Proj	Pubs
2024	Targeting Senescence to Improve Wound Healing in Aging	5K76AG083300-02
2023	Targeting Senescence to Improve Wound Healing in Aging	1K76AG083300-01
2021	Role of Senescence in the Impaired Wound Healing of Aging	5R03AG067983-02
2020	Role of Senescence in the Impaired Wound Healing of Aging	1R03AG067983-01
2013	Homeostatic Roles of Connexin43 in Response to DNA Damage	5F30AG035443-04	2
2012	Homeostatic Roles of Connexin43 in Response to DNA Damage	5F30AG035443-03	2
2011	Homeostatic Roles of Connexin43 in Response to DNA Damage	5F30AG035443-02	2
2009	Homeostatic Roles of Connexin43 in Response to DNA Damage	1F30AG035443-01	2

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Shvedova M, Thanapaul RJRS, Ha J, Dhillon J, Shin GH, Crouch J, Gower AC, Gritli S, Roh DS. Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing. Aging (Albany NY). 2024 Dec 03; 17(1):16-32.View Related Profiles.

Gower, Adam
Roh, Daniel
Shvedova, Maria

PMID: 39630941; PMCID: PMC11810067; DOI: 10.18632/aging.206165;

Gower, Adam
Roh, Daniel
Shvedova, Maria

PMID: 39229113; PMCID: PMC11370399; DOI: 10.1101/2024.08.19.608670;

Almier N, Leibowitz K, Gower AC, To S, Keller MR, Connizzo BK, Roh DS, Alani RM, Collard M. Targeting the Epigenome Reduces Keloid Fibroblast Cell Proliferation, Migration, and Invasion. J Invest Dermatol. 2025 Feb; 145(2):411-422.e7.View Related Profiles.

Gower, Adam
Connizzo, Brianne
Roh, Daniel
Alani, Rhoda

PMID: 39009280

Torres Perez-Iglesias CA, Heyman A, Koh DJ, Medina N, Roh DS, Slama J. Technical and Clinical Differences Between Transgender and Cisgender Females Undergoing Breast Augmentation. Ann Plast Surg. 2023 Nov 01; 91(5):534-539. PMID: 37823620

Levin SR, Burke PA, Brahmbhatt TS, Siracuse JJ, Slama J, Roh DS. Assessment of Risk Factors Correlated with Outcomes of Traumatic Lower Extremity Soft Tissue Reconstruction. Plast Reconstr Surg Glob Open. 2023 Apr; 11(4):e4961.View Related Profiles.

Roh, Daniel
Siracuse, Jeffrey
Burke, Peter
Levin, Scott
Brahmbhatt, Tejal

PMID: 37124392; PMCID: PMC10132714; DOI: 10.1097/GOX.0000000000004961;

Beaulieu-Jones BR, Fefferman A, Woods AP, Shewmaker G, Zhang T, Roh DS, Sachs TE, Merrill A, Ko NY, Cassidy MR. Impact of Race, Ethnicity, Primary Language, and Insurance on Reconstruction after Mastectomy for Patients with Breast Cancer at an Urban, Academic Safety-Net Hospital. J Am Coll Surg. 2023 Jun 01; 236(6):1071-1082.View Related Profiles.

Merrill, Andrea
Fefferman, Ann
Beaulieu-Jones, Brendin
Roh, Daniel
Cassidy, Michael
Ko, Naomi
Sachs, Teviah

PMID: 36524735; DOI: 10.1097/XCS.0000000000000531;

Woods AP, Papageorge MV, de Geus SWL, Alonso A, Merrill A, Cassidy MR, Roh DS, Sachs TE, McAneny D, Drake FT. ASO Visual Abstract: Impact of Patient Primary Language upon Immediate Breast Reconstruction after Mastectomy. Ann Surg Oncol. 2022 Dec; 29(13):8621-8622.View Related Profiles.

Merrill, Andrea
Roh, Daniel
McAneny, David
Drake, Frederick
Cassidy, Michael
Sachs, Teviah

PMID: 35972668

Woods AP, Papageorge MV, de Geus SWL, Alonso A, Merrill A, Cassidy MR, Roh DS, Sachs TE, McAneny D, Drake FT. Impact of Patient Primary Language upon Immediate Breast Reconstruction After Mastectomy. Ann Surg Oncol. 2022 Dec; 29(13):8610-8618.View Related Profiles.

Merrill, Andrea
Roh, Daniel
McAneny, David
Drake, Frederick
Cassidy, Michael
Sachs, Teviah

PMID: 35933541

Samdavid Thanapaul RJR, Shvedova M, Shin GH, Crouch J, Roh DS. Elevated skin senescence in young mice causes delayed wound healing. Geroscience. 2022 Jun; 44(3):1871-1878.View Related Profiles.

Roh, Daniel
Shvedova, Maria

PMID: 35399134; PMCID: PMC9213596; DOI: 10.1007/s11357-022-00551-1;

Crouch J, Shvedova M, Thanapaul RJRS, Botchkarev V, Roh D. Epigenetic Regulation of Cellular Senescence. Cells. 2022 02 15; 11(4).View Related Profiles.

Roh, Daniel
Shvedova, Maria
Botchkarev, Vladimir

PMID: 35203320; PMCID: PMC8870565; DOI: 10.3390/cells11040672;

Showing 10 of 32 results. Show More

Shvedova M, Samdavid Thanapaul RJR, Thompson EL, Niedernhofer LJ, Roh DS. Cellular Senescence in Aging, Tissue Repair, and Regeneration. Plast Reconstr Surg. 2022 Oct 01; 150:4S-11S.View Related Profiles.

Roh, Daniel
Shvedova, Maria

PMID: 36170430; PMCID: PMC9529244; DOI: 10.1097/PRS.0000000000009667;

Thanapaul RJRS, Shvedova M, Shin GH, Roh DS. An Insight into Aging, Senescence, and Their Impacts on Wound Healing. Adv Geriatr Med Res. 2021; 3(3).View Related Profiles.

Roh, Daniel
Shvedova, Maria

PMID: 34414398; PMCID: PMC8373038; DOI: 10.20900/agmr20210017;

Cassidy MR, Roh DS. Is It Time to Abandon Textured Breast Implants for Breast Cancer Reconstruction? JAMA Surg. 2020 12 01; 155(12):1140-1141.View Related Profiles.

Roh, Daniel
Cassidy, Michael

PMID: 33026418

Cuellar TA, Roh DS, Sampson CE. Dissecting Cellulitis of the Scalp: A Review and Case Studies of Surgical Reconstruction. Plast Reconstr Surg Glob Open. 2020 Aug; 8(8):e3015. PMID: 32983774; PMCID: PMC7489594; DOI: 10.1097/GOX.0000000000003015;

Roh DS, Bojovic B, Woolard AC, Donelan MB. Triangular Fossa Graft for Philtral Reconstruction After Facial Burns: A 34-Year Experience. Ann Plast Surg. 2020 02; 84(2):144-148. PMID: 31464723

Roh DS, Liao EC. Reply: CRISPR Craft: DNA Editing the Reconstructive Ladder. Plast Reconstr Surg. 2019 10; 144(4):715e-716e. PMID: 31568337; DOI: 10.1097/PRS.0000000000006052;

Roh DS, Liao EC. REPLY TO: CRISPR/Cas9-Mediated Genomic Editing: Implications for Engineering an Animal Model of Breast Implant-Associated Anaplastic Large Cell Lymphoma. Plast Reconstr Surg. 2019 Jul 01. PMID: 31274752

Dabek RJ, Roh DS, Ozdemir D, Austen WG, Bojovic B. Fractional Laser-assisted Hair Regrowth and Microneedling for the Treatment of Alopecia Areata: A Review. Cureus. 2019 Jun 19; 11(6):e4943. PMID: 31453018; PMCID: PMC6701901; DOI: 10.7759/cureus.4943;

Roh DS, Orgill DP. Discussion: The Preparation of the Recipient Site in Fat Grafting: A Comprehensive Review of the Preclinical Evidence. Plast Reconstr Surg. 2019 04; 143(4):1108-1110. PMID: 30921130; DOI: 10.1097/PRS.0000000000005404;

Roh DS, Panayi AC, Bhasin S, Orgill DP, Sinha I. Implications of Aging in Plastic Surgery. Plast Reconstr Surg Glob Open. 2019 Jan; 7(1):e2085. PMID: 30859042; PMCID: PMC6382222; DOI: 10.1097/GOX.0000000000002085;

Roh DS, Li EB, Liao EC. CRISPR Craft: DNA Editing the Reconstructive Ladder. Plast Reconstr Surg. 2018 11; 142(5):1355-1364. PMID: 30511992; DOI: 10.1097/PRS.0000000000004863;

Roh DS, Orgill DP. Discussion: Early Macrophage Infiltration Improves Fat Graft Survival by Inducing Angiogenesis and Hematopoietic Stem Cell Recruitment. Plast Reconstr Surg. 2018 02; 141(2):387-388. PMID: 29369989; DOI: 10.1097/PRS.0000000000004029;

Roh DS, Treiser MD, Lafleur EH, Chun YS. Technique to Promote Symmetry in 2-Staged Bilateral Breast Reconstruction in the Setting of Unilateral Postmastectomy Radiation. Ann Plast Surg. 2017 Apr; 78(4):386-391. PMID: 28273056; DOI: 10.1097/SAP.0000000000000892;

Roh DS, Du Y, Gabriele ML, Robinson AR, Niedernhofer LJ, Funderburgh JL. Age-related dystrophic changes in corneal endothelium from DNA repair-deficient mice. Aging Cell. 2013 Dec; 12(6):1122-31. PMID: 23927039; PMCID: PMC4116745; DOI: 10.1111/acel.12143;

Lee SE, Mehra R, Fujita M, Roh DS, Long C, Lee W, Funderburgh JL, Ayares DL, Cooper DK, Hara H. Characterization of porcine corneal endothelium for xenotransplantation. Semin Ophthalmol. 2014 May; 29(3):127-35. PMID: 23758340; DOI: 10.3109/08820538.2013.787104;

Fujita M, Mehra R, Lee SE, Roh DS, Long C, Funderburgh JL, Ayares DL, Cooper DK, Hara H. Comparison of proliferative capacity of genetically-engineered pig and human corneal endothelial cells. Ophthalmic Res. 2013; 49(3):127-38. PMID: 23258190; PMCID: PMC3763511; DOI: 10.1159/000342978;

Du Y, Roh DS, Mann MM, Funderburgh ML, Funderburgh JL, Schuman JS. Multipotent stem cells from trabecular meshwork become phagocytic TM cells. Invest Ophthalmol Vis Sci. 2012 Mar 21; 53(3):1566-75. PMID: 22297497; PMCID: PMC3339918; DOI: 10.1167/iovs.11-9134;

Hara H, Koike N, Long C, Piluek J, Roh DS, SundarRaj N, Funderburgh JL, Mizuguchi Y, Isse K, Phelps CJ, Ball SF, Ayares DL, Cooper DK. Initial in vitro investigation of the human immune response to corneal cells from genetically engineered pigs. Invest Ophthalmol Vis Sci. 2011 Jul 15; 52(8):5278-86. PMID: 21596821; PMCID: PMC3176056; DOI: 10.1167/iovs.10-6947;

Roh DS, Funderburgh JL. Rapid changes in connexin-43 in response to genotoxic stress stabilize cell-cell communication in corneal endothelium. Invest Ophthalmol Vis Sci. 2011 Jul 15; 52(8):5174-82. PMID: 21666237; PMCID: PMC3176070; DOI: 10.1167/iovs.11-7272;

Du Y, Roh DS, Funderburgh ML, Mann MM, Marra KG, Rubin JP, Li X, Funderburgh JL. Adipose-derived stem cells differentiate to keratocytes in vitro. Mol Vis. 2010 Dec 10; 16:2680-9. PMID: 21179234; PMCID: PMC3002955

Roh DS, Funderburgh JL. Impact on the corneal endothelium of mitomycin C during photorefractive keratectomy. J Refract Surg. 2009 Oct; 25(10):894-7. PMID: 19835330; PMCID: PMC2876307; DOI: 10.3928/1081597X-20090617-10;

Roh DS, Cook AL, Rhee SS, Joshi A, Kowalski R, Dhaliwal DK, Funderburgh JL. DNA cross-linking, double-strand breaks, and apoptosis in corneal endothelial cells after a single exposure to mitomycin C. Invest Ophthalmol Vis Sci. 2008 Nov; 49(11):4837-43. PMID: 18658091; PMCID: PMC2875544; DOI: 10.1167/iovs.08-2115;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 32 publications over 14 distinct years, with a maximum of 5 publications in 2019 and 2022

Bar chart showing 32 publications over 14 distinct years, with a maximum of 5 publications in 2019 and 2022

Year	Publications
2008	1
2009	1
2010	1
2011	2
2012	2
2013	2
2017	1
2018	2
2019	5
2020	3
2021	2
2022	5
2023	2
2024	3

Media Mentions

Recent (within 3 months)

ABT-263 treatment rejuvenates aged skin and enhances wound healing

Eureka Alert 2/4/2025

Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing.

Altmetric 2/4/2025

ABT-263 Treatment Rejuvenates Aged Skin and Enhances Wound Healing

Aging US 2/4/2025

Older

The Lab

Politico 12/12/2023

'Zombie cells' in the body tied to aging may actually help heal tissue damage

Live Science 10/28/2022

Textured Implants Linked to Worse Breast Cancer Outcomes

Medscape 12/22/2020

2023 Hevolution/AFAR: Hevolution/AFAR New Investigator Awards in Aging Biology and Geroscience Research

2023-2028 National Institute on Aging: Paul B. Beeson Emerging Leaders Career Development Award

2022 Buck Institute: Fellow - NIH/NIA Summer Training Course in Experimental Aging

2022 Innovations in Wound Healing Meeting: Kelmen Cohen Junior Investigator Award

2021 National Institute on Aging: Butler-Williams Scholar

2020-2023 Department of Surgery, Boston University School of Medicine: Laszlo N. Tauber Assistant Professor of Surgery

2020-2023 National Institute on Aging: GEMSSTAR award

2013 University of Pittsburgh School of Medicine: Ross H. Musgrave, M.D. Plastic Surgery Award

2008 Association for Research in Vision and Ophthalmology: Cutaneous and Ocular Toxicology Travel Grant Award

2005 University of Pittsburgh School of Medicine: Stephen Phillips Award for Best Basic Science Research Project

2005-2007 University of Pittsburgh School of Medicine : Excellence in Collaborative Learning Award

2002-2003 Fulbright : Fulbright Fellowship

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

plastic surgery
wound healing
diabetic wound healing
tissue regeneration
translational research
surgeon-scientist training
chronic wounds
skin regeneration
inflammation and repair
academic surgery
clinical outcomes research
senescence
aging
senolytics
tissue repair
scarring
fibrosis

I am an Assistant Professor of Surgery at Boston University Chobanian & Avedisian School of Medicine, and a physician-scientist within the Department of Surgery. My clinical expertise is in plastic and reconstructive surgery. I run a translational research lab focused on understanding mechanisms of tissue repair and regeneration, with a particular emphasis on aging and senescence.

I have served as a mentor for high school, undergraduates, medical students, graduate students, residents, and early-career scientists, helping them develop skills in experimental design, manuscript preparation, grant writing, and career planning. My approach to mentoring centers on supporting trainees' scientific curiosity while also guiding them toward concrete goals that align with their individual interests and long-term career trajectories. I strive to create a collaborative and inclusive environment where mentees can thrive and grow into independent investigators or clinicians.

My research is funded by the NIH and other federal and foundation sources, and I am committed to training the next generation of surgeon-scientists who will bridge the gap between clinical care and basic science discovery. I view mentorship as a lifelong commitment and a cornerstone of academic medicine.

Available to Mentor as: (Review Mentor Role Definitions):