Andrei A. Sharov, MD, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Dermatology
Dermatology (excluding Mohs Surgery)

MD, Chuvash State University
PhD, Chuvash State University



Andrey Sharov, MD, PhD is an Assistant Professor of Dermatology at the Chobanian and Avedisian School of Medicine. He received his postdoctoral training her after completing his graduate degrees in Russia. Dr. Sharov is studying molecular mechanisms of skin development, with particular emphasis on the regulation and maintenance of adult stem cells in the skin. His research focuses on dissecting the signal transduction pathways which regulate stem cell quiescence to better understand how alterations in these signaling pathways contribute to melanoma and non-melanoma skin cancers. In addition, Dr. Sharov studies a role of higher-order chromatin organization in the process of pigmentation funded by NIH/NIAMS.

Member
Boston University
Genome Science Institute




Transposable elements in the keratinocyte genome and their regulation during skin development and epidermal differentiation
03/16/2021 - 01/31/2026 (Multi-PI)
PI: Andrei A. Sharov, MD, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR078306-05

The skin of naked mole rats as a model for scar-free wound healing
09/01/2023 - 08/31/2025 (Multi-PI)
PI: Andrei A. Sharov, MD, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
4R33AR078093-03

The skin of naked mole rats as a model for scar-free wound healing
09/01/2020 - 08/31/2023 (Multi-PI)
PI: Andrei A. Sharov, MD, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R61AR078093-02

Chromatin architectural protein CTCF and regulation of skin development and tumorigenesis
02/15/2017 - 04/30/2023 (Multi-PI)
PI: Andrei A. Sharov, MD, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR071727-05

Epigenetic regulation of skin development and keratinocyte differentiation
09/01/2014 - 08/31/2020 (Multi-PI)
PI: Andrei A. Sharov, MD, PhD
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R01AR064580-05

Higher-order Chromatin Remodeling and Regulation of Pigmentation
09/16/2013 - 08/31/2016 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5R21AR063851-02

Modulation of pigmentation by PKC pathway inhibitors
12/05/2014 - 12/31/2015 (PI)
ChromaDerm, Inc


Molecular Control of Normal and Neoplastic Skin Stem Cells
07/01/2009 - 06/30/2014 (PI)
NIH/National Institute of Arthritis & Musculoskeletal & Skin Diseases
5K01AR056771-05

Role of BMP Pathway in Skin Stem Cell Quiescence
01/01/2007 - 06/30/2009 (PI)
American Skin Association

Role Smad 1/5 Proteins on Hair Follicle Development and Cycling
03/01/2006 - 02/28/2008 (PI)
North American Hair Research Society

Showing 10 of 11 results. Show All Results


Title


Yr Title Project-Sub Proj Pubs
2025 Transposable elements in the keratinocyte genome and their regulation during skin development and epidermal differentiation 5R01AR078306-05
2024 Genome transposable elements as drivers of inflammation in understudied skin types 3R01AR078306-04S1
2024 Transposable elements in the keratinocyte genome and their regulation during skin development and epidermal differentiation 5R01AR078306-04
2023 Transposable elements in the keratinocyte genome and their regulation during skin development and epidermal differentiation 5R01AR078306-03
2023 The skin of naked mole rats as a model for scar-free wound healing 4R33AR078093-03
2022 Transposable elements in the keratinocyte genome and their regulation during skin development and epidermal differentiation 5R01AR078306-02
2021 Transposable elements in the keratinocyte genome and their regulation during skin development and epidermal differentiation 1R01AR078306-01
2021 The skin of naked mole rats as a model for scar-free wound healing 5R61AR078093-02
2021 Chromatin architectural protein CTCF and regulation of skin development and tumorigenesis 5R01AR071727-05 2
2020 The skin of naked mole rats as a model for scar-free wound healing 1R61AR078093-01
Showing 10 of 26 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Athar F, Morandini F, Fatima I, Silvestri I, Kim SJ, Lee M, Liao X, Sharov A, Botchkarev V, Seluanov A, Gorbunova V. African spiny mice show resistance to DMBA/TPA-induced squamous carcinogenesis with distinct benign tumor profile. Protein Cell. 2025 Oct 31; 16(10):896-904.View Related Profiles. PMID: 40119780; PMCID: PMC12578293; DOI: 10.1093/procel/pwaf024;
     
  2. Hong J, Pham TX, Lee J, Raslan AA, Nicolas K, Sharov A, Meridew JA, Urrutia RA, Lomberk G, Huang SK, Ligresti G. Targeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis. Am J Respir Cell Mol Biol. 2025 Jun; 72(6):627-642.View Related Profiles. PMID: 39642371; PMCID: PMC12143411; DOI: 10.1165/rcmb.2024-0255OC;
     
  3. Kida M, Fatima I, Rozhkova E, Otero-Viñas M, Wu M, Kalin JH, Cole PA, Falanga V, Alani RM, Sharov AA. Inhibition of the CoREST Repressor Complex Promotes Wound Re-Epithelialization through the Regulation of Keratinocyte Migration. J Invest Dermatol. 2024 Feb; 144(2):378-386.e2.View Related Profiles. PMID: 37633457; PMCID: PMC10790709; DOI: 10.1016/j.jid.2023.07.022;
     
  4. Botchkarev VA, Fessing MY, Sharov AA. Deciphering a Message from the Nucleus: How Transcription Factors and Spatial Chromatin Interactions Orchestrate Epidermal Differentiation. J Invest Dermatol. 2023 Jul; 143(7):1117-1120.View Related Profiles. PMID: 37045617; PMCID: PMC10715816; DOI: 10.1016/j.jid.2023.02.013;
     
  5. Chen GD, Fatima I, Xu Q, Rozhkova E, Fessing MY, Mardaryev AN, Sharov AA, Xu GL, Botchkarev VA. DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation. Sci Adv. 2023 Jan 13; 9(2):eabo7605.View Related Profiles. PMID: 36630508; PMCID: PMC9833667; DOI: 10.1126/sciadv.abo7605;
     
  6. Fatima I, Chen G, Botchkareva NV, Sharov AA, Thornton D, Wilkinson HN, Hardman MJ, Grutzkau A, Pedro de Magalhaes J, Seluanov A, Smith ESJ, Gorbunova V, Mardaryev AN, Faulkes CG, Botchkarev VA. Skin Aging in Long-Lived Naked Mole-Rats Is Accompanied by Increased Expression of Longevity-Associated and Tumor Suppressor Genes. J Invest Dermatol. 2022 Nov; 142(11):2853-2863.e4.View Related Profiles. PMID: 35691364; PMCID: PMC9613526; DOI: 10.1016/j.jid.2022.04.028;
     
  7. Botchkarev VA, Sharov AA. Histone Deacetylases in the Control of Epidermal Homeostasis: From Chromatin Biology toward Therapy. J Invest Dermatol. 2022 01; 142(1):12-14.View Related Profiles. PMID: 34565558; PMCID: PMC8734647; DOI: 10.1016/j.jid.2021.06.021;
     
  8. Poterlowicz K, Yarker JL, Malashchuk I, Lajoie BR, Mardaryev AN, Gdula MR, Sharov AA, Kohwi-Shigematsu T, Botchkarev VA, Fessing MY. 5C analysis of the Epidermal Differentiation Complex locus reveals distinct chromatin interaction networks between gene-rich and gene-poor TADs in skin epithelial cells. PLoS Genet. 2017 Sep; 13(9):e1006966.View Related Profiles. PMID: 28863138; PMCID: PMC5599062; DOI: 10.1371/journal.pgen.1006966;
     
  9. Rapisarda V, Malashchuk I, Asamaowei IE, Poterlowicz K, Fessing MY, Sharov AA, Karakesisoglou I, Botchkarev VA, Mardaryev A. p63 Transcription Factor Regulates Nuclear Shape and Expression of Nuclear Envelope-Associated Genes in Epidermal Keratinocytes. J Invest Dermatol. 2017 Oct; 137(10):2157-2167.View Related Profiles. PMID: 28595999; PMCID: PMC5610935; DOI: 10.1016/j.jid.2017.05.013;
     
  10. Botchkarev VA, Sharov AA. Modeling Chemotherapy-Induced Hair Loss: From Experimental Propositions toward Clinical Reality. J Invest Dermatol. 2016 Mar; 136(3):557-9.View Related Profiles. PMID: 26902124; DOI: 10.1016/j.jid.2015.10.068;
     
Showing 10 of 29 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 29 publications over 18 distinct years, with a maximum of 3 publications in 2004 and 2014 and 2023

YearPublications
20011
20021
20032
20043
20051
20062
20072
20101
20121
20131
20143
20151
20161
20172
20211
20221
20233
20252


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