Sarah Leatherman | Profiles RNS

Sarah Leatherman, PhD

Adjunct Assistant Professor

Boston University School of Public Health

Biostatistics

PhD, Boston University
MA, Boston University
BSc, Central Michigan University

Pronouns: she/her/hers

Websites

	ResearchGate
	LinkedIn

ORCID : 0000-0002-9821-9646

Dr. Sarah Leatherman is the Deputy Director of the VA Boston Cooperative Studies Program (CSP) Coordinating Center where she oversees the design and conduct of randomized controlled clinical trials within the VA. Dr. Leatherman joined CSP in 2010 and has since focused on implementation of pragmatic comparative effectiveness trials and promotion of a learning healthcare system within the VA. As a trained biostatistician, she also oversees the integrity of multiple databases and administrative data phenotyping activities required to execute these activities. Dr. Leatherman's published work includes first-authored publications, abstracts, and presentations on pragmatic trials and use of real-world data to support clinical trials.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Ishani A, Hau C, Cushman WC, Leatherman SM, Lew RA, Glassman PA, Taylor AA, Ferguson RE. Chlorthalidone vs Hydrochlorothiazide for Hypertension Treatment After Myocardial Infarction or Stroke: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2024 May 01; 7(5):e2411081.View Related Profiles.

Lew, Robert
Ferguson, Ryan
Leatherman, Sarah

PMID: 38743423; PMCID: PMC11094558; DOI: 10.1001/jamanetworkopen.2024.11081;

Leatherman SM, Ishani A. Point-of-Care Clinical Trials in Nephrology. J Am Soc Nephrol. 2024 Jun 01; 35(6):812-814. PMID: 38419159; PMCID: PMC11164108; DOI: 10.1681/ASN.0000000000000340;

Hau C, Woods PA, Guski AS, Raju SI, Zhu L, Alba PR, Cushman WC, Glassman PA, Ishani A, Taylor AA, Ferguson RE, Leatherman SM. Strategies for secondary use of real-world clinical and administrative data for outcome ascertainment in pragmatic clinical trials. J Biomed Inform. 2024 Feb; 150:104587.View Related Profiles.

Ferguson, Ryan
Leatherman, Sarah

PMID: 38244956

Hau C, Efird JT, Leatherman SM, Soloviev OV, Glassman PA, Woods PA, Ishani A, Cushman WC, Ferguson RE. A Centralized EHR-Based Model for the Recruitment of Rural and Lower Socioeconomic Participants in Pragmatic Trials: A Secondary Analysis of the Diuretic Comparison Project. JAMA Netw Open. 2023 Sep 05; 6(9):e2332049.View Related Profiles.

Ferguson, Ryan
Leatherman, Sarah

PMID: 37656456; PMCID: PMC10474559; DOI: 10.1001/jamanetworkopen.2023.32049;

Schumann R, Yuyun M, Chandok T, Amirfarzan H, Donnelly CM, Ferguson RE, Leatherman SM. Temperature Changes During Electrophysiology Ablation in Veterans and 1-Year Success Rates: A Retrospective Pilot Analysis. J Cardiothorac Vasc Anesth. 2023 Sep; 37(9):1646-1650.View Related Profiles.

Yuyun, Matthew
Ferguson, Ryan
Leatherman, Sarah

PMID: 37344247

Klint AL, Leatherman SM, Taylor O, Glassman PA, Ferguson RE, Cushman WC, Ishani A. Telephone informed consent in a pragmatic point-of-care clinical trial embedded in primary care. Contemp Clin Trials. 2023 Aug; 131:107239.View Related Profiles.

Ferguson, Ryan
Leatherman, Sarah

PMID: 37244366

Raju S, Hau C, Woods P, Flynn M, Sadatis C, McPherson J, Tella A, Ishani A, Ferguson RE, Leatherman SM. Ascertainment of stroke from administrative data to support a pragmatic embedded clinical trial. Contemp Clin Trials. 2023 Jul; 130:107214.View Related Profiles.

Ferguson, Ryan
Leatherman, Sarah

PMID: 37137378

Leatherman SM, Hau C, Klint A, Glassman PA, Taylor AA, Ferguson RE, Cushman WC, Ishani A. The impact of COVID-19 on a large pragmatic clinical trial embedded in primary care. Contemp Clin Trials. 2023 Jun; 129:107179.View Related Profiles.

Ferguson, Ryan
Leatherman, Sarah

PMID: 37031794; PMCID: PMC10080857; DOI: 10.1016/j.cct.2023.107179;

Ishani A, Cushman WC, Leatherman SM. Chlorthalidone vs. Hydrochlorothiazide for Hypertension-Cardiovascular Events. Reply. N Engl J Med. 2023 Apr 06; 388(14):1342. PMID: 37018506; DOI: 10.1056/NEJMc2301922;

Ferguson RE, Leatherman SM, Woods P, Hau C, Lew R, Cushman WC, Brophy MT, Fiore L, Ishani A. Practical issues in pragmatic trials: the implementation of the Diuretic Comparison Project. Clin Trials. 2023 Jun; 20(3):276-283.View Related Profiles.

Fiore, Louis
Brophy, Mary
Lew, Robert
Ferguson, Ryan
Leatherman, Sarah

PMID: 36992530

Showing 10 of 32 results. Show More

Dassum SR, Ferguson R, Woods P, Flynn M, Visnaw K, Holmberg E, Schiller S, Shannon C, Brophy M, Monach P, Leatherman S, Branch-Elliman W. Patient- reported reasons for non-participation in a COVID-19 therapeutics clinical trial: Findings from a multi-center investigation. Contemp Clin Trials. 2023 Mar; 126:107082.View Related Profiles.

Brophy, Mary
Leatherman, Sarah
Branch-Elliman, Westyn

PMID: 36632925; PMCID: PMC9827740; DOI: 10.1016/j.cct.2023.107082;

Ishani A, Cushman WC, Leatherman SM, Lew RA, Woods P, Glassman PA, Taylor AA, Hau C, Klint A, Huang GD, Brophy MT, Fiore LD, Ferguson RE. Chlorthalidone vs. Hydrochlorothiazide for Hypertension-Cardiovascular Events. N Engl J Med. 2022 Dec 29; 387(26):2401-2410.View Related Profiles.

Fiore, Louis
Brophy, Mary
Lew, Robert
Ferguson, Ryan
Leatherman, Sarah

PMID: 36516076

Leatherman S, Ferguson R, Hau C, Harrington K, Granowitz C, Philip S, Toth PP, Bhatt D, Boden W. Increased residual cardiovascular risk in U.S. veterans with moderately-elevated baseline triglycerides and well-controlled LDL-C levels on statins. Front Cardiovasc Med. 2022; 9:982815.View Related Profiles.

Harrington, Kelly M
Ferguson, Ryan
Leatherman, Sarah
Boden, William

PMID: 36407462; PMCID: PMC9673755; DOI: 10.3389/fcvm.2022.982815;

Ishani A, Leatherman SM, Woods P, Hau C, Klint A, Lew RA, Taylor AA, Glassman PA, Brophy MT, Fiore LD, Ferguson RE, Cushman WC. Design of a pragmatic clinical trial embedded in the Electronic Health Record: The VA's Diuretic Comparison Project. Contemp Clin Trials. 2022 May; 116:106754.View Related Profiles.

Fiore, Louis
Brophy, Mary
Lew, Robert
Ferguson, Ryan
Leatherman, Sarah

PMID: 35390512

Branch-Elliman W, Ferguson R, Doros G, Woods P, Leatherman S, Strymish J, Datta R, Goswami R, Jankowich MD, Shah NR, Taylor TH, Page ST, Schiller SJ, Shannon C, Hau C, Flynn M, Holmberg E, Visnaw K, Dhond R, Brophy M, Monach PA. Subcutaneous sarilumab for the treatment of hospitalized patients with moderate to severe COVID19 disease: A pragmatic, embedded randomized clinical trial. PLoS One. 2022; 17(2):e0263591.View Related Profiles.

Doros, Gheorghe
Brophy, Mary
Dhond, Rupali
Leatherman, Sarah
Branch-Elliman, Westyn

PMID: 35213547; PMCID: PMC8880885; DOI: 10.1371/journal.pone.0263591;

Dhond R, Acher R, Leatherman S, Page S, Sanford R, Elbers D, Meng F, Ferguson R, Brophy MT, Do NV. Rapid implementation of a modular clinical trial informatics solution for COVID-19 research. Inform Med Unlocked. 2021; 27:100788.View Related Profiles.

Elbers, Danne
Meng, Frank
Brophy, Mary
Van Do, Nhan
Dhond, Rupali
Leatherman, Sarah

PMID: 34786452; PMCID: PMC8588694; DOI: 10.1016/j.imu.2021.100788;

Dhond R, Elbers D, Majahalme N, Dipietro S, Goryachev S, Acher R, Leatherman S, Anglin-Foote T, Liu Q, Su S, Seerapu R, Hall R, Ferguson R, Brophy MT, Ferraro J, DuVall SL, Do NV. ProjectFlow: a configurable workflow management application for point of care research. JAMIA Open. 2021 Jul; 4(3):ooab074.View Related Profiles.

Elbers, Danne
Brophy, Mary
Van Do, Nhan
Dhond, Rupali
Leatherman, Sarah

PMID: 34485848; PMCID: PMC8411372; DOI: 10.1093/jamiaopen/ooab074;

Woods P, Flynn M, Monach P, Visnaw K, Schiller S, Holmberg E, Leatherman S, Ferguson R, Branch-Elliman W. Implementation of documented and written informed consent for clinical trials of communicable diseases: Lessons learned, barriers, solutions, future directions identified during the conduct of a COVID-19 clinical trial. Contemp Clin Trials Commun. 2021 Sep; 23:100804.View Related Profiles.

Ferguson, Ryan
Leatherman, Sarah
Branch-Elliman, Westyn

PMID: 34222708; PMCID: PMC8234262; DOI: 10.1016/j.conctc.2021.100804;

Ferguson R, Leatherman S, Fiore M, Minnings K, Mosco M, Kaufman J, Kerns E, Amador JJ, Brooks DR, Fiore M, Parekh RS, Fiore L. Prevalence and Risk Factors for CKD in the General Population of Southwestern Nicaragua. J Am Soc Nephrol. 2020 07; 31(7):1585-1593.View Related Profiles.

Brooks, Daniel
Fiore, Louis
Leatherman, Sarah

PMID: 32471819; PMCID: PMC7350996; DOI: 10.1681/ASN.2019050521;

Boers M, Singh JA, Cofield SS, Bridges SL, Moreland LW, O'Dell JR, Wu H, Leatherman S, Curtis JR. A Novel Method to Combine Assessment of Benefit and Harm: Outcome Measures in Rheumatology 3×3 Methodology Applied to Two Active Comparator Trials. Arthritis Care Res (Hoboken). 2019 Feb; 71(2):319-322. PMID: 29691998; DOI: 10.1002/acr.23590;

Bansback N, Phibbs CS, Sun H, O'Dell JR, Brophy M, Keystone EC, Leatherman S, Mikuls TR, Anis AH. Triple Therapy Versus Biologic Therapy for Active Rheumatoid Arthritis: A Cost-Effectiveness Analysis. Ann Intern Med. 2017 Jul 04; 167(1):8-16.View Related Profiles.

Brophy, Mary
Leatherman, Sarah

PMID: 28554192

Huang H, Turner M, Raju S, Reich J, Leatherman S, Armstrong K, Woods P, Ferguson RE, Fiore LD, Lederle FA. Identification of Acute Decompensated Heart Failure Hospitalizations Using Administrative Data. Am J Cardiol. 2017 Jun 01; 119(11):1791-1796.View Related Profiles.

Fiore, Louis
Ferguson, Ryan
Leatherman, Sarah

PMID: 28395889; DOI: 10.1016/j.amjcard.2017.03.007;

Gradus JL, Leatherman S, Curreri A, Myers LG, Ferguson R, Miller M. Gender differences in substance abuse, PTSD and intentional self-harm among veterans health administration patients. Drug Alcohol Depend. 2017 Feb 01; 171:66-69.View Related Profiles.

Gradus, Jaimie
Ferguson, Ryan
Leatherman, Sarah

PMID: 28013099; DOI: 10.1016/j.drugalcdep.2016.11.012;

Minnings K, Fiore M, Mosco M, Ferguson R, Leatherman S, Kerns E, Kaufman J, Fiore M, Brooks D, Amador JJ, Paulsen H, Ernstberger Z, Trejo B, Sullivan E, Lichtman A, Nobil K, Lawlor M, Parker C, Parekh R, Fiore L. The Rivas Cohort Study: design and baseline characteristics of a Nicaraguan cohort. BMC Nephrol. 2016 Jul 25; 17:93.View Related Profiles.

Brooks, Daniel
Fiore, Louis
Ferguson, Ryan
Leatherman, Sarah

PMID: 27456863; PMCID: PMC4959050; DOI: 10.1186/s12882-016-0320-9;

Haupt LJ, Kazmi F, Ogilvie BW, Buckley DB, Smith BD, Leatherman S, Paris B, Parkinson O, Parkinson A. The Reliability of Estimating Ki Values for Direct, Reversible Inhibition of Cytochrome P450 Enzymes from Corresponding IC50 Values: A Retrospective Analysis of 343 Experiments. Drug Metab Dispos. 2015 Nov; 43(11):1744-50. PMID: 26354951; DOI: 10.1124/dmd.115.066597;

Miller M, Barber CW, Leatherman S. Prescription Opioid Duration of Action and the Risk of Unintentional Overdose-Reply. JAMA Intern Med. 2015 Sep; 175(9):1583. PMID: 26348519; DOI: 10.1001/jamainternmed.2015.3259;

Miller M, Barber CW, Leatherman S, Fonda J, Hermos JA, Cho K, Gagnon DR. Prescription opioid duration of action and the risk of unintentional overdose among patients receiving opioid therapy. JAMA Intern Med. 2015 Apr; 175(4):608-15.View Related Profiles.

Gagnon, David
Fonda, Jennifer
Hermos, John
Leatherman, Sarah

PMID: 25686208; DOI: 10.1001/jamainternmed.2014.8071;

Gradus JL, Leatherman S, Raju S, Ferguson R, Miller M. Posttraumatic stress disorder, depression, and non-fatal intentional self-harm in Massachusetts Veterans. Inj Epidemiol. 2014; 1(1):20.View Related Profiles.

Gradus, Jaimie
Ferguson, Ryan
Leatherman, Sarah

PMID: 26613072; PMCID: PMC4648945; DOI: 10.1186/s40621-014-0020-5;

Leatherman SM, Liang MH, Krystal JH, Lew RA, Valley D, Thwin SS, Rosenheck RA. Differences in treatment effect among clinical subgroups in a randomized clinical trial of long-acting injectable risperidone and oral antipsychotics in unstable chronic schizophrenia. J Nerv Ment Dis. 2014 Jan; 202(1):13-7.View Related Profiles.

Lew, Robert
Leatherman, Sarah
Thwin, Soe Soe

PMID: 24375206; DOI: 10.1097/NMD.0000000000000069;

O'Dell JR, Mikuls TR, Taylor TH, Ahluwalia V, Brophy M, Warren SR, Lew RA, Cannella AC, Kunkel G, Phibbs CS, Anis AH, Leatherman S, Keystone E. Therapies for active rheumatoid arthritis after methotrexate failure. N Engl J Med. 2013 Jul 25; 369(4):307-18.View Related Profiles.

Brophy, Mary
Lew, Robert
Leatherman, Sarah

PMID: 23755969; DOI: 10.1056/NEJMoa1303006;

Hoblyn JC, Rosenheck RA, Leatherman S, Weil L, Lew R. Veteran subjects willingness to participate in schizophrenia clinical trials. Psychiatr Q. 2013 Jun; 84(2):209-18.View Related Profiles.

Lew, Robert
Leatherman, Sarah

PMID: 23143523; DOI: 10.1007/s11126-012-9240-4;

Fan VS, Gaziano JM, Lew R, Bourbeau J, Adams SG, Leatherman S, Thwin SS, Huang GD, Robbins R, Sriram PS, Sharafkhaneh A, Mador MJ, Sarosi G, Panos RJ, Rastogi P, Wagner TH, Mazzuca SA, Shannon C, Colling C, Liang MH, Stoller JK, Fiore L, Niewoehner DE. A comprehensive care management program to prevent chronic obstructive pulmonary disease hospitalizations: a randomized, controlled trial. Ann Intern Med. 2012 May 15; 156(10):673-83.View Related Profiles.

Gaziano, J. Michael
Fiore, Louis
Lew, Robert
Leatherman, Sarah
Thwin, Soe Soe

PMID: 22586006; DOI: 10.1059/0003-4819-156-10-201205150-00003;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 32 publications over 12 distinct years, with a maximum of 8 publications in 2023

Bar chart showing 32 publications over 12 distinct years, with a maximum of 8 publications in 2023

Year	Publications
2012	1
2013	2
2014	2
2015	3
2016	2
2017	2
2019	1
2020	1
2021	3
2022	4
2023	8
2024	3

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Pragmatic Clinical Trials
Learning Healthcare Systems
Real World Data
Real World Clinical Trials
Biostatistics
Real World Evidence
Point of Care Clinical Trials

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