Wendy Puryear

Senior Research Associate (previously held)

Cummings Veterinary School at Tufts University

Websites

I have over twelve years of research experience in both basic and applied research, encompassing skills in Cell and Molecular Biology, Immunology, Virology, and Vaccinology. My work to date has deepened my dedication to a career in applied science. I am intrigued by the complexities of virus-host interactions and drawn to the challenge of developing ways to safely and efficiently modulate the immune system to protect against infectious disease.

Specialties:
- Viral pathogenesis and vaccine development
- Cell based assays, molecular biology, and bioinformatics

Postdoctoral Fellow (previously held)
Boston University Chobanian & Avedisian School of Medicine
Virology, Immunology & Microbiology

NIH RePORTER Research

Title

Yr	Title	Project-Sub Proj	Pubs
2010	Characterization of a novel dendritic cell receptor for HIV-1	5F32AI084558-02	4
2009	Characterization of a novel dendritic cell receptor for HIV-1	1F32AI084558-01	4

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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McCosker CM, Unal E, Gigliotti A, Puryear WB, Runstadler JA, Murray KT, King BL, Cammen KM. Molecular Mechanisms Underlying Response to Influenza in Grey Seals (Halichoerus grypus), a Potential Wild Reservoir. Mol Ecol. 2025 Aug; 34(15):e70012. PMID: 40613337; PMCID: PMC12288799; DOI: 10.1111/mec.70012;

McCosker CM, Levin M, Puryear WB, Runstadler JA, Murray KT, Cammen KM. Gray Seal (Halichoerus grypus) Pups Fail to Mount an Inflammatory Cytokine Response to Influenza A Virus. J Wildl Dis. 2025 Jul 01; 61(3):628-641. PMID: 40420394

Lowen AC, Bowman AS, Runstadler JA, Baker AL, García-Sastre A, Hensley SE, Lakdawala SS, Moncla LH, Nelson M, Pekosz A, Poulson RL, Puryear WB, Sutton TC, Tompkins SM, Webby RJ. Controlling bird flu is urgent-for dairy, wildlife, poultry, pets, and people. J Am Vet Med Assoc. 2025 Sep 01; 263(9):1192-1195. PMID: 40562366

McCarthy ML, Cammen KM, Granquist SM, Dietz R, Teilmann J, Thøstesen CB, Kjeldgaard S, Valtonen M, Kunnasranta M, Jenssen BM, Ahola MP, Bäcklin BM, Bowen WD, Puryear WB, Runstadler JA, Russell DJF, Galatius A, Tange Olsen M. Range-Wide Genomic Analysis Reveals Regional and Meta-Population Dynamics of Decline and Recovery in the Grey Seal. Mol Ecol. 2025 Jul; 34(14):e17824. PMID: 40536212; PMCID: PMC12237086; DOI: 10.1111/mec.17824;

Lowen AC, Baker AL, Bowman AS, García-Sastre A, Hensley SE, Lakdawala SS, Moncla LH, Nelson MI, Pekosz A, Poulson RL, Puryear WB, Runstadler JA, Sutton TC, Tompkins SM, Webby RJ. Pandemic risk stemming from the bovine H5N1 outbreak: an account of the knowns and unknowns. J Virol. 2025 Apr 15; 99(4):e0005225. PMID: 40013775; PMCID: PMC11998519; DOI: 10.1128/jvi.00052-25;

Runstadler JA, Puryear WB. The virus is out of the barn: the emergence of HPAI as a pathogen of avian and mammalian wildlife around the globe. Am J Vet Res. 2024 May 01; 85(5). PMID: 38593825

Puryear WB, Runstadler JA. High-pathogenicity avian influenza in wildlife: a changing disease dynamic that is expanding in wild birds and having an increasing impact on a growing number of mammals. J Am Vet Med Assoc. 2024 May 01; 262(5):601-609. PMID: 38599231

Cowell TW, Puryear W, Chen CL, Ding R, Runstadler J, Han HS. Unbiased, Cell-free Profiling of Single Influenza Genomes at High-throughput. bioRxiv. 2024 Feb 04. PMID: 38352386; PMCID: PMC10862864; DOI: 10.1101/2024.02.03.578479;

Puryear W, Sawatzki K, Hill N, Foss A, Stone JJ, Doughty L, Walk D, Gilbert K, Murray M, Cox E, Patel P, Mertz Z, Ellis S, Taylor J, Fauquier D, Smith A, DiGiovanni RA, van de Guchte A, Gonzalez-Reiche AS, Khalil Z, van Bakel H, Torchetti MK, Lantz K, Lenoch JB, Runstadler J. Highly Pathogenic Avian Influenza A(H5N1) Virus Outbreak in New England Seals, United States. Emerg Infect Dis. 2023 Apr; 29(4):786-791. PMID: 36958010; PMCID: PMC10045683; DOI: 10.3201/eid2904.221538;

Ramsey ME, Faugno AJ, Puryear WB, Lee BC, Foss AD, Lambert LH, Nargi FE, Bopp GP, Lee LP, Rudzinski CM, Ervin BL, Runstadler JA, Hill NS. Characterization of SARS-CoV-2 Aerosols Dispersed During Noninvasive Respiratory Support of Patients With COVID-19. Respir Care. 2023 Jan; 68(1):8-17. PMID: 36566031; PMCID: PMC9993517; DOI: 10.4187/respcare.10340;

Showing 10 of 37 results. Show More

Gigliotti AK, Bowen WD, Hammill MO, Puryear WB, Runstadler J, Wenzel FW, Cammen KM. Sequence Diversity and Differences at the Highly Duplicated MHC-I Gene Reflect Viral Susceptibility in Sympatric Pinniped Species. J Hered. 2022 10 21; 113(5):525-537. PMID: 35690352; PMCID: PMC9584807; DOI: 10.1093/jhered/esac030;

Gass JD, Kellogg HK, Hill NJ, Puryear WB, Nutter FB, Runstadler JA. Epidemiology and Ecology of Influenza A Viruses among Wildlife in the Arctic. Viruses. 2022 Jul 13; 14(7). PMID: 35891510; PMCID: PMC9315492; DOI: 10.3390/v14071531;

Hill NJ, Bishop MA, Trovão NS, Ineson KM, Schaefer AL, Puryear WB, Zhou K, Foss AD, Clark DE, MacKenzie KG, Gass JD, Borkenhagen LK, Hall JS, Runstadler JA. Ecological divergence of wild birds drives avian influenza spillover and global spread. PLoS Pathog. 2022 May; 18(5):e1010062. PMID: 35588106; PMCID: PMC9119557; DOI: 10.1371/journal.ppat.1010062;

Ineson KM, Hill NJ, Clark DE, MacKenzie KG, Whitney JJ, Laskaris Y, Ronconi RA, Ellis JC, Giroux JF, Lair S, Stevens S, Puryear WB, Runstadler JA. Age and season predict influenza A virus dynamics in urban gulls: consequences for natural hosts in unnatural landscapes. Ecol Appl. 2022 03; 32(2):e2497. PMID: 34783416

Cushing AC, Sawatzki K, Grome HN, Puryear WB, Kelly N, Runstadler J. DURATION OF ANTIGEN SHEDDING AND DEVELOPMENT OF ANTIBODY TITERS IN MALAYAN TIGERS (PANTHERA TIGRIS JACKSONI) NATURALLY INFECTED WITH SARS-CoV-2. J Zoo Wildl Med. 2021 Dec; 52(4):1224-1228.View Related Profiles.

Sawatzki, Kaitlin
Puryear, Wendy

PMID: 34998292

Puryear W, Sawatzki K, Bogomolni A, Hill N, Foss A, Stokholm I, Olsen MT, Nielsen O, Waltzek T, Goldstein T, Subramaniam K, Rodrigues TCS, Belaganahalli M, Doughty L, Becker L, Stokes A, Niemeyer M, Tuttle A, Romano T, Linhares MB, Fauquier D, Runstadler J. Longitudinal analysis of pinnipeds in the northwest Atlantic provides insights on endemic circulation of phocine distemper virus. Proc Biol Sci. 2021 11 10; 288(1962):20211841.View Related Profiles.

Sawatzki, Kaitlin
Puryear, Wendy

PMID: 34753354; PMCID: PMC8580419; DOI: 10.1098/rspb.2021.1841;

Stokholm I, Puryear W, Sawatzki K, Knudsen SW, Terkelsen T, Becher P, Siebert U, Olsen MT. Emergence and radiation of distemper viruses in terrestrial and marine mammals. Proc Biol Sci. 2021 10 27; 288(1961):20211969.View Related Profiles.

Sawatzki, Kaitlin
Puryear, Wendy

PMID: 34702073; PMCID: PMC8548803; DOI: 10.1098/rspb.2021.1969;

Sawatzki K, Hill NJ, Puryear WB, Foss AD, Stone JJ, Runstadler JA. Host barriers to SARS-CoV-2 demonstrated by ferrets in a high-exposure domestic setting. Proc Natl Acad Sci U S A. 2021 05 04; 118(18).View Related Profiles.

Sawatzki, Kaitlin
Puryear, Wendy

PMID: 33858941; PMCID: PMC8106344; DOI: 10.1073/pnas.2025601118;

Lacson E, Weiner D, Majchrzak K, Puryear W, Hosford J, Palmer A, Runstadler J, Meyer KB, Johnson DS. Prolonged Live SARS-CoV-2 Shedding in a Maintenance Dialysis Patient. Kidney Med. 2021 Mar-Apr; 3(2):309-311. PMID: 33521620; PMCID: PMC7834361; DOI: 10.1016/j.xkme.2020.12.001;

Krucik DDR, Mangold B, Puryear W, Keogh M, Bogomolni A, Romano T, Runstadler J, Nutter F. SERUM BIOCHEMICAL AND HEMATOLOGIC REFERENCE INTERVALS FOR WEANLING NORTHWEST ATLANTIC GRAY SEALS (HALICHOERUS GRYPUS). J Zoo Wildl Med. 2020 Mar 17; 51(1):228-231. PMID: 32212568

Seifried BM, Qi W, Yang YJ, Mai DJ, Puryear WB, Runstadler JA, Chen G, Olsen BD. Glycoprotein Mimics with Tunable Functionalization through Global Amino Acid Substitution and Copper Click Chemistry. Bioconjug Chem. 2020 03 18; 31(3):554-566. PMID: 32078297

Runstadler JA, Puryear W. A Brief Introduction to Influenza A Virus in Marine Mammals. Methods Mol Biol. 2020; 2123:429-450. PMID: 32170708

Cummings CO, Hill NJ, Puryear WB, Rogers B, Mukherjee J, Leibler JH, Rosenbaum MH, Runstadler JA. Evidence of Influenza A in Wild Norway Rats (Rattus norvegicus) in Boston, Massachusetts. Front Ecol Evol. 2019 Mar; 7.View Related Profiles.

Leibler, Jessica
Puryear, Wendy

PMID: 34660611; PMCID: PMC8519512; DOI: 10.3389/fevo.2019.00036;

Cammen KM, Schultz TF, Don Bowen W, Hammill MO, Puryear WB, Runstadler J, Wenzel FW, Wood SA, Kinnison M. Genomic signatures of population bottleneck and recovery in Northwest Atlantic pinnipeds. Ecol Evol. 2018 Jul; 8(13):6599-6614. PMID: 30038760; PMCID: PMC6053562; DOI: 10.1002/ece3.4143;

Estrin MA, Hussein ITM, Puryear WB, Kuan AC, Artim SC, Runstadler JA. Host-directed combinatorial RNAi improves inhibition of diverse strains of influenza A virus in human respiratory epithelial cells. PLoS One. 2018; 13(5):e0197246. PMID: 29775471; PMCID: PMC5959063; DOI: 10.1371/journal.pone.0197246;

Desforges JP, Bandoro C, Shehata L, Sonne C, Dietz R, Puryear WB, Runstadler JA. Environmental contaminant mixtures modulate in vitro influenza infection. Sci Total Environ. 2018 Sep 01; 634:20-28. PMID: 29626767

Lerner JE, Ono K, Hernandez KM, Runstadler JA, Puryear WB, Polito MJ. Evaluating the use of stable isotope analysis to infer the feeding ecology of a growing US gray seal (Halichoerus grypus) population. PLoS One. 2018; 13(2):e0192241. PMID: 29466372; PMCID: PMC5821315; DOI: 10.1371/journal.pone.0192241;

Spivey TJ, Lindberg MS, Meixell BW, Smith KR, Puryear WB, Davis KR, Runstadler JA, Stallknecht DE, Ramey AM. Maintenance of influenza A viruses and antibody response in mallards (Anas platyrhynchos) sampled during the non-breeding season in Alaska. PLoS One. 2017; 12(8):e0183505. PMID: 28837606; PMCID: PMC5570339; DOI: 10.1371/journal.pone.0183505;

Hill NJ, Hussein IT, Davis KR, Ma EJ, Spivey TJ, Ramey AM, Puryear WB, Das SR, Halpin RA, Lin X, Fedorova NB, Suarez DL, Boyce WM, Runstadler JA. Reassortment of Influenza A Viruses in Wild Birds in Alaska before H5 Clade 2.3.4.4 Outbreaks. Emerg Infect Dis. 2017 04; 23(4):654-657. PMID: 28322698; PMCID: PMC5367406; DOI: 10.3201/eid2304.161668;

Puryear WB, Keogh M, Hill N, Moxley J, Josephson E, Davis KR, Bandoro C, Lidgard D, Bogomolni A, Levin M, Lang S, Hammill M, Bowen D, Johnston DW, Romano T, Waring G, Runstadler J. Prevalence of influenza A virus in live-captured North Atlantic gray seals: a possible wild reservoir. Emerg Microbes Infect. 2016 Aug 03; 5(8):e81. PMID: 27485496; PMCID: PMC5034098; DOI: 10.1038/emi.2016.77;

Tang S, Puryear WB, Seifried BM, Dong X, Runstadler JA, Ribbeck K, Olsen BD. Antiviral Agents from Multivalent Presentation of Sialyl Oligosaccharides on Brush Polymers. ACS Macro Lett. 2016 Mar 15; 5(3):413-418. PMID: 35614714

Puryear WB, Akiyama H, Geer SD, Ramirez NP, Yu X, Reinhard BM, Gummuluru S. Interferon-inducible mechanism of dendritic cell-mediated HIV-1 dissemination is dependent on Siglec-1/CD169. PLoS Pathog. 2013; 9(4):e1003291.View Related Profiles.

Reinhard, Bjorn
Akiyama, Hisashi
Gummuluru, Suryaram
Kijewski, Suzanne
Puryear, Wendy

PMID: 23593001; PMCID: PMC3623718; DOI: 10.1371/journal.ppat.1003291;

Runstadler J, Hill N, Hussein IT, Puryear W, Keogh M. Connecting the study of wild influenza with the potential for pandemic disease. Infect Genet Evol. 2013 Jul; 17:162-87. PMID: 23541413; PMCID: PMC3685205; DOI: 10.1016/j.meegid.2013.02.020;

Puryear WB, Gummuluru S. Role of glycosphingolipids in dendritic cell-mediated HIV-1 trans-infection. Adv Exp Med Biol. 2013; 762:131-53.View Related Profiles.

Gummuluru, Suryaram
Puryear, Wendy

PMID: 22975874; PMCID: PMC3686569; DOI: 10.1007/978-1-4614-4433-6_5;

Puryear WB, Yu X, Ramirez NP, Reinhard BM, Gummuluru S. HIV-1 incorporation of host-cell-derived glycosphingolipid GM3 allows for capture by mature dendritic cells. Proc Natl Acad Sci U S A. 2012 May 8; 109(19):7475-80.View Related Profiles.

Reinhard, Bjorn
Gummuluru, Suryaram
Puryear, Wendy

PMID: 22529395; PMCID: PMC3358844; DOI: 10.1073/pnas.1201104109;

Malherbe DC, Doria-Rose NA, Misher L, Beckett T, Puryear WB, Schuman JT, Kraft Z, O'Malley J, Mori M, Srivastava I, Barnett S, Stamatatos L, Haigwood NL. Sequential immunization with a subtype B HIV-1 envelope quasispecies partially mimics the in vivo development of neutralizing antibodies. J Virol. 2011 Jun; 85(11):5262-74. PMID: 21430056; PMCID: PMC3094990; DOI: 10.1128/JVI.02419-10;

Provine NM, Puryear WB, Wu X, Overbaugh J, Haigwood NL. The infectious molecular clone and pseudotyped virus models of human immunodeficiency virus type 1 exhibit significant differences in virion composition with only moderate differences in infectivity and inhibition sensitivity. J Virol. 2009 Sep; 83(17):9002-7. PMID: 19535443; PMCID: PMC2738156; DOI: 10.1128/JVI.00423-09;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 37 publications over 14 distinct years, with a maximum of 5 publications in 2021 and 2025

Bar chart showing 37 publications over 14 distinct years, with a maximum of 5 publications in 2021 and 2025

Year	Publications
2009	1
2011	1
2012	1
2013	3
2016	2
2017	2
2018	4
2019	1
2020	4
2021	5
2022	3
2023	2
2024	3
2025	5

Contact for Mentoring:

617.414.8077

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