Valerie Gouon-Evans | Profiles RNS

Valerie Gouon-Evans, PhD, PharmD

Associate Professor

Boston University School of Medicine

Dept of Medicine

Gastroenterology

PhD, University of Paris Vii
MS, University of Paris Vii
PharmD, Université Paris 5 René Descartes

Pronouns: she/her/hers

Websites

	Gouon-Evans Lab
	LinkedIn
	ResearchGate

Valerie Gouon-Evans, PharmD, PhD is an Associate Professor of Medicine in the department of Gastroenterology at the Boston University School of Medicine. After completing her graduate studies in Paris, Dr. Gouon-Evans joined Dr. Pollard's Lab as a postdoctoral fellow where she studied mammary gland development and breast cancer. She then began her career as an Instructor of Gene and Cell Medicine at the Icahn School of Medicine at Mount Sinai School of Medicine in New York in the laboratory of Dr. Gordon Keller, where she pioneered protocols to efficiently generate hepatocyte-like cells from pluripotent stem cells. She quickly rose up the ranks and was promoted to Assistant Professor before arriving at Boston University. Dr. Gouon-Evans's current research interests range from liver development, regeneration, and cancer using the pluripotent stem cell platform, in vivo mouse models, and primary human tissues.

Member
Boston University
Center for Regenerative Medicine

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences

2010 Federation of American Societies for Experimental Biology (FASEB): Travel Award

2008 Federation of American Societies for Experimental Biology (FASEB): Travel Award

2007-2008 International Society for Stem Cell Research: Travel Award

BMC Research

A multi-modular approach for human pluripotent stem cell-based liver regeneration
09/15/2020 - 07/31/2024 (PI)
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
1R01DK124361-01A1

Edited stem cell-based therapy with transcript therapy for AATD-associated liver disease
07/01/2019 - 06/30/2021 (PI)
Alpha-1 Foundation

Use of Human Pluripotent Stem Cell-derived Hepatic Cells in Pediatric Liver Transplantation
07/01/2017 - 05/31/2018 (PI)
March of Dimes

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Rizvi F, Everton E, Smith AR, Liu H, Osota E, Beattie M, Tam Y, Pardi N, Weissman D, Gouon-Evans V. Author Correction: Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA. Nat Commun. 2021 May 10; 12(1):2825.View Related Profiles.

Rizvi, Fatima
Gouon-Evans, Valerie

PMID: 33972545; PMCID: PMC8110992; DOI: 10.1038/s41467-021-23322-6;

Rizvi F, Everton E, Smith AR, Liu H, Osota E, Beattie M, Tam Y, Pardi N, Weissman D, Gouon-Evans V. Murine liver repair via transient activation of regenerative pathways in hepatocytes using lipid nanoparticle-complexed nucleoside-modified mRNA. Nat Commun. 2021 01 27; 12(1):613.View Related Profiles.

Rizvi, Fatima
Gouon-Evans, Valerie

PMID: 33504774; PMCID: PMC7840919; DOI: 10.1038/s41467-021-20903-3;

Han S, Tan C, Ding J, Wang J, Ma'ayan A, Gouon-Evans V. Endothelial cells instruct liver specification of embryonic stem cell-derived endoderm through endothelial VEGFR2 signaling and endoderm epigenetic modifications. Stem Cell Res. 2018 07; 30:163-170. PMID: 29936335; DOI: 10.1016/j.scr.2018.06.004;

Bardot E, Calderon D, Santoriello F, Han S, Cheung K, Jadhav B, Burtscher I, Artap S, Jain R, Epstein J, Lickert H, Gouon-Evans V, Sharp AJ, Dubois NC. Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential. Nat Commun. 2017 02 14; 8:14428. PMID: 28195173; PMCID: PMC5316866; DOI: 10.1038/ncomms14428;

Goldman O, Cohen I, Gouon-Evans V. Functional Blood Progenitor Markers in Developing Human Liver Progenitors. Stem Cell Reports. 2016 08 09; 7(2):158-66. PMID: 27509132; PMCID: PMC4983080; DOI: 10.1016/j.stemcr.2016.07.008;

Goldman O, Gouon-Evans V. Human Pluripotent Stem Cells: Myths and Future Realities for Liver Cell Therapy. Cell Stem Cell. 2016 06 02; 18(6):703-6. PMID: 27257759; DOI: 10.1016/j.stem.2016.05.019;

Goldman O, Valdes VJ, Ezhkova E, Gouon-Evans V. The mesenchymal transcription factor SNAI-1 instructs human liver specification. Stem Cell Res. 2016 07; 17(1):62-8. PMID: 27240252; PMCID: PMC5012916; DOI: 10.1016/j.scr.2016.05.007;

Gordillo M, Evans T, Gouon-Evans V. Orchestrating liver development. Development. 2015 Jun 15; 142(12):2094-108. PMID: 26081571; PMCID: PMC4483763; DOI: 10.1242/dev.114215;

Goldman O, Han S, Hamou W, Jodon de Villeroche V, Uzan G, Lickert H, Gouon-Evans V. Endoderm generates endothelial cells during liver development. Stem Cell Reports. 2014 Oct 14; 3(4):556-65. PMID: 25358784; PMCID: PMC4223703; DOI: 10.1016/j.stemcr.2014.08.009;

Han S, Goldman O, Gouon-Evans V. Liver progenitor cell and KDR. Cell Cycle. 2014; 13(7):1051-2. PMID: 24553112; PMCID: PMC4013151; DOI: 10.4161/cc.28213;

Showing 10 of 31 results. Show More

Gouon-Evans V. The race for regeneration: Pluripotent-stem-cell-derived 3D kidney structures. Cell Stem Cell. 2014 Jan 02; 14(1):5-6. PMID: 24388170; PMCID: PMC4058857; DOI: 10.1016/j.stem.2013.12.004;

Sourisseau M, Goldman O, He W, Gori JL, Kiem HP, Gouon-Evans V, Evans MJ. Hepatic cells derived from induced pluripotent stem cells of pigtail macaques support hepatitis C virus infection. Gastroenterology. 2013 Nov; 145(5):966-969.e7. PMID: 23891978; PMCID: PMC3805793; DOI: 10.1053/j.gastro.2013.07.026;

Goldman O, Han S, Sourisseau M, Sourrisseau M, Dziedzic N, Hamou W, Corneo B, D'Souza S, Sato T, Kotton DN, Bissig KD, Kalir T, Jacobs A, Evans T, Evans MJ, Gouon-Evans V. KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development. Cell Stem Cell. 2013 Jun 6; 12(6):748-60.View Related Profiles.

Kotton, Darrell
Gouon-Evans, Valerie

PMID: 23746980; PMCID: PMC3922205; DOI: 10.1016/j.stem.2013.04.026;

Cashman TJ, Gouon-Evans V, Costa KD. Mesenchymal stem cells for cardiac therapy: practical challenges and potential mechanisms. Stem Cell Rev. 2013 Jun; 9(3):254-65. PMID: 22577007; PMCID: PMC5868420; DOI: 10.1007/s12015-012-9375-6;

Han S, Bourdon A, Hamou W, Dziedzic N, Goldman O, Gouon-Evans V. Generation of functional hepatic cells from pluripotent stem cells. J Stem Cell Res Ther. 2012 Aug 15; Suppl 10(8):1-7. PMID: 25364624; PMCID: PMC4215546; DOI: 10.4172/2157-7633.S10-008;

Kubo A, Stull R, Takeuchi M, Bonham K, Gouon-Evans V, Sho M, Iwano M, Saito Y, Keller G, Snodgrass R. Pdx1 and Ngn3 overexpression enhances pancreatic differentiation of mouse ES cell-derived endoderm population. PLoS One. 2011; 6(9):e24058. PMID: 21931641; PMCID: PMC3172220; DOI: 10.1371/journal.pone.0024058;

Christodoulou C, Longmire TA, Shen SS, Bourdon A, Sommer CA, Gadue P, Spira A, Gouon-Evans V, Murphy GJ, Mostoslavsky G, Kotton DN. Mouse ES and iPS cells can form similar definitive endoderm despite differences in imprinted genes. J Clin Invest. 2011 Jun; 121(6):2313-25.View Related Profiles.

Spira, Avrum
Sommer, Cesar
Kotton, Darrell
Murphy, George
Mostoslavsky, Gustavo
Gouon-Evans, Valerie

PMID: 21537085; PMCID: PMC3104741; DOI: 10.1172/JCI43853;

Green MD, Chen A, Nostro MC, d'Souza SL, Schaniel C, Lemischka IR, Gouon-Evans V, Keller G, Snoeck HW. Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells. Nat Biotechnol. 2011 Mar; 29(3):267-72. PMID: 21358635; PMCID: PMC4866999; DOI: 10.1038/nbt.1788;

Han S, Dziedzic N, Gadue P, Keller GM, Gouon-Evans V. An endothelial cell niche induces hepatic specification through dual repression of Wnt and Notch signaling. Stem Cells. 2011 Feb; 29(2):217-28. PMID: 21732480; PMCID: PMC3437666; DOI: 10.1002/stem.576;

Zhao X, Monson C, Gao C, Gouon-Evans V, Matsumoto N, Sadler KC, Friedman SL. Klf6/copeb is required for hepatic outgrowth in zebrafish and for hepatocyte specification in mouse ES cells. Dev Biol. 2010 Aug 01; 344(1):79-93. PMID: 20430021; PMCID: PMC2909330; DOI: 10.1016/j.ydbio.2010.04.018;

Gadue P, Gouon-Evans V, Cheng X, Wandzioch E, Zaret KS, Grompe M, Streeter PR, Keller GM. Generation of monoclonal antibodies specific for cell surface molecules expressed on early mouse endoderm. Stem Cells. 2009 Sep; 27(9):2103-13. PMID: 19522011; PMCID: PMC2890285; DOI: 10.1002/stem.147;

Ingman WV, Wyckoff J, Gouon-Evans V, Condeelis J, Pollard JW. Macrophages promote collagen fibrillogenesis around terminal end buds of the developing mammary gland. Dev Dyn. 2006 Dec; 235(12):3222-9. PMID: 17029292; DOI: 10.1002/dvdy.20972;

Gouon-Evans V, Boussemart L, Gadue P, Nierhoff D, Koehler CI, Kubo A, Shafritz DA, Keller G. BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm. Nat Biotechnol. 2006 Nov; 24(11):1402-11. PMID: 17086172; DOI: 10.1038/nbt1258;

Zhao X, Matsumoto N, Gouon-Evans V, Yea S, Loke JC, Keller G, Friedman SL. Hepatology. The role of kruppel-like factor 6 (KLF6) in differentiation of embryonic stem cells into hepatocytes. 2006.

Banaei-Bouchareb L, Gouon-Evans V, Samara-Boustani D, Castellotti MC, Czernichow P, Pollard JW, Polak M. Insulin cell mass is altered in Csf1op/Csf1op macrophage-deficient mice. J Leukoc Biol. 2004 Aug; 76(2):359-67. PMID: 15178709; DOI: 10.1189/jlb.1103591;

Iyengar P, Combs TP, Shah SJ, Gouon-Evans V, Pollard JW, Albanese C, Flanagan L, Tenniswood MP, Guha C, Lisanti MP, Pestell RG, Scherer PE. Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene. 2003 Sep 25; 22(41):6408-23. PMID: 14508521; DOI: 10.1038/sj.onc.1206737;

Gouon-Evans V, Pollard JW. Unexpected deposition of brown fat in mammary gland during postnatal development. Mol Endocrinol. 2002 Nov; 16(11):2618-27. PMID: 12403850; DOI: 10.1210/me.2001-0337;

Gouon-Evans V, Lin EY, Pollard JW. Requirement of macrophages and eosinophils and their cytokines/chemokines for mammary gland development. Breast Cancer Res. 2002; 4(4):155-64. PMID: 12100741; PMCID: PMC138736

Lin EY, Gouon-Evans V, Nguyen AV, Pollard JW. The macrophage growth factor CSF-1 in mammary gland development and tumor progression. J Mammary Gland Biol Neoplasia. 2002 Apr; 7(2):147-62. PMID: 12465600

Gouon-Evans V, Pollard JW. Eotaxin is required for eosinophil homing into the stroma of the pubertal and cycling uterus. Endocrinology. 2001 Oct; 142(10):4515-21. PMID: 11564717; DOI: 10.1210/endo.142.10.8459;

Gouon-Evans V, Rothenberg ME, Pollard JW. Postnatal mammary gland development requires macrophages and eosinophils. Development. 2000 Jun; 127(11):2269-82. PMID: 10804170

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 31 publications over 17 distinct years, with a maximum of 4 publications in 2011

Bar chart showing 31 publications over 17 distinct years, with a maximum of 4 publications in 2011

Year	Publications
2000	1
2001	1
2002	3
2003	1
2004	1
2006	3
2009	1
2010	1
2011	4
2012	1
2013	3
2014	3
2015	1
2016	3
2017	1
2018	1
2021	2

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Pluripotent Stem Cells
Liver Development
Liver Regeneration
alpha 1 Antitrypsin Deficiency
Liver Fibrosis
Liver Steatosis
nucleoside modified mRNA
Lipid Nanoparticle
Liver Injury Mouse Models
Stem Cell-based Therapy for Liver Diseases
Liver Progenitor Cells

Contact for Mentoring:

670 Albany Street
Boston MA 02118
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617.414.2971

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