Shobini Jayaraman | Profiles RNS

Shobini Jayaraman, MD, PhD

Research Scientist

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

ORCID : 0000-0003-1616-5347

Publications
Contact Info

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Jayaraman S, Choi K, Pérez A, Miñambres I, Sánchez-Quesada JL, Gursky O. Binding of human low-density lipoproteins to type-I collagen is synergistic with the pro-atherogenic lipoprotein remodeling. Biochim Biophys Acta Mol Basis Dis. 2026 Mar; 1872(3):168142.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 41419069; PMCID: PMC12756824; DOI: 10.1016/j.bbadis.2025.168142;

Hicks CW, Prokaeva T, Spencer B, Jayaraman S, Huda N, Wong S, Chen H, Sanchorawala V, Lavatelli F, Gursky O. Cryo-EM of Cardiac AL-224L Amyloid Reveals Shared Structural Motifs and Mutation-induced Differences in ?6 Light Chain Fibrils. J Mol Biol. 2026 Feb 01; 438(3):169591.View Related Profiles.

Huda, Noorul
Gursky, Olga
Jayaraman, Shobini
Prokaeva, Tatiana
Sanchorawala, Vaishali

PMID: 41389958; PMCID: PMC12811844; DOI: 10.1016/j.jmb.2025.169591;

Hicks CW, Prokaeva T, Spencer B, Jayaraman S, Huda N, Wong S, Chen H, Sanchorawala V, Lavatelli F, Gursky O. Cryo-EM of cardiac AL-224L amyloid reveals shared features in ?6 light chain fibril folds. bioRxiv. 2025 Jul 01.View Related Profiles.

Huda, Noorul
Gursky, Olga
Jayaraman, Shobini
Prokaeva, Tatiana
Sanchorawala, Vaishali

PMID: 40631131; PMCID: PMC12236830; DOI: 10.1101/2025.06.25.661559;

Prokaeva T, Jayaraman S, Klimtchuk E, Burke N, Spencer B, Nedelkov D, Chen H, Dasari S, McPhail ED, Pereira L, Payne MC, Wong S, Burks EJ, Sanchorawala V, Gursky O. An unusual phenotype of hereditary AApoAI amyloidosis caused by a novel Asp20Tyr substitution is linked to pH-dependent aggregation of apolipoprotein A-I. Biochim Biophys Acta Mol Basis Dis. 2025 Jun; 1871(5):167820.View Related Profiles.

Klimtchuk, Elena
Burks, Eric
Pereira, Lucas
Burke , Natasha
Gursky, Olga
Jayaraman, Shobini
Prokaeva, Tatiana
Sanchorawala, Vaishali

PMID: 40164396; PMCID: PMC11998993; DOI: 10.1016/j.bbadis.2025.167820;

Jayaraman S, Urdaneta A, Fandrich M, Gursky O. Serum Amyloid A Binding to Glycosaminoglycans is Synergistic with Amyloid Formation: Therapeutic Targeting in the Inflammation-linked Amyloidosis. J Mol Biol. 2025 Apr 15; 437(8):169007.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 39954777; PMCID: PMC11903164; DOI: 10.1016/j.jmb.2025.169007;

Lewkowicz E, Jayaraman S, Gursky O. Molecular basis for non-invasive diagnostics of cardiac amyloids using bone tracers. Biomater Sci. 2024 Aug 20; 12(17):4275-4282.View Related Profiles.

Lewkowicz, Emily
Gursky, Olga
Jayaraman, Shobini

PMID: 39046441; PMCID: PMC11334954; DOI: 10.1039/d4bm00816b;

Jayaraman S, Narula N, Narula J, Gursky O. Amyloid and collagen templates in aortic valve calcification. Trends Mol Med. 2024 Nov; 30(11):1010-1019.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 38845326; PMCID: PMC11563925; DOI: 10.1016/j.molmed.2024.04.015;

Jayaraman S, Pérez A, Miñambres I, Sánchez-Quesada JL, Gursky O. LDL binding to cell receptors and extracellular matrix is proatherogenic in obesity but improves after bariatric surgery. J Lipid Res. 2023 Nov; 64(11):100451.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 37777014; PMCID: PMC10665669; DOI: 10.1016/j.jlr.2023.100451;

Jayaraman S, Urdaneta A, Bullitt E, Fändrich M, Gursky O. Lipid clearance and amyloid formation by serum amyloid A: exploring the links between beneficial and pathologic actions of an enigmatic protein. J Lipid Res. 2023 Sep; 64(9):100429.View Related Profiles.

Bullitt, Esther
Gursky, Olga
Jayaraman, Shobini

PMID: 37604227; PMCID: PMC10509712; DOI: 10.1016/j.jlr.2023.100429;

Jayaraman S, Pérez A, Miñambres I, Sánchez-Quesada JL, Gursky O. Heparin binding triggers human VLDL remodeling by circulating lipoprotein lipase: Relevance to VLDL functionality in health and disease. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 01; 1867(1):159064.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 34610468; PMCID: PMC8595799; DOI: 10.1016/j.bbalip.2021.159064;

Showing 10 of 47 results. Show More

Lewkowicz E, Jayaraman S, Gursky O. Protein Amyloid Cofactors: Charged Side-Chain Arrays Meet Their Match? Trends Biochem Sci. 2021 08; 46(8):626-629.View Related Profiles.

Lewkowicz, Emily
Gursky, Olga
Jayaraman, Shobini

PMID: 34210544; PMCID: PMC8415129; DOI: 10.1016/j.tibs.2021.05.003;

Jayaraman S, Chavez OR, Pérez A, Miñambres I, Sánchez-Quesada JL, Gursky O. Binding to heparin triggers deleterious structural and biochemical changes in human low-density lipoprotein, which are amplified in hyperglycemia. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 08; 1865(8):158712.View Related Profiles.

Gursky, Olga
Chavez, Olivia
Jayaraman, Shobini

PMID: 32289504; PMCID: PMC7269877; DOI: 10.1016/j.bbalip.2020.158712;

Jayaraman S, Fändrich M, Gursky O. Synergy between serum amyloid A and secretory phospholipase A2. Elife. 2019 05 21; 8.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 31111824; PMCID: PMC6557629; DOI: 10.7554/eLife.46630;

Jayaraman S, Baveghems C, Chavez OR, Rivas-Urbina A, Sánchez-Quesada JL, Gursky O. Effects of triacylglycerol on the structural remodeling of human plasma very low- and low-density lipoproteins. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 07; 1864(7):1061-1071.View Related Profiles.

Gursky, Olga
Chavez, Olivia
Jayaraman, Shobini

PMID: 30844432; PMCID: PMC6482102; DOI: 10.1016/j.bbalip.2019.03.001;

Wilson CJ, Das M, Jayaraman S, Gursky O, Engen JR. Effects of Disease-Causing Mutations on the Conformation of Human Apolipoprotein A-I in Model Lipoproteins. Biochemistry. 2018 07 31; 57(30):4583-4596.View Related Profiles.

Das, Madhurima
Gursky, Olga
Jayaraman, Shobini

PMID: 30004693; PMCID: PMC6067968; DOI: 10.1021/acs.biochem.8b00538;

Jayaraman S, Gantz DL, Haupt C, Fändrich M, Gursky O. Serum amyloid A sequesters diverse phospholipids and their hydrolytic products, hampering fibril formation and proteolysis in a lipid-dependent manner. Chem Commun (Camb). 2018 Apr 03; 54(28):3532-3535.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 29565436; PMCID: PMC5882536; DOI: 10.1039/C8CC01424H;

Jayaraman S, Gantz DL, Haupt C, Gursky O. Serum amyloid A forms stable oligomers that disrupt vesicles at lysosomal pH and contribute to the pathogenesis of reactive amyloidosis. Proc Natl Acad Sci U S A. 2017 08 08; 114(32):E6507-E6515.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 28743750; PMCID: PMC5559045; DOI: 10.1073/pnas.1707120114;

Frame NM, Jayaraman S, Gantz DL, Gursky O. Serum amyloid A self-assembles with phospholipids to form stable protein-rich nanoparticles with a distinct structure: A hypothetical function of SAA as a "molecular mop" in immune response. J Struct Biol. 2017 Dec; 200(3):293-302.View Related Profiles.

Frame, Nicholas
Gursky, Olga
Jayaraman, Shobini

PMID: 28645735; PMCID: PMC6042646; DOI: 10.1016/j.jsb.2017.06.007;

Jayaraman S, Sánchez-Quesada JL, Gursky O. Triglyceride increase in the core of high-density lipoproteins augments apolipoprotein dissociation from the surface: Potential implications for treatment of apolipoprotein deposition diseases. Biochim Biophys Acta Mol Basis Dis. 2017 01; 1863(1):200-210.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 27768903; PMCID: PMC5154891; DOI: 10.1016/j.bbadis.2016.10.010;

Jayaraman S, Haupt C, Gursky O. Paradoxical effects of SAA on lipoprotein oxidation suggest a new antioxidant function for SAA. J Lipid Res. 2016 Dec; 57(12):2138-2149.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 27744369; PMCID: PMC5321215; DOI: 10.1194/jlr.M071191;

Rull A, Jayaraman S, Gantz DL, Rivas-Urbina A, Pérez-Cuellar M, Ordóñez-Llanos J, Sánchez-Quesada JL, Gursky O. Thermal stability of human plasma electronegative low-density lipoprotein: A paradoxical behavior of low-density lipoprotein aggregation. Biochim Biophys Acta. 2016 09; 1861(9 Pt A):1015-24.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 27233433; PMCID: PMC5572826; DOI: 10.1016/j.bbalip.2016.05.008;

Jayaraman S, Haupt C, Gursky O. Thermal transitions in serum amyloid A in solution and on the lipid: implications for structure and stability of acute-phase HDL. J Lipid Res. 2015 Aug; 56(8):1531-42.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 26022803; PMCID: PMC4513994; DOI: 10.1194/jlr.M059162;

Chan GK, Witkowski A, Gantz DL, Zhang TO, Zanni MT, Jayaraman S, Cavigiolio G. Myeloperoxidase-mediated Methionine Oxidation Promotes an Amyloidogenic Outcome for Apolipoprotein A-I. J Biol Chem. 2015 Apr 24; 290(17):10958-71. PMID: 25759391; PMCID: PMC4409257; DOI: 10.1074/jbc.M114.630442;

Das M, Mei X, Jayaraman S, Atkinson D, Gursky O. Amyloidogenic mutations in human apolipoprotein A-I are not necessarily destabilizing - a common mechanism of apolipoprotein A-I misfolding in familial amyloidosis and atherosclerosis. FEBS J. 2014 Jun; 281(11):2525-42.View Related Profiles.

Atkinson, David
Das, Madhurima
Gursky, Olga
Jayaraman, Shobini
Mei, Xiaohu

PMID: 24702826; PMCID: PMC4047191; DOI: 10.1111/febs.12809;

Cavigiolio G, Jayaraman S. Proteolysis of apolipoprotein A-I by secretory phospholipase A2: a new link between inflammation and atherosclerosis. J Biol Chem. 2014 Apr 4; 289(14):10011-23. PMID: 24523407; PMCID: PMC3974973; DOI: 10.1074/jbc.M113.525717;

Gao X, Yuan S, Jayaraman S, Gursky O. Role of apolipoprotein A-II in the structure and remodeling of human high-density lipoprotein (HDL): protein conformational ensemble on HDL. Biochemistry. 2012 Jun 12; 51(23):4633-41.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini
Yuan, Shujun
Gao, Xuan

PMID: 22631438; PMCID: PMC5603225; DOI: 10.1021/bi300555d;

Jayaraman S, Cavigiolio G, Gursky O. Folded functional lipid-poor apolipoprotein A-I obtained by heating of high-density lipoproteins: relevance to high-density lipoprotein biogenesis. Biochem J. 2012 Mar 15; 442(3):703-12.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 22150513; PMCID: PMC3857142; DOI: 10.1042/BJ20111831;

Jayaraman S, Abe-Dohmae S, Yokoyama S, Cavigiolio G. Impact of self-association on function of apolipoprotein A-I. J Biol Chem. 2011 Oct 14; 286(41):35610-23. PMID: 21835924; PMCID: PMC3195568; DOI: 10.1074/jbc.M111.262485;

Jayaraman S, Jasuja R, Zakharov MN, Gursky O. Pressure perturbation calorimetry of lipoproteins reveals an endothermic transition without detectable volume changes. Implications for adsorption of apolipoprotein to a phospholipid surface. Biochemistry. 2011 May 17; 50(19):3919-27.View Related Profiles.

Zakharov, Mikhail
Gursky, Olga
Jasuja, Ravi
Jayaraman, Shobini

PMID: 21452855; PMCID: PMC5601316; DOI: 10.1021/bi200090y;

Jayaraman S, Gantz DL, Gursky O. Effects of phospholipase A(2) and its products on structural stability of human LDL: relevance to formation of LDL-derived lipid droplets. J Lipid Res. 2011 Mar; 52(3):549-57.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 21220788; PMCID: PMC3035691; DOI: 10.1194/jlr.M012567;

Jayaraman S, Benjwal S, Gantz DL, Gursky O. Effects of cholesterol on thermal stability of discoidal high density lipoproteins. J Lipid Res. 2010 Feb; 51(2):324-33.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 19700415; PMCID: PMC2803234; DOI: 10.1194/jlr.M000117;

Gao X, Yuan S, Jayaraman S, Gursky O. Differential stability of high-density lipoprotein subclasses: effects of particle size and protein composition. J Mol Biol. 2009 Apr 3; 387(3):628-38.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini
Yuan, Shujun
Gao, Xuan

PMID: 19236880; PMCID: PMC2706704; DOI: 10.1016/j.jmb.2009.02.036;

Guha M, Gao X, Jayaraman S, Gursky O. Correlation of structural stability with functional remodeling of high-density lipoproteins: the importance of being disordered. Biochemistry. 2008 Nov 4; 47(44):11393-7.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini
Gao, Xuan

PMID: 18839964; PMCID: PMC2822716; DOI: 10.1021/bi8014746;

Jayaraman S, Gantz DL, Gursky O. Effects of protein oxidation on the structure and stability of model discoidal high-density lipoproteins. Biochemistry. 2008 Mar 25; 47(12):3875-82.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 18302337; PMCID: PMC2823073; DOI: 10.1021/bi7023783;

Gao X, Jayaraman S, Gursky O. Mild oxidation promotes and advanced oxidation impairs remodeling of human high-density lipoprotein in vitro. J Mol Biol. 2008 Feb 29; 376(4):997-1007.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini
Gao, Xuan

PMID: 18190928; PMCID: PMC2276461; DOI: 10.1016/j.jmb.2007.12.030;

Jayaraman S, Gantz DL, Gursky O. Effects of oxidation on the structure and stability of human low-density lipoprotein. Biochemistry. 2007 May 15; 46(19):5790-7.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 17444660

Benjwal S, Jayaraman S, Gursky O. Role of secondary structure in protein-phospholipid surface interactions: reconstitution and denaturation of apolipoprotein C-I:DMPC complexes. Biochemistry. 2007 Apr 3; 46(13):4184-94.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 17341095; PMCID: PMC2584444; DOI: 10.1021/bi062175c;

Jayaraman S, Gantz DL, Gursky O. Effects of salt on the thermal stability of human plasma high-density lipoprotein. Biochemistry. 2006 Apr 11; 45(14):4620-8.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 16584197

Benjwal S, Jayaraman S, Gursky O. Electrostatic effects on the stability of discoidal high-density lipoproteins. Biochemistry. 2005 Aug 2; 44(30):10218-26.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 16042399

Jayaraman S, Gantz D, Gursky O. Structural basis for thermal stability of human low-density lipoprotein. Biochemistry. 2005 Mar 15; 44(10):3965-71.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 15751972

Jayaraman S, Gantz DL, Gursky O. Kinetic stabilization and fusion of apolipoprotein A-2:DMPC disks: comparison with apoA-1 and apoC-1. Biophys J. 2005 Apr; 88(4):2907-18.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 15681655; PMCID: PMC1305385; DOI: 10.1529/biophysj.104.055921;

Jayaraman S, Gantz DL, Gursky O. Poly(ethylene glycol)-induced fusion and destabilization of human plasma high-density lipoproteins. Biochemistry. 2004 May 11; 43(18):5520-31.View Related Profiles.

Gursky, Olga
Jayaraman, Shobini

PMID: 15122918

Crocker E, Patel AB, Eilers M, Jayaraman S, Getmanova E, Reeves PJ, Ziliox M, Khorana HG, Sheves M, Smith SO. Dipolar assisted rotational resonance NMR of tryptophan and tyrosine in rhodopsin. J Biomol NMR. 2004 May; 29(1):11-20. PMID: 15017136

J Shobini, A K Mishra, and Nagasuma Chandra . Conformation of gramicidin-A in CTAB micellar media. J Photochem Photobiol B . 2003; 70(2):117-24.
J. Shobini and A. K. Mishra . Effect of a Decapeptide (VPDLLADLLK) on the Phase Transition of Dimyristoylphosphatidylcholine Lipid Bilayer. J Colloid Interface Sci . 2001; 240(1):24-29.
J Shobini, A K Mishra, K Sandhya and N Chandra . Interaction of coumarin derivatives with human serum albumin: investigation by fluorescence spectroscopic technique and modeling studies. Spectrochim Acta A Mol Biomol Spectrosc . 2001; 57A(5):1133-47.
J Shobini and A K Mishra . Effect of leucinyl-phenylalanyl-valine on DMPC liposome membrane. Spectrochim Acta A Mol Biomol Spectrosc . 2000; 56A(11):2239-48.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 47 publications over 22 distinct years, with a maximum of 5 publications in 2025

Bar chart showing 47 publications over 22 distinct years, with a maximum of 5 publications in 2025

Year	Publications
2000	1
2001	2
2003	1
2004	2
2005	3
2006	1
2007	3
2008	2
2009	2
2011	3
2012	2
2014	2
2015	2
2016	3
2017	2
2018	2
2019	2
2020	1
2021	2
2023	2
2024	2
2025	5

Contact for Mentoring:

700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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