Shinichiro Kurosawa, MD, PhD
Associate Professor
Boston University School of Medicine
Dept of Pathology & Laboratory Medicine

MD, Gunma University
PhD, Gunma University



Expertise includes: Internal Medicine; Hematology; Thrombosis and Hemostasis; Disseminated Intravascular Coagulation (DIC); Thrombotic Microangiopathy (TMA); Sepsis and septic shock; Infectious diseases; Protein C pathway; Cytokine, chemokines and biomarkers; Development of pre-clinical animal models of human diseases; Shiga-toxins; and Hemolytic Uremic Syndrome (HUS).

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




PRECLINICAL MODELS OF INFECTIOUS DISEASES
07/14/2017 - 07/13/2024 (PI)
NIH/National Institute of Allergy & Infectious Diseases

DEVELOPMENT AND TREATMENT OF PRE-CLINICAL EHEC MODELS WITH HUS
08/01/2016 - 07/31/2018 (PI)
NIH/National Institute of Allergy & Infectious Diseases
4R01AI102931-04

EVALUATING THE IMPACT OF DELAYED ADMINISTRATION OF SHIGAMB (ANTI-STX2) ANTIBODY ON DEVELOPMENT OF STX2-IN
02/01/2015 - 03/31/2017 (Co-PI)
PI: Deborah J. Stearns-Kurosawa, PhD
BELLUS Health Inc.

DEVELOPMENT AND TREATMENT OF PRE-CLINICAL EHEC MODELS WITH HUS
08/01/2013 - 07/31/2016 (PI)
NIH/National Institutes of Health
5R01AI102931-03

ROLE OF INTER-ALPHA INHIBITORS IN ANTHRAX INTOXICATION
06/01/2011 - 02/28/2015 (PI)
ProThera, Inc. NIH NIAID
5R42AI062095-05

TRANSLATION OF IMMUNOLOGICAL TECHNOLOGIES FOR BASIC RESEARCH INTO PRE-CLINICAL NONHUMAN PRIMATE (BABOON) MODELS TO EVALUATE PROTECTION FROM B ANTHRACIS
09/01/2008 - 08/31/2014 (PI)
Oklahoma Medical Research Foundation NIH NIAID
5U19AI062629-09

TRANSLATION OF IMMUNOLOGICAL TECHNOLOGIES FOR BASIC RESEARCH INTO PRE-CLINICAL NONHUMAN PRIMATE (BABOON) MODELS TO EVALUATE PROTECTION FROM B ANTHRACIS
09/01/2011 - 08/31/2012 (PI)
Oklahoma Medical Research Foundation

SHIGA-TOXINS: PRE-CLINICAL ANIMAL MODEL DEVELOPMENT AND THERAPEUTIC TESTING
09/01/2007 - 08/31/2012 (PI)
NIH/National Institute on Drug Abuse
5U01AI075386-04




Yr Title Project-Sub Proj Pubs
2016 Development and Treatment of Pre-Clinical EHEC Models with HUS 4R01AI102931-04
2015 Development and Treatment of Pre-Clinical EHEC Models with HUS 5R01AI102931-03
2014 Development and Treatment of Pre-Clinical EHEC Models with HUS 5R01AI102931-02
2013 Development and Treatment of Pre-Clinical EHEC Models with HUS 1R01AI102931-01A1
2013 Translation of immunologic technologies from basic research into pre-clinical non 5U19AI062629-10-7121 97
2012 Translation of immunologic technologies from basic research into pre-clinical non 5U19AI062629-09-8069 97
2011 SHIGA-TOXINS: PRE-CLINICAL ANIMAL MODEL DEVELOPMENT AND THERAPEUTIC TESTING 5U01AI075386-05 8
2011 Translation of immunologic technologies from basic research into pre-clinical non 5U19AI062629-08-8069 97
2010 SHIGA-TOXINS: PRE-CLINICAL ANIMAL MODEL DEVELOPMENT AND THERAPEUTIC TESTING 5U01AI075386-04 8
2010 Translation of immunologic technologies from basic research into pre-clinical non 5U19AI062629-07-8069 97
Showing 10 of 25 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Hall G, Kurosawa S, Stearns-Kurosawa D. Dextran sulfate sodium colitis facilitates colonization with Shiga-toxin producing E. coli: A novel murine model for the study of Shiga toxicosis. Infect Immun. 2018 Aug 27.View Related Profiles. PMID: 30150257.
     
  2. Kara V, Duan C, Gupta K, Kurosawa S, Stearns-Kurosawa DJ, Ekinci KL. Microfluidic detection of movements of Escherichia coli for rapid antibiotic susceptibility testing. Lab Chip. 2018 02 27; 18(5):743-753.View Related Profiles. PMID: 29387860.
     
  3. Hall G, Kurosawa S, Stearns-Kurosawa DJ. Shiga Toxin Therapeutics: Beyond Neutralization. Toxins (Basel). 2017 Sep 19; 9(9).View Related Profiles. PMID: 28925976.
     
  4. Mayer CL, Parello CS, Lee BC, Itagaki K, Kurosawa S, Stearns-Kurosawa DJ. Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga Toxins and Host Damage-Associated Molecular Patterns. Front Immunol. 2015; 6:155.View Related Profiles. PMID: 25904918; DOI: 10.3389/fimmu.2015.00155;.
     
  5. Parello CS, Mayer CL, Lee BC, Motomochi A, Kurosawa S, Stearns-Kurosawa DJ. Shiga toxin 2-induced endoplasmic reticulum stress is minimized by activated protein C but does not correlate with lethal kidney injury. Toxins (Basel). 2015 Jan; 7(1):170-86.View Related Profiles. PMID: 25609181; PMCID: PMC4303821; DOI: 10.3390/toxins7010170;.
     
  6. Kurosawa S, Stearns-Kurosawa DJ. Complement, thrombotic microangiopathy and disseminated intravascular coagulation. J Intensive Care. 2014; 2(1):65.View Related Profiles. PMID: 25705421; DOI: 10.1186/s40560-014-0061-4;.
     
  7. Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, Kurosawa S, Stepien D, Valentine C, Remick DG. Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev. 2013 Jul; 93(3):1247-88.View Related Profiles. PMID: 23899564; DOI: 10.1152/physrev.00037.2012;.
     
  8. Coggeshall KM, Lupu F, Ballard J, Metcalf JP, James JA, Farris D, Kurosawa S. The sepsis model: an emerging hypothesis for the lethality of inhalation anthrax. J Cell Mol Med. 2013 Jul; 17(7):914-20. PMID: 23742651; PMCID: PMC3729634; DOI: 10.1111/jcmm.12075;.
     
  9. Lee BC, Mayer CL, Leibowitz CS, Stearns-Kurosawa DJ, Kurosawa S. Quiescent complement in nonhuman primates during E coli Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy. Blood. 2013 Aug 1; 122(5):803-6.View Related Profiles. PMID: 23733336; PMCID: PMC3731933; DOI: 10.1182/blood-2013-03-490060;.
     
  10. Stearns-Kurosawa DJ, Oh SY, Cherla RP, Lee MS, Tesh VL, Papin J, Henderson J, Kurosawa S. Distinct renal pathology and a chemotactic phenotype after enterohemorrhagic Escherichia coli shiga toxins in non-human primate models of hemolytic uremic syndrome. Am J Pathol. 2013 Apr; 182(4):1227-38.View Related Profiles. PMID: 23402998; PMCID: PMC3620421; DOI: 10.1016/j.ajpath.2012.12.026;.
     
Showing 10 of 23 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 23 publications over 12 distinct years, with a maximum of 5 publications in 2013

YearPublications
20021
20031
20062
20083
20101
20112
20122
20135
20141
20152
20171
20182
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Disease models of Infection
Disseminated Intravascular Coagulation
Hemolytic Uremic Syndrome
Sepsis
Shiga-toxin
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670 Albany St Biosquare III
Boston MA 02118
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