Shinichiro Kurosawa, MD, PhD
Associate Professor
Boston University School of Medicine
Dept of Pathology & Laboratory Medicine

MD, Gunma University
PhD, Gunma University



Expertise includes: Internal Medicine; Hematology; Thrombosis and Hemostasis; Disseminated Intravascular Coagulation (DIC); Thrombotic Microangiopathy (TMA); Sepsis and septic shock; Infectious diseases; Protein C pathway; Cytokine, chemokines and biomarkers; Development of pre-clinical animal models of human diseases; Shiga-toxins; and Hemolytic Uremic Syndrome (HUS).

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




Development and Treatment of Pre-Clinical EHEC Models with HUS
08/01/2016 - 07/31/2017 (PI)
NIH/National Institute of Allergy & Infectious Diseases
4R01AI102931-04

Evaluating the Impact of delayed administration of Shigamb (anti-Stx2) antibody on development of Stx2-in
02/01/2015 - 03/31/2017 (Co-PI)
PI: Deborah J. Stearns-Kurosawa, PhD
BELLUS Health Inc.

Development and Treatment of Pre-Clinical EHEC Models with HUS
08/01/2013 - 07/31/2016 (PI)
NIH/National Institutes of Health
5R01AI102931-03

Role of Inter-Alpha Inhibitors in Anthrax Intoxication
06/01/2011 - 02/28/2015 (PI)
ProThera, Inc. NIH NIAID
5R42AI062095-05

Translation of immunological Technologies for Basic Research into Pre-Clinical Nonhuman Primate (Baboon) Models to Evaluate Protection from B Anthracis
09/01/2008 - 08/31/2014 (PI)
Oklahoma Medical Research Foundation NIH NIAID
5U19AI062629-09

Translation of immunological Technologies for Basic Research into Pre-Clinical Nonhuman Primate (Baboon) Models to Evaluate Protection from B Anthracis
09/01/2011 - 08/31/2012 (PI)
Oklahoma Medical Research Foundation

Shiga-Toxins: Pre-Clinical Animal Model Development and Therapeutic Testing
09/01/2007 - 08/31/2012 (PI)
NIH/National Institute on Drug Abuse
5U01AI075386-04




Yr Title Project-Sub Proj Pubs
2016 Development and Treatment of Pre-Clinical EHEC Models with HUS 4R01AI102931-04
2015 Development and Treatment of Pre-Clinical EHEC Models with HUS 5R01AI102931-03
2014 Development and Treatment of Pre-Clinical EHEC Models with HUS 5R01AI102931-02
2013 Development and Treatment of Pre-Clinical EHEC Models with HUS 1R01AI102931-01A1
2013 Translation of immunologic technologies from basic research into pre-clinical non 5U19AI062629-10-7121 97
2012 Translation of immunologic technologies from basic research into pre-clinical non 5U19AI062629-09-8069 97
2011 SHIGA-TOXINS: PRE-CLINICAL ANIMAL MODEL DEVELOPMENT AND THERAPEUTIC TESTING 5U01AI075386-05 8
2011 Translation of immunologic technologies from basic research into pre-clinical non 5U19AI062629-08-8069 97
2010 SHIGA-TOXINS: PRE-CLINICAL ANIMAL MODEL DEVELOPMENT AND THERAPEUTIC TESTING 5U01AI075386-04 8
2010 Translation of immunologic technologies from basic research into pre-clinical non 5U19AI062629-07-8069 97
Showing 10 of 25 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Mayer CL, Parello CS, Lee BC, Itagaki K, Kurosawa S, Stearns-Kurosawa DJ. Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga Toxins and Host Damage-Associated Molecular Patterns. Front Immunol. 2015; 6:155.View Related Profiles. PMID: 25904918; DOI: 10.3389/fimmu.2015.00155;.
  2. Parello CS, Mayer CL, Lee BC, Motomochi A, Kurosawa S, Stearns-Kurosawa DJ. Shiga toxin 2-induced endoplasmic reticulum stress is minimized by activated protein C but does not correlate with lethal kidney injury. Toxins (Basel). 2015 Jan; 7(1):170-86.View Related Profiles. PMID: 25609181; PMCID: PMC4303821; DOI: 10.3390/toxins7010170;.
  3. Kurosawa S, Stearns-Kurosawa DJ. Complement, thrombotic microangiopathy and disseminated intravascular coagulation. J Intensive Care. 2014; 2(1):65.View Related Profiles. PMID: 25705421; DOI: 10.1186/s40560-014-0061-4;.
  4. Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, Kurosawa S, Stepien D, Valentine C, Remick DG. Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev. 2013 Jul; 93(3):1247-88.View Related Profiles. PMID: 23899564; DOI: 10.1152/physrev.00037.2012;.
  5. Coggeshall KM, Lupu F, Ballard J, Metcalf JP, James JA, Farris D, Kurosawa S. The sepsis model: an emerging hypothesis for the lethality of inhalation anthrax. J Cell Mol Med. 2013 Jul; 17(7):914-20. PMID: 23742651; PMCID: PMC3729634; DOI: 10.1111/jcmm.12075;.
  6. Lee BC, Mayer CL, Leibowitz CS, Stearns-Kurosawa DJ, Kurosawa S. Quiescent complement in nonhuman primates during E coli Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy. Blood. 2013 Aug 1; 122(5):803-6.View Related Profiles. PMID: 23733336; PMCID: PMC3731933; DOI: 10.1182/blood-2013-03-490060;.
  7. Stearns-Kurosawa DJ, Oh SY, Cherla RP, Lee MS, Tesh VL, Papin J, Henderson J, Kurosawa S. Distinct renal pathology and a chemotactic phenotype after enterohemorrhagic Escherichia coli shiga toxins in non-human primate models of hemolytic uremic syndrome. Am J Pathol. 2013 Apr; 182(4):1227-38.View Related Profiles. PMID: 23402998; PMCID: PMC3620421; DOI: 10.1016/j.ajpath.2012.12.026;.
  8. Sursal T, Stearns-Kurosawa DJ, Itagaki K, Oh SY, Sun S, Kurosawa S, Hauser CJ. Plasma bacterial and mitochondrial DNA distinguish bacterial sepsis from sterile systemic inflammatory response syndrome and quantify inflammatory tissue injury in nonhuman primates. Shock. 2013 Jan; 39(1):55-62.View Related Profiles. PMID: 23247122; PMCID: PMC3537509; DOI: 10.1097/SHK.0b013e318276f4ca;.
  9. Mayer CL, Leibowitz CS, Kurosawa S, Stearns-Kurosawa DJ. Shiga toxins and the pathophysiology of hemolytic uremic syndrome in humans and animals. Toxins (Basel). 2012 Nov; 4(11):1261-87.View Related Profiles. PMID: 23202315; PMCID: PMC3509707; DOI: 10.3390/toxins4111261;.
  10. Ghosh CC, Mukherjee A, David S, Knaus UG, Stearns-Kurosawa DJ, Kurosawa S, Parikh SM. Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):10024-9.View Related Profiles. PMID: 22665799; PMCID: PMC3382507; DOI: 10.1073/pnas.1120755109;.
Showing 10 of 20 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 20 publications over 10 distinct years, with a maximum of 5 publications in 2013

YearPublications
20021
20031
20062
20083
20101
20112
20122
20135
20141
20152
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Disease models of Infection
Disseminated Intravascular Coagulation
Hemolytic Uremic Syndrome
Sepsis
Shiga-toxin
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670 Albany St Biosquare III
Boston MA 02118
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