Shinichiro Kurosawa, MD, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

MD, Gunma University
PhD, Gunma University



Expertise includes: Internal Medicine; Hematology; Thrombosis and Hemostasis; Disseminated Intravascular Coagulation (DIC); Thrombotic Microangiopathy (TMA); Sepsis and septic shock; Infectious diseases; Protein C pathway; Cytokine, chemokines and biomarkers; Development of pre-clinical animal models of human diseases; Shiga-toxins; and Hemolytic Uremic Syndrome (HUS).

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Development and Treatment of Pre-Clinical EHEC Models with HUS
08/01/2016 - 07/31/2018 (PI)
NIH/National Institute of Allergy & Infectious Diseases
4R01AI102931-04

Evaluating the Impact of delayed administration of Shigamb (anti-Stx2) antibody on development of Stx2-in
02/01/2015 - 03/31/2017 (Co-Investigator)
PI: Deborah J. Stearns-Kurosawa, PhD
BELLUS Health Inc.


Development and Treatment of Pre-Clinical EHEC Models with HUS
08/01/2013 - 07/31/2016 (PI)
NIH/National Institutes of Health
5R01AI102931-03

Role of Inter-Alpha Inhibitors in Anthrax Intoxication
06/01/2011 - 02/28/2015 (Subcontract PI)
ProThera, Inc. NIH NIAID
5R42AI062095-05

Translation of immunological Technologies for Basic Research into Pre-Clinical Nonhuman Primate (Baboon) Models to Evaluate Protection from B Anthracis
09/01/2008 - 08/31/2014 (Subcontract PI)
Oklahoma Medical Research Foundation NIH NIAID
5U19AI062629-09

Translation of immunological Technologies for Basic Research into Pre-Clinical Nonhuman Primate (Baboon) Models to Evaluate Protection from B Anthracis
09/01/2011 - 08/31/2012 (PI)
Oklahoma Medical Research Foundation


Shiga-Toxins: Pre-Clinical Animal Model Development and Therapeutic Testing
09/01/2007 - 08/31/2012 (PI)
NIH/National Institute on Drug Abuse
5U01AI075386-04



Title


Yr Title Project-Sub Proj Pubs
2016 Development and Treatment of Pre-Clinical EHEC Models with HUS 4R01AI102931-04 5
2015 Development and Treatment of Pre-Clinical EHEC Models with HUS 5R01AI102931-03 5
2014 Development and Treatment of Pre-Clinical EHEC Models with HUS 5R01AI102931-02 5
2013 Development and Treatment of Pre-Clinical EHEC Models with HUS 1R01AI102931-01A1 5
2013 Translation of immunologic technologies from basic research into pre-clinical non 5U19AI062629-10-7121 131
2012 Translation of immunologic technologies from basic research into pre-clinical non 5U19AI062629-09-8069 131
2011 SHIGA-TOXINS: PRE-CLINICAL ANIMAL MODEL DEVELOPMENT AND THERAPEUTIC TESTING 5U01AI075386-05 9
2011 Translation of immunologic technologies from basic research into pre-clinical non 5U19AI062629-08-8069 131
2010 SHIGA-TOXINS: PRE-CLINICAL ANIMAL MODEL DEVELOPMENT AND THERAPEUTIC TESTING 5U01AI075386-04 9
2010 Translation of immunologic technologies from basic research into pre-clinical non 5U19AI062629-07-8069 131
Showing 10 of 25 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Hall G, Kurosawa S, Stearns-Kurosawa DJ. Infection of Immunocompetent Conventional Mice with Shiga Toxin-Producing E. coli: The DSS + STEC Model. Methods Mol Biol. 2021; 2291:353-364.View Related Profiles. PMID: 33704763
     
  2. Feng F, Thompson MP, Thomas BE, Duffy ER, Kim J, Kurosawa S, Tashjian JY, Wei Y, Andry C, Stearns-Kurosawa DJ. A computational solution to improve biomarker reproducibility during long-term projects. PLoS One. 2019; 14(4):e0209060.View Related Profiles. PMID: 30995241; PMCID: PMC6469750; DOI: 10.1371/journal.pone.0209060;
     
  3. Hall G, Kurosawa S, Stearns-Kurosawa DJ. Dextran Sulfate Sodium Colitis Facilitates Colonization with Shiga Toxin-Producing Escherichia coli: a Novel Murine Model for the Study of Shiga Toxicosis. Infect Immun. 2018 11; 86(11).View Related Profiles. PMID: 30150257; PMCID: PMC6204700; DOI: 10.1128/IAI.00530-18;
     
  4. Kara V, Duan C, Gupta K, Kurosawa S, Stearns-Kurosawa DJ, Ekinci KL. Microfluidic detection of movements of Escherichia coli for rapid antibiotic susceptibility testing. Lab Chip. 2018 02 27; 18(5):743-753.View Related Profiles. PMID: 29387860; PMCID: PMC5829026; DOI: 10.1039/c7lc01019b;
     
  5. Hall G, Kurosawa S, Stearns-Kurosawa DJ. Shiga Toxin Therapeutics: Beyond Neutralization. Toxins (Basel). 2017 Sep 19; 9(9).View Related Profiles. PMID: 28925976; PMCID: PMC5618224; DOI: 10.3390/toxins9090291;
     
  6. Mayer CL, Parello CS, Lee BC, Itagaki K, Kurosawa S, Stearns-Kurosawa DJ. Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga Toxins and Host Damage-Associated Molecular Patterns. Front Immunol. 2015; 6:155.View Related Profiles. PMID: 25904918; PMCID: PMC4387861; DOI: 10.3389/fimmu.2015.00155;
     
  7. Parello CS, Mayer CL, Lee BC, Motomochi A, Kurosawa S, Stearns-Kurosawa DJ. Shiga toxin 2-induced endoplasmic reticulum stress is minimized by activated protein C but does not correlate with lethal kidney injury. Toxins (Basel). 2015 Jan; 7(1):170-86.View Related Profiles. PMID: 25609181; PMCID: PMC4303821; DOI: 10.3390/toxins7010170;
     
  8. Kurosawa S, Stearns-Kurosawa DJ. Complement, thrombotic microangiopathy and disseminated intravascular coagulation. J Intensive Care. 2014; 2(1):65.View Related Profiles. PMID: 25705421; PMCID: PMC4336180; DOI: 10.1186/s40560-014-0061-4;
     
  9. Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, Kurosawa S, Stepien D, Valentine C, Remick DG. Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev. 2013 Jul; 93(3):1247-88.View Related Profiles. PMID: 23899564; PMCID: PMC3962548; DOI: 10.1152/physrev.00037.2012;
     
  10. Coggeshall KM, Lupu F, Ballard J, Metcalf JP, James JA, Farris D, Kurosawa S. The sepsis model: an emerging hypothesis for the lethality of inhalation anthrax. J Cell Mol Med. 2013 Jul; 17(7):914-20. PMID: 23742651; PMCID: PMC3729634; DOI: 10.1111/jcmm.12075;
     
Showing 10 of 25 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 25 publications over 14 distinct years, with a maximum of 5 publications in 2013

YearPublications
20021
20031
20062
20083
20101
20112
20122
20135
20141
20152
20171
20182
20191
20211

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Disease models of Infection
Disseminated Intravascular Coagulation
Hemolytic Uremic Syndrome
Sepsis
Shiga-toxin
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