Keywords
Last Name

Shinichiro Kurosawa, MD, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine
Address670 Albany St Biosquare III
Boston MA 02118
Phone(617) 414-7091
ORCID ORCID Icon0000-0002-1868-1479
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Research Expertise & Professional Interests
Expertise includes: Internal Medicine; Hematology; Thrombosis and Hemostasis; Disseminated Intravascular Coagulation (DIC); Thrombotic Microangiopathy (TMA); Sepsis and septic shock; Infectious diseases; Protein C pathway; Cytokine, chemokines and biomarkers; Development of pre-clinical animal models of human diseases; Shiga-toxins; and Hemolytic Uremic Syndrome (HUS).

 Self-Described Keywords
  • Disease models of Infection
  • Disseminated Intravascular Coagulation
  • Hemolytic Uremic Syndrome
  • Sepsis
  • Shiga-toxin
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Mayer CL, Parello CS, Lee BC, Itagaki K, Kurosawa S, Stearns-Kurosawa DJ. Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga Toxins and Host Damage-Associated Molecular Patterns. Front Immunol. 2015; 6:155. PMID: 25904918.
    View in: PubMed
  2. Parello CS, Mayer CL, Lee BC, Motomochi A, Kurosawa S, Stearns-Kurosawa DJ. Shiga toxin 2-induced endoplasmic reticulum stress is minimized by activated protein C but does not correlate with lethal kidney injury. Toxins (Basel). 2015 Jan; 7(1):170-86. PMID: 25609181.
    View in: PubMed
  3. Kurosawa S, Stearns-Kurosawa DJ. Complement, thrombotic microangiopathy and disseminated intravascular coagulation. J Intensive Care. 2014; 2(1):65. PMID: 25705421.
    View in: PubMed
  4. Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, Kurosawa S, Stepien D, Valentine C, Remick DG. Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev. 2013 Jul; 93(3):1247-88. PMID: 23899564.
    View in: PubMed
  5. Coggeshall KM, Lupu F, Ballard J, Metcalf JP, James JA, Farris D, Kurosawa S. The sepsis model: an emerging hypothesis for the lethality of inhalation anthrax. J Cell Mol Med. 2013 Jul; 17(7):914-20. PMID: 23742651.
    View in: PubMed
  6. Lee BC, Mayer CL, Leibowitz CS, Stearns-Kurosawa DJ, Kurosawa S. Quiescent complement in nonhuman primates during E coli Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy. Blood. 2013 Aug 1; 122(5):803-6. PMID: 23733336.
    View in: PubMed
  7. Stearns-Kurosawa DJ, Oh SY, Cherla RP, Lee MS, Tesh VL, Papin J, Henderson J, Kurosawa S. Distinct renal pathology and a chemotactic phenotype after enterohemorrhagic Escherichia coli shiga toxins in non-human primate models of hemolytic uremic syndrome. Am J Pathol. 2013 Apr; 182(4):1227-38. PMID: 23402998.
    View in: PubMed
  8. Sursal T, Stearns-Kurosawa DJ, Itagaki K, Oh SY, Sun S, Kurosawa S, Hauser CJ. Plasma bacterial and mitochondrial DNA distinguish bacterial sepsis from sterile systemic inflammatory response syndrome and quantify inflammatory tissue injury in nonhuman primates. Shock. 2013 Jan; 39(1):55-62. PMID: 23247122.
    View in: PubMed
  9. Mayer CL, Leibowitz CS, Kurosawa S, Stearns-Kurosawa DJ. Shiga toxins and the pathophysiology of hemolytic uremic syndrome in humans and animals. Toxins (Basel). 2012 Nov; 4(11):1261-87. PMID: 23202315.
    View in: PubMed
  10. Ghosh CC, Mukherjee A, David S, Knaus UG, Stearns-Kurosawa DJ, Kurosawa S, Parikh SM. Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):10024-9. PMID: 22665799.
    View in: PubMed
  11. Stearns-Kurosawa DJ, Collins V, Freeman S, Debord D, Nishikawa K, Oh SY, Leibowitz CS, Kurosawa S. Rescue from lethal Shiga toxin 2-induced renal failure with a cell-permeable peptide. Pediatr Nephrol. 2011 Nov; 26(11):2031-9. PMID: 21603905.
    View in: PubMed
  12. Stearns-Kurosawa DJ, Osuchowski MF, Valentine C, Kurosawa S, Remick DG. The pathogenesis of sepsis. Annu Rev Pathol. 2011; 6:19-48. PMID: 20887193.
    View in: PubMed
  13. Stearns-Kurosawa DJ, Collins V, Freeman S, Tesh VL, Kurosawa S. Distinct physiologic and inflammatory responses elicited in baboons after challenge with Shiga toxin type 1 or 2 from enterohemorrhagic Escherichia coli. Infect Immun. 2010 Jun; 78(6):2497-504. PMID: 20308301.
    View in: PubMed
  14. Reiner AP, Carty CL, Jenny NS, Nievergelt C, Cushman M, Stearns-Kurosawa DJ, Kurosawa S, Kuller LH, Lange LA. PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study. J Thromb Haemost. 2008 Oct; 6(10):1625-32. PMID: 18680534.
    View in: PubMed
  15. Matsumoto T, Kaneko T, Seto M, Wada H, Kobayashi T, Nakatani K, Tonomura H, Tono Y, Ohyabu M, Nobori T, Shiku H, Sudo A, Uchida A, Kurosawa DJ, Kurosawa S. The membrane proteinase 3 expression on neutrophils was downregulated after treatment with infliximab in patients with rheumatoid arthritis. Clin Appl Thromb Hemost. 2008 Apr; 14(2):186-92. PMID: 18372277.
    View in: PubMed
  16. Kurosawa S, Stearns-Kurosawa DJ, Kinasewitz GT. Soluble thrombomodulin: a sign of bad times. Crit Care Med. 2008 Mar; 36(3):985-7. PMID: 18431290.
    View in: PubMed
  17. Stearns-Kurosawa DJ, Lupu F, Taylor FB, Kinasewitz G, Kurosawa S. Sepsis and pathophysiology of anthrax in a nonhuman primate model. Am J Pathol. 2006 Aug; 169(2):433-44. PMID: 16877346.
    View in: PubMed
  18. Matsumoto T, Kaneko T, Wada H, Kobayashi T, Abe Y, Nobori T, Shiku H, Stearns-Kurosawa DJ, Kurosawa S. Proteinase 3 expression on neutrophil membranes from patients with infectious disease. Shock. 2006 Aug; 26(2):128-33. PMID: 16878019.
    View in: PubMed
  19. Kaneko T, Stearns-Kurosawa DJ, Taylor F, Twigg M, Osaki K, Kinasewitz GT, Peer G, Kurosawa S. Reduced neutrophil CD10 expression in nonhuman primates and humans after in vivo challenge with E. coli or lipopolysaccharide. Shock. 2003 Aug; 20(2):130-7. PMID: 12865656.
    View in: PubMed
  20. Stearns-Kurosawa DJ, Swindle K, D'Angelo A, Della Valle P, Fattorini A, Caron N, Grimaux M, Woodhams B, Kurosawa S. Plasma levels of endothelial protein C receptor respond to anticoagulant treatment. Blood. 2002 Jan 15; 99(2):526-30. PMID: 11781234.
    View in: PubMed
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