Deborah J. Stearns-Kurosawa, PhD
Emeritus Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

PhD, Cleveland State University
BS, Pennsylvania State University

Graduate Education and Administration
My position as Associate Provost and Associate Dean ad interim has oversight of the PhD and Master's programs within the Graduate Medical Sciences of BU's School of Medicine. Our group takes care of the graduate students from matriculation to graduation and alumni development. My responsibilities are to ensure we provide the highest quality graduate education in the basic and biomedical sciences. Providing resources, budgets, high caliber faculty, thought leaders and career opportunities are our priorities. Our diverse students not only learn the latest in their field of interest, but contribute to paradigm shifts and moving their field forward.

Research Interests (joint appointment in Department of Pathology)
Why is it that some people get a bacterial infection, feel lousy for a few days, take antibiotics and then forget about it when they go back to class or work, but other people get the same infection and die in two weeks in the intensive care unit? It’s all about what pathogen is invading and how our bodies respond to the infection. It’s a highly orchestrated response that requires input from our immune, coagulation, neurologic, and inflammatory pathways. Research interests include:

• Study of enterohemorrhagic Shiga toxin-producing E.coli infection and the toxins from these bacteria. The E.coli O157:H7 serotype is the most common clinical problem.
• Development of models and cell systems to study thrombotic microangiopathies such as HUS, aHUS,TTP and the related DIC

Boston University
Evans Center for Interdisciplinary Biomedical Research

Boston University
Genome Science Institute

A Rapid and Sensitive Antibiotic Susceptibility Test for Urinary Tract Infections
05/22/2018 - 04/30/2022 (Multi-PI)
PI: Deborah J. Stearns-Kurosawa, PhD
NIH/National Institute of Allergy & Infectious Diseases

Evaluating the Impact of delayed administration of Shigamb (anti-Stx2) antibody on development of Stx2-in
02/01/2015 - 03/31/2017 (PI)
BELLUS Health Inc.


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Hall G, Kurosawa S, Stearns-Kurosawa DJ. Infection of Immunocompetent Conventional Mice with Shiga Toxin-Producing E. coli: The DSS + STEC Model. Methods Mol Biol. 2021; 2291:353-364.View Related Profiles. PMID: 33704763
  2. Feng F, Thompson MP, Thomas BE, Duffy ER, Kim J, Kurosawa S, Tashjian JY, Wei Y, Andry C, Stearns-Kurosawa DJ. A computational solution to improve biomarker reproducibility during long-term projects. PLoS One. 2019; 14(4):e0209060.View Related Profiles. PMID: 30995241; PMCID: PMC6469750; DOI: 10.1371/journal.pone.0209060;
  3. Hall G, Kurosawa S, Stearns-Kurosawa DJ. Dextran Sulfate Sodium Colitis Facilitates Colonization with Shiga Toxin-Producing Escherichia coli: a Novel Murine Model for the Study of Shiga Toxicosis. Infect Immun. 2018 11; 86(11).View Related Profiles. PMID: 30150257; PMCID: PMC6204700; DOI: 10.1128/IAI.00530-18;
  4. Kara V, Duan C, Gupta K, Kurosawa S, Stearns-Kurosawa DJ, Ekinci KL. Microfluidic detection of movements of Escherichia coli for rapid antibiotic susceptibility testing. Lab Chip. 2018 02 27; 18(5):743-753.View Related Profiles. PMID: 29387860; PMCID: PMC5829026; DOI: 10.1039/c7lc01019b;
  5. Hall G, Kurosawa S, Stearns-Kurosawa DJ. Shiga Toxin Therapeutics: Beyond Neutralization. Toxins (Basel). 2017 Sep 19; 9(9).View Related Profiles. PMID: 28925976; PMCID: PMC5618224; DOI: 10.3390/toxins9090291;
  6. Mayer CL, Parello CS, Lee BC, Itagaki K, Kurosawa S, Stearns-Kurosawa DJ. Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga Toxins and Host Damage-Associated Molecular Patterns. Front Immunol. 2015; 6:155.View Related Profiles. PMID: 25904918; PMCID: PMC4387861; DOI: 10.3389/fimmu.2015.00155;
  7. Parello CS, Mayer CL, Lee BC, Motomochi A, Kurosawa S, Stearns-Kurosawa DJ. Shiga toxin 2-induced endoplasmic reticulum stress is minimized by activated protein C but does not correlate with lethal kidney injury. Toxins (Basel). 2015 Jan; 7(1):170-86.View Related Profiles. PMID: 25609181; PMCID: PMC4303821; DOI: 10.3390/toxins7010170;
  8. Kurosawa S, Stearns-Kurosawa DJ. Complement, thrombotic microangiopathy and disseminated intravascular coagulation. J Intensive Care. 2014; 2(1):65.View Related Profiles. PMID: 25705421; PMCID: PMC4336180; DOI: 10.1186/s40560-014-0061-4;
  9. Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, Kurosawa S, Stepien D, Valentine C, Remick DG. Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev. 2013 Jul; 93(3):1247-88.View Related Profiles. PMID: 23899564; PMCID: PMC3962548; DOI: 10.1152/physrev.00037.2012;
  10. Lee BC, Mayer CL, Leibowitz CS, Stearns-Kurosawa DJ, Kurosawa S. Quiescent complement in nonhuman primates during E coli Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy. Blood. 2013 Aug 1; 122(5):803-6.View Related Profiles. PMID: 23733336; PMCID: PMC3731933; DOI: 10.1182/blood-2013-03-490060;
Showing 10 of 41 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 41 publications over 22 distinct years, with a maximum of 4 publications in 2013

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

infectious disease
nonhuman primate models
pre-clinical models
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670 Albany St
Boston MA 02118
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