Keywords
Last Name

Deborah J. Stearns-Kurosawa, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine
Address670 Albany St Biosquare III
Boston MA 02118
Phone(617) 414-7092
ORCID ORCID Icon0000-0003-2486-923X
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Research Expertise & Professional Interests
Expertise in the development and characterization of animal models of infectious disease to identify host-pathogen interactions and evidence-based therapeutic interventions.

 Self-Described Keywords
  • infectious disease
  • nonhuman primate models
  • pre-clinical models
  • sepsis
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Mayer CL, Parello CS, Lee BC, Itagaki K, Kurosawa S, Stearns-Kurosawa DJ. Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga Toxins and Host Damage-Associated Molecular Patterns. Front Immunol. 2015; 6:155. PMID: 25904918.
    View in: PubMed
  2. Parello CS, Mayer CL, Lee BC, Motomochi A, Kurosawa S, Stearns-Kurosawa DJ. Shiga toxin 2-induced endoplasmic reticulum stress is minimized by activated protein C but does not correlate with lethal kidney injury. Toxins (Basel). 2015 Jan; 7(1):170-86. PMID: 25609181.
    View in: PubMed
  3. Kurosawa S, Stearns-Kurosawa DJ. Complement, thrombotic microangiopathy and disseminated intravascular coagulation. J Intensive Care. 2014; 2(1):65. PMID: 25705421.
    View in: PubMed
  4. Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, Kurosawa S, Stepien D, Valentine C, Remick DG. Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev. 2013 Jul; 93(3):1247-88. PMID: 23899564.
    View in: PubMed
  5. Lee BC, Mayer CL, Leibowitz CS, Stearns-Kurosawa DJ, Kurosawa S. Quiescent complement in nonhuman primates during E coli Shiga toxin-induced hemolytic uremic syndrome and thrombotic microangiopathy. Blood. 2013 Aug 1; 122(5):803-6. PMID: 23733336.
    View in: PubMed
  6. Stearns-Kurosawa DJ, Oh SY, Cherla RP, Lee MS, Tesh VL, Papin J, Henderson J, Kurosawa S. Distinct renal pathology and a chemotactic phenotype after enterohemorrhagic Escherichia coli shiga toxins in non-human primate models of hemolytic uremic syndrome. Am J Pathol. 2013 Apr; 182(4):1227-38. PMID: 23402998.
    View in: PubMed
  7. Sursal T, Stearns-Kurosawa DJ, Itagaki K, Oh SY, Sun S, Kurosawa S, Hauser CJ. Plasma bacterial and mitochondrial DNA distinguish bacterial sepsis from sterile systemic inflammatory response syndrome and quantify inflammatory tissue injury in nonhuman primates. Shock. 2013 Jan; 39(1):55-62. PMID: 23247122.
    View in: PubMed
  8. Mayer CL, Leibowitz CS, Kurosawa S, Stearns-Kurosawa DJ. Shiga toxins and the pathophysiology of hemolytic uremic syndrome in humans and animals. Toxins (Basel). 2012 Nov; 4(11):1261-87. PMID: 23202315.
    View in: PubMed
  9. Ghosh CC, Mukherjee A, David S, Knaus UG, Stearns-Kurosawa DJ, Kurosawa S, Parikh SM. Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):10024-9. PMID: 22665799.
    View in: PubMed
  10. Stearns-Kurosawa DJ, Collins V, Freeman S, Debord D, Nishikawa K, Oh SY, Leibowitz CS, Kurosawa S. Rescue from lethal Shiga toxin 2-induced renal failure with a cell-permeable peptide. Pediatr Nephrol. 2011 Nov; 26(11):2031-9. PMID: 21603905.
    View in: PubMed
  11. Stearns-Kurosawa DJ, Osuchowski MF, Valentine C, Kurosawa S, Remick DG. The pathogenesis of sepsis. Annu Rev Pathol. 2011; 6:19-48. PMID: 20887193.
    View in: PubMed
  12. Stearns-Kurosawa DJ, Collins V, Freeman S, Tesh VL, Kurosawa S. Distinct physiologic and inflammatory responses elicited in baboons after challenge with Shiga toxin type 1 or 2 from enterohemorrhagic Escherichia coli. Infect Immun. 2010 Jun; 78(6):2497-504. PMID: 20308301.
    View in: PubMed
  13. Reiner AP, Carty CL, Jenny NS, Nievergelt C, Cushman M, Stearns-Kurosawa DJ, Kurosawa S, Kuller LH, Lange LA. PROC, PROCR and PROS1 polymorphisms, plasma anticoagulant phenotypes, and risk of cardiovascular disease and mortality in older adults: the Cardiovascular Health Study. J Thromb Haemost. 2008 Oct; 6(10):1625-32. PMID: 18680534.
    View in: PubMed
  14. Kurosawa S, Stearns-Kurosawa DJ, Kinasewitz GT. Soluble thrombomodulin: a sign of bad times. Crit Care Med. 2008 Mar; 36(3):985-7. PMID: 18431290.
    View in: PubMed
  15. McMeekin DS, Sill MW, Darcy KM, Stearns-Kurosawa DJ, Webster K, Waggoner S, Benbrook D. A phase II trial of thalidomide in patients with refractory leiomyosarcoma of the uterus and correlation with biomarkers of angiogenesis: a gynecologic oncology group study. Gynecol Oncol. 2007 Sep; 106(3):596-603. PMID: 17597196.
    View in: PubMed
  16. McMeekin DS, Sill MW, Benbrook D, Darcy KM, Stearns-Kurosawa DJ, Eaton L, Yamada SD. A phase II trial of thalidomide in patients with refractory endometrial cancer and correlation with angiogenesis biomarkers: a Gynecologic Oncology Group study. Gynecol Oncol. 2007 May; 105(2):508-16. PMID: 17306350.
    View in: PubMed
  17. Stearns-Kurosawa DJ, Lupu F, Taylor FB, Kinasewitz G, Kurosawa S. Sepsis and pathophysiology of anthrax in a nonhuman primate model. Am J Pathol. 2006 Aug; 169(2):433-44. PMID: 16877346.
    View in: PubMed
  18. Matsumoto T, Kaneko T, Wada H, Kobayashi T, Abe Y, Nobori T, Shiku H, Stearns-Kurosawa DJ, Kurosawa S. Proteinase 3 expression on neutrophil membranes from patients with infectious disease. Shock. 2006 Aug; 26(2):128-33. PMID: 16878019.
    View in: PubMed
  19. Ireland H, Konstantoulas CJ, Cooper JA, Hawe E, Humphries SE, Mather H, Goodall AH, Hogwood J, Juhan-Vague I, Yudkin JS, di Minno G, Margaglione M, Hamsten A, Miller GJ, Bauer KA, Kim YT, Stearns-Kurosawa DJ, Kurosawa S. EPCR Ser219Gly: elevated sEPCR, prothrombin F1+2, risk for coronary heart disease, and increased sEPCR shedding in vitro. Atherosclerosis. 2005 Dec; 183(2):283-92. PMID: 15921688.
    View in: PubMed
  20. Kaneko T, Stearns-Kurosawa DJ, Taylor F, Twigg M, Osaki K, Kinasewitz GT, Peer G, Kurosawa S. Reduced neutrophil CD10 expression in nonhuman primates and humans after in vivo challenge with E. coli or lipopolysaccharide. Shock. 2003 Aug; 20(2):130-7. PMID: 12865656.
    View in: PubMed
  21. Stearns-Kurosawa DJ, Burgin C, Parker D, Comp P, Kurosawa S. Bimodal distribution of soluble endothelial protein C receptor levels in healthy populations. J Thromb Haemost. 2003 Apr; 1(4):855-6. PMID: 12871429.
    View in: PubMed
  22. Boomsma MM, Stearns-Kurosawa DJ, Stegeman CA, Raschi E, Meroni PL, Kurosawa S, Tervaert JW. Plasma levels of soluble endothelial cell protein C receptor in patients with Wegener's granulomatosis. Clin Exp Immunol. 2002 Apr; 128(1):187-94. PMID: 12033194.
    View in: PubMed
  23. Stearns-Kurosawa DJ, Swindle K, D'Angelo A, Della Valle P, Fattorini A, Caron N, Grimaux M, Woodhams B, Kurosawa S. Plasma levels of endothelial protein C receptor respond to anticoagulant treatment. Blood. 2002 Jan 15; 99(2):526-30. PMID: 11781234.
    View in: PubMed
  24. Kurosawa S, Esmon CT, Stearns-Kurosawa DJ. The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18. J Immunol. 2000 Oct 15; 165(8):4697-703. PMID: 11035113.
    View in: PubMed
  25. Taylor FB, Stearns-Kurosawa DJ, Kurosawa S, Ferrell G, Chang AC, Laszik Z, Kosanke S, Peer G, Esmon CT. The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis. Blood. 2000 Mar 1; 95(5):1680-6. PMID: 10688824.
    View in: PubMed
  26. Esmon CT, Xu J, Gu JM, Qu D, Laszik Z, Ferrell G, Stearns-Kurosawa DJ, Kurosawa S, Taylor FB, Esmon NL. Endothelial protein C receptor. Thromb Haemost. 1999 Aug; 82(2):251-8. PMID: 10605711.
    View in: PubMed
  27. Esmon CT, Gu JM, Xu J, Qu D, Stearns-Kurosawa DJ, Kurosawa S. Regulation and functions of the protein C anticoagulant pathway. Haematologica. 1999 Apr; 84(4):363-8. PMID: 10190952.
    View in: PubMed
  28. Esmon CT, Fukudome K, Mather T, Bode W, Regan LM, Stearns-Kurosawa DJ, Kurosawa S. Inflammation, sepsis, and coagulation. Haematologica. 1999 Mar; 84(3):254-9. PMID: 10189392.
    View in: PubMed
  29. Smirnov MD, Safa O, Regan L, Mather T, Stearns-Kurosawa DJ, Kurosawa S, Rezaie AR, Esmon NL, Esmon CT. A chimeric protein C containing the prothrombin Gla domain exhibits increased anticoagulant activity and altered phospholipid specificity. J Biol Chem. 1998 Apr 10; 273(15):9031-40. PMID: 9535891.
    View in: PubMed
  30. Kurosawa S, Stearns-Kurosawa DJ, Carson CW, D'Angelo A, Della Valle P, Esmon CT. Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvement of different pathological processes. Blood. 1998 Jan 15; 91(2):725-7. PMID: 9427734.
    View in: PubMed
  31. Kurosawa S, Stearns-Kurosawa DJ, Hidari N, Esmon CT. Identification of functional endothelial protein C receptor in human plasma. J Clin Invest. 1997 Jul 15; 100(2):411-8. PMID: 9218519.
    View in: PubMed
  32. Esmon CT, Ding W, Yasuhiro K, Gu JM, Ferrell G, Regan LM, Stearns-Kurosawa DJ, Kurosawa S, Mather T, Laszik Z, Esmon NL. The protein C pathway: new insights. Thromb Haemost. 1997 Jul; 78(1):70-4. PMID: 9198130.
    View in: PubMed
  33. Stearns-Kurosawa DJ, Kurosawa S, Mollica JS, Ferrell GL, Esmon CT. The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10212-6. PMID: 8816778.
    View in: PubMed
  34. Fukudome K, Kurosawa S, Stearns-Kurosawa DJ, He X, Rezaie AR, Esmon CT. The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor. J Biol Chem. 1996 Jul 19; 271(29):17491-8. PMID: 8663475.
    View in: PubMed
  35. Regan LM, Stearns-Kurosawa DJ, Kurosawa S, Mollica J, Fukudome K, Esmon CT. The endothelial cell protein C receptor. Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors. J Biol Chem. 1996 Jul 19; 271(29):17499-503. PMID: 8663474.
    View in: PubMed
  36. Wakita K, Stearns-Kurosawa DJ, Marumoto Y. The effect of calcium ionophore A23187 on tissue factor activity and mRNA in endothelial cells. Thromb Res. 1994 Apr 15; 74(2):95-103. PMID: 8029820.
    View in: PubMed
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