Sarah Noton

Postdoctoral Fellow (previously held)

Boston University Chobanian & Avedisian School of Medicine

Virology, Immunology & Microbiology

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Cressey TN, Shareef AM, Kleiner VA, Noton SL, Byrne PO, McLellan JS, Mühlberger E, Fearns R. Distinctive features of the respiratory syncytial virus priming loop compared to other non-segmented negative strand RNA viruses. PLoS Pathog. 2022 06; 18(6):e1010451.View Related Profiles.

Muhlberger, Elke
Fearns, Rachel
Noton, Sarah

PMID: 35731802; PMCID: PMC9255747; DOI: 10.1371/journal.ppat.1010451;

Braun MR, Noton SL, Blanchard EL, Shareef A, Santangelo PJ, Johnson WE, Fearns R. Respiratory syncytial virus M2-1 protein associates non-specifically with viral messenger RNA and with specific cellular messenger RNA transcripts. PLoS Pathog. 2021 05; 17(5):e1009589.View Related Profiles.

Fearns, Rachel
Noton, Sarah
Johnson, William

PMID: 34003848; PMCID: PMC8162694; DOI: 10.1371/journal.ppat.1009589;

Rhodin MHJ, McAllister NV, Castillo J, Noton SL, Fearns R, Kim IJ, Yu J, Blaisdell TP, Panarese J, Shook BC, Or YS, Goodwin B, Lin K. EDP-938, a novel nucleoprotein inhibitor of respiratory syncytial virus, demonstrates potent antiviral activities in vitro and in a non-human primate model. PLoS Pathog. 2021 03; 17(3):e1009428.View Related Profiles.

Fearns, Rachel
Noton, Sarah

PMID: 33720995; PMCID: PMC7993833; DOI: 10.1371/journal.ppat.1009428;

Blanchard EL, Braun MR, Lifland AW, Ludeke B, Noton SL, Vanover D, Zurla C, Fearns R, Santangelo PJ. Polymerase-tagged respiratory syncytial virus reveals a dynamic rearrangement of the ribonucleocapsid complex during infection. PLoS Pathog. 2020 10; 16(10):e1008987.View Related Profiles.

Braun, Molly
Fearns, Rachel
Noton, Sarah

PMID: 33031461; PMCID: PMC7575074; DOI: 10.1371/journal.ppat.1008987;

Pan J, Qian X, Lattmann S, El Sahili A, Yeo TH, Jia H, Cressey T, Ludeke B, Noton S, Kalocsay M, Fearns R, Lescar J. Structure of the human metapneumovirus polymerase phosphoprotein complex. Nature. 2020 01; 577(7789):275-279.View Related Profiles.

Fearns, Rachel
Noton, Sarah

PMID: 31698413; PMCID: PMC6949429; DOI: 10.1038/s41586-019-1759-1;

Noton SL, Tremaglio CZ, Fearns R. Killing two birds with one stone: How the respiratory syncytial virus polymerase initiates transcription and replication. PLoS Pathog. 2019 02; 15(2):e1007548.View Related Profiles.

Fearns, Rachel
Noton, Sarah

PMID: 30817806; PMCID: PMC6394897; DOI: 10.1371/journal.ppat.1007548;

Cressey TN, Noton SL, Nagendra K, Braun MR, Fearns R. Mechanism for de novo initiation at two sites in the respiratory syncytial virus promoter. Nucleic Acids Res. 2018 07 27; 46(13):6785-6796.View Related Profiles.

Braun, Molly
Fearns, Rachel
Noton, Sarah

PMID: 29873775; PMCID: PMC6061868; DOI: 10.1093/nar/gky480;

Atienza BJP, Jensen LD, Noton SL, Ansalem AKV, Hobman T, Fearns R, Marchant DJ, West FG. Dual Catalytic Synthesis of Antiviral Compounds Based on Metallocarbene-Azide Cascade Chemistry. J Org Chem. 2018 07 06; 83(13):6829-6842.View Related Profiles.

Fearns, Rachel
Noton, Sarah

PMID: 29663810

Braun MR, Deflubé LR, Noton SL, Mawhorter ME, Tremaglio CZ, Fearns R. RNA elongation by respiratory syncytial virus polymerase is calibrated by conserved region V. PLoS Pathog. 2017 12; 13(12):e1006803.View Related Profiles.

Deflube, Laure
Braun, Molly
Fearns, Rachel
Noton, Sarah

PMID: 29281742; PMCID: PMC5760109; DOI: 10.1371/journal.ppat.1006803;

McCutcheon KM, Jordan R, Mawhorter ME, Noton SL, Powers JG, Fearns R, Cihlar T, Perron M. The Interferon Type I/III Response to Respiratory Syncytial Virus Infection in Airway Epithelial Cells Can Be Attenuated or Amplified by Antiviral Treatment. J Virol. 2016 Feb; 90(4):1705-17.View Related Profiles.

Fearns, Rachel
Noton, Sarah

PMID: 26608311; PMCID: PMC4733981; DOI: 10.1128/JVI.02417-15;

Showing 10 of 22 results. Show More

Noton SL, Nagendra K, Dunn EF, Mawhorter ME, Yu Q, Fearns R. Respiratory Syncytial Virus Inhibitor AZ-27 Differentially Inhibits Different Polymerase Activities at the Promoter. J Virol. 2015 Aug; 89(15):7786-98.View Related Profiles.

Dunn, Ewan
Fearns, Rachel
Noton, Sarah

PMID: 25995255; PMCID: PMC4505683; DOI: 10.1128/JVI.00530-15;

Noton SL, Fearns R. Initiation and regulation of paramyxovirus transcription and replication. Virology. 2015 May; 479-480:545-54.View Related Profiles.

Fearns, Rachel
Noton, Sarah

PMID: 25683441; PMCID: PMC4424093; DOI: 10.1016/j.virol.2015.01.014;

Munday DC, Wu W, Smith N, Fix J, Noton SL, Galloux M, Touzelet O, Armstrong SD, Dawson JM, Aljabr W, Easton AJ, Rameix-Welti MA, de Oliveira AP, Simabuco FM, Ventura AM, Hughes DJ, Barr JN, Fearns R, Digard P, Eléouët JF, Hiscox JA. Interactome analysis of the human respiratory syncytial virus RNA polymerase complex identifies protein chaperones as important cofactors that promote L-protein stability and RNA synthesis. J Virol. 2015 Jan 15; 89(2):917-30.View Related Profiles.

Fearns, Rachel
Noton, Sarah

PMID: 25355874; PMCID: PMC4300676; DOI: 10.1128/JVI.01783-14;

Noton SL, Aljabr W, Hiscox JA, Matthews DA, Fearns R. Factors affecting de novo RNA synthesis and back-priming by the respiratory syncytial virus polymerase. Virology. 2014 Aug; 462-463:318-27.View Related Profiles.

Fearns, Rachel
Noton, Sarah

PMID: 25010481; PMCID: PMC4125506; DOI: 10.1016/j.virol.2014.05.032;

Tremaglio CZ, Noton SL, Deflubé LR, Fearns R. Respiratory syncytial virus polymerase can initiate transcription from position 3 of the leader promoter. J Virol. 2013 Mar; 87(6):3196-207.View Related Profiles.

Tremaglio, Chadene
Deflube, Laure
Fearns, Rachel
Noton, Sarah

PMID: 23283954; PMCID: PMC3592119; DOI: 10.1128/JVI.02862-12;

Noton SL, Deflubé LR, Tremaglio CZ, Fearns R. The respiratory syncytial virus polymerase has multiple RNA synthesis activities at the promoter. PLoS Pathog. 2012; 8(10):e1002980.View Related Profiles.

Tremaglio, Chadene
Deflube, Laure
Fearns, Rachel
Noton, Sarah

PMID: 23093940; PMCID: PMC3475672; DOI: 10.1371/journal.ppat.1002980;

Noton SL, Fearns R. The first two nucleotides of the respiratory syncytial virus antigenome RNA replication product can be selected independently of the promoter terminus. RNA. 2011 Oct; 17(10):1895-906.View Related Profiles.

Fearns, Rachel
Noton, Sarah

PMID: 21878549; PMCID: PMC3185921; DOI: 10.1261/rna.2813411;

Noton SL, Cowton VM, Zack CR, McGivern DR, Fearns R. Evidence that the polymerase of respiratory syncytial virus initiates RNA replication in a nontemplated fashion. Proc Natl Acad Sci U S A. 2010 Jun 1; 107(22):10226-31.View Related Profiles.

Fearns, Rachel
Noton, Sarah

PMID: 20479224; PMCID: PMC2890450; DOI: 10.1073/pnas.0913065107;

Bruce EA, Medcalf L, Crump CM, Noton SL, Stuart AD, Wise HM, Elton D, Bowers K, Digard P. Budding of filamentous and non-filamentous influenza A virus occurs via a VPS4 and VPS28-independent pathway. Virology. 2009 Aug 1; 390(2):268-78. PMID: 19524996; DOI: 10.1016/j.virol.2009.05.016;

Hamirally S, Kamil JP, Ndassa-Colday YM, Lin AJ, Jahng WJ, Baek MC, Noton S, Silva LA, Simpson-Holley M, Knipe DM, Golan DE, Marto JA, Coen DM. Viral mimicry of Cdc2/cyclin-dependent kinase 1 mediates disruption of nuclear lamina during human cytomegalovirus nuclear egress. PLoS Pathog. 2009 Jan; 5(1):e1000275.View Related Profiles.

Simpson-Holley, Martha R
Noton, Sarah

PMID: 19165338; PMCID: PMC2625439; DOI: 10.1371/journal.ppat.1000275;

Noton SL, Simpson-Holley M, Medcalf E, Wise HM, Hutchinson EC, McCauley JW, Digard P. Studies of an influenza A virus temperature-sensitive mutant identify a late role for NP in the formation of infectious virions. J Virol. 2009 Jan; 83(2):562-71.View Related Profiles.

Simpson-Holley, Martha R
Noton, Sarah

PMID: 18987140; PMCID: PMC2612366; DOI: 10.1128/JVI.01424-08;

Noton SL, Medcalf E, Fisher D, Mullin AE, Elton D, Digard P. Identification of the domains of the influenza A virus M1 matrix protein required for NP binding, oligomerization and incorporation into virions. J Gen Virol. 2007 Aug; 88(Pt 8):2280-90. PMID: 17622633; PMCID: PMC2884976; DOI: 10.1099/vir.0.82809-0;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 22 publications over 15 distinct years, with a maximum of 3 publications in 2015

Bar chart showing 22 publications over 15 distinct years, with a maximum of 3 publications in 2015

Year	Publications
2007	1
2008	1
2009	2
2010	1
2011	1
2012	1
2013	1
2014	2
2015	3
2017	1
2018	2
2019	2
2020	1
2021	2
2022	1

Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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617.638.4035

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