My thesis project is focused on describing a novel mediator of fibrosis in adipose tissue and characterizing extracellular matrix remodeling that occurs with adipose tissue fibrosis.
• I have validated a novel mediator (Aortic Carboxypeptidase-Like Protein) of metabolic diseases (type II diabetes, morbid obesity etc.,) for targeting by therapeutics.
• I have developed and refined an ex vivo tissue system to develop rapid adipose tissue fibrosis to understand the composition, mechanical and structural properties of adipose tissue fibrosis as well as the impact on non pathogenic cells in the tissue.
Scientific techniques employed include confocal microscopy, nanoindentation, immunofluorescence, immunohistochemistry, fluorescence activated cell sorting, tissue culture techniques, in vivo studies (mouse) and molecular biology techniques (Western blot, PCR, qPCR etc.,).
Pre-Doctoral Trainee (previously held)
Boston University School of Medicine, Graduate Medical Sciences
Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
to make corrections and additions.
Lee MJ, Pickering RT, Shibad V, Wu Y, Karastergiou K, Jager M, Layne MD, Fried SK. Impaired Glucocorticoid Suppression of TGFß Signaling in Human Omental Adipose Tissues Limits Adipogenesis and May Promote Fibrosis. Diabetes. 2019 03; 68(3):587-597.View Related Profiles. PMID: 30530781
Jager M, Lee MJ, Li C, Farmer SR, Fried SK, Layne MD. Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated in fibrotic white adipose tissue. PLoS One. 2018; 13(5):e0197777.View Related Profiles. PMID: 29799877
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