Mike Jager, PhD
Senior Consultant
TRINITY - Management Consulting

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My thesis project is focused on describing a novel mediator of fibrosis in adipose tissue and characterizing extracellular matrix remodeling that occurs with adipose tissue fibrosis.

• I have validated a novel mediator (Aortic Carboxypeptidase-Like Protein) of metabolic diseases (type II diabetes, morbid obesity etc.,) for targeting by therapeutics.
• I have developed and refined an ex vivo tissue system to develop rapid adipose tissue fibrosis to understand the composition, mechanical and structural properties of adipose tissue fibrosis as well as the impact on non pathogenic cells in the tissue.

Scientific techniques employed include confocal microscopy, nanoindentation, immunofluorescence, immunohistochemistry, fluorescence activated cell sorting, tissue culture techniques, in vivo studies (mouse) and molecular biology techniques (Western blot, PCR, qPCR etc.,).

Predoctoral Trainee (previously held)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Biochemistry & Cell Biology


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Lee MJ, Pickering RT, Shibad V, Wu Y, Karastergiou K, Jager M, Layne MD, Fried SK. Impaired Glucocorticoid Suppression of TGFß Signaling in Human Omental Adipose Tissues Limits Adipogenesis and May Promote Fibrosis. Diabetes. 2019 03; 68(3):587-597.View Related Profiles. PMID: 30530781; PMCID: PMC6385749; DOI: 10.2337/db18-0955;
     
  2. Jager M, Lee MJ, Li C, Farmer SR, Fried SK, Layne MD. Aortic carboxypeptidase-like protein enhances adipose tissue stromal progenitor differentiation into myofibroblasts and is upregulated in fibrotic white adipose tissue. PLoS One. 2018; 13(5):e0197777.View Related Profiles. PMID: 29799877; PMCID: PMC5969754; DOI: 10.1371/journal.pone.0197777;
     

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 2 publications over 1 distinct years, with a maximum of 2 publications in 2018

YearPublications
20182

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