Kathleen Kantak, PhD
Professor
Boston University College of Arts and Sciences
Dept of Psychological and Brain Sciences

PhD, Syracuse University




Dr. Kantak began as an Assistant Professor in the Department of Psychology at Boston University in 1982 and founded the Laboratory of Behavioral Neuroscience. She is concurrently affiliated with the Center for Neuroscience, the Interdisciplinary Graduate and Undergraduate Programs in Neuroscience, the Bimolecular Pharmacology Graduate Training Program, and the Transformative Training Program in Addiction Science at Boston University. She also holds an appointment at Harvard Medical School, Department of Psychiatry (Psychobiology) in conjunction with the Division of Behavioral Biology at the New England Primate Research Center. Dr. Kantak has received grant funding from the National Institute on Drug Abuse since 1987 to study various aspects of drug addiction, including medication development and other treatment modalities.

Her current research focuses on cognitive aspects of addiction-related behavior. Her overall goal is to conduct translational research using trans-species behavioral models of cognition and drug abuse and to interface her work with that of neurobiologists to understand mechanisms and with that of clinicians to improve drug addiction treatment outcomes.

Using intravenous drug self-administration procedures in rats, Dr. Kantak has investigated how multiple memory systems regulate drug-seeking and drug-taking behavior as well as how drug exposure influences the neurocognitive functioning of multiple memory systems. In addition, she spearheaded the effort to develop animal protocols that model exposure therapy targeting drug-related cues in clinical populations. She incorporates cognitive-enhancing pharmacotherapy and brief interventions with environmental enrichment or targeted cognitive training to improve extinction learning for relapse prevention. Within the context of these studies, she and her collaborators elaborate the neurosubstrates and neuroplasticity changes associated with these therapeutic strategies as well as translate these approaches to nonhuman primates and human subjects. In another line of research, Dr. Kantak evaluates frontostriatal and medial temporal lobe neurocognitive deficits in rats with an Attention Deficit/Hyperactivity Disorder phenotype. Focusing on the adolescent developmental period, she evaluates the response of rats with an ADHD phenotype to stimulant and non-stimulant medications, particularly in terms of comorbidity between ADHD and later vulnerability to drug addiction.

Professor
Boston University College of Arts and Sciences
Neuroscience


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Graduate Medical Sciences




Mechanisms of Extinction Memory Enhancement for Cocaine Addiction Treatment
09/15/2017 - 07/31/2022 (PI)
NIH/National Institute on Drug Abuse
5R01DA043454-04

Nature and Predictors of Impaired Harm Avoidance in Polysubstance Abuse
07/01/2018 - 06/30/2021 (Multi-PI)
PI: Kathleen Kantak, PhD
NIH/National Institute on Drug Abuse
5R21DA045148-02

Function-Specific Serotonergic Neurons, Discrete Prelimbic Targets, and Addiction
04/01/2014 - 03/31/2017 (Subcontract PI)
President and Fellows of Harvard College NIH NIDA
5R21DA036056-02

Cognitive Aspects of Addiction-Related Behavior
07/01/2009 - 06/30/2016 (PI)
NIH/National Institute on Drug Abuse
5R01DA011716-15

STRATEGIES FOR ENHANCING EXTINCTION OF DRUG-SEEKING BEHAVIOR
09/01/2007 - 08/31/2014 (PI)
NIH/National Institute on Drug Abuse
5R01DA024315-05



Title


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Kantak KM. Corrigendum to "Adolescent-onset vs. adult-onset cocaine use: Impact on cognitive functioning in animal models and opportunities for translation" [Pharmacol. Biochem. Behav. Volume 196, September (2020) 172994]. Pharmacol Biochem Behav. 2021 Apr 30; 206:173191. PMID: 33940254
     
  2. Wang Y, Taylor E, Zikopoulos B, Seta F, Huang N, Hamilton JA, Kantak KM, Morgan KG. Aging-induced microbleeds of the mouse thalamus compared to sensorimotor and memory defects. Neurobiol Aging. 2021 Apr; 100:39-47.View Related Profiles. PMID: 33477010
     
  3. Slade E, Dwoskin LP, Zhang GQ, Talbert JC, Chen J, Freeman PR, Kantak KM, Hankosky ER, Fouladvand S, Meadows AL, Bush HM. Integrating data science into the translational science research spectrum: A substance use disorder case study. J Clin Transl Sci. 2020 Aug 19; 5(1):e29. PMID: 33948252
     
  4. Kantak KM, Gauthier JM, Mathieson E, Knyazhanskaya E, Rodriguez-Echemendia P, Man HY. Sex differences in the effects of a combined behavioral and pharmacological treatment strategy for cocaine relapse prevention in an animal model of cue exposure therapy. Behav Brain Res. 2020 10 01; 395:112839. PMID: 32750464
     
  5. Kantak KM. Adolescent-onset vs. adult-onset cocaine use: Impact on cognitive functioning in animal models and opportunities for translation. Pharmacol Biochem Behav. 2020 09; 196:172994. PMID: 32659242
     
  6. Baskin BM, Mai JJ, Dymecki SM, Kantak KM. Cocaine reward and memory after chemogenetic inhibition of distinct serotonin neuron subtypes in mice. Psychopharmacology (Berl). 2020 Sep; 237(9):2633-2648. PMID: 32494973
     
  7. Bryant CD, Smith DJ, Kantak KM, Nowak TS, Williams RW, Damaj MI, Redei EE, Chen H, Mulligan MK. Facilitating Complex Trait Analysis via Reduced Complexity Crosses. Trends Genet. 2020 08; 36(8):549-562.View Related Profiles. PMID: 32482413
     
  8. Hastings MH, Gauthier JM, Mabry K, Tran A, Man HY, Kantak KM. Facilitative effects of environmental enrichment for cocaine relapse prevention are dependent on extinction training context and involve increased TrkB signaling in dorsal hippocampus and ventromedial prefrontal cortex. Behav Brain Res. 2020 05 27; 386:112596.View Related Profiles. PMID: 32194188
     
  9. Fouladvand S, Hankosky ER, Bush H, Chen J, Dwoskin LP, Freeman PR, Henderson DW, Kantak K, Talbert J, Tao S, Zhang GQ. Predicting substance use disorder using long-term attention deficit hyperactivity disorder medication records in Truven. Health Informatics J. 2020 06; 26(2):787-802. PMID: 31106686
     
  10. Fouladvand S, Hankosky ER, Henderson DW, Bush H, Chen J, Dwoskin LP, Freeman PR, Kantak K, Talbert J, Tao S, Zhang GQ. Predicting Substance Use Disorder in ADHD Patients using Long-Short Term Memory Model. 2018 IEEE Int Conf Healthc Inform Workshop (2018). 2018 Jun; 2018:49-50. PMID: 31380010
     
Showing 10 of 109 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 102 publications over 36 distinct years, with a maximum of 7 publications in 1981 and 2015 and 2020

YearPublications
19802
19817
19842
19862
19882
19892
19905
19912
19922
19951
19961
19971
19981
19991
20001
20015
20022
20033
20044
20051
20062
20072
20085
20094
20105
20116
20125
20133
20143
20157
20162
20171
20181
20191
20207
20211

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