Juan I. Fuxman Bass, PhD
Associate Professor
Boston University College of Arts and Sciences
Biology

PhD, University of Buenos Aires
MS, University of Buenos Aires
BS, University of Buenos Aires



Our lab studies the mechanisms controlling gene expression in health and disease using a combination of high-throughput assays, bioinformatics, and molecular and functional studies. Transcriptional regulation plays a fundamental role in development, homeostasis, and the response to environmental cues such as pathogen infections. Indeed, gene dysregulation has been associated with multiple diseases such as immune disorders, developmental malformations, and cancer. Our long-term goal is to answer central questions in gene regulation such as: through which mechanisms are immune genes regulated during inflammatory processes? How can we modulate gene expression to treat different pathologies? Through which mechanisms do genetic variants, isoforms, and fusions affect gene expression in cancer and other diseases? How do viruses perturb and leverage host transcriptional programs?

Current projects in the lab include: 1) Viral transcriptional regulators: Virus encode for transcriptional regulators that affect the expression of viral and host genes. Our goal is to characterize the functions of these regulators, determine their roles in disease, and identify small molecules or peptides that can inhibit their function. 2) Viral cis-regulatory elements: viruses sense the cellular environment to regulate sets of genes necessary for replication. One major viral sensing mechanism involves the recruitment of host transcription factors that act downstream of different cellular signaling pathways to cis-regulatory elements in the viral genome. Our lab aims to identify the full repertoire of viral elements, their mechanisms of regulation, and their variation across isolates with the ultimate goal of identifying organismal and environmental conditions that can reactivate latent viruses and to design therapeutics to treat viral infections. 3) Effect of genetic variation on gene regulatory networks: Genetic variants in non-coding sequences as well as amino acid sequence variants, isoforms and fusions in transcription factors can have major effects on gene expression and disease. Our goal is to determine the molecular mechanisms by which these variants perturb host networks in the context of cancer and genetic disorders.


Structure and Function of Immune Gene Regulatory Networks
09/20/2023 - 07/31/2028 (PI)
NIH/National Institute of General Medical Sciences
5R35GM128625-07

Characterization of the gene regulatory network governing the first cell fate decision in mammalian embryonic development
07/12/2022 - 03/31/2027 (Subcontract PI)
University of Massachusetts Memorial Medical Center NIH NICHD
5R01HD104971-03

Structure and Function of Immune Gene Regulatory Networks
08/01/2018 - 09/19/2023 (PI)
NIH/National Institute of General Medical Sciences
5R35GM128625-05

Rewiring of Regulatory Networks in Breast Cancer by Transcription Factor Isoforms
09/17/2018 - 08/31/2023 (Subcontract PI)
Dana-Farber Cancer Institute NIH NCI
5U01CA232161-05

Rewiring of Regulatory Networks in Breast Cancer by Transcription Factor Isoforms
09/01/2021 - 08/31/2022 (Subcontract PI)
Dana-Farber Cancer Institute NIH NCI
5U01CA232161-04

Delineation of ctyokine gene regulatory network and rewiring in disease
09/15/2016 - 07/31/2018 (PI)
NIH/National Institute of General Medical Sciences
5R00GM114296-03



Title


Yr Title Project-Sub Proj Pubs
2024 Characterization of the gene regulatory network governing the first cell fate decision in mammalian embryonic development 5R01HD104971-03
2024 Structure and Function of Immune Gene Regulatory Networks 3R35GM128625-07S1
2024 Structure and Function of Immune Gene Regulatory Networks 5R35GM128625-07
2023 Characterization of the gene regulatory network governing the first cell fate decision in mammalian embryonic development 5R01HD104971-02
2023 Structure and Function of Immune Gene Regulatory Networks 2R35GM128625-06
2022 Characterization of the gene regulatory network governing the first cell fate decision in mammalian embryonic development 1R01HD104971-01A1
2022 Rewiring of regulatory networks in breast cancer by transcription factor isoforms 5U01CA232161-05
2022 Structure and Function of Immune Gene Regulatory Networks 5R35GM128625-05
2021 Rewiring of regulatory networks in breast cancer by transcription factor isoforms 5U01CA232161-04
2021 Structure and Function of Immune Gene Regulatory Networks 5R35GM128625-04 2
Showing 10 of 19 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Lu Y, Berenson A, Lane R, Guelin I, Li Z, Chen Y, Shah S, Yin M, Soto-Ugaldi LF, Fiszbein A, Fuxman Bass JI. A large-scale cancer-specific protein-DNA interaction network. Life Sci Alliance. 2024 Oct; 7(10). PMID: 39013578; DOI: 10.26508/lsa.202402641;
     
  2. Moyer DC, Reimertz J, Segrè D, Fuxman Bass JI. Semi-Automatic Detection of Errors in Genome-Scale Metabolic Models. bioRxiv. 2024 Jun 27.View Related Profiles. PMID: 38979177; DOI: 10.1101/2024.06.24.600481;
     
  3. Rottenberg JT, Taslim TH, Soto-Ugaldi LF, Martinez-Cuesta L, Martinez-Calejman C, Fuxman Bass JI. Viral cis-regulatory elements as sensors of cellular states and environmental cues. Trends Genet. 2024 Sep; 40(9):772-783. PMID: 38821843; DOI: 10.1016/j.tig.2024.05.004;
     
  4. He ?? XA, Berenson A, Bernard M, Weber C, Cook LE, Visel A, Fuxman Bass JI, Fisher S. Identification of conserved skeletal enhancers associated with craniosynostosis risk genes. Hum Mol Genet. 2024 May 04; 33(10):837-849. PMID: 37883470; DOI: 10.1093/hmg/ddad182;
     
  5. Lambourne L, Mattioli K, Santoso C, Sheynkman G, Inukai S, Kaundal B, Berenson A, Spirohn-Fitzgerald K, Bhattacharjee A, Rothman E, Shrestha S, Laval F, Yang Z, Bisht D, Sewell JA, Li G, Prasad A, Phanor S, Lane R, Campbell DM, Hunt T, Balcha D, Gebbia M, Twizere JC, Hao T, Frankish A, Riback JA, Salomonis N, Calderwood MA, Hill DE, Sahni N, Vidal M, Bulyk ML, Fuxman Bass JI. Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms. bioRxiv. 2024 Apr 10. PMID: 38617209; DOI: 10.1101/2024.03.12.584681;
     
  6. Lu Y, Berenson A, Lane R, Guelin I, Li Z, Chen Y, Shah S, Yin M, Soto-Ugaldi LF, Fiszbein A, Fuxman Bass JI. A large-scale cancer-specific protein-DNA interaction network. bioRxiv. 2024 Jan 29. PMID: 38352498; DOI: 10.1101/2024.01.24.577099;
     
  7. Patalano SD, Fuxman Bass P, Fuxman Bass JI. Transcription factors in the development and treatment of immune disorders. Transcription. 2023 Dec 15; 1-23. PMID: 38100543; DOI: 10.1080/21541264.2023.2294623;
     
  8. Berenson A, Lane R, Soto-Ugaldi LF, Patel M, Ciausu C, Li Z, Chen Y, Shah S, Santoso C, Liu X, Spirohn K, Hao T, Hill DE, Vidal M, Fuxman Bass JI. Paired yeast one-hybrid assays to detect DNA-binding cooperativity and antagonism across transcription factors. Nat Commun. 2023 Oct 18; 14(1):6570. PMID: 37853017; DOI: 10.1038/s41467-023-42445-6;
     
  9. Nora EP, Aerts S, Wittkopp PJ, Bussemaker HJ, Bulyk M, Sinha S, Zeitlinger J, Crocker J, Fuxman Bass JI. Emerging questions in transcriptional regulation. Cell Syst. 2023 Apr 19; 14(4):247-251. PMID: 37080160; DOI: 10.1016/j.cels.2023.03.005;
     
  10. Carrasco Pro S, Hook H, Bray D, Berenzy D, Moyer D, Yin M, Labadorf AT, Tewhey R, Siggers T, Fuxman Bass JI. Widespread perturbation of ETS factor binding sites in cancer. Nat Commun. 2023 Feb 17; 14(1):913.View Related Profiles. PMID: 36808133; DOI: 10.1038/s41467-023-36535-8;
     
Showing 10 of 50 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 50 publications over 15 distinct years, with a maximum of 7 publications in 2021

YearPublications
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20082
20102
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20153
20166
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20193
20203
20217
20221
20235
20246


2022 Keystone Symposia Early Career Investigator Award
2019 International Cytokine & Interferon Society: Milstein Young Investigator Award
2007 Argentine Immunology Society: “Leonardo Satz” Award (award to the best oral presentation)
2005 University Students: Bronze Medal in the 8th Iberoamerican Mathematical Olympiad
2004 National Academy of Medicine Award
2004 Argentine Council for the Information and Development of Biotechnology Award
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