Keywords
Last Name

Shannon Fisher, MD, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics
Address72 E. Concord St Housman (R)
Boston MA
 Research Expertise & Professional Interests
Dr. Fisher’s work has been instrumental in establishing the zebrafish as a model organism for the study of skeletal dysplasias, including her identical for a zebrafish model for Osteogenesis Imperfection and publication of the first osteoblast markers. She pioneered the use of zebrafish to analyze transcriptional and regulatory elements from the human genome, and has identified and studied dozens of enhancers associated with skeletal genes. Her most recent efforts are focused on skull development, an area of tremendous clinical relevance not well studied in zebrafish.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J. The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development. 2016 Jul 15; 143(14):2677-88. PMID: 27287806.
    View in: PubMed
  2. Kague E, Roy P, Asselin G, Hu G, Simonet J, Stanley A, Albertson C, Fisher S. Osterix/Sp7 limits cranial bone initiation sites and is required for formation of sutures. Dev Biol. 2016 May 15; 413(2):160-72. PMID: 26992365.
    View in: PubMed
  3. Esteves FF, Springhorn A, Kague E, Taylor E, Pyrowolakis G, Fisher S, Bier E. BMPs regulate msx gene expression in the dorsal neuroectoderm of Drosophila and vertebrates by distinct mechanisms. PLoS Genet. 2014 Sep; 10(9):e1004625. PMID: 25210771.
    View in: PubMed
  4. Costa AM, Pereira-Castro I, Ricardo E, Spencer F, Fisher S, da Costa LT. GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos. PLoS One. 2013; 8(7):e67694. PMID: 23840876.
    View in: PubMed
  5. Kague E, Gallagher M, Burke S, Parsons M, Franz-Odendaal T, Fisher S. Skeletogenic fate of zebrafish cranial and trunk neural crest. PLoS One. 2012; 7(11):e47394. PMID: 23155370.
    View in: PubMed
  6. Hu G, Codina M, Fisher S. Multiple enhancers associated with ACAN suggest highly redundant transcriptional regulation in cartilage. Matrix Biol. 2012 Jul; 31(6):328-37. PMID: 22820679.
    View in: PubMed
  7. Maragh S, Miller RA, Bessling SL, McGaughey DM, Wessels MW, de Graaf B, Stone EA, Bertoli-Avella AM, Gearhart JD, Fisher S, McCallion AS. Identification of RNA binding motif proteins essential for cardiovascular development. BMC Dev Biol. 2011 Oct 19; 11:62. PMID: 22011202.
    View in: PubMed
  8. Hu G, Goll MG, Fisher S. FC31 integrase mediates efficient cassette exchange in the zebrafish germline. Dev Dyn. 2011 Sep; 240(9):2101-7. PMID: 21805532.
    View in: PubMed
  9. Knopf F, Hammond C, Chekuru A, Kurth T, Hans S, Weber CW, Mahatma G, Fisher S, Brand M, Schulte-Merker S, Weidinger G. Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Dev Cell. 2011 May 17; 20(5):713-24. PMID: 21571227.
    View in: PubMed
  10. Kague E, Weber C, Fisher S. Mosaic zebrafish transgenesis for evaluating enhancer sequences. J Vis Exp. 2010 Jul 16; (41). PMID: 20679998.
    View in: PubMed
  11. Kague E, Bessling SL, Lee J, Hu G, Passos-Bueno MR, Fisher S. Functionally conserved cis-regulatory elements of COL18A1 identified through zebrafish transgenesis. Dev Biol. 2010 Jan 15; 337(2):496-505. PMID: 19895802.
    View in: PubMed
  12. Brown AM, Fisher S, Iovine MK. Osteoblast maturation occurs in overlapping proximal-distal compartments during fin regeneration in zebrafish. Dev Dyn. 2009 Nov; 238(11):2922-8. PMID: 19842180.
    View in: PubMed
  13. Pashos EE, Kague E, Fisher S. Evaluation of cis-regulatory function in zebrafish. Brief Funct Genomic Proteomic. 2008 Nov; 7(6):465-73. PMID: 18820318.
    View in: PubMed
  14. Gerdes JM, Liu Y, Zaghloul NA, Leitch CC, Lawson SS, Kato M, Beachy PA, Beales PL, DeMartino GN, Fisher S, Badano JL, Katsanis N. Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet. 2007 Nov; 39(11):1350-60. PMID: 17906624.
    View in: PubMed
  15. Xie J, Bessling SL, Cooper TK, Dietz HC, McCallion AS, Fisher S. Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases. Genetics. 2007 Jun; 176(2):1339-42. PMID: 17483412.
    View in: PubMed
  16. Fisher S, Grice EA, Vinton RM, Bessling SL, McCallion AS. Conservation of RET regulatory function from human to zebrafish without sequence similarity. Science. 2006 Apr 14; 312(5771):276-9. PMID: 16556802.
    View in: PubMed
  17. Fisher S, Grice EA, Vinton RM, Bessling SL, Urasaki A, Kawakami K, McCallion AS. Evaluating the biological relevance of putative enhancers using Tol2 transposon-mediated transgenesis in zebrafish. Nat Protoc. 2006; 1(3):1297-305. PMID: 17406414.
    View in: PubMed
  18. Badano JL, Leitch CC, Ansley SJ, May-Simera H, Lawson S, Lewis RA, Beales PL, Dietz HC, Fisher S, Katsanis N. Dissection of epistasis in oligogenic Bardet-Biedl syndrome. Nature. 2006 Jan 19; 439(7074):326-30. PMID: 16327777.
    View in: PubMed
  19. Ross AJ, May-Simera H, Eichers ER, Kai M, Hill J, Jagger DJ, Leitch CC, Chapple JP, Munro PM, Fisher S, Tan PL, Phillips HM, Leroux MR, Henderson DJ, Murdoch JN, Copp AJ, Eliot MM, Lupski JR, Kemp DT, Dollfus H, Tada M, Katsanis N, Forge A, Beales PL. Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat Genet. 2005 Oct; 37(10):1135-40. PMID: 16170314.
    View in: PubMed
  20. Xie J, Fisher S. Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms. Development. 2005 Jan; 132(2):383-91. PMID: 15604098.
    View in: PubMed
  21. Flores MV, Tsang VW, Hu W, Kalev-Zylinska M, Postlethwait J, Crosier P, Crosier K, Fisher S. Duplicate zebrafish runx2 orthologues are expressed in developing skeletal elements. Gene Expr Patterns. 2004 Sep; 4(5):573-81. PMID: 15261836.
    View in: PubMed
  22. Fisher S, Jagadeeswaran P, Halpern ME. Radiographic analysis of zebrafish skeletal defects. Dev Biol. 2003 Dec 01; 264(1):64-76. PMID: 14623232.
    View in: PubMed
  23. Goldsmith MI, Fisher S, Waterman R, Johnson SL. Saltatory control of isometric growth in the zebrafish caudal fin is disrupted in long fin and rapunzel mutants. Dev Biol. 2003 Jul 15; 259(2):303-17. PMID: 12871703.
    View in: PubMed
  24. Fisher S, Halpern ME. Patterning the zebrafish axial skeleton requires early chordin function. Nat Genet. 1999 Dec; 23(4):442-6. PMID: 10581032.
    View in: PubMed
  25. Miller-Bertoglio VE, Fisher S, Sánchez A, Mullins MC, Halpern ME. Differential regulation of chordin expression domains in mutant zebrafish. Dev Biol. 1997 Dec 15; 192(2):537-50. PMID: 9441687.
    View in: PubMed
  26. Fisher S, Amacher SL, Halpern ME. Loss of cerebum function ventralizes the zebrafish embryo. Development. 1997 Apr; 124(7):1301-11. PMID: 9118801.
    View in: PubMed
  27. Fisher S, Gearhart JD, Oster-Granite ML. Expression of the amyloid precursor protein gene in mouse oocytes and embryos. Proc Natl Acad Sci U S A. 1991 Mar 01; 88(5):1779-82. PMID: 1900367.
    View in: PubMed
  28. Fisher S, Oster-Granite ML. Developmental expression of amyloid precursor protein in normal and trisomy 16 mice. Adv Exp Med Biol. 1990; 265:311-8. PMID: 1974107.
    View in: PubMed
  29. O'Hara BF, Fisher S, Oster-Granite ML, Gearhart JD, Reeves RH. Developmental expression of the amyloid precursor protein, growth-associated protein 43, and somatostatin in normal and trisomy 16 mice. Brain Res Dev Brain Res. 1989 Oct 01; 49(2):300-4. PMID: 2572360.
    View in: PubMed
  30. Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L, Oster-Granite ML, Neve RL. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science. 1989 Jul 28; 245(4916):417-20. PMID: 2474201.
    View in: PubMed
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