Mary Fisher | Profiles RNS

Shannon Fisher, MD, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

MD, Johns Hopkins University School of Medicine
PhD, Johns Hopkins University School of Medicine
BS, Purdue University

Websites

	BUSM
	BU Research
	BUGMS
	Research Gate

ORCID : 0000-0002-0765-3800

Dr. Fisher’s work has been instrumental in establishing the zebrafish as a model organism for the study of skeletal dysplasias, including her identical for a zebrafish model for Osteogenesis Imperfection and publication of the first osteoblast markers. She pioneered the use of zebrafish to analyze transcriptional and regulatory elements from the human genome, and has identified and studied dozens of enhancers associated with skeletal genes. Her most recent efforts are focused on skull development, an area of tremendous clinical relevance not well studied in zebrafish.

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Smad6 deficient zebrafish as a model for multifactorial craniosynostosis
07/01/2021 - 06/30/2024 (PI)
NIH/National Institute of Dental & Craniofacial Research
5R21DE029916-02

Screen for mutations affecting skull and suture formation In zebrafish
11/07/2015 - 05/31/2020 (PI)
NIH/National Institute of Dental & Craniofacial Research
5R01DE022955-06

Anatomical atlas and transgenic toolkit for late skull formation in zebrafish
10/01/2015 - 04/30/2019 (PI)
NIH/National Institute of Dental & Craniofacial Research
5U01DE024434-06

Title

Yr	Title	Project-Sub Proj	Pubs
2022	Smad6 deficient zebrafish as a model for multifactorial craniosynostosis	5R21DE029916-02
2021	Smad6 deficient zebrafish as a model for multifactorial craniosynostosis	1R21DE029916-01A1
2018	Anatomical atlas and transgenic toolkit for late skull formation in zebrafish	5U01DE024434-06	10
2017	Screen for mutations affecting skull and suture formation in zebrafish	5R01DE022955-06	2
2017	Anatomical atlas and transgenic toolkit for late skull formation in zebrafish	5U01DE024434-05	10
2016	Screen for mutations affecting skull and suture formation in zebrafish	5R01DE022955-05	2
2016	Anatomical atlas and transgenic toolkit for late skull formation in zebrafish	5U01DE024434-04	10
2015	Screen for mutations affecting skull and suture formation in zebrafish	7R01DE022955-04	2
2015	Anatomical atlas and transgenic toolkit for late skull formation in zebrafish	7U01DE024434-03	10
2015	Anatomical atlas and transgenic toolkit for late skull formation in zebrafish	5U01DE024434-02	10

Showing 10 of 27 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J, Chai Y. The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development. 2016 Jul 15; 143(14):2677-88. PMID: 27287806; PMCID: PMC4958338; DOI: 10.1242/dev.135434;

Kague E, Roy P, Asselin G, Hu G, Simonet J, Stanley A, Albertson C, Fisher S. Osterix/Sp7 limits cranial bone initiation sites and is required for formation of sutures. Dev Biol. 2016 May 15; 413(2):160-72. PMID: 26992365; PMCID: PMC5469377; DOI: 10.1016/j.ydbio.2016.03.011;

Esteves FF, Springhorn A, Kague E, Taylor E, Pyrowolakis G, Fisher S, Bier E. BMPs regulate msx gene expression in the dorsal neuroectoderm of Drosophila and vertebrates by distinct mechanisms. PLoS Genet. 2014 Sep; 10(9):e1004625. PMID: 25210771; PMCID: PMC4161316; DOI: 10.1371/journal.pgen.1004625;

Costa AM, Pereira-Castro I, Ricardo E, Spencer F, Fisher S, da Costa LT. GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos. PLoS One. 2013; 8(7):e67694. PMID: 23840876; PMCID: PMC3698143; DOI: 10.1371/journal.pone.0067694;

Kague E, Gallagher M, Burke S, Parsons M, Franz-Odendaal T, Fisher S. Skeletogenic fate of zebrafish cranial and trunk neural crest. PLoS One. 2012; 7(11):e47394. PMID: 23155370; PMCID: PMC3498280; DOI: 10.1371/journal.pone.0047394;

Hu G, Codina M, Fisher S. Multiple enhancers associated with ACAN suggest highly redundant transcriptional regulation in cartilage. Matrix Biol. 2012 Jul; 31(6):328-37. PMID: 22820679; PMCID: PMC3508301; DOI: 10.1016/j.matbio.2012.06.001;

Maragh S, Miller RA, Bessling SL, McGaughey DM, Wessels MW, de Graaf B, Stone EA, Bertoli-Avella AM, Gearhart JD, Fisher S, McCallion AS. Identification of RNA binding motif proteins essential for cardiovascular development. BMC Dev Biol. 2011 Oct 19; 11:62. PMID: 22011202; PMCID: PMC3277282; DOI: 10.1186/1471-213X-11-62;

Hu G, Goll MG, Fisher S. FC31 integrase mediates efficient cassette exchange in the zebrafish germline. Dev Dyn. 2011 Sep; 240(9):2101-7. PMID: 21805532; PMCID: PMC3938014; DOI: 10.1002/dvdy.22699;

Knopf F, Hammond C, Chekuru A, Kurth T, Hans S, Weber CW, Mahatma G, Fisher S, Brand M, Schulte-Merker S, Weidinger G. Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Dev Cell. 2011 May 17; 20(5):713-24. PMID: 21571227; DOI: 10.1016/j.devcel.2011.04.014;

Kague E, Weber C, Fisher S. Mosaic zebrafish transgenesis for evaluating enhancer sequences. J Vis Exp. 2010 Jul 16; (41). PMID: 20679998; PMCID: PMC3156073; DOI: 10.3791/1722;

Showing 10 of 30 results. Show More

Kague E, Bessling SL, Lee J, Hu G, Passos-Bueno MR, Fisher S. Functionally conserved cis-regulatory elements of COL18A1 identified through zebrafish transgenesis. Dev Biol. 2010 Jan 15; 337(2):496-505. PMID: 19895802; DOI: 10.1016/j.ydbio.2009.10.028;

Brown AM, Fisher S, Iovine MK. Osteoblast maturation occurs in overlapping proximal-distal compartments during fin regeneration in zebrafish. Dev Dyn. 2009 Nov; 238(11):2922-8. PMID: 19842180; PMCID: PMC2788789; DOI: 10.1002/dvdy.22114;

Pashos EE, Kague E, Fisher S. Evaluation of cis-regulatory function in zebrafish. Brief Funct Genomic Proteomic. 2008 Nov; 7(6):465-73. PMID: 18820318; DOI: 10.1093/bfgp/eln045;

Gerdes JM, Liu Y, Zaghloul NA, Leitch CC, Lawson SS, Kato M, Beachy PA, Beales PL, DeMartino GN, Fisher S, Badano JL, Katsanis N. Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet. 2007 Nov; 39(11):1350-60. PMID: 17906624; DOI: 10.1038/ng.2007.12;

Xie J, Bessling SL, Cooper TK, Dietz HC, McCallion AS, Fisher S. Manipulating mitotic recombination in the zebrafish embryo through RecQ helicases. Genetics. 2007 Jun; 176(2):1339-42. PMID: 17483412; PMCID: PMC1894594; DOI: 10.1534/genetics.107.072983;

Fisher S, Grice EA, Vinton RM, Bessling SL, McCallion AS. Conservation of RET regulatory function from human to zebrafish without sequence similarity. Science. 2006 Apr 14; 312(5771):276-9. PMID: 16556802; DOI: 10.1126/science.1124070;

Fisher S, Grice EA, Vinton RM, Bessling SL, Urasaki A, Kawakami K, McCallion AS. Evaluating the biological relevance of putative enhancers using Tol2 transposon-mediated transgenesis in zebrafish. Nat Protoc. 2006; 1(3):1297-305. PMID: 17406414; DOI: 10.1038/nprot.2006.230;

Badano JL, Leitch CC, Ansley SJ, May-Simera H, Lawson S, Lewis RA, Beales PL, Dietz HC, Fisher S, Katsanis N. Dissection of epistasis in oligogenic Bardet-Biedl syndrome. Nature. 2006 Jan 19; 439(7074):326-30. PMID: 16327777; DOI: 10.1038/nature04370;

Ross AJ, May-Simera H, Eichers ER, Kai M, Hill J, Jagger DJ, Leitch CC, Chapple JP, Munro PM, Fisher S, Tan PL, Phillips HM, Leroux MR, Henderson DJ, Murdoch JN, Copp AJ, Eliot MM, Lupski JR, Kemp DT, Dollfus H, Tada M, Katsanis N, Forge A, Beales PL. Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. Nat Genet. 2005 Oct; 37(10):1135-40. PMID: 16170314; DOI: 10.1038/ng1644;

Xie J, Fisher S. Twisted gastrulation enhances BMP signaling through chordin dependent and independent mechanisms. Development. 2005 Jan; 132(2):383-91. PMID: 15604098; DOI: 10.1242/dev.01577;

Flores MV, Tsang VW, Hu W, Kalev-Zylinska M, Postlethwait J, Crosier P, Crosier K, Fisher S. Duplicate zebrafish runx2 orthologues are expressed in developing skeletal elements. Gene Expr Patterns. 2004 Sep; 4(5):573-81. PMID: 15261836; DOI: 10.1016/j.modgep.2004.01.016;

Fisher S, Jagadeeswaran P, Halpern ME. Radiographic analysis of zebrafish skeletal defects. Dev Biol. 2003 Dec 01; 264(1):64-76. PMID: 14623232

Goldsmith MI, Fisher S, Waterman R, Johnson SL. Saltatory control of isometric growth in the zebrafish caudal fin is disrupted in long fin and rapunzel mutants. Dev Biol. 2003 Jul 15; 259(2):303-17. PMID: 12871703

Fisher S, Halpern ME. Patterning the zebrafish axial skeleton requires early chordin function. Nat Genet. 1999 Dec; 23(4):442-6. PMID: 10581032; DOI: 10.1038/70557;

Miller-Bertoglio VE, Fisher S, Sánchez A, Mullins MC, Halpern ME. Differential regulation of chordin expression domains in mutant zebrafish. Dev Biol. 1997 Dec 15; 192(2):537-50. PMID: 9441687; DOI: 10.1006/dbio.1997.8788;

Fisher S, Amacher SL, Halpern ME. Loss of cerebum function ventralizes the zebrafish embryo. Development. 1997 Apr; 124(7):1301-11. PMID: 9118801

Fisher S, Gearhart JD, Oster-Granite ML. Expression of the amyloid precursor protein gene in mouse oocytes and embryos. Proc Natl Acad Sci U S A. 1991 Mar 01; 88(5):1779-82. PMID: 1900367; PMCID: PMC51108

Fisher S, Oster-Granite ML. Developmental expression of amyloid precursor protein in normal and trisomy 16 mice. Adv Exp Med Biol. 1990; 265:311-8. PMID: 1974107

O'Hara BF, Fisher S, Oster-Granite ML, Gearhart JD, Reeves RH. Developmental expression of the amyloid precursor protein, growth-associated protein 43, and somatostatin in normal and trisomy 16 mice. Brain Res Dev Brain Res. 1989 Oct 01; 49(2):300-4. PMID: 2572360

Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L, Oster-Granite ML, Neve RL. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science. 1989 Jul 28; 245(4916):417-20. PMID: 2474201

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 30 publications over 18 distinct years, with a maximum of 3 publications in 2011

Bar chart showing 30 publications over 18 distinct years, with a maximum of 3 publications in 2011

Year	Publications
1989	2
1990	1
1991	1
1997	2
1999	1
2003	2
2004	2
2005	2
2006	2
2007	2
2008	1
2009	2
2010	1
2011	3
2012	2
2013	1
2014	1
2016	2

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