Daniel Segre | Profiles RNS

Daniel Segrè, Ph.D.

Professor

Boston University College of Arts and Sciences

Biology

PhD, Weizmann Institute of Science
MSc, University of Trieste
BSc, University of Trieste

Websites

	LinkedIn
	Google Scholar
	ResearchGate

ORCID : 0000-0003-4859-1914

Prof. Daniel Segrè is a Professor of Biology, Biomedical Engineering and Physics, and a core faculty member in the Bioinformatics Graduate Program at Boston University. He is a member of the Biological Design Center and the founding director of the Boston University Microbiome Initiative. After training in Physics in Trieste, Italy, Prof. Segrè obtained a Ph.D. in the Life Sciences at the Weizmann Institute, Israel, where he studied the origin and evolution of living systems. As a postdoctoral fellow at Harvard Medical School, and later as a faculty at Boston University, Prof. Segrè started developing mathematical and computational approaches for understanding metabolism at multiple scales, from individual organisms to large-scale ecosystems. Current work in the Segrè lab is focused on predicting, designing and experimentally testing metabolic activity in microbes and microbial communities, with applications in human microbiome research, marine and soil biogeochemical cycling, and synthetic ecology. Among other contributions, the Segrè group has implemented models for the early emergence of biochemical networks, pioneered algorithms for the design of new putative inter-species interactions, and developed COMETS (Computation Of Microbial Ecosystems in Time and Space), a quantitative framework for simulating microbial ecosystem metabolism in spatially structured environments.

BU Research
NIH RePORTER Research

Predoctoral Training in Bioinformatics and Computational Biology
07/01/2023 - 06/30/2028 (Multi-PI)
PI: Daniel Segrè, Ph.D.
NIH/National Institute of General Medical Sciences
5T32GM150533-02

Center for Chemical Currencies of a Microbial Planet (C-CoMP)
10/01/2021 - 09/30/2026 (Subcontract PI)
Woods Hole Oceanographic Institution National Science Fdn
OCE-2019589

m-CAFEs: Microbial Community Analysis & Functional Evaluation in Soils Scientific Focus Area
06/29/2020 - 09/30/2026 (Subcontract PI)
Lawrence Berkeley National Laboratory Department of Energy
DE-AC02-05CH11231

NSF-BSF: Cell death, metabolism and the emergency of long-term survival through microbial interactions in Prochlorococcus, a globally abundant marine model cyanobacterium
09/01/2023 - 08/31/2026 (PI)
National Science Foundation
IOS-2246707

Spatio-temporal mechanistic modeling of whole-cell tumor metabolism
05/01/2023 - 04/30/2025 (Multi-PI)
PI: Daniel Segrè, Ph.D.
NIH/National Cancer Institute
5R21CA279630-02

The aphrodisiac gut: defining the factors promoting yeast mating within insect intestines
10/04/2021 - 10/03/2024 (PI)
Human Frontier Science Program (France)

Microbiome-based biomarkers and models of lung cancer development and treatment
12/01/2022 - 11/30/2023 (Subcontract PI)
Rutgers, The State University of New Jersey NIH NCI
7R21CA260382-02

Predoctoral Training in Bioinformatics and Computational Biology
06/01/2018 - 06/30/2023 (Key Person / Mentor)
PI: Thomas D. Tullius, PhD
NIH/National Institute of General Medical Sciences
5T32GM100842-10

Microbiome-based biomarkers and models of lung cancer development and treatment
12/08/2021 - 08/31/2022 (Multi-PI)
PI: Daniel Segrè, Ph.D.
NIH/National Cancer Institute
1R21CA260382-01A1

Collaborative Research: Molecular Mechanisms and Biogeochemical Consequences of Decomposer Species Interactions During Succession in Ecosystems
09/01/2015 - 08/31/2021 (Multi-PI)
PI: Daniel Segrè, Ph.D.
National Science Foundation
DEB-1457695

Showing 10 of 34 results. Show All Results

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Predoctoral Training in Bioinformatics and Computational Biology	5T32GM150533-02
2024	Spatio-temporal mechanistic modeling of whole-cell tumor metabolism	5R21CA279630-02
2023	Predoctoral Training in Bioinformatics and Computational Biology	1T32GM150533-01
2023	Spatio-temporal mechanistic modeling of whole-cell tumor metabolism	1R21CA279630-01
2023	Microbiome-based biomarkers and models of lung cancer development and treatment	7R21CA260382-02
2022	Microbiome-based biomarkers and models of lung cancer development and treatment	1R21CA260382-01A1
2019	A platform for mining, visualization and design of microbial interaction networks	5R01GM121950-03	9
2018	A platform for mining, visualization and design of microbial interaction networks	5R01GM121950-02	9
2018	Cultivation, Nature, Ecology and Pathogenicity of the Uncultivable Oral Microbiom	5R01DE024468-05	19
2017	A platform for mining, visualization and design of microbial interaction networks	1R01GM121950-01	9

Showing 10 of 24 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Silverstein MR, Bhatnagar JM, Segrè D. Metabolic complexity drives divergence in microbial communities. Nat Ecol Evol. 2024 Aug; 8(8):1493-1504. PMID: 38956426; DOI: 10.1038/s41559-024-02440-6;

Moyer DC, Reimertz J, Segrè D, Fuxman Bass JI. Semi-Automatic Detection of Errors in Genome-Scale Metabolic Models. bioRxiv. 2024 Jun 27.View Related Profiles.

Segre, Daniel
Fuxman Bass, Juan

PMID: 38979177; PMCID: PMC11230171; DOI: 10.1101/2024.06.24.600481;

Givati S, Forchielli E, Aharonovich D, Barak N, Weissberg O, Belkin N, Rahav E, Segrè D, Sher D. Diversity in the utilization of different molecular classes of dissolved organic matter by heterotrophic marine bacteria. Appl Environ Microbiol. 2024 Jul 24; 90(7):e0025624. PMID: 38920365; PMCID: PMC11267927; DOI: 10.1128/aem.00256-24;

Herbst K, Wang T, Forchielli EJ, Thommes M, Paschalidis IC, Segrè D. Multi-Attribute Subset Selection enables prediction of representative phenotypes across microbial populations. Commun Biol. 2024 Apr 03; 7(1):407.View Related Profiles.

Segre, Daniel
Paschalidis, Ioannis

PMID: 38570615; PMCID: PMC10991586; DOI: 10.1038/s42003-024-06093-w;

Silverstein M, Bhatnagar JM, Segrè D. Metabolic complexity drives divergence in microbial communities. bioRxiv. 2023 Aug 03. PMID: 37577626; PMCID: PMC10418233; DOI: 10.1101/2023.08.03.551516;

Kishore D, Birzu G, Hu Z, DeLisi C, Korolev KS, Segrè D. Inferring microbial co-occurrence networks from amplicon data: a systematic evaluation. mSystems. 2023 Aug 31; 8(4):e0096122.View Related Profiles.

Segre, Daniel
Birzu, Gabriel

PMID: 37338270; PMCID: PMC10469762; DOI: 10.1128/msystems.00961-22;

Jo C, Bernstein DB, Vaisman N, Frydman HM, Segrè D. Construction and Modeling of a Coculture Microplate for Real-Time Measurement of Microbial Interactions. mSystems. 2023 Apr 27; 8(2):e0001721.View Related Profiles.

Segre, Daniel
Frydman, Horacio

PMID: 36802169; PMCID: PMC10134821; DOI: 10.1128/msystems.00017-21;

Segrè D, Mitri S, Shou W, Süel GM, Mizrahi I, Kelly L, Rebolleda-Gómez M, Ratzke C, Ogbunugafor CB, Schwartzman JA, Kryazhimskiy S, Leventhal GE, Kost C, Bell T. What do you most want to understand about how collective features emerge in microbial communities? Cell Syst. 2023 Feb 15; 14(2):91-97. PMID: 36796334; DOI: 10.1016/j.cels.2023.01.001;

Silverstein MR, Segrè D, Bhatnagar JM. Environmental microbiome engineering for the mitigation of climate change. Glob Chang Biol. 2023 Apr; 29(8):2050-2066. PMID: 36661406; DOI: 10.1111/gcb.16609;

Jo C, Zhang J, Tam JM, Church GM, Khalil AS, Segrè D, Tang TC. Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability. Mater Today Bio. 2023 Apr; 19:100560.View Related Profiles.

Khalil, Ahmad
Segre, Daniel

PMID: 36756210; PMCID: PMC9900623; DOI: 10.1016/j.mtbio.2023.100560;

Showing 10 of 60 results. Show More

Pacheco AR, Pauvert C, Kishore D, Segrè D. Toward FAIR Representations of Microbial Interactions. mSystems. 2022 Oct 26; 7(5):e0065922. PMID: 36005399; PMCID: PMC9599284; DOI: 10.1128/msystems.00659-22;

Golden A, Dukovski I, Segrè D, Korolev KS. Growth instabilities shape morphology and genetic diversity of microbial colonies. Phys Biol. 2022 Aug 19; 19(5). PMID: 35901792; PMCID: PMC11209841; DOI: 10.1088/1478-3975/ac8514;

Forchielli E, Sher D, Segrè D. Metabolic Phenotyping of Marine Heterotrophs on Refactored Media Reveals Diverse Metabolic Adaptations and Lifestyle Strategies. mSystems. 2022 Aug 30; 7(4):e0007022. PMID: 35856685; PMCID: PMC9426600; DOI: 10.1128/msystems.00070-22;

Zomorrodi AR, Hemez C, Arranz-Gibert P, Wu T, Isaacs FJ, Segrè D. Computational design and engineering of an Escherichia coli strain producing the nonstandard amino acid para-aminophenylalanine. iScience. 2022 Jul 15; 25(7):104562. PMID: 35789833; PMCID: PMC9249619; DOI: 10.1016/j.isci.2022.104562;

Moran MA, Kujawinski EB, Schroer WF, Amin SA, Bates NR, Bertrand EM, Braakman R, Brown CT, Covert MW, Doney SC, Dyhrman ST, Edison AS, Eren AM, Levine NM, Li L, Ross AC, Saito MA, Santoro AE, Segrè D, Shade A, Sullivan MB, Vardi A. Microbial metabolites in the marine carbon cycle. Nat Microbiol. 2022 Apr; 7(4):508-523. PMID: 35365785; DOI: 10.1038/s41564-022-01090-3;

Zoccarato L, Sher D, Miki T, Segrè D, Grossart HP. A comparative whole-genome approach identifies bacterial traits for marine microbial interactions. Commun Biol. 2022 Mar 28; 5(1):276. PMID: 35347228; PMCID: PMC8960797; DOI: 10.1038/s42003-022-03184-4;

Goldford JE, George AB, Flamholz AI, Segrè D. Protein cost minimization promotes the emergence of coenzyme redundancy. Proc Natl Acad Sci U S A. 2022 Apr 05; 119(14):e2110787119. PMID: 35344442; PMCID: PMC9168515; DOI: 10.1073/pnas.2110787119;

Dukovski I, Bajic D, Chacón JM, Quintin M, Vila JCC, Sulheim S, Pacheco AR, Bernstein DB, Riehl WJ, Korolev KS, Sanchez A, Harcombe WR, Segrè D. A metabolic modeling platform for the computation of microbial ecosystems in time and space (COMETS). Nat Protoc. 2021 Nov; 16(11):5030-5082. PMID: 34635859; PMCID: PMC10824140; DOI: 10.1038/s41596-021-00593-3;

Moyer D, Pacheco AR, Bernstein DB, Segrè D. Stoichiometric Modeling of Artificial String Chemistries Reveals Constraints on Metabolic Network Structure. J Mol Evol. 2021 Aug; 89(7):472-483. PMID: 34230992; PMCID: PMC8318951; DOI: 10.1007/s00239-021-10018-0;

Pacheco AR, Segrè D. An evolutionary algorithm for designing microbial communities via environmental modification. J R Soc Interface. 2021 Jun; 18(179):20210348. PMID: 34157894; PMCID: PMC8220269; DOI: 10.1098/rsif.2021.0348;

DiMucci D, Kon M, Segrè D. BowSaw: Inferring Higher-Order Trait Interactions Associated With Complex Biological Phenotypes. Front Mol Biosci. 2021; 8:663532. PMID: 34222331; PMCID: PMC8245782; DOI: 10.3389/fmolb.2021.663532;

Roth Rosenberg D, Haber M, Goldford J, Lalzar M, Aharonovich D, Al-Ashhab A, Lehahn Y, Segrè D, Steindler L, Sher D. Particle-associated and free-living bacterial communities in an oligotrophic sea are affected by different environmental factors. Environ Microbiol. 2021 Aug; 23(8):4295-4308. PMID: 34036706; DOI: 10.1111/1462-2920.15611;

Kuo T, Du W, Miyachi Y, Dadi PK, Jacobson DA, Segrè D, Accili D. Antagonistic epistasis of Hnf4a and FoxO1 metabolic networks through enhancer interactions in ß-cell function. Mol Metab. 2021 Nov; 53:101256. PMID: 34048961; PMCID: PMC8225970; DOI: 10.1016/j.molmet.2021.101256;

Pacheco AR, Osborne ML, Segrè D. Non-additive microbial community responses to environmental complexity. Nat Commun. 2021 Apr 22; 12(1):2365. PMID: 33888697; PMCID: PMC8062479; DOI: 10.1038/s41467-021-22426-3;

Zhao Y, Federico A, Faits T, Manimaran S, Segrè D, Monti S, Johnson WE. animalcules: interactive microbiome analytics and visualization in R. Microbiome. 2021 03 28; 9(1):76.View Related Profiles.

Segre, Daniel
Monti, Stefano
Johnson, William

PMID: 33775256; PMCID: PMC8006385; DOI: 10.1186/s40168-021-01013-0;

Bernstein DB, Sulheim S, Almaas E, Segrè D. Addressing uncertainty in genome-scale metabolic model reconstruction and analysis. Genome Biol. 2021 Feb 18; 22(1):64. PMID: 33602294; PMCID: PMC7890832; DOI: 10.1186/s13059-021-02289-z;

Ofaim S, Sulheim S, Almaas E, Sher D, Segrè D. Dynamic Allocation of Carbon Storage and Nutrient-Dependent Exudation in a Revised Genome-Scale Model of Prochlorococcus. Front Genet. 2021; 12:586293. PMID: 33633777; PMCID: PMC7900632; DOI: 10.3389/fgene.2021.586293;

Jinich A, Sanchez-Lengeling B, Ren H, Goldford JE, Noor E, Sanders JN, Segrè D, Aspuru-Guzik A. A thermodynamic atlas of carbon redox chemical space. Proc Natl Acad Sci U S A. 2020 Dec 29; 117(52):32910-32918. PMID: 33376214; PMCID: PMC7777073; DOI: 10.1073/pnas.2005642117;

DeLisi C, Patrinos A, MacCracken M, Drell D, Annas G, Arkin A, Church G, Cook-Deegan R, Jacoby H, Lidstrom M, Melillo J, Milo R, Paustian K, Reilly J, Roberts RJ, Segrè D, Solomon S, Woolf D, Wullschleger SD, Yang X. The Role of Synthetic Biology in Atmospheric Greenhouse Gas Reduction: Prospects and Challenges. Biodes Res. 2020; 2020:1016207.View Related Profiles.

Segre, Daniel
Annas, George

PMID: 37849905; PMCID: PMC10521736; DOI: 10.34133/2020/1016207;

Goldford JE, Hartman H, Marsland R, Segrè D. Environmental boundary conditions for the origin of life converge to an organo-sulfur metabolism. Nat Ecol Evol. 2019 Dec; 3(12):1715-1724. PMID: 31712697; PMCID: PMC6881557; DOI: 10.1038/s41559-019-1018-8;

Lancet D, Segrè D, Kahana A. Twenty Years of "Lipid World": A Fertile Partnership with David Deamer. Life (Basel). 2019 Sep 20; 9(4). PMID: 31547028; PMCID: PMC6958426; DOI: 10.3390/life9040077;

Saifuddin M, Bhatnagar JM, Segrè D, Finzi AC. Microbial carbon use efficiency predicted from genome-scale metabolic models. Nat Commun. 2019 Aug 08; 10(1):3568. PMID: 31395870; PMCID: PMC6687798; DOI: 10.1038/s41467-019-11488-z;

Bernstein DB, Dewhirst FE, Segrè D. Metabolic network percolation quantifies biosynthetic capabilities across the human oral microbiome. Elife. 2019 Jun 13; 8. PMID: 31194675; PMCID: PMC6609349; DOI: 10.7554/eLife.39733;

Pacheco AR, Segrè D. A multidimensional perspective on microbial interactions. FEMS Microbiol Lett. 2019 Jun 01; 366(11). PMID: 31187139; PMCID: PMC6610204; DOI: 10.1093/femsle/fnz125;

Thommes M, Wang T, Zhao Q, Paschalidis IC, Segrè D. Designing Metabolic Division of Labor in Microbial Communities. mSystems. 2019; 4(2).View Related Profiles.

Segre, Daniel
Paschalidis, Ioannis

PMID: 30984871

Succurro A, Segrè D, Ebenhöh O. Emergent Subpopulation Behavior Uncovered with a Community Dynamic Metabolic Model of Escherichia coli Diauxic Growth. mSystems. 2019; 4(1). PMID: 30944873; PMCID: PMC6446979; DOI: 10.1128/mSystems.00230-18;

Pacheco AR, Moel M, Segrè D. Costless metabolic secretions as drivers of interspecies interactions in microbial ecosystems. Nat Commun. 2019 Jan 09; 10(1):103. PMID: 30626871; PMCID: PMC6327061; DOI: 10.1038/s41467-018-07946-9;

DiMucci D, Kon M, Segrè D. Machine Learning Reveals Missing Edges and Putative Interaction Mechanisms in Microbial Ecosystem Networks. mSystems. 2018; 3(5). PMID: 30417106; PMCID: PMC6208640; DOI: 10.1128/mSystems.00181-18;

Maoz BM, Herland A, FitzGerald EA, Grevesse T, Vidoudez C, Pacheco AR, Sheehy SP, Park TE, Dauth S, Mannix R, Budnik N, Shores K, Cho A, Nawroth JC, Segrè D, Budnik B, Ingber DE, Parker KK. A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells. Nat Biotechnol. 2018 Oct; 36(9):865-874. PMID: 30125269; PMCID: PMC9254231; DOI: 10.1038/nbt.4226;

Goldford JE, Lu N, Bajic D, Estrela S, Tikhonov M, Sanchez-Gorostiaga A, Segrè D, Mehta P, Sanchez A. Emergent simplicity in microbial community assembly. Science. 2018 Aug 03; 361(6401):469-474. PMID: 30072533; PMCID: PMC6405290; DOI: 10.1126/science.aat1168;

Zomorrodi AR, Segrè D. Genome-driven evolutionary game theory helps understand the rise of metabolic interdependencies in microbial communities. Nat Commun. 2017 Nov 16; 8(1):1563. PMID: 29146901; PMCID: PMC5691134; DOI: 10.1038/s41467-017-01407-5;

Reznik E, Christodoulou D, Goldford JE, Briars E, Sauer U, Segrè D, Noor E. Genome-Scale Architecture of Small Molecule Regulatory Networks and the Fundamental Trade-Off between Regulation and Enzymatic Activity. Cell Rep. 2017 Sep 12; 20(11):2666-2677. PMID: 28903046; PMCID: PMC5600504; DOI: 10.1016/j.celrep.2017.08.066;

Goldford JE, Hartman H, Smith TF, Segrè D. Remnants of an Ancient Metabolism without Phosphate. Cell. 2017 Mar 09; 168(6):1126-1134.e9. PMID: 28262353; DOI: 10.1016/j.cell.2017.02.001;

Jacobs C, Lambourne L, Xia Y, Segrè D. Upon Accounting for the Impact of Isoenzyme Loss, Gene Deletion Costs Anticorrelate with Their Evolutionary Rates. PLoS One. 2017; 12(1):e0170164. PMID: 28107392; PMCID: PMC5249160; DOI: 10.1371/journal.pone.0170164;

Zhao Q, Stettner AI, Reznik E, Paschalidis ICh, Segrè D. Mapping the landscape of metabolic goals of a cell. Genome Biol. 2016 May 23; 17(1):109.View Related Profiles.

Segre, Daniel
Paschalidis, Ioannis

PMID: 27215445

Granger BR, Chang YC, Wang Y, DeLisi C, Segrè D, Hu Z. Visualization of Metabolic Interaction Networks in Microbial Communities Using VisANT 5.0. PLoS Comput Biol. 2016 Apr; 12(4):e1004875. PMID: 27081850; PMCID: PMC4833320; DOI: 10.1371/journal.pcbi.1004875;

Zomorrodi AR, Segrè D. Synthetic Ecology of Microbes: Mathematical Models and Applications. J Mol Biol. 2016 Feb 27; 428(5 Pt B):837-61. PMID: 26522937; PMCID: PMC4798899; DOI: 10.1016/j.jmb.2015.10.019;

Chubiz LM, Granger BR, Segrè D, Harcombe WR. Species interactions differ in their genetic robustness. Front Microbiol. 2015; 6:271. PMID: 25926820; PMCID: PMC4396422; DOI: 10.3389/fmicb.2015.00271;

Sridhara V, Meyer AG, Rai P, Barrick JE, Ravikumar P, Segrè D, Wilke CO. Predicting growth conditions from internal metabolic fluxes in an in-silico model of E. coli. PLoS One. 2014; 9(12):e114608. PMID: 25502413; PMCID: PMC4264753; DOI: 10.1371/journal.pone.0114608;

Brinsmade SR, Alexander EL, Livny J, Stettner AI, Segrè D, Rhee KY, Sonenshein AL. Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):8227-32. PMID: 24843172; PMCID: PMC4050614; DOI: 10.1073/pnas.1321308111;

Harcombe WR, Riehl WJ, Dukovski I, Granger BR, Betts A, Lang AH, Bonilla G, Kar A, Leiby N, Mehta P, Marx CJ, Segrè D. Metabolic resource allocation in individual microbes determines ecosystem interactions and spatial dynamics. Cell Rep. 2014 May 22; 7(4):1104-15. PMID: 24794435; PMCID: PMC4097880; DOI: 10.1016/j.celrep.2014.03.070;

Gomes AL, Galagan JE, Segrè D. Resource competition may lead to effective treatment of antibiotic resistant infections. PLoS One. 2013; 8(12):e80775.View Related Profiles.

Segre, Daniel
Galagan, James

PMID: 24349015; PMCID: PMC3862480; DOI: 10.1371/journal.pone.0080775;

Mazumdar V, Amar S, Segrè D. Metabolic proximity in the order of colonization of a microbial community. PLoS One. 2013; 8(10):e77617.View Related Profiles.

Segre, Daniel
Amar, Salomon

PMID: 24204896; PMCID: PMC3813667; DOI: 10.1371/journal.pone.0077617;

Reznik E, Mehta P, Segrè D. Flux imbalance analysis and the sensitivity of cellular growth to changes in metabolite pools. PLoS Comput Biol. 2013; 9(8):e1003195. PMID: 24009492; PMCID: PMC3757068; DOI: 10.1371/journal.pcbi.1003195;

Anton BP, Chang YC, Brown P, Choi HP, Faller LL, Guleria J, Hu Z, Klitgord N, Levy-Moonshine A, Maksad A, Mazumdar V, McGettrick M, Osmani L, Pokrzywa R, Rachlin J, Swaminathan R, Allen B, Housman G, Monahan C, Rochussen K, Tao K, Bhagwat AS, Brenner SE, Columbus L, de Crécy-Lagard V, Ferguson D, Fomenkov A, Gadda G, Morgan RD, Osterman AL, Rodionov DA, Rodionova IA, Rudd KE, Söll D, Spain J, Xu SY, Bateman A, Blumenthal RM, Bollinger JM, Chang WS, Ferrer M, Friedberg I, Galperin MY, Gobeill J, Haft D, Hunt J, Karp P, Klimke W, Krebs C, Macelis D, Madupu R, Martin MJ, Miller JH, O'Donovan C, Palsson B, Ruch P, Setterdahl A, Sutton G, Tate J, Yakunin A, Tchigvintsev D, Plata G, Hu J, Greiner R, Horn D, Sjölander K, Salzberg SL, Vitkup D, Letovsky S, Segrè D, DeLisi C, Roberts RJ, Steffen M, Kasif S. The COMBREX project: design, methodology, and initial results. PLoS Biol. 2013; 11(8):e1001638.View Related Profiles.

Segre, Daniel
Choi, Han-Pil
Steffen, Martin
Kasif, Simon

PMID: 24013487; PMCID: PMC3754883; DOI: 10.1371/journal.pbio.1001638;

Reznik E, Chaudhary O, Segrè D. The average enzyme principle. FEBS Lett. 2013 Sep 02; 587(17):2891-4. PMID: 23892076; PMCID: PMC3983706; DOI: 10.1016/j.febslet.2013.07.032;

Stettner AI, Segrè D. The cost of efficiency in energy metabolism. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9629-30. PMID: 23729810; PMCID: PMC3683743; DOI: 10.1073/pnas.1307485110;

Reznik E, Yohe S, Segrè D. Invariance and optimality in the regulation of an enzyme. Biol Direct. 2013 Mar 22; 8:7. PMID: 23522082; PMCID: PMC3665469; DOI: 10.1186/1745-6150-8-7;

Reznik E, Kaper TJ, Segrè D. The dynamics of hybrid metabolic-genetic oscillators. Chaos. 2013 Mar; 23(1):013132. PMID: 23556969; DOI: 10.1063/1.4793573;

Collins SB, Reznik E, Segrè D. Temporal expression-based analysis of metabolism. PLoS Comput Biol. 2012; 8(11):e1002781. PMID: 23209390; PMCID: PMC3510039; DOI: 10.1371/journal.pcbi.1002781;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 60 publications over 13 distinct years, with a maximum of 10 publications in 2021

Bar chart showing 60 publications over 13 distinct years, with a maximum of 10 publications in 2021

Year	Publications
2012	1
2013	8
2014	3
2015	2
2016	2
2017	4
2018	3
2019	8
2020	2
2021	10
2022	7
2023	6
2024	4

Featured Videos

JGI2021 Meeting: Daniel Segre

Daniel Segrè: Spatio-temporal Modeling of Multicellular Metabolism

Daniel Segrè | Workshop Metabolism and mathematical models: Two for a tango

2024 American Association for the Advancement of Science (AAAS): Election to 2023 Fellow

2021 Recipient of Human Frontiers Science Program research grant award

2017 Boston University Evans Center: r Interdisciplinary Biological Research Excellent Research Collaborator Award

2016 NASA-NSF Origins of Life Ideas Lab: Selected for participation

2016 Recipient of Human Frontiers Science Program research grant award

2016 The White House, Washington DC: Attendee at Launch of National Microbiome Initiative

2014 Collective Behavior (organized by National Academy of Sciences, the National Academy of Engineering,: National Academies Keck Futures Initiative (NAKFI) workshop

2013 DuPont’s Horizons in Biotechnology distinguished speaker

2012 University of Minnesota: Keynote Speaker, Synthetic Ecology Symposium

2010 "The strategies of Life", Trieste, Italy (outreach event, III Conference of the Italian Society for : Panelist/Keynote speaker, Public debate

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