Thomas Tullius | Profiles RNS

Thomas D. Tullius, PhD

Professor

Boston University College of Arts and Sciences

Chemistry

PhD, Stanford University
BS, University of California, Los Angeles

Websites

	Tullius Group Home Page
	Chemistry Faculty
	Bioinformatics Program
	Google Scholar
	Public Relations - BU Experts

ORCID : 0000-0003-4425-796X

Tom Tullius conducts research in genomics, structural biology, and biophysical chemistry. In addition to Chemistry, he is Professor of Pharmacology and Professor of Experimental Therapeutics in the Chobanian and Avedisian School of Medicine. He is an elected Fellow of the American Association for the Advancement of Science and he is on the Editorial Advisory Board of the Chemistry Central Journal. Professor Tullius is a faculty affiliate and Director of the Boston University Bioinformatics Program.

The Tullius Group introduced hydroxyl radical footprinting, which is widely used for the structural study of DNA, DNA-protein complexes, and RNA. They investigate the connection between structural properties of DNA and genomics, including evolutionary selection for DNA structure in the human genome. Their human genome studies were initiated with funding from the ENCODE (Encyclopedia of DNA Elements) Pilot Project, which was organized by the National Human Genome Research Institute of the NIH to discover functional elements in the human genome.

Measurement of the Deuterium Kinetic Isotope Effect on Hydroxyl Radical Cleavage of RNA aims to synthesize a complete set of nucleoside and deoxynucleoside triphosphates specifically deuterated at each sugar carbon atom. The deuterated nucleoside triphosphates are used in kinetic isotope effect experiments on hydroxyl radical cleavage of RNA, to provide more detailed information on the structural features of RNA to which the hydroxyl radical is sensitive. The goal of this work is the development of a chemical probe of RNA structure of unprecedented resolution.

Genome damage and aging: whole-genome maps of oxidative DNA lesions at single-nucleotide resolution investigates a new way to map, at single nucleotide resolution for an entire genome, the sites of oxidative damage that are induced in the DNA backbone by the hydroxyl radical. The study uses an advanced sequencing platform to comprehensively identify sites of DNA strand breaks. With these experiments it is possible to visualize, at single-nucleotide resolution, what parts of a genome are sensitive to attack by the hydroxyl radical and what parts are resistant. This work will provide unique new information on how oxidative damage affects the genome and so contributes to aging.

Techniques & Resources:

ORChID (OH Radical Cleavage Intensity Database) – Database of experimentally determined hydroxyl radical cleavage patterns of naked DNA molecules. Algorithm to predict the cleavage pattern of any DNA sequence.

ORChID in the UCSC Genome Browser – ORChID values predicted for the human genome. The data is viewable and available for download from the UCSC genome browser.

Chai regions in the UCSC Genome Browser – Chai is a structure-informed evolutionary sequence constraint detection algorithm. Chai-identified regions are available from the UCSC genome browser.

Professor
Boston University Chobanian & Avedisian School of Medicine
Pharmacology, Physiology & Biophysics

Director
Boston University
Bioinformatics Graduate Program

Member
Boston University
BU-BMC Cancer Center

Member
Boston University
Evans Center for Interdisciplinary Biomedical Research

Member
Boston University
Genome Science Institute

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Predoctoral Training in Bioinformatics and Computational Biology
07/01/2023 - 06/30/2028 (Multi-PI)
PI: Thomas D. Tullius, PhD
NIH/National Institute of General Medical Sciences
5T32GM150533-02

Predoctoral Training in Bioinformatics and Computational Biology
06/01/2018 - 06/30/2023 (PI)
NIH/National Institute of General Medical Sciences
5T32GM100842-10

Chemical probing of RNA tertiary structure in a whole transcriptome at single-atom resolution
07/01/2016 - 06/30/2022 (PI)
National Science Foundation
MCB-1616388

Predoctoral Training in Bioinformatics and Computational Biology
07/01/2016 - 06/30/2018 (PI)
NIH/National Institute of General Medical Sciences
4T32GM100842-05

Genome Analysis Based on the Integration of DNA Sequence and Shape
02/01/2014 - 01/31/2018 (Subcontract PI)
University of Southern California NIH NIGMS
5R01GM106056-04

Predoctoral Training in Bioinformatics and Computational Biology
07/01/2012 - 06/30/2016 (PI)
NIH/National Institute of General Medical Sciences
5T32GM100842-04

GENOME DAMAGE AND AGING: WHOLE-GENOME MAPS OF OXIDATIVE DNA LESIONS AT SINGLE-NUCLEOTIDE RESOLUTION
11/01/2009 - 10/31/2014 (PI)
Ellison Medical Foundation

NATIONAL CENTER: MULTI-SCALE STUDY OF CELLULAR NETWORKS
09/01/2010 - 07/31/2013 (Subcontract PI)
Trustees Of Columbia University In The City Of New York NIH NCI
5U54CA121852-08

Billing Agreement: Off Campus funding for Eric Bishop.
07/01/2011 - 06/30/2012 (PI)
President and Fellows of Harvard College

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Predoctoral Training in Bioinformatics and Computational Biology	5T32GM150533-02
2023	Predoctoral Training in Bioinformatics and Computational Biology	1T32GM150533-01
2022	Predoctoral Training in Bioinformatics and Computational Biology	5T32GM100842-10
2021	Predoctoral Training in Bioinformatics and Computational Biology	5T32GM100842-09	7
2021	Predoctoral Training in Bioinformatics and Computational Biology	3T32GM100842-09S1	7
2020	Predoctoral Training in Bioinformatics and Computational Biology	5T32GM100842-08	7
2019	Predoctoral Training in Bioinformatics and Computational Biology	5T32GM100842-07	7
2016	Predoctoral Training in Bioinformatics and Computational Biology	4T32GM100842-05	7
2015	Predoctoral Training in Bioinformatics and Computational Biology	5T32GM100842-04	7
2014	Predoctoral Training in Bioinformatics and Computational Biology	5T32GM100842-03	7

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Azad RN, Zafiropoulos D, Ober D, Jiang Y, Chiu TP, Sagendorf JM, Rohs R, Tullius TD. Experimental maps of DNA structure at nucleotide resolution distinguish intrinsic from protein-induced DNA deformations. Nucleic Acids Res. 2018 03 16; 46(5):2636-2647. PMID: 29390080; DOI: 10.1093/nar/gky033;

Chiu TP, Yang L, Zhou T, Main BJ, Parker SC, Nuzhdin SV, Tullius TD, Rohs R. 28 GBshape: a genome browser database for DNA shape annotations. J Biomol Struct Dyn. 2015; 33 Suppl 1:16. PMID: 26103240; DOI: 10.1080/07391102.2015.1032568;

Chiu TP, Yang L, Zhou T, Main BJ, Parker SC, Nuzhdin SV, Tullius TD, Rohs R. GBshape: a genome browser database for DNA shape annotations. Nucleic Acids Res. 2015 Jan; 43(Database issue):D103-9. PMID: 25326329; PMCID: PMC4384032; DOI: 10.1093/nar/gku977;

Ingle S, Azad RN, Jain SS, Tullius TD. Chemical probing of RNA with the hydroxyl radical at single-atom resolution. Nucleic Acids Res. 2014 Nov 10; 42(20):12758-67. PMID: 25313156; PMCID: PMC4227780; DOI: 10.1093/nar/gku934;

Ho JW, Jung YL, Liu T, Alver BH, Lee S, Ikegami K, Sohn KA, Minoda A, Tolstorukov MY, Appert A, Parker SC, Gu T, Kundaje A, Riddle NC, Bishop E, Egelhofer TA, Hu SS, Alekseyenko AA, Rechtsteiner A, Asker D, Belsky JA, Bowman SK, Chen QB, Chen RA, Day DS, Dong Y, Dose AC, Duan X, Epstein CB, Ercan S, Feingold EA, Ferrari F, Garrigues JM, Gehlenborg N, Good PJ, Haseley P, He D, Herrmann M, Hoffman MM, Jeffers TE, Kharchenko PV, Kolasinska-Zwierz P, Kotwaliwale CV, Kumar N, Langley SA, Larschan EN, Latorre I, Libbrecht MW, Lin X, Park R, Pazin MJ, Pham HN, Plachetka A, Qin B, Schwartz YB, Shoresh N, Stempor P, Vielle A, Wang C, Whittle CM, Xue H, Kingston RE, Kim JH, Bernstein BE, Dernburg AF, Pirrotta V, Kuroda MI, Noble WS, Tullius TD, Kellis M, MacAlpine DM, Strome S, Elgin SC, Liu XS, Lieb JD, Ahringer J, Karpen GH, Park PJ. Comparative analysis of metazoan chromatin organization. Nature. 2014 Aug 28; 512(7515):449-52. PMID: 25164756; PMCID: PMC4227084; DOI: 10.1038/nature13415;

Bishop EP, Rohs R, Parker SC, West SM, Liu P, Mann RS, Honig B, Tullius TD. A map of minor groove shape and electrostatic potential from hydroxyl radical cleavage patterns of DNA. ACS Chem Biol. 2011 Dec 16; 6(12):1314-20. PMID: 21967305; PMCID: PMC3241897; DOI: 10.1021/cb200155t;

Parker SC, Tullius TD. DNA shape, genetic codes, and evolution. Curr Opin Struct Biol. 2011 Jun; 21(3):342-7. PMID: 21439813; PMCID: PMC3112471; DOI: 10.1016/j.sbi.2011.03.002;

Parker SC, Harlap A, Tullius TD. A computational method to search for DNA structural motifs in functional genomic elements. Methods Mol Biol. 2011; 759:367-79. PMID: 21863498; DOI: 10.1007/978-1-61779-173-4_21;

Parker SC, Hansen L, Abaan HO, Tullius TD, Margulies EH. Local DNA topography correlates with functional noncoding regions of the human genome. Science. 2009 Apr 17; 324(5925):389-92. PMID: 19286520; PMCID: PMC2749491; DOI: 10.1126/science.1169050;

Jain SS, Tullius TD. Footprinting protein-DNA complexes using the hydroxyl radical. Nat Protoc. 2008; 3(6):1092-1100. PMID: 18546600

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Parker SC, Margulies EH, Tullius TD. The relationship between fine scale DNA structure, GC content, and functional elements in 1% of the human genome. Genome Inform. 2008; 20:199-211. PMID: 19425134

Wang Q, Tullius TD, Levin JR. Effects of discontinuities in the DNA template on abortive initiation and promoter escape by Escherichia coli RNA polymerase. J Biol Chem. 2007 Sep 14; 282(37):26917-27. PMID: 17650506

Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Thurman RE, Kuehn MS, Taylor CM, Neph S, Koch CM, Asthana S, Malhotra A, Adzhubei I, Greenbaum JA, Andrews RM, Flicek P, Boyle PJ, Cao H, Carter NP, Clelland GK, Davis S, Day N, Dhami P, Dillon SC, Dorschner MO, Fiegler H, Giresi PG, Goldy J, Hawrylycz M, Haydock A, Humbert R, James KD, Johnson BE, Johnson EM, Frum TT, Rosenzweig ER, Karnani N, Lee K, Lefebvre GC, Navas PA, Neri F, Parker SC, Sabo PJ, Sandstrom R, Shafer A, Vetrie D, Weaver M, Wilcox S, Yu M, Collins FS, Dekker J, Lieb JD, Tullius TD, Crawford GE, Sunyaev S, Noble WS, Dunham I, Denoeud F, Reymond A, Kapranov P, Rozowsky J, Zheng D, Castelo R, Frankish A, Harrow J, Ghosh S, Sandelin A, Hofacker IL, Baertsch R, Keefe D, Dike S, Cheng J, Hirsch HA, Sekinger EA, Lagarde J, Abril JF, Shahab A, Flamm C, Fried C, Hackermüller J, Hertel J, Lindemeyer M, Missal K, Tanzer A, Washietl S, Korbel J, Emanuelsson O, Pedersen JS, Holroyd N, Taylor R, Swarbreck D, Matthews N, Dickson MC, Thomas DJ, Weirauch MT, Gilbert J, Drenkow J, Bell I, Zhao X, Srinivasan KG, Sung WK, Ooi HS, Chiu KP, Foissac S, Alioto T, Brent M, Pachter L, Tress ML, Valencia A, Choo SW, Choo CY, Ucla C, Manzano C, Wyss C, Cheung E, Clark TG, Brown JB, Ganesh M, Patel S, Tammana H, Chrast J, Henrichsen CN, Kai C, Kawai J, Nagalakshmi U, Wu J, Lian Z, Lian J, Newburger P, Zhang X, Bickel P, Mattick JS, Carninci P, Hayashizaki Y, Weissman S, Hubbard T, Myers RM, Rogers J, Stadler PF, Lowe TM, Wei CL, Ruan Y, Struhl K, Gerstein M, Antonarakis SE, Fu Y, Green ED, Karaöz U, Siepel A, Taylor J, Liefer LA, Wetterstrand KA, Good PJ, Feingold EA, Guyer MS, Cooper GM, Asimenos G, Dewey CN, Hou M, Nikolaev S, Montoya-Burgos JI, Löytynoja A, Whelan S, Pardi F, Massingham T, Huang H, Zhang NR, Holmes I, Mullikin JC, Ureta-Vidal A, Paten B, Seringhaus M, Church D, Rosenbloom K, Kent WJ, Stone EA, Batzoglou S, Goldman N, Hardison RC, Haussler D, Miller W, Sidow A, Trinklein ND, Zhang ZD, Barrera L, Stuart R, King DC, Ameur A, Enroth S, Bieda MC, Kim J, Bhinge AA, Jiang N, Liu J, Yao F, Vega VB, Lee CW, Ng P, Shahab A, Yang A, Moqtaderi Z, Zhu Z, Xu X, Squazzo S, Oberley MJ, Inman D, Singer MA, Richmond TA, Munn KJ, Rada-Iglesias A, Wallerman O, Komorowski J, Fowler JC, Couttet P, Bruce AW, Dovey OM, Ellis PD, Langford CF, Nix DA, Euskirchen G, Hartman S, Urban AE, Kraus P, Van Calcar S, Heintzman N, Kim TH, Wang K, Qu C, Hon G, Luna R, Glass CK, Rosenfeld MG, Aldred SF, Cooper SJ, Halees A, Lin JM, Shulha HP, Zhang X, Xu M, Haidar JN, Yu Y, Ruan Y, Iyer VR, Green RD, Wadelius C, Farnham PJ, Ren B, Harte RA, Hinrichs AS, Trumbower H, Clawson H, Hillman-Jackson J, Zweig AS, Smith K, Thakkapallayil A, Barber G, Kuhn RM, Karolchik D, Armengol L, Bird CP, de Bakker PI, Kern AD, Lopez-Bigas N, Martin JD, Stranger BE, Woodroffe A, Davydov E, Dimas A, Eyras E, Hallgrímsdóttir IB, Huppert J, Zody MC, Abecasis GR, Estivill X, Bouffard GG, Guan X, Hansen NF, Idol JR, Maduro VV, Maskeri B, McDowell JC, Park M, Thomas PJ, Young AC, Blakesley RW, Muzny DM, Sodergren E, Wheeler DA, Worley KC, Jiang H, Weinstock GM, Gibbs RA, Graves T, Fulton R, Mardis ER, Wilson RK, Clamp M, Cuff J, Gnerre S, Jaffe DB, Chang JL, Lindblad-Toh K, Lander ES, Koriabine M, Nefedov M, Osoegawa K, Yoshinaga Y, Zhu B, de Jong PJ. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007 Jun 14; 447(7146):799-816.View Related Profiles.

Tullius, Thomas
Zhang, Xiaoling

PMID: 17571346; PMCID: PMC2212820; DOI: 10.1038/nature05874;

Greenbaum JA, Pang B, Tullius TD. Construction of a genome-scale structural map at single-nucleotide resolution. Genome Res. 2007 Jun; 17(6):947-53. PMID: 17568010; PMCID: PMC1891353; DOI: 10.1101/gr.6073107;

Greenbaum JA, Parker SC, Tullius TD. Detection of DNA structural motifs in functional genomic elements. Genome Res. 2007 Jun; 17(6):940-6. PMID: 17568009; PMCID: PMC1891352; DOI: 10.1101/gr.5602807;

Danford AJ, Wang D, Wang Q, Tullius TD, Lippard SJ. Platinum anticancer drug damage enforces a particular rotational setting of DNA in nucleosomes. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12311-6. PMID: 16116097; PMCID: PMC1194956; DOI: 10.1073/pnas.0506025102;

Tullius TD, Greenbaum JA. Mapping nucleic acid structure by hydroxyl radical cleavage. Curr Opin Chem Biol. 2005 Apr; 9(2):127-34. PMID: 15811796

Deardorff D, Dorhout P, Haegel N, Iverson BL, Morrison M, Pladziewicz J, Selen M, Tullius TD, Zwier TS. Research Corporation and John Schaefer. Science. 2004 Nov 12; 306(5699):1133. PMID: 15539585

Guo H, Tullius TD. Gapped DNA is anisotropically bent. Proc Natl Acad Sci U S A. 2003 Apr 1; 100(7):3743-7. PMID: 12644712; PMCID: PMC152992

Chen B, Jamieson ER, Tullius TD. A general synthesis of specifically deuterated nucleotides for studies of DNA and RNA. Bioorg Med Chem Lett. 2002 Nov 4; 12(21):3093-6. PMID: 12372509

Frazee RW, Taylor JA, Tullius TD. Interchange of DNA-binding modes in the deformed and ultrabithorax homeodomains: a structural role for the N-terminal arm. J Mol Biol. 2002 Nov 1; 323(4):665-83. PMID: 12419257

Tullius TD. Probing DNA structure with hydroxyl radicals. Curr Protoc Nucleic Acid Chem. 2002 Feb; Chapter 6:Unit 6.7. PMID: 18428898; DOI: 10.1002/0471142700.nc0607s07;

Levin JR, Blake JJ, Ganunis RA, Tullius TD. The roles of specific template nucleosides in the formation of stable transcription complexes by Escherichia coli RNA polymerase. J Biol Chem. 2000 Mar 10; 275(10):6885-93. PMID: 10702248

Widlund HR, Kuduvalli PN, Bengtsson M, Cao H, Tullius TD, Kubista M. Nucleosome structural features and intrinsic properties of the TATAAACGCC repeat sequence. J Biol Chem. 1999 Nov 5; 274(45):31847-52. PMID: 10542209

Jamison McDaniels CP, Jensen LT, Srinivasan C, Winge DR, Tullius TD. The yeast transcription factor Mac1 binds to DNA in a modular fashion. J Biol Chem. 1999 Sep 17; 274(38):26962-7. PMID: 10480908

Balasubramanian B, Pogozelski WK, Tullius TD. DNA strand breaking by the hydroxyl radical is governed by the accessible surface areas of the hydrogen atoms of the DNA backbone. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):9738-43. PMID: 9707545; PMCID: PMC21406

Pogozelski WK, Tullius TD. Oxidative Strand Scission of Nucleic Acids: Routes Initiated by Hydrogen Abstraction from the Sugar Moiety. Chem Rev. 1998 May 07; 98(3):1089-1108. PMID: 11848926

Draganescu A, Tullius TD. The DNA binding specificity of engrailed homeodomain. J Mol Biol. 1998 Feb 27; 276(3):529-36. PMID: 9551094

Eijkelenboom AP, van den Ent FM, Vos A, Doreleijers JF, Hård K, Tullius TD, Plasterk RH, Kaptein R, Boelens R. The solution structure of the amino-terminal HHCC domain of HIV-2 integrase: a three-helix bundle stabilized by zinc. Curr Biol. 1997 Oct 1; 7(10):739-46. PMID: 9368756

Shadle SE, Allen DF, Guo H, Pogozelski WK, Bashkin JS, Tullius TD. Quantitative analysis of electrophoresis data: novel curve fitting methodology and its application to the determination of a protein-DNA binding constant. Nucleic Acids Res. 1997 Feb 15; 25(4):850-60. PMID: 9016637; PMCID: PMC146501

Ganunis RM, Guo H, Tullius TD. Effect of the crystallizing agent 2-methyl-2,4-pentanediol on the structure of adenine tract DNA in solution. Biochemistry. 1996 Oct 29; 35(43):13729-32. PMID: 8901514

Draganescu A, Tullius TD. Targeting of nucleic acids by iron complexes. Met Ions Biol Syst. 1996; 33:453-84. PMID: 8742852

Tullius T. Homeodomains: together again for the first time. Structure. 1995 Nov 15; 3(11):1143-5. PMID: 8591025

Kimball AS, Kimball ML, Jayaram M, Tullius TD. Chemical probe and missing nucleoside analysis of Flp recombinase bound to the recombination target sequence. Nucleic Acids Res. 1995 Aug 11; 23(15):3009-17. PMID: 7659525; PMCID: PMC307143

Draganescu A, Levin JR, Tullius TD. Homeodomain proteins: what governs their ability to recognize specific DNA sequences? J Mol Biol. 1995 Jul 28; 250(5):595-608. PMID: 7623378

Kuduvalli PN, Townsend CA, Tullius TD. Cleavage by calicheamicin gamma 1I of DNA in a nucleosome formed on the 5S RNA gene of Xenopus borealis. Biochemistry. 1995 Mar 28; 34(12):3899-906. PMID: 7696253

Mah SC, Townsend CA, Tullius TD. Hydroxyl radical footprinting of calicheamicin. Relationship of DNA binding to cleavage. Biochemistry. 1994 Jan 18; 33(2):614-21. PMID: 8286393

Kimball AS, Lee J, Jayaram M, Tullius TD. Sequence-specific cleavage of DNA via nucleophilic attack of hydrogen peroxide, assisted by Flp recombinase. Biochemistry. 1993 May 11; 32(18):4698-701. PMID: 8490015

Bashkin J, Hayes JJ, Tullius TD, Wolffe AP. Structure of DNA in a nucleosome core at high salt concentration and at high temperature. Biochemistry. 1993 Mar 2; 32(8):1895-8. PMID: 8383529

Price MA, Tullius TD. How the structure of an adenine tract depends on sequence context: a new model for the structure of TnAn DNA sequences. Biochemistry. 1993 Jan 12; 32(1):127-36. PMID: 8380329

Hayes JJ, Tullius TD. Structure of the TFIIIA-5 S DNA complex. J Mol Biol. 1992 Sep 20; 227(2):407-17. PMID: 1404361

Price MA, Tullius TD. Using hydroxyl radical to probe DNA structure. Methods Enzymol. 1992; 212:194-219. PMID: 1325598

Hayes JJ, Bashkin J, Tullius TD, Wolffe AP. The histone core exerts a dominant constraint on the structure of DNA in a nucleosome. Biochemistry. 1991 Aug 27; 30(34):8434-40. PMID: 1653013

Tullius TD. DNA footprinting with the hydroxyl radical. Free Radic Res Commun. 1991; 12-13 Pt 2:521-9. PMID: 1648010

Dixon WJ, Hayes JJ, Levin JR, Weidner MF, Dombroski BA, Tullius TD. Hydroxyl radical footprinting. Methods Enzymol. 1991; 208:380-413. PMID: 1664026

Tullius TD. Bioinorganic chemistry. J Cell Biochem. 1991 Jan; 45(1):5-6. PMID: 1706345; DOI: 10.1002/jcb.240450104;

Guo Q, Lu M, Churchill ME, Tullius TD, Kallenbach NR. Asymmetric structure of a three-arm DNA junction. Biochemistry. 1990 Dec 11; 29(49):10927-34. PMID: 2176888

Hayes JJ, Tullius TD, Wolffe AP. The structure of DNA in a nucleosome. Proc Natl Acad Sci U S A. 1990 Oct; 87(19):7405-9. PMID: 2170977; PMCID: PMC54755

Kimball A, Guo Q, Lu M, Cunningham RP, Kallenbach NR, Seeman NC, Tullius TD. Construction and analysis of parallel and antiparallel Holliday junctions. J Biol Chem. 1990 Sep 05; 265(25):15348. PMID: 2394725

Buchman C, Skroch P, Dixon W, Tullius TD, Karin M. A single amino acid change in CUP2 alters its mode of DNA binding. Mol Cell Biol. 1990 Sep; 10(9):4778-87. PMID: 2167439; PMCID: PMC361081

Churchill ME, Tullius TD, Klug A. Mode of interaction of the zinc finger protein TFIIIA with a 5S RNA gene of Xenopus. Proc Natl Acad Sci U S A. 1990 Jul; 87(14):5528-32. PMID: 2164687; PMCID: PMC54358

Churchill ME, Hayes JJ, Tullius TD. Detection of drug binding to DNA by hydroxyl radical footprinting. Relationship of distamycin binding sites to DNA structure and positioned nucleosomes on 5S RNA genes of Xenopus. Biochemistry. 1990 Jun 26; 29(25):6043-50. PMID: 1696501

Kimball A, Guo Q, Lu M, Cunningham RP, Kallenbach NR, Seeman NC, Tullius TD. Construction and analysis of parallel and antiparallel Holliday junctions. J Biol Chem. 1990 Apr 25; 265(12):6544-7. PMID: 2157702

Hayes JJ, Kam L, Tullius TD. Footprinting protein-DNA complexes with gamma-rays. Methods Enzymol. 1990; 186:545-9. PMID: 2172714

Hayes JJ, Tullius TD. The missing nucleoside experiment: a new technique to study recognition of DNA by protein. Biochemistry. 1989 Nov 28; 28(24):9521-7. PMID: 2611245

Kimball AS, Milman G, Tullius TD. High-resolution footprints of the DNA-binding domain of Epstein-Barr virus nuclear antigen 1. Mol Cell Biol. 1989 Jun; 9(6):2738-42. PMID: 2548088; PMCID: PMC362348

Shafer GE, Price MA, Tullius TD. Use of the hydroxyl radical and gel electrophoresis to study DNA structure. Electrophoresis. 1989 May-Jun; 10(5-6):397-404. PMID: 2504579

Hayes J, Tullius TD, Wolffe AP. A protein-protein interaction is essential for stable complex formation on a 5 S RNA gene. J Biol Chem. 1989 Apr 15; 264(11):6009-12. PMID: 2703476

Tullius TD. Physical studies of protein-DNA complexes by footprinting. Annu Rev Biophys Biophys Chem. 1989; 18:213-37. PMID: 2660824

Chen JH, Churchill ME, Tullius TD, Kallenbach NR, Seeman NC. Construction and analysis of monomobile DNA junctions. Biochemistry. 1988 Aug 9; 27(16):6032-8. PMID: 3191106

Churchill ME, Tullius TD, Kallenbach NR, Seeman NC. A Holliday recombination intermediate is twofold symmetric. Proc Natl Acad Sci U S A. 1988 Jul; 85(13):4653-6. PMID: 3387432; PMCID: PMC280493

Tullius TD. DNA footprinting with hydroxyl radical. Nature. 1988 Apr 14; 332(6165):663-4. PMID: 2833707

Vrana KE, Churchill ME, Tullius TD, Brown DD. Mapping functional regions of transcription factor TFIIIA. Mol Cell Biol. 1988 Apr; 8(4):1684-96. PMID: 2837652; PMCID: PMC363329

Burkhoff AM, Tullius TD. Structural details of an adenine tract that does not cause DNA to bend. Nature. 1988 Feb 4; 331(6155):455-7. PMID: 3340190

Burkhoff AM, Tullius TD. The unusual conformation adopted by the adenine tracts in kinetoplast DNA. Cell. 1987 Mar 27; 48(6):935-43. PMID: 3030560

Tullius TD, Dombroski BA, Churchill ME, Kam L. Hydroxyl radical footprinting: a high-resolution method for mapping protein-DNA contacts. Methods Enzymol. 1987; 155:537-58. PMID: 2828876

Tullius TD, Dombroski BA. Hydroxyl radical "footprinting": high-resolution information about DNA-protein contacts and application to lambda repressor and Cro protein. Proc Natl Acad Sci U S A. 1986 Aug; 83(15):5469-73. PMID: 3090544; PMCID: PMC386308

Tullius TD, Dombroski BA. Iron(II) EDTA used to measure the helical twist along any DNA molecule. Science. 1985 Nov 8; 230(4726):679-81. PMID: 2996145

Frank P, Licht A, Tullius TD, Hodgson KO, Pecht I. A selenomethionine-containing azurin from an auxotroph of Pseudomonas aeruginosa. J Biol Chem. 1985 May 10; 260(9):5518-25. PMID: 2985597

Tullius TD, Lippard SJ. Ethidium bromide changes the nuclease-sensitive DNA binding sites of the antitumor drug cis-diamminedichloroplatinum(II). Proc Natl Acad Sci U S A. 1982 Jun; 79(11):3489-92. PMID: 6954494; PMCID: PMC346446

Ushay HM, Tullius TD, Lippard SJ. Inhibition of the BamHI cleavage and unwinding of pBR322 deoxyribonucleic acid by the antitumor drug cis-dichlorodiammineplatinum(II). Biochemistry. 1981 Jun 23; 20(13):3744-8. PMID: 6268142

Tullius TD, Frank P, Hodgson KO. Characterization of the blue copper site in oxidized azurin by extended x-ray absorption fine structure: Determination of a short Cu-S distance. Proc Natl Acad Sci U S A. 1978 Sep; 75(9):4069-73. PMID: 16592557

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 71 publications over 29 distinct years, with a maximum of 8 publications in 1990