Joe Tien | Profiles RNS

Joe Tien, PhD

Associate Professor

Boston University College of Engineering

Biomedical Engineering

PhD, Harvard University
MA, Harvard University
BS, University of California, Irvine

Websites

	Google Scholar
	College of Engineering Faculty
	The Tien Group
	ResearchGate

ORCID : 0000-0003-4283-3986

Dr. Tien and his group focus on the engineering of functional tissues through control of the cellular microenvironment. Of particular interest is the synthesis of microvascular networks that can serve as in vitro models of microcirculatory diseases or as ex vivo scaffolds for the perfusion of macroscopic tissues. Members of the group apply their understanding of fundamental biology to design structured biomaterials that orient, localize, or alter cellular interactions to elicit desired behavior. This work uses techniques adapted from molecular biology, surface chemistry, materials science, and lithography, and develops new technologies in-house as needed.

BU Research
NIH RePORTER Research

Engineered Invasive Human Breast Tumors with Intergrated Capillaries and Lymphatics
04/01/2017 - 03/31/2023 (PI)
NIH/National Cancer Institute
5U01CA214292-05

Persufflation of composite tissue transplants
09/01/2017 - 09/30/2022 (PI)
Department of Defense/Army Medical Research Acquisition Activity

(Re)vascularization of decellularized scaffolds
07/01/2017 - 04/30/2020 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
5R03EB024660-02

Persufflation of composite tissue transplants
09/01/2017 - 12/31/2019 (PI)
Department of Defense/Army Medical Research Acquisition Activity

Billing Agreement for Lin Jin
09/04/2017 - 09/02/2018 (Subcontract PI)
The General Hospital Corporation d/b/a Massachusetts General Hospital NASA
NNX15AL18G

In Vivo Microsurgical Anastomosis of Prevascularized Tissues
09/23/2014 - 12/31/2017 (PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
5R03EB018851-02

Title

Yr	Title	Project-Sub Proj	Pubs
2021	Engineered Invasive Human Breast Tumors with Integrated Capillaries and Lymphatics	5U01CA214292-05	6
2020	Engineered Invasive Human Breast Tumors with Integrated Capillaries and Lymphatics	5U01CA214292-04	6
2019	Engineered invasive human breast tumors with integrated capillaries and lymphatics	3U01CA214292-03S1	6
2019	Engineered Invasive Human Breast Tumors with Integrated Capillaries and Lymphatics	5U01CA214292-03	6
2018	(Re)vascularization of decellularized scaffolds	5R03EB024660-02	1
2018	Engineered Invasive Human Breast Tumors with Integrated Capillaries and Lymphatics	5U01CA214292-02	6
2017	(Re)vascularization of decellularized scaffolds	1R03EB024660-01	1
2017	Engineered Invasive Human Breast Tumors with Integrated Capillaries and Lymphatics	1U01CA214292-01	6
2015	In Vivo Microsurgical Anastomosis of Prevascularized Tissues	5R03EB018851-02	2
2014	In Vivo Microsurgical Anastomosis of Prevascularized Tissues	1R03EB018851-01	2

Showing 10 of 21 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Leggett SE, Brennan MC, Martinez S, Tien J, Nelson CM. Relatively Rare Populations of Invasive Cells Drive Progression of Heterogeneous Tumors. Cell Mol Bioeng. 2024 Feb; 17(1):7-24. PMID: 38435793; PMCID: PMC10902221; DOI: 10.1007/s12195-023-00792-w;

Dance YW, Obenreder MC, Seibel AJ, Meshulam T, Ogony JW, Lahiri N, Pacheco-Spann L, Radisky DC, Layne MD, Farmer SR, Nelson CM, Tien J. Adipose Cells Induce Escape from an Engineered Human Breast Microtumor Independently of their Obesity Status. Cell Mol Bioeng. 2023 Feb; 16(1):23-39.View Related Profiles.

Tien, Joe
Layne, Matthew
Farmer, Stephen
Meshulam, Tova

PMID: 36660589; PMCID: PMC9842842; DOI: 10.1007/s12195-022-00750-y;

Seibel AJ, Kelly OM, Dance YW, Nelson CM, Tien J. Role of Lymphatic Endothelium in Vascular Escape of Engineered Human Breast Microtumors. Cell Mol Bioeng. 2022 Dec; 15(6):553-569. PMID: 36531861; PMCID: PMC9751254; DOI: 10.1007/s12195-022-00745-9;

Tien J, Ghani U. Methods for Forming Human Lymphatic Microvessels In Vitro and Assessing their Drainage Function. Methods Mol Biol. 2022; 2394:651-668. PMID: 35094351; DOI: 10.1007/978-1-0716-1811-0_34;

Dance YW, Meshulam T, Seibel AJ, Obenreder MC, Layne MD, Nelson CM, Tien J. Adipose Stroma Accelerates the Invasion and Escape of Human Breast Cancer Cells from an Engineered Microtumor. Cell Mol Bioeng. 2022 Feb; 15(1):15-29.View Related Profiles.

Tien, Joe
Layne, Matthew
Meshulam, Tova

PMID: 35096184; PMCID: PMC8761189; DOI: 10.1007/s12195-021-00697-6;

Rabie EM, Zhang SX, Kourouklis AP, Kilinc AN, Simi AK, Radisky DC, Tien J, Nelson CM. Matrix degradation and cell proliferation are coupled to promote invasion and escape from an engineered human breast microtumor. Integr Biol (Camb). 2021 02 03; 13(1):17-29. PMID: 33497442; PMCID: PMC7856634; DOI: 10.1093/intbio/zyaa026;

Tien J, Dance YW, Ghani U, Seibel AJ, Nelson CM. Interstitial Hypertension Suppresses Escape of Human Breast Tumor Cells Via Convection of Interstitial Fluid. Cell Mol Bioeng. 2021 Apr; 14(2):147-159. PMID: 33868497; PMCID: PMC8010070; DOI: 10.1007/s12195-020-00661-w;

Tien J, Li X, Linville RM, Feldman EJ. Comparison of blind deconvolution- and Patlak analysis-based methods for determining vascular permeability. Microvasc Res. 2021 01; 133:104102. PMID: 33166578; DOI: 10.1016/j.mvr.2020.104102;

Tien J, Ghani U, Dance YW, Seibel AJ, Karakan MÇ, Ekinci KL, Nelson CM. Matrix Pore Size Governs Escape of Human Breast Cancer Cells from a Microtumor to an Empty Cavity. iScience. 2020 Nov 20; 23(11):101673. PMID: 33163933; PMCID: PMC7599434; DOI: 10.1016/j.isci.2020.101673;

Tien J, Dance YW. Microfluidic Biomaterials. Adv Healthc Mater. 2021 02; 10(4):e2001028. PMID: 32893494; PMCID: PMC7889648; DOI: 10.1002/adhm.202001028;

Showing 10 of 46 results. Show More

Li X, Xu J, Bartolák-Suki E, Jiang J, Tien J. Evaluation of 1-mm-diameter endothelialized dense collagen tubes in vascular microsurgery. J Biomed Mater Res B Appl Biomater. 2020 08; 108(6):2441-2449.View Related Profiles.

Bartolak-Suki, Erzsebet
Tien, Joe

PMID: 32017412; DOI: 10.1002/jbm.b.34576;

Tien J. Tissue Engineering of the Microvasculature. Compr Physiol. 2019 06 12; 9(3):1155-1212. PMID: 31187896; PMCID: PMC7025285; DOI: 10.1002/cphy.c180037;

Li X, Xia J, Nicolescu CT, Massidda MW, Ryan TJ, Tien J. Engineering of microscale vascularized fat that responds to perfusion with lipoactive hormones. Biofabrication. 2018 10 30; 11(1):014101. PMID: 30284537; PMCID: PMC6252090; DOI: 10.1088/1758-5090/aae5fe;

Thompson RL, Margolis EA, Ryan TJ, Coisman BJ, Price GM, Wong KHK, Tien J. Design principles for lymphatic drainage of fluid and solutes from collagen scaffolds. J Biomed Mater Res A. 2018 Jan; 106(1):106-114. PMID: 28879690; PMCID: PMC5761349; DOI: 10.1002/jbm.a.36211;

Li X, Xu J, Nicolescu CT, Marinelli JT, Tien J. Generation, Endothelialization, and Microsurgical Suture Anastomosis of Strong 1-mm-Diameter Collagen Tubes. Tissue Eng Part A. 2017 04; 23(7-8):335-344. PMID: 27998245; PMCID: PMC5397228; DOI: 10.1089/ten.TEA.2016.0339;

Piotrowski-Daspit AS, Simi AK, Pang MF, Tien J, Nelson CM. A 3D Culture Model to Study How Fluid Pressure and Flow Affect the Behavior of Aggregates of Epithelial Cells. Methods Mol Biol. 2017; 1501:245-257. PMID: 27796957; DOI: 10.1007/978-1-4939-6475-8_12;

Piotrowski-Daspit AS, Tien J, Nelson CM. Interstitial fluid pressure regulates collective invasion in engineered human breast tumors via Snail, vimentin, and E-cadherin. Integr Biol (Camb). 2016 Mar 14; 8(3):319-31. PMID: 26853861; PMCID: PMC4792648; DOI: 10.1039/c5ib00282f;

Linville RM, Boland NF, Covarrubias G, Price GM, Tien J. Physical and Chemical Signals That Promote Vascularization of Capillary-Scale Channels. Cell Mol Bioeng. 2016 Mar 01; 9(1):73-84. PMID: 27110295; PMCID: PMC4838400; DOI: 10.1007/s12195-016-0429-8;

Tien J, Li L, Ozsun O, Ekinci KL. Dynamics of Interstitial Fluid Pressure in Extracellular Matrix Hydrogels in Microfluidic Devices. J Biomech Eng. 2015 Sep; 137(9). PMID: 26158922; DOI: 10.1115/1.4031020;

Profitós JM, Mouhaman A, Lee S, Garabed R, Moritz M, Piperata B, Tien J, Bisesi M, Lee J. Muddying the waters: a new area of concern for drinking water contamination in Cameroon. Int J Environ Res Public Health. 2014 Nov 28; 11(12):12454-72. PMID: 25464137; PMCID: PMC4276624; DOI: 10.3390/ijerph111212454;

Ozsun O, Thompson RL, Ekinci KL, Tien J. Non-invasive mapping of interstitial fluid pressure in microscale tissues. Integr Biol (Camb). 2014 Oct; 6(10):979-87. PMID: 25181983; DOI: 10.1039/c4ib00164h;

Chan KLS, Khankhel AH, Thompson RL, Coisman BJ, Wong KHK, Truslow JG, Tien J. Crosslinking of collagen scaffolds promotes blood and lymphatic vascular stability. J Biomed Mater Res A. 2014 Sep; 102(9):3186-3195. PMID: 24151175; PMCID: PMC3995898; DOI: 10.1002/jbm.a.34990;

Tien J, Nelson CM. Microstructured extracellular matrices in tissue engineering and development: an update. Ann Biomed Eng. 2014 Jul; 42(7):1413-23. PMID: 24030067; DOI: 10.1007/s10439-013-0912-5;

Truslow JG, Tien J. Determination of vascular permeability coefficients under slow luminal filling. Microvasc Res. 2013 Nov; 90:117-20. PMID: 23891569; PMCID: PMC3849343; DOI: 10.1016/j.mvr.2013.07.003;

Wong KH, Truslow JG, Khankhel AH, Chan KL, Tien J. Artificial lymphatic drainage systems for vascularized microfluidic scaffolds. J Biomed Mater Res A. 2013 Aug; 101(8):2181-90. PMID: 23281125; PMCID: PMC3620968; DOI: 10.1002/jbm.a.34524;

Tien J, Truslow JG, Nelson CM. Modulation of invasive phenotype by interstitial pressure-driven convection in aggregates of human breast cancer cells. PLoS One. 2012; 7(9):e45191. PMID: 23028839; PMCID: PMC3445465; DOI: 10.1371/journal.pone.0045191;

Wong KH, Chan JM, Kamm RD, Tien J. Microfluidic models of vascular functions. Annu Rev Biomed Eng. 2012; 14:205-30. PMID: 22540941; DOI: 10.1146/annurev-bioeng-071811-150052;

Leung AD, Wong KH, Tien J. Plasma expanders stabilize human microvessels in microfluidic scaffolds. J Biomed Mater Res A. 2012 Jul; 100(7):1815-22. PMID: 22489049; PMCID: PMC3360840; DOI: 10.1002/jbm.a.34137;

Truslow JG, Tien J. Perfusion systems that minimize vascular volume fraction in engineered tissues. Biomicrofluidics. 2011 Jun; 5(2):22201. PMID: 21799708; PMCID: PMC3145227; DOI: 10.1063/1.3576926;

Price GM, Tien J. Methods for forming human microvascular tubes in vitro and measuring their macromolecular permeability. Methods Mol Biol. 2011; 671:281-93. PMID: 20967637; DOI: 10.1007/978-1-59745-551-0_17;

Price GM, Wong KH, Truslow JG, Leung AD, Acharya C, Tien J. Effect of mechanical factors on the function of engineered human blood microvessels in microfluidic collagen gels. Biomaterials. 2010 Aug; 31(24):6182-9.View Related Profiles.

Acharya, Chitrangada
Tien, Joe

PMID: 20537705; PMCID: PMC2884145; DOI: 10.1016/j.biomaterials.2010.04.041;

Wong KH, Truslow JG, Tien J. The role of cyclic AMP in normalizing the function of engineered human blood microvessels in microfluidic collagen gels. Biomaterials. 2010 Jun; 31(17):4706-14. PMID: 20303168; PMCID: PMC2854201; DOI: 10.1016/j.biomaterials.2010.02.041;

Truslow JG, Price GM, Tien J. Computational design of drainage systems for vascularized scaffolds. Biomaterials. 2009 Sep; 30(26):4435-43. PMID: 19481796; PMCID: PMC2726043; DOI: 10.1016/j.biomaterials.2009.04.053;

Price GM, Chu KK, Truslow JG, Tang-Schomer MD, Golden AP, Mertz J, Tien J. Bonding of macromolecular hydrogels using perturbants. J Am Chem Soc. 2008 May 28; 130(21):6664-5.View Related Profiles.

Mertz, Jerome
Tien, Joe

PMID: 18454530; PMCID: PMC2394282; DOI: 10.1021/ja711340d;

Price GM, Chrobak KM, Tien J. Effect of cyclic AMP on barrier function of human lymphatic microvascular tubes. Microvasc Res. 2008 May; 76(1):46-51. PMID: 18440562; PMCID: PMC2574545; DOI: 10.1016/j.mvr.2008.02.003;

Golden AP, Tien J. Fabrication of microfluidic hydrogels using molded gelatin as a sacrificial element. Lab Chip. 2007 Jun; 7(6):720-5. PMID: 17538713; DOI: 10.1039/b618409j;

Nelson CM, Tien J. Microstructured extracellular matrices in tissue engineering and development. Curr Opin Biotechnol. 2006 Oct; 17(5):518-23. PMID: 16971111; DOI: 10.1016/j.copbio.2006.08.011;

Chrobak KM, Potter DR, Tien J. Formation of perfused, functional microvascular tubes in vitro. Microvasc Res. 2006 May; 71(3):185-96. PMID: 16600313; DOI: 10.1016/j.mvr.2006.02.005;

Chen CS, Tan J, Tien J. Mechanotransduction at cell-matrix and cell-cell contacts. Annu Rev Biomed Eng. 2004; 6:275-302.View Related Profiles.

Chen, Christopher
Tien, Joe

PMID: 15255771; DOI: 10.1146/annurev.bioeng.6.040803.140040;

Tang MD, Golden AP, Tien J. Molding of three-dimensional microstructures of gels. J Am Chem Soc. 2003 Oct 29; 125(43):12988-9. PMID: 14570447; DOI: 10.1021/ja037677h;

Gray DS, Tien J, Chen CS. Repositioning of cells by mechanotaxis on surfaces with micropatterned Young's modulus. J Biomed Mater Res A. 2003 Sep 01; 66(3):605-14.View Related Profiles.

Chen, Christopher
Tien, Joe

PMID: 12918044; DOI: 10.1002/jbm.a.10585;

Tan JL, Tien J, Pirone DM, Gray DS, Bhadriraju K, Chen CS. Cells lying on a bed of microneedles: an approach to isolate mechanical force. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1484-9.View Related Profiles.

Chen, Christopher
Tien, Joe

PMID: 12552122; PMCID: PMC149857; DOI: 10.1073/pnas.0235407100;

Clark TD, Ferrigno R, Tien J, Paul KE, Whitesides GM. Template-directed self-assembly of 10-microm-sized hexagonal plates. J Am Chem Soc. 2002 May 15; 124(19):5419-26. PMID: 11996582; DOI: 10.1021/ja020056o;

Tien J, Nelson CM, Chen CS. Fabrication of aligned microstructures with a single elastomeric stamp. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):1758-62.View Related Profiles.

Chen, Christopher
Tien, Joe

PMID: 11842197; PMCID: PMC122266; DOI: 10.1073/pnas.042493399;

Tien J, Chen CS. Patterning the cellular microenvironment. IEEE Eng Med Biol Mag. 2002 Jan-Feb; 21(1):95-8.View Related Profiles.

Chen, Christopher
Tien, Joe

PMID: 11935995; DOI: 10.1109/memb.2002.993201;

Dike LE, Chen CS, Mrksich M, Tien J, Whitesides GM, Ingber DE. Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates. In Vitro Cell Dev Biol Anim. 1999 Sep; 35(8):441-8. PMID: 10501083

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 46 publications over 22 distinct years, with a maximum of 5 publications in 2020