Jean-Jacques Soghomonian, PhD
Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Anatomy & Neurobiology

PhD, Université de Montréal
MSc, Aix-Marseille Université

Research focuses on the functional neuroanatomy of the basal ganglia and the neurobiological basis of motor control, sensorimotor integration and learning. We are particularly interested in the mechanisms of regulation of GABAergic neurons in the basal ganglia of normal animals and experimental models of Parkinson's disease. Experimental approaches include analysis of protein/peptide expression by quantitative in situ hybridization histochemistry, immunohistochemistry and Western-blotting and analysis of behavioral activity.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

Neurochemical Alterations in the Speech and Language Network in the Autism Brain
03/01/2017 - 09/30/2020 (PI)
Hussman Institute for Autism

Quantitative Neurochemical Analysis of the Basal Ganglia in ASC Impacting Motor, Limbic, and Cognitive Regions and their Interactions with Thalmo-cortical and Cerebellar Projections
01/15/2015 - 05/31/2018 (PI)
The John P. Hussman Foundation

Role of Gad1 in I-DOPA- Induced Dyskinesa
09/01/2011 - 12/31/2013 (PI)
Michael J. Fox Foundation for Parkinson's Research

Behavioral Sensitization and Parkinson’s Disease
03/01/2002 - 08/31/2008 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5 R01 NS40783 05

Levodopa-Induced Plasticity in the Basal Ganglia
04/01/2002 - 03/31/2004 (Dept Sponsor)
NIH/National Institute of Neurological Disorders & Stroke
5 F31 NS42499 02

Effects of Intermittent vs Continuous L-DOPA on GABAergic Neurons of the Basal Ganglia
07/01/2000 - 06/30/2001 (PI)
Parkinson's Disease Foundation


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Soghomonian JJ. The cortico-striatal circuitry in autism-spectrum disorders: a balancing act. Front Cell Neurosci. 2023; 17:1329095. PMID: 38273975; PMCID: PMC10808402; DOI: 10.3389/fncel.2023.1329095;
  2. Brandenburg C, Soghomonian JJ, Zhang K, Sulkaj I, Randolph B, Kachadoorian M, Blatt GJ. Increased Dopamine Type 2 Gene Expression in the Dorsal Striatum in Individuals With Autism Spectrum Disorder Suggests Alterations in Indirect Pathway Signaling and Circuitry. Front Cell Neurosci. 2020; 14:577858. PMID: 33240045; PMCID: PMC7681004; DOI: 10.3389/fncel.2020.577858;
  3. Subramanian K, Brandenburg C, Orsati F, Soghomonian JJ, Hussman JP, Blatt GJ. Basal ganglia and autism - a translational perspective. Autism Res. 2017 Nov; 10(11):1751-1775. PMID: 28730641
  4. Soghomonian JJ, Zhang K, Reprakash S, Blatt GJ. Decreased parvalbumin mRNA levels in cerebellar Purkinje cells in autism. Autism Res. 2017 Nov; 10(11):1787-1796.View Related Profiles. PMID: 28707805
  5. Zhang K, Chammas C, Soghomonian JJ. Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned mice. Neuroscience. 2015 Sep 10; 303:586-94.View Related Profiles. PMID: 26188284; DOI: 10.1016/j.neuroscience.2015.07.032;
  6. Zhang K, Hill K, Labak S, Blatt GJ, Soghomonian JJ. Loss of glutamic acid decarboxylase (Gad67) in Gpr88-expressing neurons induces learning and social behavior deficits in mice. Neuroscience. 2014 Sep 5; 275:238-47.View Related Profiles. PMID: 24952328; DOI: 10.1016/j.neuroscience.2014.06.020;
  7. Lanoue AC, Blatt GJ, Soghomonian JJ. Decreased parvalbumin mRNA expression in dorsolateral prefrontal cortex in Parkinson's disease. Brain Res. 2013 Sep 19; 1531:37-47.View Related Profiles. PMID: 23891794; PMCID: PMC3816277; DOI: 10.1016/j.brainres.2013.07.025;
  8. Lanoue AC, Dumitriu A, Myers RH, Soghomonian JJ. Decreased glutamic acid decarboxylase mRNA expression in prefrontal cortex in Parkinson's disease. Exp Neurol. 2010 Nov; 226(1):207-17.View Related Profiles. PMID: 20832408; PMCID: PMC3108022; DOI: 10.1016/j.expneurol.2010.09.001;
  9. Soghomonian JJ, Sethares C, Peters A. Effects of age on axon terminals forming axosomatic and axodendritic inhibitory synapses in prefrontal cortex. Neuroscience. 2010 Jun 16; 168(1):74-81.View Related Profiles. PMID: 20302918; PMCID: PMC2873101; DOI: 10.1016/j.neuroscience.2010.03.020;
  10. Yamamoto N, Soghomonian JJ. Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats. Neuroscience. 2009 Nov 10; 163(4):1171-80. PMID: 19660528; PMCID: PMC2760628; DOI: 10.1016/j.neuroscience.2009.07.060;
Showing 10 of 60 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 60 publications over 28 distinct years, with a maximum of 5 publications in 1992


In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Basal Ganglia
Chemical and Functional Neuroanatomy
GABAergic neurons
Gene Expression
Monoaminergic neurons
Parkinson's disease

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:

72 E. Concord St Instructional (L)
Boston MA 02118
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