Inna Afasizheva, PhD
Associate Professor
Boston University Henry M. Goldman School of Dental Medicine
Molecular & Cell Biology

PhD, Russian Academy of Medical Sciences
MS, Moscow State University
BS, Moscow State University



Her research interests are molecular biology, mitochondrial gene expression, and RNA editing.

Member
Boston University
Genome Science Institute


Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences




Decoding the mitochondrial proteomes of six pathogenic protozoa
11/01/2022 - 10/31/2025 (PI)
Howard Hughes Medical Institute


Repeat-containing RNA Binding Proteins of Trypanosomes
02/24/2020 - 01/31/2025 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI113157-10

Repeat-containing RNA Binding Proteins of Trypanosomes
01/05/2015 - 02/23/2020 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R01AI113157-05



Title


Yr Title Project-Sub Proj Pubs
2024 REPEAT-CONTAINING RNA BINDING PROTEINS OF TRYPANOSOMES 5R01AI113157-10
2023 REPEAT-CONTAINING RNA BINDING PROTEINS OF TRYPANOSOMES 5R01AI113157-09
2022 REPEAT-CONTAINING RNA BINDING PROTEINS OF TRYPANOSOMES 5R01AI113157-08
2021 REPEAT-CONTAINING RNA BINDING PROTEINS OF TRYPANOSOMES 5R01AI113157-07 6
2020 REPEAT-CONTAINING RNA BINDING PROTEINS OF TRYPANOSOMES 2R01AI113157-06 6
2019 Repeat-containing RNA Binding Proteins of Trypanosomes 5R01AI113157-05 6
2018 Repeat-containing RNA Binding Proteins of Trypanosomes 5R01AI113157-04 6
2017 Repeat-containing RNA Binding Proteins of Trypanosomes 5R01AI113157-03 6
2016 Repeat-containing RNA Binding Proteins of Trypanosomes 5R01AI113157-02 6
2015 Repeat-containing RNA Binding Proteins of Trypanosomes 1R01AI113157-01A1 6

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Plaza-Pegueroles A, Aphasizheva I, Aphasizhev R, Fernández-Tornero C, Ruiz FM. The cryo-EM structure of trypanosome 3-methylcrotonyl-CoA carboxylase provides mechanistic and dynamic insights into its enzymatic function. Structure. 2024 Jul 11; 32(7):930-940.e3.View Related Profiles. PMID: 38593794; PMCID: PMC11246232; DOI: 10.1016/j.str.2024.03.010;
     
  2. Liu S, Wang H, Li X, Zhang F, Lee JKJ, Li Z, Yu C, Hu JJ, Zhao X, Suematsu T, Alvarez-Cabrera AL, Liu Q, Zhang L, Huang L, Aphasizheva I, Aphasizhev R, Zhou ZH. Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing. Science. 2023 Jul 07; 381(6653):eadg4725.View Related Profiles. PMID: 37410820; PMCID: PMC10704856; DOI: 10.1126/science.adg4725;
     
  3. Aphasizhev R, Aphasizheva I. A new class of antiparasitic drugs. Science. 2023 Jun 30; 380(6652):1320-1321.View Related Profiles. PMID: 37384682; PMCID: PMC10690620; DOI: 10.1126/science.adi5925;
     
  4. Silveira d'Almeida G, Casius A, Henderson JC, Knuesel S, Aphasizhev R, Aphasizheva I, Manning AC, Lowe TM, Alfonzo JD. tRNATyr has an unusually short half-life in Trypanosoma brucei. RNA. 2023 Aug; 29(8):1243-1254.View Related Profiles. PMID: 37197826; PMCID: PMC10351884; DOI: 10.1261/rna.079674.123;
     
  5. Lee JKJ, Liu YT, Hu JJ, Aphasizheva I, Aphasizhev R, Zhou ZH. CryoEM reveals oligomeric isomers of a multienzyme complex and assembly mechanics. J Struct Biol X. 2023; 7:100088.View Related Profiles. PMID: 37128595; PMCID: PMC10148081; DOI: 10.1016/j.yjsbx.2023.100088;
     
  6. Hu JJ, Lee JKJ, Liu YT, Yu C, Huang L, Aphasizheva I, Aphasizhev R, Zhou ZH. Discovery, structure, and function of filamentous 3-methylcrotonyl-CoA carboxylase. Structure. 2023 Jan 05; 31(1):100-110.e4.View Related Profiles. PMID: 36543169; PMCID: PMC9825669; DOI: 10.1016/j.str.2022.11.015;
     
  7. Aphasizheva I, Suematsu T, Vacas A, Wang H, Fan C, Zhao X, Zhang L, Aphasizhev R. CTS tag-based methods for investigating mitochondrial RNA modification factors in Trypanosoma brucei. Methods Enzymol. 2021; 658:83-109.View Related Profiles. PMID: 34517961; PMCID: PMC9805619; DOI: 10.1016/bs.mie.2021.06.004;
     
  8. Aphasizheva I, Aphasizhev R. Mitochondrial RNA quality control in trypanosomes. Wiley Interdiscip Rev RNA. 2021 May; 12(3):e1638.View Related Profiles. PMID: 33331073; PMCID: PMC9805618; DOI: 10.1002/wrna.1638;
     
  9. Aphasizheva I, Yu T, Suematsu T, Liu Q, Mesitov MV, Yu C, Huang L, Zhang L, Aphasizhev R. Poly(A) binding KPAF4/5 complex stabilizes kinetoplast mRNAs in Trypanosoma brucei. Nucleic Acids Res. 2020 09 04; 48(15):8645-8662.View Related Profiles. PMID: 32614436; PMCID: PMC7470953; DOI: 10.1093/nar/gkaa575;
     
  10. Aphasizheva I, Alfonzo J, Carnes J, Cestari I, Cruz-Reyes J, Göringer HU, Hajduk S, Lukeš J, Madison-Antenucci S, Maslov DA, McDermott SM, Ochsenreiter T, Read LK, Salavati R, Schnaufer A, Schneider A, Simpson L, Stuart K, Yurchenko V, Zhou ZH, Zíková A, Zhang L, Zimmer S, Aphasizhev R. Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes. Trends Parasitol. 2020 04; 36(4):337-355.View Related Profiles. PMID: 32191849; PMCID: PMC7083771; DOI: 10.1016/j.pt.2020.01.006;
     
Showing 10 of 48 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 48 publications over 24 distinct years, with a maximum of 5 publications in 2016

YearPublications
19971
19983
19991
20021
20033
20043
20061
20073
20082
20091
20103
20113
20132
20142
20151
20165
20171
20181
20191
20203
20211
20221
20234
20241


They Fell in Love with Each Other, Then with the Same Science

BU Today 7/18/2023

BU Researchers Join $100 Million Effort to Fight Future Deadly Pathogens

The Brink 2/17/2023

Promotions to Associate Professor Go to 16 on Medical Campus

BU Today 7/6/2018
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Boston MA 02118
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