Ian Francis
Predoctoral Trainee
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Virology, Immunology & Microbiology

My interests lie in vaccine development. Specifically I am working on the human pathogen Neisseria gonorrhoeae (Ng). In 2012 there were greater than 330,000 new gonorrhea cases in the US and more than 100 million cases worldwide. Gonorrhea can present as urethritis in men and more seriously, pelvic inflammatory disease with infertility as a possible outcome in women. While this outcome is preventable with antibiotic treatment, the rapid development of resistance has led the CDC to identify Ng as an “immediate public health threat that requires urgent and aggressive action” towards new therapeutics and vaccines. This drive for innovation faces a significant challenge in the human-specific adaptations of Ng. We are working with our collaborators to develop a humanized transgenic mouse model of disease that will serve as the platform for our future testing of Neisseria gonorrhoeae vaccine antigen candidates.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Francis IP, Lui X, Wetzler LM. Isolation of Naturally Released Gonococcal Outer Membrane Vesicles as Vaccine Antigens. Methods Mol Biol. 2019; 1997:121-141.View Related Profiles. PMID: 31119622
  2. Francis IP, Islam EA, Gower AC, Shaik-Dasthagirisaheb YB, Gray-Owen SD, Wetzler LM. Murine host response to Neisseria gonorrhoeae upper genital tract infection reveals a common transcriptional signature, plus distinct inflammatory responses that vary between reproductive cycle phases. BMC Genomics. 2018 Aug 22; 19(1):627.View Related Profiles. PMID: 30134832; PMCID: PMC6106831; DOI: 10.1186/s12864-018-5000-7;
  3. Islam EA, Anipindi VC, Francis I, Shaik-Dasthagirisaheb Y, Xu S, Leung N, Sintsova A, Amin M, Kaushic C, Wetzler LM, Gray-Owen SD. Specific Binding to Differentially Expressed Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules Determines the Outcome of Neisseria gonorrhoeae Infections along the Female Reproductive Tract. American Association for Microbiology: Infection and Immunity. 2018. View Publication
  4. Pendergrass SA, Lemaire R, Francis IP, Mahoney JM, Lafyatis R, Whitfield ML. Intrinsic gene expression subsets of diffuse cutaneous systemic sclerosis are stable in serial skin biopsies. J Invest Dermatol. 2012 May; 132(5):1363-73.View Related Profiles. PMID: 22318389; PMCID: PMC3326181; DOI: 10.1038/jid.2011.472;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 4 publications over 3 distinct years, with a maximum of 2 publications in 2018


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