Hiroshi Mashimo is currently Chief of Gastroenterology at the VA Boston Healthcare System, Assistant Professor of Medicine at Harvard Medical School and Adjunct Assistant Professor Of Medicine at Chobanian and Avedisian School of Medicine. He obtained his A.B. at Harvard College and his M.S., M.D. and Ph.D. degrees at Albert Einstein College of Medicine. He completed his medical internship, residency, and gastroenterology fellowship at Massachusetts General Hospital. His interest in molecular physiology led to advanced research and clinical training at Harvard Medical School, with Dr Daniel K. Podolsky and Dr Mark C. Fishman at Massachusetts General Hospital, and with Dr Raj K. Goyal at Beth Israel Hospital. His pioneering work using genetically altered mice models to understand basic gastrointestinal physiology has led to important understandings of the distinct roles of various mediators such as nitric oxide synthases and vasoactive intestinal peptides in the field of gastrointestinal motility. He has continued his interest in clinical gastrointestinal motility as Director of the Swallowing and Motility Disorders services at the VA Boston Healthcare, and is involved with training and teaching of students, residents and fellows at Brigham and Women's Hospital, the VA Boston Healthcare, and Harvard Medical School. He has published numerous original and review articles in various medical and scientific journals.
VA Boston Healthcare System
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- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
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- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from the Boston VA. We are only showing grant title, and only for people in the role of PI.
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Title
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Stochastic Resonance Stimulation in the Gastrointestinal Tract
(PI)
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Tethered Capsule Imaging of the Esophagus
(PI)
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A 52-week, Randomized, Double-blind, Placebo-Controlled, Phase 3 Study to Evaluate the Safety and Efficacy of Relamorelin in Patients with Diabetic Gastroparesis (RLM-MD-04)
(PI)
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Optical Biopsy Using Optical Coherence Tomography
(PI)
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Publications listed below are automatically derived from MEDLINE/PubMed and other
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Triadafilopoulos G, Mashimo H, Tatum R, O'Clarke J, Hawn M. Mixed Esophageal Disease (MED): A New Concept. Dig Dis Sci. 2023 Sep; 68(9):3542-3554. PMID: 37470896
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Kumar S, Zhao J, Talluri S, Buon L, Mu S, Potluri LB, Liao C, Shi J, Chakraborty C, Gonzalez GB, Tai YT, Patel J, Pal J, Mashimo H, Samur MK, Munshi NC, Shammas MA. Elevated APE1 Dysregulates Homologous Recombination and Cell Cycle Driving Genomic Evolution, Tumorigenesis, and Chemoresistance in Esophageal Adenocarcinoma. Gastroenterology. 2023 Aug; 165(2):357-373.View Related Profiles. PMID: 37178737; PMCID: PMC10524563; DOI: 10.1053/j.gastro.2023.04.035;
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Guadagnoli L, Mashimo H, Lo WK. Assessment of Post-traumatic Stress Disorder Among Objective Esophageal Motility and Reflux Phenotypes in Symptomatic Veterans. J Clin Psychol Med Settings. 2023 Sep; 30(3):606-617. PMID: 36378471
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Zhang J, Nguyen T, Potsaid B, Jayaraman V, Burgner C, Chen S, Li J, Liang K, Cable A, Traverso G, Mashimo H, Fujimoto JG. Multi-MHz MEMS-VCSEL swept-source optical coherence tomography for endoscopic structural and angiographic imaging with miniaturized brushless motor probes. Biomed Opt Express. 2021 Apr 01; 12(4):2384-2403. PMID: 33996236; PMCID: PMC8086463; DOI: 10.1364/BOE.420394;
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Fass OZ, Mashimo H. The Effect of Bariatric Surgery and Endoscopic Procedures on Gastroesophageal Reflux Disease. J Neurogastroenterol Motil. 2021 Jan 30; 27(1):35-45. PMID: 33380553; PMCID: PMC7786084; DOI: 10.5056/jnm20169;
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Nguyen TH, Ahsen OO, Liang K, Zhang J, Mashimo H, Fujimoto JG. Correction of circumferential and longitudinal motion distortion in high-speed catheter/endoscope-based optical coherence tomography. Biomed Opt Express. 2021 Jan 01; 12(1):226-246. PMID: 33520383; PMCID: PMC7818954; DOI: 10.1364/BOE.409074;
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Rodriguez-Diaz E, Baffy G, Lo WK, Mashimo H, Vidyarthi G, Mohapatra SS, Singh SK. Real-time artificial intelligence-based histologic classification of colorectal polyps with augmented visualization. Gastrointest Endosc. 2021 03; 93(3):662-670.View Related Profiles. PMID: 32949567
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Liang K, Ahsen OO, Murphy A, Zhang J, Nguyen TH, Potsaid B, Figueiredo M, Huang Q, Mashimo H, Fujimoto JG. Tethered capsule en face optical coherence tomography for imaging Barrett's oesophagus in unsedated patients. BMJ Open Gastroenterol. 2020 09; 7(1). PMID: 32883714; PMCID: PMC7473663; DOI: 10.1136/bmjgast-2020-000444;
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Banting SP, Badgery HE, Read M, Mashimo H. Rethinking gastroesophageal reflux disorder. Ann N Y Acad Sci. 2020 12; 1482(1):177-192. PMID: 32875572
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Samel NS, Huang Q, Mashimo H. Automated imaging cytometry reveals dysplastic indices of colonic serrated adenomas. Future Sci OA. 2020 Feb 21; 6(4):FSO459. PMID: 32257372; PMCID: PMC7117562; DOI: 10.2144/fsoa-2019-0111;
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Spechler SJ, Hunter JG, Jones KM, Lee R, Smith BR, Mashimo H, Sanchez VM, Dunbar KB, Pham TH, Murthy UK, Kim T, Jackson CS, Wallen JM, von Rosenvinge EC, Pearl JP, Laine L, Kim AW, Kaz AM, Tatum RP, Gellad ZF, Lagoo-Deenadayalan S, Rubenstein JH, Ghaferi AA, Lo WK, Fernando RS, Chan BS, Paski SC, Provenzale D, Castell DO, Lieberman D, Souza RF, Chey WD, Warren SR, Davis-Karim A, Melton SD, Genta RM, Serpi T, Biswas K, Huang GD. Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn. N Engl J Med. 2019 10 17; 381(16):1513-1523.View Related Profiles. PMID: 31618539
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Ahsen OO, Liang K, Lee HC, Wang Z, Fujimoto JG, Mashimo H. Assessment of chronic radiation proctopathy and radiofrequency ablation treatment follow-up with optical coherence tomography angiography: A pilot study. World J Gastroenterol. 2019 Apr 28; 25(16):1997-2009. PMID: 31086467; PMCID: PMC6487379; DOI: 10.3748/wjg.v25.i16.1997;
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Goyal RK, Guo Y, Mashimo H. Advances in the physiology of gastric emptying. Neurogastroenterol Motil. 2019 04; 31(4):e13546. PMID: 30740834; PMCID: PMC6850045; DOI: 10.1111/nmo.13546;
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Mkarimi M, Mashimo H. Advanced Imaging for Barrett's Esophagus and Early Neoplasia: Surface and Subsurface Imaging for Diagnosis and Management. Curr Gastroenterol Rep. 2018 Oct 09; 20(12):54. PMID: 30302571
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Ahsen OO, Liang K, Lee HC, Giacomelli MG, Wang Z, Potsaid B, Figueiredo M, Huang Q, Jayaraman V, Fujimoto JG, Mashimo H. Assessment of Barrett's esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography. Endoscopy. 2019 04; 51(4):355-359. PMID: 30261534; PMCID: PMC6674974; DOI: 10.1055/a-0725-7995;
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Inadomi J, Alastal H, Bonavina L, Gross S, Hunt RH, Mashimo H, di Pietro M, Rhee H, Shah M, Tolone S, Wang DH, Xie SH. Recent advances in Barrett's esophagus. Ann N Y Acad Sci. 2018 12; 1434(1):227-238. PMID: 29974975
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Huang Q, Cheng Y, Chen L, Mingzhan D, Wang Y, Xu G, Shi J, Fan X, Zhou X, Zhang Y, Guo L, Liu T, Zhou D, Mashimo H, Gold JS, Zou X. Low risk of lymph node metastasis in 495 early gastric cardiac carcinomas: a multicenter clinicopathologic study of 2101 radical gastrectomies for early gastric carcinoma. Mod Pathol. 2018 10; 31(10):1599-1607. PMID: 29802360
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Liang K, Wang Z, Ahsen OO, Lee HC, Potsaid BM, Jayaraman V, Cable A, Mashimo H, Li X, Fujimoto JG. Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo. Optica. 2018 Jan 20; 5(1):36-43. PMID: 29682598; PMCID: PMC5909979; DOI: 10.1364/OPTICA.5.000036;
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Tsai TH, Leggett CL, Trindade AJ, Sethi A, Swager AF, Joshi V, Bergman JJ, Mashimo H, Nishioka NS, Namati E. Optical coherence tomography in gastroenterology: a review and future outlook. J Biomed Opt. 2017 Dec; 22(12):1-17. PMID: 29260538
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Ahsen OO, Lee HC, Liang K, Wang Z, Figueiredo M, Huang Q, Potsaid B, Jayaraman V, Fujimoto JG, Mashimo H. Ultrahigh-speed endoscopic optical coherence tomography and angiography enables delineation of lateral margins of endoscopic mucosal resection: a case report. Therap Adv Gastroenterol. 2017 Dec; 10(12):931-936. PMID: 29204188; PMCID: PMC5703108; DOI: 10.1177/1756283X17739503;
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Liang K, Ahsen OO, Wang Z, Lee HC, Liang W, Potsaid BM, Tsai TH, Giacomelli MG, Jayaraman V, Mashimo H, Li X, Fujimoto JG. Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source. Opt Lett. 2017 Aug 15; 42(16):3193-3196. PMID: 28809905; PMCID: PMC5875690; DOI: 10.1364/OL.42.003193;
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Lee HC, Ahsen OO, Liu JJ, Tsai TH, Huang Q, Mashimo H, Fujimoto JG. Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography. J Biomed Opt. 2017 07 01; 22(7):76001. PMID: 28687822; PMCID: PMC5499807; DOI: 10.1117/1.JBO.22.7.076001;
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Lee HC, Ahsen OO, Liang K, Wang Z, Figueiredo M, Giacomelli MG, Potsaid B, Huang Q, Mashimo H, Fujimoto JG. Endoscopic optical coherence tomography angiography microvascular features associated with dysplasia in Barrett's esophagus (with video). Gastrointest Endosc. 2017 Sep; 86(3):476-484.e3. PMID: 28167119; PMCID: PMC5545067; DOI: 10.1016/j.gie.2017.01.034;
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Shapiro M, Nandi B, Gonzalez G, Prabhala RH, Mashimo H, Huang Q, Frank NY, Munshi NC, Gold JS. Deficiency of the immunostimulatory cytokine IL-21 promotes intestinal neoplasia via dysregulation of the Th1/Th17 axis. Oncoimmunology. 2017; 6(1):e1261776.View Related Profiles. PMID: 28197386; PMCID: PMC5283644; DOI: 10.1080/2162402X.2016.1261776;
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Tang Q, Wang J, Frank A, Lin J, Li Z, Chen CW, Jin L, Wu T, Greenwald BD, Mashimo H, Chen Y. Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography. Biomed Opt Express. 2016 Dec 01; 7(12):5218-5232. PMID: 28018738; PMCID: PMC5175565; DOI: 10.1364/BOE.7.005218;
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Liang K, Ahsen OO, Lee HC, Wang Z, Potsaid BM, Figueiredo M, Jayaraman V, Cable AE, Huang Q, Mashimo H, Fujimoto JG. Volumetric Mapping of Barrett's Esophagus and Dysplasia With en face Optical Coherence Tomography Tethered Capsule. Am J Gastroenterol. 2016 11; 111(11):1664-1666. PMID: 27808130; PMCID: PMC5289388; DOI: 10.1038/ajg.2016.419;
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Lee HC, Ahsen OO, Liang K, Wang Z, Cleveland C, Booth L, Potsaid B, Jayaraman V, Cable AE, Mashimo H, Langer R, Traverso G, Fujimoto JG. Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromotor balloon catheter. Biomed Opt Express. 2016 Aug 1; 7(8):2927-42. PMID: 27570688; PMCID: PMC4986804; DOI: 10.1364/BOE.7.002927;
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Zhao X, Mashimo H. Current and Emerging Medical Therapies for Gastroparesis. Curr Treat Options Gastroenterol. 2015 Dec; 13(4):452-72. PMID: 26507073; DOI: 10.1007/s11938-015-0071-x;
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Lo WK, Mashimo H. Critical Assessment of Endoscopic Techniques for Gastroesophageal Reflux Disease. J Clin Gastroenterol. 2015 Oct; 49(9):720-4. PMID: 26241152; DOI: 10.1097/MCG.0000000000000389;
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Huang Q, Shi J, Sun Q, Gold JS, Chen J, Wu H, Yu H, Zhang Y, Mashimo H, Yu C, Manasco T, Guan W, Lauwers GY. Clinicopathological characterisation of small (2?cm or less) proximal and distal gastric carcinomas in a Chinese population. Pathology. 2015 Oct; 47(6):526-32. PMID: 26166663; PMCID: PMC4699347; DOI: 10.1097/PAT.0000000000000276;
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Huang Q, Fang C, Shi J, Sun Q, Wu H, Gold JS, Weber HC, Guan W, Zhang Y, Yu C, Zou X, Mashimo H. Differences in Clinicopathology of Early Gastric Carcinoma between Proximal and Distal Location in 438 Chinese Patients. Sci Rep. 2015; 5:13439.View Related Profiles. PMID: 26310451; PMCID: PMC4550893; DOI: 10.1038/srep13439;
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Gonzalez G, Huang Q, Mashimo H. Characterization of oncocytes in deep esophageal glands. Dis Esophagus. 2016 Aug; 29(6):670-80. PMID: 26245938; DOI: 10.1111/dote.12382;
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Fang C, Huang Q, Lu L, Shi J, Sun Q, Xu GF, Gold J, Mashimo H, Zou XP. Risk factors of early proximal gastric carcinoma in Chinese diagnosed using WHO criteria. J Dig Dis. 2015 Jun; 16(6):327-36. PMID: 25754397; DOI: 10.1111/1751-2980.12240;
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Liang K, Traverso G, Lee HC, Ahsen OO, Wang Z, Potsaid B, Giacomelli M, Jayaraman V, Barman R, Cable A, Mashimo H, Langer R, Fujimoto JG. Ultrahigh speed en face OCT capsule for endoscopic imaging. Biomed Opt Express. 2015 Apr 1; 6(4):1146-63. PMID: 25909001; PMCID: PMC4399656; DOI: 10.1364/BOE.6.001146;
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Tsai TH, Lee HC, Ahsen OO, Liang K, Giacomelli MG, Potsaid BM, Tao YK, Jayaraman V, Figueiredo M, Huang Q, Cable AE, Fujimoto J, Mashimo H. Ultrahigh speed endoscopic optical coherence tomography for gastroenterology. Biomed Opt Express. 2014 Dec 1; 5(12):4387-404. PMID: 25574446; PMCID: PMC4285613; DOI: 10.1364/BOE.5.004387;
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Bennett M, Mashimo H. Molecular markers and imaging tools to identify malignant potential in Barrett's esophagus. World J Gastrointest Pathophysiol. 2014 Nov 15; 5(4):438-49. PMID: 25400987; PMCID: PMC4231508; DOI: 10.4291/wjgp.v5.i4.438;
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Ahsen OO, Lee HC, Giacomelli MG, Wang Z, Liang K, Tsai TH, Potsaid B, Mashimo H, Fujimoto JG. Correction of rotational distortion for catheter-based en face OCT and OCT angiography. Opt Lett. 2014 Oct 15; 39(20):5973-6. PMID: 25361133; PMCID: PMC4370282; DOI: 10.1364/OL.39.005973;
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Dowli A, Mattar A, Mashimo H, Huang Q, Cohen D, Fisichella PM, Lebenthal A. A pedunculated giant esophageal liposarcoma: a case report and literature review. J Gastrointest Surg. 2014 Dec; 18(12):2208-13.View Related Profiles. PMID: 25190025; DOI: 10.1007/s11605-014-2628-8;
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Bajpai M, Das KM, Lefferts J, Lisovsky M, Mashimo H, Phillips WA, Srivastava A, To H. Molecular epidemiology of and genetic susceptibility to esophageal cancer. Ann N Y Acad Sci. 2014 Sep; 1325:40-8. PMID: 25266013; DOI: 10.1111/nyas.12517;
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Akiyama J, Komanduri S, Konda VJ, Mashimo H, Noria S, Triadafilopoulos G. Endoscopy for diagnosis and treatment in esophageal cancers: high-technology assessment. Ann N Y Acad Sci. 2014 Sep; 1325:77-88. PMID: 25266017; DOI: 10.1111/nyas.12526;
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Tsai TH, Ahsen OO, Lee HC, Liang K, Figueiredo M, Tao YK, Giacomelli MG, Potsaid BM, Jayaraman V, Huang Q, Cable AE, Fujimoto JG, Mashimo H. Endoscopic optical coherence angiography enables 3-dimensional visualization of subsurface microvasculature. Gastroenterology. 2014 Dec; 147(6):1219-21. PMID: 25172015; PMCID: PMC4415681; DOI: 10.1053/j.gastro.2014.08.034;
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Shi J, Sun Q, Xu BY, Yu HP, Zhang YF, Zou XP, Huang L, Gold JS, Mashimo H, Yu CG, Huang Q. Changing trends in the proportions of small (= 2?cm) proximal and non-proximal gastric carcinomas treated at a high-volume tertiary medical center in China. J Dig Dis. 2014 Jul; 15(7):359-66. PMID: 24720626; DOI: 10.1111/1751-2980.12151;
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Rustagi T, Corbett FS, Mashimo H. Treatment of chronic radiation proctopathy with radiofrequency ablation (with video). Gastrointest Endosc. 2015 Feb; 81(2):428-36. PMID: 24973172; DOI: 10.1016/j.gie.2014.04.038;
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Naidu H, Huang Q, Mashimo H. Gastric antral vascular ectasia: the evolution of therapeutic modalities. Endosc Int Open. 2014 Jun; 2(2):E67-73. PMID: 26135263; PMCID: PMC4423327; DOI: 10.1055/s-0034-1365525;
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Franciosa M, Mashimo H. Stretta radiofrequency treatment for GERD: a safe and effective modality. Am J Gastroenterol. 2013 Oct; 108(10):1654-5.View Related Profiles. PMID: 24091508
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Locke GR, Horwhat J, Mashimo H, Savarino E, Zentilin P, Savarino V, Zerbib F, Armbruster SP, Wong RK, Moawad F. Endotherapy for and tailored approaches to treating GERD, and refractory GERD. Ann N Y Acad Sci. 2013 Oct; 1300:166-86. PMID: 24117641; DOI: 10.1111/nyas.12240;
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Chan WW, Mashimo H. Lubiprostone Increases Small Intestinal Smooth Muscle Contractions Through a Prostaglandin E Receptor 1 (EP1)-mediated Pathway. J Neurogastroenterol Motil. 2013 Jul; 19(3):312-8. PMID: 23875097; PMCID: PMC3714408; DOI: 10.5056/jnm.2013.19.3.312;
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Mashimo H. Subsquamous intestinal metaplasia after ablation of Barrett's esophagus: frequency and importance. Curr Opin Gastroenterol. 2013 Jul; 29(4):454-9. PMID: 23674187; DOI: 10.1097/MOG.0b013e3283622796;
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Tsai TH, Potsaid B, Tao YK, Jayaraman V, Jiang J, Heim PJ, Kraus MF, Zhou C, Hornegger J, Mashimo H, Cable AE, Fujimoto JG. Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology. Biomed Opt Express. 2013 Jul 1; 4(7):1119-32. PMID: 23847737; PMCID: PMC3704093; DOI: 10.1364/BOE.4.001119;
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Sun Q, Huang Q, Feng AN, Fan XS, Wu HY, Mashimo H, Zhou Q, Chen J, Lauwers GY. Columnar-lined esophagus in Chinese patients with proximal gastric carcinomas. J Dig Dis. 2013 Jan; 14(1):22-8. PMID: 23134360; DOI: 10.1111/1751-2980.12007;
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Tsai TH, Zhou C, Tao YK, Lee HC, Ahsen OO, Figueiredo M, Kirtane T, Adler DC, Schmitt JM, Huang Q, Fujimoto JG, Mashimo H. Structural markers observed with endoscopic 3-dimensional optical coherence tomography correlating with Barrett's esophagus radiofrequency ablation treatment response (with videos). Gastrointest Endosc. 2012 Dec; 76(6):1104-12. PMID: 22831857; PMCID: PMC3485415; DOI: 10.1016/j.gie.2012.05.024;
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Zhang YF, Shi J, Yu HP, Feng AN, Fan XS, Lauwers GY, Mashimo H, Gold JS, Chen G, Huang Q. Factors predicting survival in patients with proximal gastric carcinoma involving the esophagus. World J Gastroenterol. 2012 Jul 21; 18(27):3602-9. PMID: 22826627; PMCID: PMC3400864; DOI: 10.3748/wjg.v18.i27.3602;
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Tsai TH, Zhou C, Lee HC, Tao YK, Ahsen OO, Figueiredo M, Adler DC, Schmitt JM, Huang Q, Fujimoto JG, Mashimo H. Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett's Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography. Gastroenterol Res Pract. 2012; 2012:684832. PMID: 22844274; PMCID: PMC3400425; DOI: 10.1155/2012/684832;
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Huang Q, Shi J, Sun Q, Fan X, Feng A, Wu H, Zhou Q, Yu C, Mashimo H, Lauwers GY. Distal esophageal carcinomas in Chinese patients vary widely in histopathology, but adenocarcinomas remain rare. Hum Pathol. 2012 Dec; 43(12):2138-48. PMID: 22658274; DOI: 10.1016/j.humpath.2012.02.018;
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Zhou C, Kirtane T, Tsai TH, Lee HC, Adler DC, Schmitt JM, Huang Q, Fujimoto JG, Mashimo H. Cervical inlet patch-optical coherence tomography imaging and clinical significance. World J Gastroenterol. 2012 May 28; 18(20):2502-10. PMID: 22654447; PMCID: PMC3360448; DOI: 10.3748/wjg.v18.i20.2502;
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Zhou C, Tsai TH, Lee HC, Kirtane T, Figueiredo M, Tao YK, Ahsen OO, Adler DC, Schmitt JM, Huang Q, Fujimoto JG, Mashimo H. Characterization of buried glands before and after radiofrequency ablation by using 3-dimensional optical coherence tomography (with videos). Gastrointest Endosc. 2012 Jul; 76(1):32-40. PMID: 22482920; PMCID: PMC3396122; DOI: 10.1016/j.gie.2012.02.003;
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Zhou C, Kirtane T, Tsai TH, Lee HC, Adler DC, Schmitt J, Huang Q, Fujimoto JG, Mashimo H. Three-dimensional endoscopic optical coherence tomography imaging of cervical inlet patch. Gastrointest Endosc. 2012 Mar; 75(3):675-7; discussion 677. PMID: 22341118; PMCID: PMC3365542; DOI: 10.1016/j.gie.2011.11.009;
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Shaheen NJ, Overholt BF, Sampliner RE, Wolfsen HC, Wang KK, Fleischer DE, Sharma VK, Eisen GM, Fennerty MB, Hunter JG, Bronner MP, Goldblum JR, Bennett AE, Mashimo H, Rothstein RI, Gordon SR, Edmundowicz SA, Madanick RD, Peery AF, Muthusamy VR, Chang KJ, Kimmey MB, Spechler SJ, Siddiqui AA, Souza RF, Infantolino A, Dumot JA, Falk GW, Galanko JA, Jobe BA, Hawes RH, Hoffman BJ, Sharma P, Chak A, Lightdale CJ. Durability of radiofrequency ablation in Barrett's esophagus with dysplasia. Gastroenterology. 2011 Aug; 141(2):460-8. PMID: 21679712; PMCID: PMC3152658; DOI: 10.1053/j.gastro.2011.04.061;
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Huang Q, Shi J, Feng A, Fan X, Zhang L, Mashimo H, Cohen D, Lauwers G. Gastric cardiac carcinomas involving the esophagus are more adequately staged as gastric cancers by the 7th edition of the American Joint Commission on Cancer Staging System. Mod Pathol. 2011 Jan; 24(1):138-46. PMID: 20852593; DOI: 10.1038/modpathol.2010.183;
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Aguirre AD, Chen Y, Bryan B, Mashimo H, Huang Q, Connolly JL, Fujimoto JG. Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy. J Biomed Opt. 2010 Jan-Feb; 15(1):016025. PMID: 20210470; PMCID: PMC2847935; DOI: 10.1117/1.3322704;
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Adler DC, Zhou C, Tsai TH, Lee HC, Becker L, Schmitt JM, Huang Q, Fujimoto JG, Mashimo H. Three-dimensional optical coherence tomography of Barrett's esophagus and buried glands beneath neosquamous epithelium following radiofrequency ablation. Endoscopy. 2009 Sep; 41(9):773-6. PMID: 19746317; PMCID: PMC2890226; DOI: 10.1055/s-0029-1215045;
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Shaheen NJ, Sharma P, Overholt BF, Wolfsen HC, Sampliner RE, Wang KK, Galanko JA, Bronner MP, Goldblum JR, Bennett AE, Jobe BA, Eisen GM, Fennerty MB, Hunter JG, Fleischer DE, Sharma VK, Hawes RH, Hoffman BJ, Rothstein RI, Gordon SR, Mashimo H, Chang KJ, Muthusamy VR, Edmundowicz SA, Spechler SJ, Siddiqui AA, Souza RF, Infantolino A, Falk GW, Kimmey MB, Madanick RD, Chak A, Lightdale CJ. Radiofrequency ablation in Barrett's esophagus with dysplasia. N Engl J Med. 2009 May 28; 360(22):2277-88. PMID: 19474425; DOI: 10.1056/NEJMoa0808145;
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Becker L, Mashimo H. Further promise of stem cells therapies in the enteric nervous system. Gastroenterology. 2009 Jun; 136(7):2055-8. PMID: 19409291; DOI: 10.1053/j.gastro.2009.04.022;
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Adler DC, Zhou C, Tsai TH, Schmitt J, Huang Q, Mashimo H, Fujimoto JG. Three-dimensional endomicroscopy of the human colon using optical coherence tomography. Opt Express. 2009 Jan 19; 17(2):784-96. PMID: 19158891; PMCID: PMC2886288; DOI: 10.1364/oe.17.000784;
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Zhou C, Adler DC, Becker L, Chen Y, Tsai TH, Figueiredo M, Schmitt JM, Fujimoto JG, Mashimo H. Effective treatment of chronic radiation proctitis using radiofrequency ablation. Therap Adv Gastroenterol. 2009 Jan 01; 2(3):149-156. PMID: 20593010; PMCID: PMC2893353; DOI: 10.1177/1756283X08103341;
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Becker L, Huang Q, Mashimo H. Immunostaining of Lgr5, an intestinal stem cell marker, in normal and premalignant human gastrointestinal tissue. ScientificWorldJournal. 2008; 8:1168-76. PMID: 19030762; PMCID: PMC5848685; DOI: 10.1100/tsw.2008.148;
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Sivarao DV, Mashimo H, Goyal RK. Pyloric sphincter dysfunction in nNOS-/- and W/Wv mutant mice: animal models of gastroparesis and duodenogastric reflux. Gastroenterology. 2008 Oct; 135(4):1258-66. PMID: 18640116; PMCID: PMC2745304; DOI: 10.1053/j.gastro.2008.06.039;
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Chen Y, Aguirre AD, Hsiung PL, Huang SW, Mashimo H, Schmitt JM, Fujimoto JG. Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues. Opt Express. 2008 Feb 18; 16(4):2469-85. PMID: 18542326
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Zhang Y, Mashimo H, Paterson WG. Regional differences in nitrergic innervation of the smooth muscle of murine lower oesophageal sphincter. Br J Pharmacol. 2008 Feb; 153(3):517-27. PMID: 18037919; PMCID: PMC2241796; DOI: 10.1038/sj.bjp.0707573;
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Chen Y, Aguirre AD, Hsiung PL, Desai S, Herz PR, Pedrosa M, Huang Q, Figueiredo M, Huang SW, Koski A, Schmitt JM, Fujimoto JG, Mashimo H. Ultrahigh resolution optical coherence tomography of Barrett's esophagus: preliminary descriptive clinical study correlating images with histology. Endoscopy. 2007 Jul; 39(7):599-605.View Related Profiles. PMID: 17611914
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Hsiung PL, Pantanowitz L, Aguirre AD, Chen Y, Phatak D, Ko TH, Bourquin S, Schnitt SJ, Raza S, Connolly JL, Mashimo H, Fujimoto JG. Ultrahigh-resolution and 3-dimensional optical coherence tomography ex vivo imaging of the large and small intestines. Gastrointest Endosc. 2005 Oct; 62(4):561-74. PMID: 16185971
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Terauchi A, Kobayashi D, Mashimo H. Distinct roles of nitric oxide synthases and interstitial cells of Cajal in rectoanal relaxation. Am J Physiol Gastrointest Liver Physiol. 2005 Aug; 289(2):G291-9. PMID: 15845873
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Mashimo H, Wagh MS, Goyal RK. Surveillance and screening for Barrett esophagus and adenocarcinoma. J Clin Gastroenterol. 2005 Apr; 39(4 Suppl 2):S33-41. PMID: 15758657
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Herz P, Chen Y, Aguirre A, Fujimoto J, Mashimo H, Schmitt J, Koski A, Goodnow J, Petersen C. Ultrahigh resolution optical biopsy with endoscopic optical coherence tomography. Opt Express. 2004 Jul 26; 12(15):3532-42. PMID: 19483882
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Vallance BA, Dijkstra G, Qiu B, van der Waaij LA, van Goor H, Jansen PL, Mashimo H, Collins SM. Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity. Am J Physiol Gastrointest Liver Physiol. 2004 Oct; 287(4):G865-74. PMID: 15217783
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Chang HY, Mashimo H, Goyal RK. Musings on the wanderer: what's new in our understanding of vago-vagal reflex? IV. Current concepts of vagal efferent projections to the gut. Am J Physiol Gastrointest Liver Physiol. 2003 Mar; 284(3):G357-66. PMID: 12576302
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Sivarao DV, Mashimo HL, Thatte HS, Goyal RK. Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice. Gastroenterology. 2001 Jul; 121(1):34-42. PMID: 11438492
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Li XD, Boppart SA, Van Dam J, Mashimo H, Mutinga M, Drexler W, Klein M, Pitris C, Krinsky ML, Brezinski ME, Fujimoto JG. Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett's esophagus. Endoscopy. 2000 Dec; 32(12):921-30. PMID: 11147939; DOI: 10.1055/s-2000-9626;
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Mashimo H, Kjellin A, Goyal RK. Gastric stasis in neuronal nitric oxide synthase-deficient knockout mice. Gastroenterology. 2000 Sep; 119(3):766-73. PMID: 10982771
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Mashimo H, Goyal RK. Lessons from genetically engineered animal models. IV. Nitric oxide synthase gene knockout mice. Am J Physiol. 1999 Oct; 277(4 Pt 1):G745-50. PMID: 10516139
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Kim CD, Goyal RK, Mashimo H. Neuronal NOS provides nitrergic inhibitory neurotransmitter in mouse lower esophageal sphincter. Am J Physiol. 1999 Aug; 277(2 Pt 1):G280-4. PMID: 10444441
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Valenzuela D, Han X, Mende U, Fankhauser C, Mashimo H, Huang P, Pfeffer J, Neer EJ, Fishman MC. G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart. Proc Natl Acad Sci U S A. 1997 Mar 4; 94(5):1727-32. PMID: 9050846; PMCID: PMC19984
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Mashimo H, Wu DC, Podolsky DK, Fishman MC. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science. 1996 Oct 11; 274(5285):262-5. PMID: 8824194
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Behar O, Golden JA, Mashimo H, Schoen FJ, Fishman MC. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature. 1996 Oct 10; 383(6600):525-8. PMID: 8849723; DOI: 10.1038/383525a0;
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Mashimo H, He XD, Huang PL, Fishman MC, Goyal RK. Neuronal constitutive nitric oxide synthase is involved in murine enteric inhibitory neurotransmission. J Clin Invest. 1996 Jul 1; 98(1):8-13. PMID: 8690808; PMCID: PMC507393; DOI: 10.1172/JCI118781;
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Carpenter C, Honkanen AA, Mashimo H, Goss KA, Huang P, Fishman MC, Asaad M, Dorso CR, Cheung H. Renal abnormalities in mutant mice. Nature. 1996 Mar 28; 380(6572):292. PMID: 8598926; DOI: 10.1038/380292a0;
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Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman MC. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 1995 Sep 21; 377(6546):239-42. PMID: 7545787; DOI: 10.1038/377239a0;
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Mashimo H, Podolsky DK, Fishman MC. Structure and expression of murine intestinal trefoil factor: high evolutionary conservation and postnatal expression. Biochem Biophys Res Commun. 1995 May 5; 210(1):31-7. PMID: 7741746; DOI: 10.1006/bbrc.1995.1623;
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Strittmatter SM, Fankhauser C, Huang PL, Mashimo H, Fishman MC. Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43. Cell. 1995 Feb 10; 80(3):445-52. PMID: 7859286
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Mashimo H, Chorney MJ, Pontarotti P, Fisher DA, Hood L, Nathenson SG. Nucleotide sequence of the BALB/c H-2T region gene, T3d. Immunogenetics. 1992; 36(5):326-32. PMID: 1339405
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Zeff RA, Nakagawa M, Mashimo H, Gopas J, Nathenson SG. Failure of cell surface expression of a class I major histocompatibility antigen caused by somatic point mutation. Transplantation. 1990 Apr; 49(4):803-8. PMID: 2326874
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Chorney MJ, Mashimo H, Bushkin Y, Nathenson SG. Characterization of the thymus leukemia (TL) product encoded by the BALB/c T3c gene by DNA-mediated gene transfer. Comparison to the T13c product and BALB/c leukemia TL. J Immunol. 1989 Dec 1; 143(11):3762-8. PMID: 2584718
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Pontarotti PA, Mashimo H, Zeff RA, Fisher DA, Hood L, Mellor A, Flavell RA, Nathenson SG. Conservation and diversity in the class I genes of the major histocompatibility complex: sequence analysis of a Tlab gene and comparison with a Tlac gene. Proc Natl Acad Sci U S A. 1986 Mar; 83(6):1782-6. PMID: 3456611; PMCID: PMC323168
This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
| Year | Publications |
|---|
| 1986 | 1 |
| 1989 | 1 |
| 1990 | 1 |
| 1992 | 1 |
| 1995 | 3 |
| 1996 | 4 |
| 1997 | 1 |
| 1999 | 2 |
| 2000 | 2 |
| 2001 | 1 |
| 2003 | 1 |
| 2004 | 2 |
| 2005 | 3 |
| 2007 | 2 |
| 2008 | 3 |
| 2009 | 5 |
| 2010 | 2 |
| 2011 | 4 |
| 2012 | 7 |
| 2013 | 7 |
| 2014 | 11 |
| 2015 | 7 |
| 2016 | 4 |
| 2017 | 5 |
| 2018 | 5 |
| 2019 | 3 |
| 2020 | 6 |
| 2021 | 2 |
| 2022 | 1 |
| 2023 | 2 |
I serve on NIH T32 training grants in Gastroenterology at MGH, BIDMC, and BWH and have mentored numerous Gastroenterology and Research Fellows from Harvard and Boston Universities and M.I.T. who now hold academic positions and are thought-leaders. I helped structure and implement the Motility Training Program, an important ACGME component of Gastroenterology training programs. I directed a monthly multidisciplinary Boston Swallowing and Motility Disorders Group meeting and initiated and co-direct the annual Harvard CME course on gastrointestinal motility disorders, which enjoyed its sixteenth successful course. I serve on thesis committees, and I have authored chapters in the Joslin Diabetes textbook and in the Lange Current Diagnosis and Treatment of Gastroenterology, Hepatology and Endoscopy. I am a major contributor to the web-based resource for gastrointestinal motility disorders through Nature Publishing Company. I also served as a Tutor and Lecturer in the HMS Gastrointestinal Physiology course directed by Dr. Helen Shields (one of the highest ranked courses in the HMS curriculum), and participate in the transitional lecture series for the HST Students. I have mentored researchers in both clinical and basic sciences, and have published with them numerous papers in gastrointestinal motility, stem cells, and gene delivery systems. I advised on several company faculty councils for the making of educational slide sets on gastroesophageal reflux, Barrett disease, chronic constipation, and irritable bowel syndrome. Such educational work is being acknowledged through invited presentations, plenary session lectures, chairing of sessions at national and international meetings, and visiting professorships.
Available to Mentor as: (Review Mentor Role Definitions):
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Advisor
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Career Mentor
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Co-Mentor or Peer Mentor
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Education Mentor
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Project Mentor
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Research / Scholarly Mentor