Hiroshi Mashimo is currently Chief of Gastroenterology at the VA Boston Healthcare System, Assistant Professor of Medicine at Harvard Medical School and Adjunct Assistant Professor Of Medicine at Chobanian and Avedisian School of Medicine. He obtained his A.B. at Harvard College and his M.S., M.D. and Ph.D. degrees at Albert Einstein College of Medicine. He completed his medical internship, residency, and gastroenterology fellowship at Massachusetts General Hospital. His interest in molecular physiology led to advanced research and clinical training at Harvard Medical School, with Dr Daniel K. Podolsky and Dr Mark C. Fishman at Massachusetts General Hospital, and with Dr Raj K. Goyal at Beth Israel Hospital. His pioneering work using genetically altered mice models to understand basic gastrointestinal physiology has led to important understandings of the distinct roles of various mediators such as nitric oxide synthases and vasoactive intestinal peptides in the field of gastrointestinal motility. He has continued his interest in clinical gastrointestinal motility as Director of the Swallowing and Motility Disorders services at the VA Boston Healthcare, and is involved with training and teaching of students, residents and fellows at Brigham and Women's Hospital, the VA Boston Healthcare, and Harvard Medical School. He has published numerous original and review articles in various medical and scientific journals.
VA Boston Healthcare System
Stochastic Resonance Stimulation in the Gastrointestinal Tract
Tethered Capsule Imaging of the Esophagus
A 52-week, Randomized, Double-blind, Placebo-Controlled, Phase 3 Study to Evaluate the Safety and Efficacy of Relamorelin in Patients with Diabetic Gastroparesis (RLM-MD-04)
Optical Biopsy Using Optical Coherence Tomography
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Triadafilopoulos G, Mashimo H, Tatum R, O'Clarke J, Hawn M. Mixed Esophageal Disease (MED): A New Concept. Dig Dis Sci. 2023 Sep; 68(9):3542-3554. PMID: 37470896
Kumar S, Zhao J, Talluri S, Buon L, Mu S, Potluri LB, Liao C, Shi J, Chakraborty C, Gonzalez GB, Tai YT, Patel J, Pal J, Mashimo H, Samur MK, Munshi NC, Shammas MA. Elevated APE1 Dysregulates Homologous Recombination and Cell Cycle Driving Genomic Evolution, Tumorigenesis, and Chemoresistance in Esophageal Adenocarcinoma. Gastroenterology. 2023 Aug; 165(2):357-373.View Related Profiles. PMID: 37178737; PMCID: PMC10524563; DOI: 10.1053/j.gastro.2023.04.035;
Guadagnoli L, Mashimo H, Lo WK. Assessment of Post-traumatic Stress Disorder Among Objective Esophageal Motility and Reflux Phenotypes in Symptomatic Veterans. J Clin Psychol Med Settings. 2023 Sep; 30(3):606-617. PMID: 36378471
Zhang J, Nguyen T, Potsaid B, Jayaraman V, Burgner C, Chen S, Li J, Liang K, Cable A, Traverso G, Mashimo H, Fujimoto JG. Multi-MHz MEMS-VCSEL swept-source optical coherence tomography for endoscopic structural and angiographic imaging with miniaturized brushless motor probes. Biomed Opt Express. 2021 Apr 01; 12(4):2384-2403. PMID: 33996236; PMCID: PMC8086463; DOI: 10.1364/BOE.420394;
Fass OZ, Mashimo H. The Effect of Bariatric Surgery and Endoscopic Procedures on Gastroesophageal Reflux Disease. J Neurogastroenterol Motil. 2021 Jan 30; 27(1):35-45. PMID: 33380553; PMCID: PMC7786084; DOI: 10.5056/jnm20169;
Nguyen TH, Ahsen OO, Liang K, Zhang J, Mashimo H, Fujimoto JG. Correction of circumferential and longitudinal motion distortion in high-speed catheter/endoscope-based optical coherence tomography. Biomed Opt Express. 2021 Jan 01; 12(1):226-246. PMID: 33520383; PMCID: PMC7818954; DOI: 10.1364/BOE.409074;
Rodriguez-Diaz E, Baffy G, Lo WK, Mashimo H, Vidyarthi G, Mohapatra SS, Singh SK. Real-time artificial intelligence-based histologic classification of colorectal polyps with augmented visualization. Gastrointest Endosc. 2021 03; 93(3):662-670.View Related Profiles. PMID: 32949567
Banting SP, Badgery HE, Read M, Mashimo H. Rethinking gastroesophageal reflux disorder. Ann N Y Acad Sci. 2020 12; 1482(1):177-192. PMID: 32875572
Liang K, Ahsen OO, Murphy A, Zhang J, Nguyen TH, Potsaid B, Figueiredo M, Huang Q, Mashimo H, Fujimoto JG. Tethered capsule en face optical coherence tomography for imaging Barrett's oesophagus in unsedated patients. BMJ Open Gastroenterol. 2020 09; 7(1). PMID: 32883714; PMCID: PMC7473663; DOI: 10.1136/bmjgast-2020-000444;
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I serve on NIH T32 training grants in Gastroenterology at MGH, BIDMC, and BWH and have mentored numerous Gastroenterology and Research Fellows from Harvard and Boston Universities and M.I.T. who now hold academic positions and are thought-leaders. I helped structure and implement the Motility Training Program, an important ACGME component of Gastroenterology training programs. I directed a monthly multidisciplinary Boston Swallowing and Motility Disorders Group meeting and initiated and co-direct the annual Harvard CME course on gastrointestinal motility disorders, which enjoyed its sixteenth successful course. I serve on thesis committees, and I have authored chapters in the Joslin Diabetes textbook and in the Lange Current Diagnosis and Treatment of Gastroenterology, Hepatology and Endoscopy. I am a major contributor to the web-based resource for gastrointestinal motility disorders through Nature Publishing Company. I also served as a Tutor and Lecturer in the HMS Gastrointestinal Physiology course directed by Dr. Helen Shields (one of the highest ranked courses in the HMS curriculum), and participate in the transitional lecture series for the HST Students. I have mentored researchers in both clinical and basic sciences, and have published with them numerous papers in gastrointestinal motility, stem cells, and gene delivery systems. I advised on several company faculty councils for the making of educational slide sets on gastroesophageal reflux, Barrett disease, chronic constipation, and irritable bowel syndrome. Such educational work is being acknowledged through invited presentations, plenary session lectures, chairing of sessions at national and international meetings, and visiting professorships.
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