I am a medical oncologist who has clinical and research expertise in genitourinary medical oncology as well as clinical trials. My clinical practice is at Boston Medical Center and includes adult patients with cancers of the prostate, kidney, bladder, testicles and penis, as well as other solid cancers. My treatment expertise is in hormonal agents, chemotherapy, immunotherapy, targeted therapies, radioactive pharmaceuticals, bone targeted therapies, supportive and palliative care. I am also an educator in the Chobanian and Avedisian School of Medicine and Boston Medical Center Hematology and Oncology Fellowship Program.
Diversity, Equity, Inclusion and Accessibility
I am deeply committed to promoting diversity and inclusion in academia and medicine. I welcome and celebrate individuals of all races, ethnicities, social backgrounds, religion, gender, sex, age, disability, sexual orientation, veteran status, and national origin. I am a part of a dedicated team of healthcare professionals, researchers, students and staff that serves the communities of Boston and its surroundings. I have great pride working at a large academic medical center and safety-net hospital that shares my goal to provide equitable cutting edge clinical care and research opportunities to our patients. I am dedicated to continuing research, clinical and career mentorship for trainees at all levels at Chobanian and Avedisian School of Medicine and Boston Medical Center. My clinical research is focused on improving equity in prostate cancer care and these initiatives have been supported through grant funded research (e.g. DOD and NIH) and have resulted in peer reviewed publications.
Member
Boston University
BU-BMC Cancer Center
Member
Boston University
Evans Center for Interdisciplinary Biomedical Research
This tab shows grant data from BMC Sponsored Research. It includes:
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from BU Sponsored Research. It includes:
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data that did not automatically get imported into Profiles
from BU or BMC sources.
- Grant title
- Project period and this person’s role on the grant
- PI name, if this person is not the PI (the name will link if PI has a BU Profile)
- Funding source(s). An arrow indicates the flow of funding if multiple sponsors.
- Some grants will show an agency award/project number, and may be a link.
- Data is sorted by project end date, and updated monthly.
This tab shows grant data from the Boston VA. We are only showing grant title, and only for people in the role of PI.
A Phase 3, Randomized, Double-Blind, Multicenter Trial Comparing Orternel (TAK-700) Plus Prednisone06/01/2011 - 11/16/2015 (PI)
Millennium Pharmaceuticals, Inc.
A Randomized phase 3 Study Comparing Cabazitaxel/Prednisone in Combination with Custirsen to Cabazitaxel/Prednisone for second line chemotherapy in men with metastatic castrte resistant prostate cance09/28/2012 - 08/13/2015 (PI)
OncoGenex Technologies, Inc
A phase 3, Randomized, Double-blind, controlled study of cabozantinib (XL184) vs. Prednisone in Metastatic castration resistant prostate cancer patients who have received prior cocetaxel and prior abi10/19/2012 - 10/19/2014 (PI)
Exelixis, Inc
A Phase 3, Randomized, Double-Blind, Multicenter Trial Comparing Orternel (TAK-700) Plus Prednisone06/01/2011 - 05/31/2014 (PI)
Millennium Pharmaceuticals, Inc.
A Phase 3, Randomized, Double-Blind, Multicenter Trial Comparing Orteronel (TAK-700) Plus Prednisone with Placebo Plus Prednisone in Patients with Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer06/01/2011 - 05/31/2014 (PI)
Millennium Pharmaceuticals, Inc.
DFCI 21-575 - A Phase 2 study of avelumab, axitinib and palbociclib in metastatic renal cell carcinoma03/21/2022 - 03/20/2024 (PI)
Dana Farber Cancer Institute
Precision Interception of Aggressive Prostate Cancer in African American Men09/18/2018 - 08/31/2022 (PI)
Dana Farber Cancer Institute National Cancer Inst5P20CA233255-03
CA209-9KD-07012/03/2018 - 12/03/2021 (PI)
Bristol-Myers Squibb Company
SGN22E-003: An open-label, randomized, controlled phase 3 study of enfortumab vedotin in combination with pembrolizumab with or without chemotherapy, versus chemotherapy alone in previously untreated locally advanced or metastatic urothelial cancer10/02/2020 - 10/01/2021 (PI)
Seattle Genetics, Inc.
Racial Differences in Androgen Receptor Splice Variants in Men with Localized Prostate Cancer03/01/2018 - 05/31/2021 (PI)
The General Hospital Corporation / MGH Dept of Defense
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Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
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to make corrections and additions.
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Khosla H, Bhatt S, Wang MJ, Gignac G, Mittal K, Patel J. Enfortumab-vedotin use for urothelial carcinoma in two patients on hemodialysis. J Oncol Pharm Pract. 2024 Jul; 30(5):941-944. PMID: 38470473
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Gunn CM, Gignac G, Hardy B, Zayhowski K, Pankowska M, Loo S, Wang C. Characterizing Referrals for Prostate Cancer Genetic Services in a Safety-Net Hospital. JCO Oncol Pract. 2023 Oct; 19(10):852-859.View Related Profiles. PMID: 37384869; DOI: 10.1200/OP.23.00055;
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Jafari N, Chen A, Kolla M, Pompa IR, Qiu Y, Yu R, Llevenes P, Ennis CS, Mori J, Mahdaviani K, Halpin M, Gignac GA, Heaphy CM, Monti S, Denis GV. Novel plasma exosome biomarkers for prostate cancer progression in co-morbid metabolic disease. Adv Cancer Biol Metastasis. 2022 Dec; 6.View Related Profiles. PMID: 36644690; PMCID: PMC9836031; DOI: 10.1016/j.adcanc.2022.100073;
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Quintiliani LM, Murray GF, Waite K, Salerno K, Gignac GA, Yuh D, Volandes A, Paasche-Orlow MK. "I'm in My Feelings Now": Examination of Advance Care Planning Video Declarations by People with Advanced Cancer from a Safety Net Hospital. J Palliat Med. 2023 Jan; 26(1):28-34.View Related Profiles. PMID: 35708552
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Mori JO, Shafran JS, Stojanova M, Katz MH, Gignac GA, Wisco JJ, Heaphy CM, Denis GV. Novel forms of prostate cancer chemoresistance to successful androgen deprivation therapy demand new approaches: Rationale for targeting BET proteins. Prostate. 2022 Jun; 82(10):1005-1015.View Related Profiles. PMID: 35403746; PMCID: PMC11134172; DOI: 10.1002/pros.24351;
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Chua S, Qureshi MM, Boyd G, Gignac GA, Hirsch AE. Outcomes for Young Men With Localized Intermediate-Risk Prostate Cancer: An Analysis of the NCDB. Clin Genitourin Cancer. 2020 10; 18(5):e531-e542.View Related Profiles. PMID: 32220567
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Karantanos T, Karanika S, Seth B, Gignac G. The absolute lymphocyte count can predict the overall survival of patients with non-small cell lung cancer on nivolumab: a clinical study. Clin Transl Oncol. 2019 Feb; 21(2):206-212.View Related Profiles. PMID: 29948974
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Kan CK, Qureshi MM, Gupta A, Agarwal A, Gignac GA, Bloch BN, Thoreson N, Hirsch AE. Risk factors involved in treatment delays and differences in treatment type for patients with prostate cancer by risk category in an academic safety net hospital. Adv Radiat Oncol. 2018 Apr-Jun; 3(2):181-189.View Related Profiles. PMID: 29904743; PMCID: PMC6000162; DOI: 10.1016/j.adro.2017.12.002;
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Showing 10 of 22 results.
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Gunnarsson O, Basaria S, Gignac GA. Cardiometabolic and skeletal risk factors in black men with prostate cancer starting androgen deprivation therapy. Cancers (Basel). 2015; 7(2):679-87. PMID: 25913100; PMCID: PMC4491678; DOI: 10.3390/cancers7020679;
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Gunnarsson O, Basaria S, Gignac G. The prevalence of metabolic risk factors in black men with prostate cancer undergoing consideration for androgen-deprivation therapy. J Clin Oncol. 2011 May 20; 29(15_suppl):e15082. PMID: 28020432
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Hirsch AE, Cuaron JJ, Janicek MJ, Mui K, Lee RJ, Wang DS, Babayan RK, Zumwalt AC, Gignac GA, Tao W, Ozonoff A, Zietman AL. Anatomic differences after robotic-assisted radical prostatectomy and open prostatectomy: implications for radiation field design. Pract Radiat Oncol. 2011 Apr-Jun; 1(2):115-25.View Related Profiles. PMID: 24673925; DOI: 10.1016/j.prro.2010.11.007;
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Ariel E. Hirsch, John J. Cuaron, Milos J. Janicek, Kit Mui, Richard J. Lee, David S. Wang, Richard K. Babayan, Ann C. Zumwalt, Gretchen A. Gignac, Wen Tao, Alexander Ozonoff, Anthony L. Zietman et al. . Anatomic differences after robotic-assisted radical prostatectomy and open prostatectomy: implications for radiation field design. Practical Radiation Oncology. 2011; 1(2):115-125.
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Chi D, Hirsch AE, Gignac GA. Biochemical failure after radiation therapy for prostate cancer: Racial differences. J Clin Oncol. 2009 May 20; 27(15_suppl):e16071.View Related Profiles. PMID: 27963037
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Dickstein RJ, Kreshover JE, Milose JC, Gignac GA. Metastatic prostate cancer at diagnosis: Clinical presentation in the post-PSA era. J Clin Oncol. 2009 May 20; 27(15_suppl):e16159. PMID: 27963401
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Morris MJ, Pandit-Taskar N, Carrasquillo J, Divgi CR, Slovin S, Kelly WK, Rathkopf D, Gignac GA, Solit D, Schwartz L, Stephenson RD, Hong C, Delacruz A, Curley T, Heller G, Jia X, O'Donoghue J, Larson S, Scher HI. Phase I study of samarium-153 lexidronam with docetaxel in castration-resistant metastatic prostate cancer. J Clin Oncol. 2009 May 20; 27(15):2436-42. PMID: 19364960; PMCID: PMC2684850; DOI: 10.1200/JCO.2008.20.4164;
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Gignac GA, Morris MJ, Heller G, Schwartz LH, Scher HI. Assessing outcomes in prostate cancer clinical trials: a twenty-first century tower of Babel. Cancer. 2008 Sep 1; 113(5):966-74. PMID: 18661513; PMCID: PMC2708077; DOI: 10.1002/cncr.23719;
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Danila DC, Heller G, Gignac GA, Gonzalez-Espinoza R, Anand A, Tanaka E, Lilja H, Schwartz L, Larson S, Fleisher M, Scher HI. Circulating tumor cell number and prognosis in progressive castration-resistant prostate cancer. Clin Cancer Res. 2007 Dec 1; 13(23):7053-8. PMID: 18056182
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Gignac GA, Morris MJ, Hussain M. Castration resistant, taxane naïve metastatic prostate cancer: current clinical approaches and future directions. J Urol. 2007 Sep; 178(3 Pt 2):S30-5. PMID: 17644121
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Gignac GA, Morris MJ, Schwartz LH, Lis E, Scher HI. Magnetic resonance imaging of the bone marrow (MRBM) as an outcome measure for patients with metastatic prostate cancer. J Clin Oncol. 2006 Jun 20; 24(18_suppl):14521. PMID: 27954667
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Vaughn DJ, Gignac GA, Meadows AT. Long-term medical care of testicular cancer survivors. Ann Intern Med. 2002 Mar 19; 136(6):463-70. PMID: 11900499
This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
| Year | Publications |
|---|
| 2002 | 1 |
| 2006 | 1 |
| 2007 | 2 |
| 2008 | 1 |
| 2009 | 3 |
| 2011 | 3 |
| 2015 | 1 |
| 2016 | 1 |
| 2017 | 1 |
| 2018 | 1 |
| 2020 | 1 |
| 2022 | 3 |
| 2023 | 2 |
| 2024 | 1 |