Gary Gilbert, MD
Adjunct Associate Professor
Boston University School of Medicine
Dept of Medicine
Hematology & Medical Oncology

MD, Loma Linda University




Dr. Gary Gilbert, M.D. is the Deputy Associate Chief of Staff for Research and Development at the VA Boston Healthcare System. In his capacity, he oversees the basic science activities at all three campuses and has charge of major initiatives to import new technical capabilities and build a major expansion of the animal facilities He also serves as a member of BVARI’s Board of Directors. Dr. Gilbert is Associate Physician in Medicine, Brigham and Women’s Hospital and the Associate Professor of Medicine, Harvard medical School.

His research interests target understanding the mechanisms through which activity of blood coagulation proteins is regulated on cell membranes. He has four categories of research in his laboratory:

1. To study the characterization of the mechanism through which lactadherin binds to membranes and functions as an anticoagulant in vitro. This includes structure-function studies to identify essential features of the interaction.

2. To utilize lactadherin and probes derived from lactadherin to identify procoagulant membranes in vivo and to probe the importance.

3. To identify the functional amino acids on the membrane-interactive C1 and C2 domains of factor VIII. This project may lead to engineering factor VIII so that the product molecule has higher specific activity and a slower rate of clearance.

4. To seek to determine through what mechanisms phospholipid molecules activate the factor VIIIa-factor IXa enzyme complex. This information will provide improved basic insight and, possibly, a novel approach to treatment of hemophilia patients that have developed inhibitory antibodies to factor VIII.

VA Boston Healthcare System







Yr Title Project-Sub Proj Pubs
2019 Endothelial topography, phosphatidylserine, and procoagulant activity 5I01BX001352-07
2018 Endothelial topography, phosphatidylserine, and procoagulant activity 5I01BX001352-06
2017 Endothelial topography, phosphatidylserine, and procoagulant activity 2I01BX001352-05
2015 Endothelial cell phosphatidylserine, topography, and procoagulant activity 5I01BX001352-04
2014 Endothelial cell phosphatidylserine, topography, and procoagulant activity 5I01BX001352-03
2013 Endothelial cell phosphatidylserine, topography, and procoagulant activity 5I01BX001352-02
2002 PHOSPHOLIPID BINDING STRUCTURES OF FACTOR VIII 5P01HL042443-14-7 92
2001 PHOSPHOLIPID BINDING STRUCTURES OF FACTOR VIII 5P01HL042443-13-7 92
2001 FUNCTION OF FACTOR VIII ON THE PLATELET MEMBRANE 5R01HL057867-04 4
2000 PHOSPHOLIPID BINDING STRUCTURES OF FACTOR VIII 5P01HL042443-12-7 92
Showing 10 of 21 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Gilbert GE. The evolving understanding of factor VIII binding sites and implications for the treatment of hemophilia A. Blood Rev. 2019 01; 33:1-5. PMID: 29866493; DOI: 10.1016/j.blre.2018.05.001;.
     
  2. Sakurai Y, Hardy ET, Ahn B, Tran R, Fay ME, Ciciliano JC, Mannino RG, Myers DR, Qiu Y, Carden MA, Baldwin WH, Meeks SL, Gilbert GE, Jobe SM, Lam WA. A microengineered vascularized bleeding model that integrates the principal components of hemostasis. Nat Commun. 2018 02 06; 9(1):509. PMID: 29410404; DOI: 10.1038/s41467-018-02990-x;.
     
  3. Gilbert GE. Inhibitory antibodies against factor VIII C1 domain. Blood. 2016 10 20; 128(16):2001-2002. PMID: 28157676; DOI: 10.1182/blood-2016-08-727818;.
     
  4. Gao C, Xie R, Yu C, Ma R, Dong W, Meng H, Zhang Y, Si Y, Zhang Z, Novakovic V, Zhang Y, Kou J, Bi Y, Li B, Xie R, Gilbert GE, Zhou J, Shi J. Thrombotic Role of Blood and Endothelial Cells in Uremia through Phosphatidylserine Exposure and Microparticle Release. PLoS One. 2015; 10(11):e0142835. PMID: 26580207; DOI: 10.1371/journal.pone.0142835;.
     
  5. Gilbert GE, Novakovic VA, Shi J, Rasmussen J, Pipe SW. Platelet binding sites for factor VIII in relation to fibrin and phosphatidylserine. Blood. 2015 Sep 03; 126(10):1237-44. PMID: 26162408; DOI: 10.1182/blood-2015-01-620245;.
     
  6. Pantazatos D, Gessner CR, Woods VL, Gilbert GE. Changes in the Factor VIII C2 domain upon membrane binding determined by hydrogen-deuterium exchange MS. Biochem J. 2014 Aug 01; 461(3):443-51. PMID: 24814520; DOI: 10.1042/BJ20140121;.
     
  7. Gilbert GE. Factor VIII inhibitor epitopes and an enigma. Blood. 2013 Dec 19; 122(26):4160-1. PMID: 24357711; DOI: 10.1182/blood-2013-10-531822;.
     
  8. Nyegaard S, Novakovic VA, Rasmussen JT, Gilbert GE. Lactadherin inhibits secretory phospholipase A2 activity on pre-apoptotic leukemia cells. PLoS One. 2013; 8(10):e77143. PMID: 24194865; DOI: 10.1371/journal.pone.0077143;.
     
  9. Gao C, Xie R, Li W, Zhou J, Liu S, Cao F, Liu Y, Ma R, Si Y, Liu Y, Bi Y, Gilbert GE, Shi J. Endothelial cell phagocytosis of senescent neutrophils decreases procoagulant activity. Thromb Haemost. 2013 Jun; 109(6):1079-90. PMID: 23571768; DOI: 10.1160/TH12-12-0894;.
     
  10. Gilbert GE, Novakovic VA, Kaufman RJ, Miao H, Pipe SW. Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity. Blood. 2012 Aug 30; 120(9):1923-32. PMID: 22613792; DOI: 10.1182/blood-2012-01-408245;.
     
Showing 10 of 53 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 53 publications over 26 distinct years, with a maximum of 5 publications in 2009

YearPublications
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19953
19962
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19983
19991
20001
20012
20021
20043
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20114
20123
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20141
20152
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20182
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72 E. Concord St Building A
Boston MA 02118
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