David Thornton | Profiles RNS

David J. Thornton, MD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Infectious Diseases

MD, Stanford University School of Medicine
MS, Stanford University
AB, Harvard College

Websites

	Harvard Catalyst
	ResearchGate

Dr. Thornton, MD practices Infectious Disease in West Roxbury, MA. Dr. Thornton graduated from Stanford University School of Medicine in 1997 and has been in practice for 22 years. He completed a residency at Boston University Medical Center.

VA Boston Healthcare System

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Mair I, Bennett AR, Forman R, Othman AA, Logunova L, Smith H, Lowe AE, Bradley JE, Thornton DJ, Else KJ. T. Muris Infection Dynamics of a Fresh, Wild Isolate: Is the Established E Isolate Still Relevant? Parasite Immunol. 2024 Nov; 46(11):e13072. PMID: 39480064

Dubaissi E, Hilton EN, Lilley S, Collins R, Holt C, March P, Danahay H, Gosling M, Grencis RK, Roberts IS, Thornton DJ. The Tmem16a chloride channel is required for mucin maturation after secretion from goblet-like cells in the Xenopus tropicalis tadpole skin. Sci Rep. 2024 Oct 26; 14(1):25555. PMID: 39461969; PMCID: PMC11514049; DOI: 10.1038/s41598-024-76482-y;

Kishimoto H, Ridley C, Inoue K, Thornton DJ. Assessment of polymeric mucin-drug interactions. PLoS One. 2024; 19(6):e0306058. PMID: 38935605; PMCID: PMC11210812; DOI: 10.1371/journal.pone.0306058;

Bennett AR, Mair I, Muir A, Smith H, Logunova L, Wolfenden A, Fenn J, Lowe AE, Bradley JE, Else KJ, Thornton DJ. Sex drives colonic mucin sialylation in wild mice. Sci Rep. 2024 Mar 23; 14(1):6954. PMID: 38521809; PMCID: PMC10960830; DOI: 10.1038/s41598-024-57249-x;

Herrera JA, Dingle LA, Monetero MA, Venkateswaran RV, Blaikley JF, Granato F, Pearson S, Lawless C, Thornton DJ. Morphologically intact airways in lung fibrosis have an abnormal proteome. Respir Res. 2023 Apr 01; 24(1):99. PMID: 37005656; PMCID: PMC10066954; DOI: 10.1186/s12931-023-02400-x;

Funjika E, Colombo SAP, Hayes KS, Tozer MJ, Tyrrell KA, Cai S, Faniyi AA, Shears RK, Dooley M, Alshammari Y, Alhazmi W, Assas M, Almilaibary A, Jackson-Jones LH, Thornton DJ, Worthington JJ, Grencis RK. High-fat diet-induced resistance to helminth infection via alternative induction of type 2 immunity. Mucosal Immunol. 2023 Feb; 16(1):27-38. PMID: 36690078

Ehre C, Hansson GC, Thornton DJ, Ostedgaard LS. Mucus aberrant properties in CF: Insights from cells and animal models. J Cyst Fibros. 2023 Mar; 22 Suppl 1(Suppl 1):S23-S26. PMID: 36117114; PMCID: PMC10018425; DOI: 10.1016/j.jcf.2022.08.019;

Kishimoto H, Ridley C, Thornton DJ. The lipophilic cyclic peptide cyclosporin A induces aggregation of gel-forming mucins. Sci Rep. 2022 Apr 13; 12(1):6153. PMID: 35418571

Duque-Correa MA, Goulding D, Rodgers FH, Gillis JA, Cormie C, Rawlinson KA, Bancroft AJ, Bennett HM, Lotkowska ME, Reid AJ, Speak AO, Scott P, Redshaw N, Tolley C, McCarthy C, Brandt C, Sharpe C, Ridley C, Moya JG, Carneiro CM, Starborg T, Hayes KS, Holroyd N, Sanders M, Thornton DJ, Grencis RK, Berriman M. Defining the early stages of intestinal colonisation by whipworms. Nat Commun. 2022 Apr 01; 13(1):1725. PMID: 35365634

Ramphul M, Welsh KG, May RD, Ghebre MA, Rapley L, Cohen ES, Herath A, Monteiro W, Rousseau K, Thornton DJ, Brightling CE, Gaillard EA. Sputum biomarkers during acute severe asthma attacks in children-a case-control study. Acta Paediatr. 2022 Mar; 111(3):620-627. PMID: 34773288

Showing 10 of 146 results. Show More

Carpenter J, Wang Y, Gupta R, Li Y, Haridass P, Subramani DB, Reidel B, Morton L, Ridley C, O'Neal WK, Buisine MP, Ehre C, Thornton DJ, Kesimer M. Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B. Proc Natl Acad Sci U S A. 2021 Sep 28; 118(39). PMID: 34548396

McShane A, Bath J, Jaramillo AM, Ridley C, Walsh AA, Evans CM, Thornton DJ, Ribbeck K. Mucus. Curr Biol. 2021 Aug 09; 31(15):R938-R945. PMID: 34375594

Holliday SB, Sreenivasan S, Elbogen E, Thornton D, McGuire J. Factors associated with repeat sexual offending among U.S. military veterans compared to civilians. Int J Forensic Ment Health. 2022; 21(2):120-132. PMID: 35845180

Fillmore NR, Elbers DC, La J, Feldman TC, Sung FC, Hall RB, Nguyen V, Link N, Zwolinski R, Dipietro S, Miller SJ, Aleksanyan A, Goryachev SD, Corcoran P, Bergstrom SJ, Parenteau MA, Sprague RS, Thornton DJ, Driver JA, Strymish JM, Evans S, Colonna B, Brophy MT, Do NV. Corrigendum to: An Application to Support COVID-19 Occupational Health and Patient Tracking at a Veterans Affairs Medical Center. J Am Med Inform Assoc. 2021 03 01; 28(3):673.View Related Profiles.

Elbers, Danne
Thornton, David
La, Jennifer
Brophy, Mary
Fillmore, Nathanael

PMID: 33306790; PMCID: PMC7799026; DOI: 10.1093/jamia/ocaa317;

Morgan LE, Jaramillo AM, Shenoy SK, Raclawska D, Emezienna NA, Richardson VL, Hara N, Harder AQ, NeeDell JC, Hennessy CE, El-Batal HM, Magin CM, Grove Villalon DE, Duncan G, Hanes JS, Suk JS, Thornton DJ, Holguin F, Janssen WJ, Thelin WR, Evans CM. Disulfide disruption reverses mucus dysfunction in allergic airway disease. Nat Commun. 2021 Jan 11; 12(1):249. PMID: 33431872

Fillmore NR, Elbers DC, La J, Feldman TC, Sung FC, Hall RB, Nguyen V, Link N, Zwolinski R, Dipietro S, Miller SJ, Aleksanyan A, Goryachev SD, Corcoran P, Bergstrom SJ, Parenteau MA, Sprague RS, Thornton DJ, Driver JA, Strymish JM, Evans S, Colonna B, Brophy MT, Do NV. An application to support COVID-19 occupational health and patient tracking at a Veterans Affairs medical center. J Am Med Inform Assoc. 2020 11 01; 27(11):1716-1720.View Related Profiles.

Elbers, Danne
Thornton, David
La, Jennifer
Brophy, Mary
Fillmore, Nathanael
Van Do, Nhan

PMID: 33067628; PMCID: PMC7665524; DOI: 10.1093/jamia/ocaa162;

Yakovchenko V, DeSotto K, Drainoni ML, Lukesh W, Miller DR, Park A, Shao Q, Thornton DJ, Gifford AL. Using Lean-Facilitation to Improve Quality of Hepatitis C Testing in Primary Care. J Gen Intern Med. 2021 02; 36(2):349-357.View Related Profiles.

Gifford, Allen
Thornton, David
Drainoni, Mari-Lynn

PMID: 32930938; PMCID: PMC7878607; DOI: 10.1007/s11606-020-06210-5;

Denneny E, Sahota J, Beatson R, Thornton D, Burchell J, Porter J. Mucins and their receptors in chronic lung disease. Clin Transl Immunology. 2020; 9(3):e01120. PMID: 32194962

Ramsey KA, Chen ACH, Radicioni G, Lourie R, Martin M, Broomfield A, Sheng YH, Hasnain SZ, Radford-Smith G, Simms LA, Burr L, Thornton DJ, Bowler SD, Livengood S, Ceppe A, Knowles MR, Noone PG, Donaldson SH, Hill DB, Ehre C, Button B, Alexis NE, Kesimer M, Boucher RC, McGuckin MA. Airway Mucus Hyperconcentration in Non-Cystic Fibrosis Bronchiectasis. Am J Respir Crit Care Med. 2020 Mar 15; 201(6):661-670. PMID: 31765597

Hakim A, Braun H, Thornton D, Strymish J. Successful treatment of methicillin-sensitive Staphylococcus aureus tricuspid-valve endocarditis with dalbavancin as an outpatient in a person who injects drugs: A case report. Int J Infect Dis. 2020 Feb; 91:202-205. PMID: 31841726

Hughes GW, Ridley C, Collins R, Roseman A, Ford R, Thornton DJ. The MUC5B mucin polymer is dominated by repeating structural motifs and its topology is regulated by calcium and pH. Sci Rep. 2019 Nov 22; 9(1):17350. PMID: 31758042

Glover M, Colombo SAP, Thornton DJ, Grencis RK. Trickle infection and immunity to Trichuris muris. PLoS Pathog. 2019 Nov; 15(11):e1007926. PMID: 31730667

Campbell L, Hepworth MR, Whittingham-Dowd J, Thompson S, Bancroft AJ, Hayes KS, Shaw TN, Dickey BF, Flamar AL, Artis D, Schwartz DA, Evans CM, Roberts IS, Thornton DJ, Grencis RK. ILC2s mediate systemic innate protection by priming mucus production at distal mucosal sites. J Exp Med. 2019 Dec 02; 216(12):2714-2723. PMID: 31582416

Ridley C, Lockhart-Cairns MP, Collins RF, Jowitt TA, Subramani DB, Kesimer M, Baldock C, Thornton DJ. The C-terminal dimerization domain of the respiratory mucin MUC5B functions in mucin stability and intracellular packaging before secretion. J Biol Chem. 2019 Nov 08; 294(45):17105-17116. PMID: 31570524

Ronan MV, Menon A, Swamy L, Thornton D. Experiential Learning Through Local Implementation of a National Chief Resident in Quality and Patient Safety Curriculum. Am J Med Qual. 2020 Mar/Apr; 35(2):171-176.View Related Profiles.

Thornton, David
Swamy, Lakshman
Ronan, Matthew

PMID: 31248264

Bancroft AJ, Levy CW, Jowitt TA, Hayes KS, Thompson S, Mckenzie EA, Ball MD, Dubaissi E, France AP, Bellina B, Sharpe C, Mironov A, Brown SL, Cook PC, S MacDonald A, Thornton DJ, Grencis RK. The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function. Nat Commun. 2019 May 28; 10(1):2344. PMID: 31138806

Fernandez-Petty CM, Hughes GW, Bowers HL, Watson JD, Rosen BH, Townsend SM, Santos C, Ridley CE, Chu KK, Birket SE, Li Y, Leung HM, Mazur M, Garcia BA, Evans TIA, Libby EF, Hathorne H, Hanes J, Tearney GJ, Clancy JP, Engelhardt JF, Swords WE, Thornton DJ, Wiesmann WP, Baker SM, Rowe SM. A glycopolymer improves vascoelasticity and mucociliary transport of abnormal cystic fibrosis mucus. JCI Insight. 2019 Apr 18; 4(8). PMID: 30996141

Svedberg FR, Brown SL, Krauss MZ, Campbell L, Sharpe C, Clausen M, Howell GJ, Clark H, Madsen J, Evans CM, Sutherland TE, Ivens AC, Thornton DJ, Grencis RK, Hussell T, Cunoosamy DM, Cook PC, MacDonald AS. The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation. Nat Immunol. 2019 May; 20(5):571-580. PMID: 30936493

Rubin BK, Thornton DJ. Dropping acid: why is cystic fibrosis mucus abnormal? Eur Respir J. 2018 Dec; 52(6). PMID: 30523208

Ridley C, Thornton DJ. Mucins: the frontline defence of the lung. Biochem Soc Trans. 2018 Oct 19; 46(5):1099-1106. PMID: 30154090

Shears RK, Bancroft AJ, Hughes GW, Grencis RK, Thornton DJ. Extracellular vesicles induce protective immunity against Trichuris muris. Parasite Immunol. 2018 Jul; 40(7):e12536. PMID: 29746004

Melo-Gonzalez F, Fenton TM, Forss C, Smedley C, Goenka A, MacDonald AS, Thornton DJ, Travis MA. Intestinal mucin activates human dendritic cells and IL-8 production in a glycan-specific manner. J Biol Chem. 2018 Jun 01; 293(22):8543-8553. PMID: 29581231

Shears RK, Bancroft AJ, Sharpe C, Grencis RK, Thornton DJ. Vaccination Against Whipworm: Identification of Potential Immunogenic Proteins in Trichuris muris Excretory/Secretory Material. Sci Rep. 2018 Mar 14; 8(1):4508. PMID: 29540816

Sharpe C, Thornton DJ, Grencis RK. A sticky end for gastrointestinal helminths; the role of the mucus barrier. Parasite Immunol. 2018 Apr; 40(4):e12517. PMID: 29355990

Anderson MC, Chaze T, Coïc YM, Injarabian L, Jonsson F, Lombion N, Selimoglu-Buet D, Souphron J, Ridley C, Vonaesch P, Baron B, Arena ET, Tinevez JY, Nigro G, Nothelfer K, Solary E, Lapierre V, Lazure T, Matondo M, Thornton D, Sansonetti PJ, Baleux F, Marteyn BS. MUB40 Binds to Lactoferrin and Stands as a Specific Neutrophil Marker. Cell Chem Biol. 2018 Apr 19; 25(4):483-493.e9. PMID: 29478905

Swamy L, Worsham C, Bialas MJ, Wertz C, Thornton D, Breu A, Ronan M. The 60-Minute Root Cause Analysis: A Workshop to Engage Interdisciplinary Clinicians in Quality Improvement. MedEdPORTAL. 2018 02 15; 14:10685.View Related Profiles.

Breu, Anthony
Thornton, David
Swamy, Lakshman
Ronan, Matthew

PMID: 30800885; PMCID: PMC6342415; DOI: 10.15766/mep_2374-8265.10685;

Trillo-Muyo S, Nilsson HE, Recktenwald CV, Ermund A, Ridley C, Meiss LN, Bähr A, Klymiuk N, Wine JJ, Koeck PJB, Thornton DJ, Hebert H, Hansson GC. Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers. J Biol Chem. 2018 Apr 13; 293(15):5746-5754. PMID: 29440393

Dubaissi E, Rousseau K, Hughes GW, Ridley C, Grencis RK, Roberts IS, Thornton DJ. Functional characterization of the mucus barrier on the Xenopus tropicalis skin surface. Proc Natl Acad Sci U S A. 2018 Jan 23; 115(4):726-731. PMID: 29311327

Ermund A, Meiss LN, Rodriguez-Pineiro AM, Bähr A, Nilsson HE, Trillo-Muyo S, Ridley C, Thornton DJ, Wine JJ, Hebert H, Klymiuk N, Hansson GC. The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin. Biochem Biophys Res Commun. 2017 Oct 21; 492(3):331-337. PMID: 28859985

Welsh KG, Rousseau K, Fisher G, Bonser LR, Bradding P, Brightling CE, Thornton DJ, Gaillard EA. MUC5AC and a Glycosylated Variant of MUC5B Alter Mucin Composition in Children With Acute Asthma. Chest. 2017 Oct; 152(4):771-779. PMID: 28716644

Hasnain SZ, Dawson PA, Lourie R, Hutson P, Tong H, Grencis RK, McGuckin MA, Thornton DJ. Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion. PLoS Pathog. 2017 Feb; 13(2):e1006218. PMID: 28192541

Stukus DR, Kempe E, Leber A, Thornton D, Scherzer R. Use of Food Allergy Panels by Pediatric Care Providers Compared With Allergists. Pediatrics. 2016 Dec; 138(6). PMID: 27940693

Davies-Strickleton H, Singh P, Deckert-Gaudig T, Deckert V, Rousseau K, Ridley CE, Dowd SE, Doig AJ, Pudney PD, Thornton DJ, Blanch EW. Secondary Structure and Glycosylation of Mucus Glycoproteins by Raman Spectroscopies. Anal Chem. 2016 Dec 06; 88(23):11609-11615. PMID: 27791356

Dickey BF, Fahy JV, Kesimer M, Boucher RC, Evans CM, Thornton D. Measuring Airway Mucin 2 in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization. Ann Am Thorac Soc. 2016 Nov; 13(11):2103-2104. PMID: 27831803

Ridley C, Kirkham S, Williamson SJ, Davis CW, Woodman P, Thornton DJ. Biosynthesis of the polymeric gel-forming mucin MUC5B. Am J Physiol Lung Cell Mol Physiol. 2016 May 15; 310(10):L993-L1002. PMID: 26993521

Sorokin V, Alkhoury R, Al-Rawabdeh S, Houston RH, Thornton D, Kerlin B, O'Brien S, Baker P, Boesel C, Uddin M, Yin H, Kahwash S. Reference Range of Platelet Delta Granules in the Pediatric Age Group: An Ultrastructural Study of Platelet Whole Mount Preparations from Healthy Volunteers. Pediatr Dev Pathol. 2016; 19(6):498-501. PMID: 26670096

Wang H, Kim JJ, Denou E, Gallagher A, Thornton DJ, Shajib MS, Xia L, Schertzer JD, Grencis RK, Philpott DJ, Khan WI. New Role of Nod Proteins in Regulation of Intestinal Goblet Cell Response in the Context of Innate Host Defense in an Enteric Parasite Infection. Infect Immun. 2016 Jan; 84(1):275-85. PMID: 26527214

Peffers MJ, Thornton DJ, Clegg PD. Characterization of neopeptides in equine articular cartilage degradation. J Orthop Res. 2016 Jan; 34(1):106-20. PMID: 26124002; PMCID: PMC4737130; DOI: 10.1002/jor.22963;

Georgiades P, di Cola E, Heenan RK, Pudney PD, Thornton DJ, Waigh TA. A combined small-angle X-ray and neutron scattering study of the structure of purified soluble gastrointestinal mucins. Biopolymers. 2014 Dec; 101(12):1154-64. PMID: 25041765

Davies HS, Pudney PD, Georgiades P, Waigh TA, Hodson NW, Ridley CE, Blanch EW, Thornton DJ. Reorganisation of the salivary mucin network by dietary components: insights from green tea polyphenols. PLoS One. 2014; 9(9):e108372. PMID: 25264771

Georgiades P, Pudney PD, Rogers S, Thornton DJ, Waigh TA. Tea derived galloylated polyphenols cross-link purified gastrointestinal mucins. PLoS One. 2014; 9(8):e105302. PMID: 25162539

Ridley C, Kouvatsos N, Raynal BD, Howard M, Collins RF, Desseyn JL, Jowitt TA, Baldock C, Davis CW, Hardingham TE, Thornton DJ. Assembly of the respiratory mucin MUC5B: a new model for a gel-forming mucin. J Biol Chem. 2014 Jun 06; 289(23):16409-20. PMID: 24778189

Georgiades P, Pudney PD, Thornton DJ, Waigh TA. Particle tracking microrheology of purified gastrointestinal mucins. Biopolymers. 2014 Apr; 101(4):366-77. PMID: 23955640

Ehre C, Ridley C, Thornton DJ. Cystic fibrosis: an inherited disease affecting mucin-producing organs. Int J Biochem Cell Biol. 2014 Jul; 52:136-45. PMID: 24685676

Dubaissi E, Rousseau K, Lea R, Soto X, Nardeosingh S, Schweickert A, Amaya E, Thornton DJ, Papalopulu N. A secretory cell type develops alongside multiciliated cells, ionocytes and goblet cells, and provides a protective, anti-infective function in the frog embryonic mucociliary epidermis. Development. 2014 Apr; 141(7):1514-25. PMID: 24598166

Horsley A, Rousseau K, Ridley C, Flight W, Jones A, Waigh TA, Thornton DJ. Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis. J Cyst Fibros. 2014 May; 13(3):260-6. PMID: 24332705

Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM. Muc5b is required for airway defence. Nature. 2014 Jan 16; 505(7483):412-6. PMID: 24317696

Thornton D, Stappers B, Bailes M, Barsdell B, Bates S, Bhat ND, Burgay M, Burke-Spolaor S, Champion DJ, Coster P, D'Amico N, Jameson A, Johnston S, Keith M, Kramer M, Levin L, Milia S, Ng C, Possenti A, van Straten W. A population of fast radio bursts at cosmological distances. Science. 2013 Jul 05; 341(6141):53-6. PMID: 23828936

Bell PA, Wagener R, Zaucke F, Koch M, Selley J, Warwood S, Knight D, Boot-Handford RP, Thornton DJ, Briggs MD. Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures. Biol Open. 2013 Aug 15; 2(8):802-11. PMID: 23951406

Maischberger E, Cummins CA, Fitzpatrick E, Gallagher ME, Worrall S, Rousseau K, Thornton DJ, Meijer WG, Miranda-Casoluengo R, Duggan VE, Carrington SD, Irwin JA, Reid CJ. The expression of mucin genes and the presence of mucin gene products in the equine endometrium. Res Vet Sci. 2013 Aug; 95(1):169-75. PMID: 23583093

Harrop CA, Gore RB, Evans CM, Thornton DJ, Herrick SE. TGF-ß2 decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells. Exp Lung Res. 2013 Feb; 39(1):39-47. PMID: 23249391

Hasnain SZ, Gallagher AL, Grencis RK, Thornton DJ. A new role for mucins in immunity: insights from gastrointestinal nematode infection. Int J Biochem Cell Biol. 2013 Feb; 45(2):364-74. PMID: 23107603

Hasnain SZ, McGuckin MA, Grencis RK, Thornton DJ. Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier. PLoS Negl Trop Dis. 2012; 6(10):e1856. PMID: 23071854

Farnell E, Rousseau K, Thornton DJ, Bowyer P, Herrick SE. Expression and secretion of Aspergillus fumigatus proteases are regulated in response to different protein substrates. Fungal Biol. 2012 Sep; 116(9):1003-12. PMID: 22954343

Bell PA, Piróg KA, Fresquet M, Thornton DJ, Boot-Handford RP, Briggs MD. Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation. Arthritis Rheum. 2012 May; 64(5):1529-39. PMID: 22083516

Barbier D, Garcia-Verdugo I, Pothlichet J, Khazen R, Descamps D, Rousseau K, Thornton D, Si-Tahar M, Touqui L, Chignard M, Sallenave JM. Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway. Am J Respir Cell Mol Biol. 2012 Aug; 47(2):149-57. PMID: 22383584

Harrop CA, Thornton DJ, McGuckin MA. Detecting, visualising, and quantifying mucins. Methods Mol Biol. 2012; 842:49-66. PMID: 22259129

Linares LA, Thornton DJ, Strymish J, Baker E, Gupta K. Electronic memorandum decreases unnecessary antimicrobial use for asymptomatic bacteriuria and culture-negative pyuria. Infect Control Hosp Epidemiol. 2011 Jul; 32(7):644-8.View Related Profiles.

Thornton, David
Gupta, Kalpana

PMID: 21666393; DOI: 10.1086/660764;

Rousseau K, Cardwell JM, Humphrey E, Newton R, Knight D, Clegg P, Thornton DJ. Muc5b is the major polymeric mucin in mucus from thoroughbred horses with and without airway mucus accumulation. PLoS One. 2011; 6(5):e19678. PMID: 21602926; PMCID: PMC3094342; DOI: 10.1371/journal.pone.0019678;

Hasnain SZ, Evans CM, Roy M, Gallagher AL, Kindrachuk KN, Barron L, Dickey BF, Wilson MS, Wynn TA, Grencis RK, Thornton DJ. Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med. 2011 May 09; 208(5):893-900. PMID: 21502330

Hasnain SZ, Thornton DJ, Grencis RK. Changes in the mucosal barrier during acute and chronic Trichuris muris infection. Parasite Immunol. 2011 Jan; 33(1):45-55. PMID: 21155842

Nundlall S, Rajpar MH, Bell PA, Clowes C, Zeeff LA, Gardner B, Thornton DJ, Boot-Handford RP, Briggs MD. An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia. Cell Stress Chaperones. 2010 Nov; 15(6):835-49. PMID: 20428984

Hasnain SZ, Wang H, Ghia JE, Haq N, Deng Y, Velcich A, Grencis RK, Thornton DJ, Khan WI. Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection. Gastroenterology. 2010 May; 138(5):1763-71. PMID: 20138044

Rajpar MH, McDermott B, Kung L, Eardley R, Knowles L, Heeran M, Thornton DJ, Wilson R, Bateman JF, Poulsom R, Arvan P, Kadler KE, Briggs MD, Boot-Handford RP. Targeted induction of endoplasmic reticulum stress induces cartilage pathology. PLoS Genet. 2009 Oct; 5(10):e1000691. PMID: 19834559

Viollet L, Gailey S, Thornton DJ, Friedman NR, Flanigan KM, Mahan JD, Mendell JR. Utility of cystatin C to monitor renal function in Duchenne muscular dystrophy. Muscle Nerve. 2009 Sep; 40(3):438-42. PMID: 19623638

Kesimer M, Kiliç N, Mehrotra R, Thornton DJ, Sheehan JK. Identification of salivary mucin MUC7 binding proteins from Streptococcus gordonii. BMC Microbiol. 2009 Aug 11; 9:163. PMID: 19671172

Quinn RP, Mahoney SJ, Wilkinson BM, Thornton DJ, Stirling CJ. A novel role for Gtb1p in glucose trimming of N-linked glycans. Glycobiology. 2009 Dec; 19(12):1408-16. PMID: 19542522

Innes AL, Carrington SD, Thornton DJ, Kirkham S, Rousseau K, Dougherty RH, Raymond WW, Caughey GH, Muller SJ, Fahy JV. Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma. Am J Respir Crit Care Med. 2009 Aug 01; 180(3):203-10. PMID: 19423716

Kesimer M, Kirkham S, Pickles RJ, Henderson AG, Alexis NE, Demaria G, Knight D, Thornton DJ, Sheehan JK. Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways? Am J Physiol Lung Cell Mol Physiol. 2009 Jan; 296(1):L92-L100. PMID: 18931053

Kirkham S, Kolsum U, Rousseau K, Singh D, Vestbo J, Thornton DJ. MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008 Nov 15; 178(10):1033-9. PMID: 18776153

Rousseau K, Kirkham S, Johnson L, Fitzpatrick B, Howard M, Adams EJ, Rogers DF, Knight D, Clegg P, Thornton DJ. Proteomic analysis of polymeric salivary mucins: no evidence for MUC19 in human saliva. Biochem J. 2008 Aug 01; 413(3):545-52. PMID: 18426393

Heazlewood CK, Cook MC, Eri R, Price GR, Tauro SB, Taupin D, Thornton DJ, Png CW, Crockford TL, Cornall RJ, Adams R, Kato M, Nelms KA, Hong NA, Florin TH, Goodnow CC, McGuckin MA. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med. 2008 Mar 04; 5(3):e54. PMID: 18318598

Thornton DJ, Rousseau K, McGuckin MA. Structure and function of the polymeric mucins in airways mucus. Annu Rev Physiol. 2008; 70:459-86. PMID: 17850213

Fresquet M, Jowitt TA, Ylöstalo J, Coffey P, Meadows RS, Ala-Kokko L, Thornton DJ, Briggs MD. Structural and functional characterization of recombinant matrilin-3 A-domain and implications for human genetic bone diseases. J Biol Chem. 2007 Nov 30; 282(48):34634-43. PMID: 17881354

Piróg-Garcia KA, Meadows RS, Knowles L, Heinegård D, Thornton DJ, Kadler KE, Boot-Handford RP, Briggs MD. Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP. Hum Mol Genet. 2007 Sep 01; 16(17):2072-88. PMID: 17588960

Davies JR, Kirkham S, Svitacheva N, Thornton DJ, Carlstedt I. MUC16 is produced in tracheal surface epithelium and submucosal glands and is present in secretions from normal human airway and cultured bronchial epithelial cells. Int J Biochem Cell Biol. 2007; 39(10):1943-54. PMID: 17604678

Leighton MP, Nundlall S, Starborg T, Meadows RS, Suleman F, Knowles L, Wagener R, Thornton DJ, Kadler KE, Boot-Handford RP, Briggs MD. Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation. Hum Mol Genet. 2007 Jul 15; 16(14):1728-41. PMID: 17517694

Askari JA, Thornton DJ, Humphries JD, Buckley PA, Humphries MJ. The alternatively spliced type III connecting segment of fibronectin is a zinc-binding module. Matrix Biol. 2007 Jul; 26(6):485-93. PMID: 17490871

Plumb DA, Dhir V, Mironov A, Ferrara L, Poulsom R, Kadler KE, Thornton DJ, Briggs MD, Boot-Handford RP. Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens. J Biol Chem. 2007 Apr 27; 282(17):12791-5. PMID: 17331945

Rousseau K, Kirkham S, McKane S, Newton R, Clegg P, Thornton DJ. Muc5b and Muc5ac are the major oligomeric mucins in equine airway mucus. Am J Physiol Lung Cell Mol Physiol. 2007 Jun; 292(6):L1396-404. PMID: 17293373

Belluoccio D, Wilson R, Thornton DJ, Wallis TP, Gorman JJ, Bateman JF. Proteomic analysis of mouse growth plate cartilage. Proteomics. 2006 Dec; 6(24):6549-53. PMID: 17163436

Solages A, Vita JA, Thornton DJ, Murray J, Heeren T, Craven DE, Horsburgh CR. Endothelial function in HIV-infected persons. Clin Infect Dis. 2006 May 1; 42(9):1325-32.View Related Profiles.

Horsburgh, C.
Thornton, David
Vita, Joseph
Heeren, Timothy

PMID: 16586393; PMCID: PMC2737346; DOI: 10.1086/503261;

Ballance S, Howard M, White KN, McCrohan CR, Thornton DJ, Sheehan JK. Partial characterisation of high-molecular weight glycoconjugates in the trail mucus of the freshwater pond snail Lymnaea stagnalis. Comp Biochem Physiol B Biochem Mol Biol. 2004 Apr; 137(4):475-86. PMID: 15081999

Sheehan JK, Kirkham S, Howard M, Woodman P, Kutay S, Brazeau C, Buckley J, Thornton DJ. Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin. J Biol Chem. 2004 Apr 09; 279(15):15698-705. PMID: 14749330

Fleming CA, Christiansen D, Nunes D, Heeren T, Thornton D, Horsburgh CR, Koziel MJ, Graham C, Craven DE. Health-related quality of life of patients with HIV disease: impact of hepatitis C coinfection. Clin Infect Dis. 2004 Feb 15; 38(4):572-8.View Related Profiles.

Horsburgh, C.
Thornton, David
Nunes, David
Heeren, Timothy

PMID: 14765352

Middleton AM, Chadwick MV, Nicholson AG, Wilson R, Thornton DJ, Kirkham S, Sheehan JK. Interaction between mycobacteria and mucus on a human respiratory tissue organ culture model with an air interface. Exp Lung Res. 2004; 30(1):17-29. PMID: 14967601

Thornton DJ, Sheehan JK. From mucins to mucus: toward a more coherent understanding of this essential barrier. Proc Am Thorac Soc. 2004; 1(1):54-61. PMID: 16113413

Gray T, Coakley R, Hirsh A, Thornton D, Kirkham S, Koo JS, Burch L, Boucher R, Nettesheim P. Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia. Am J Physiol Lung Cell Mol Physiol. 2004 Feb; 286(2):L320-30. PMID: 14527933

Allen S, Lu H, Thornton D, Tokatlidis K. Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10. J Biol Chem. 2003 Oct 03; 278(40):38505-13. PMID: 12882976

Raynal BD, Hardingham TE, Sheehan JK, Thornton DJ. Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus. J Biol Chem. 2003 Aug 01; 278(31):28703-10. PMID: 12756239

van Deursen FJ, Thornton DJ, Matthews KR. A reproducible protocol for analysis of the proteome of Trypanosoma brucei by 2-dimensional gel electrophoresis. Mol Biochem Parasitol. 2003 Apr 25; 128(1):107-10. PMID: 12706805

Fleming CA, Craven DE, Thornton D, Tumilty S, Nunes D. Hepatitis C virus and human immunodeficiency virus coinfection in an urban population: low eligibility for interferon treatment. Clin Infect Dis. 2003 Jan 1; 36(1):97-100.View Related Profiles.

Thornton, David
Nunes, David

PMID: 12491208

Craven DE, De Rosa FG, Thornton D. Nosocomial pneumonia: emerging concepts in diagnosis, management, and prophylaxis. Curr Opin Crit Care. 2002 Oct; 8(5):421-9. PMID: 12357110

Vial S, Lu H, Allen S, Savory P, Thornton D, Sheehan J, Tokatlidis K. Assembly of Tim9 and Tim10 into a functional chaperone. J Biol Chem. 2002 Sep 27; 277(39):36100-8. PMID: 12138093

Raynal BD, Hardingham TE, Thornton DJ, Sheehan JK. Concentrated solutions of salivary MUC5B mucin do not replicate the gel-forming properties of saliva. Biochem J. 2002 Mar 01; 362(Pt 2):289-96. PMID: 11853536

Kirkham S, Sheehan JK, Knight D, Richardson PS, Thornton DJ. Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B. Biochem J. 2002 Feb 01; 361(Pt 3):537-46. PMID: 11802783

Thornton DJ, Davies JR, Kirkham S, Gautrey A, Khan N, Richardson PS, Sheehan JK. Identification of a nonmucin glycoprotein (gp-340) from a purified respiratory mucin preparation: evidence for an association involving the MUC5B mucin. Glycobiology. 2001 Nov; 11(11):969-77. PMID: 11744631

Tselepis C, Kwan AP, Thornton D, Sheehan J. The biochemical characterization of aggrecan from normal and tibial-dyschondroplastic chicken growth-plate cartilage. Biochem J. 2000 Oct 15; 351 Pt 2(Pt 2):517-25. PMID: 11023839

Thornton DJ, Gray T, Nettesheim P, Howard M, Koo JS, Sheehan JK. Characterization of mucins from cultured normal human tracheobronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2000 Jun; 278(6):L1118-28. PMID: 10835316

Sheehan JK, Brazeau C, Kutay S, Pigeon H, Kirkham S, Howard M, Thornton DJ. Physical characterization of the MUC5AC mucin: a highly oligomeric glycoprotein whether isolated from cell culture or in vivo from respiratory mucous secretions. Biochem J. 2000 Apr 01; 347 Pt 1(Pt 1):37-44. PMID: 10727399

Reardon AJ, Le Goff M, Briggs MD, McLeod D, Sheehan JK, Thornton DJ, Bishop PN. Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix. J Biol Chem. 2000 Jan 21; 275(3):2123-9. PMID: 10636917

Thornton DJ, Khan N, Sheehan JK. Separation and identification of mucins and their glycoforms. Methods Mol Biol. 2000; 125:77-85. PMID: 10820751

McGuckin MA, Thornton DJ. Detection and quantitation of mucins using chemical, lectin, and antibody methods. Methods Mol Biol. 2000; 125:45-55. PMID: 10820748

Sheehan JK, Thornton DJ. Heterogeneity and size distribution of gel-forming mucins. Methods Mol Biol. 2000; 125:87-96. PMID: 10820752

Aksoy N, Thornton DJ, Corfield A, Paraskeva C, Sheehan JK. A study of the intracellular and secreted forms of the MUC2 mucin from the PC/AA intestinal cell line. Glycobiology. 1999 Jul; 9(7):739-46. PMID: 10362844

Sheehan JK, Howard M, Richardson PS, Longwill T, Thornton DJ. Physical characterization of a low-charge glycoform of the MUC5B mucin comprising the gel-phase of an asthmatic respiratory mucous plug. Biochem J. 1999 Mar 01; 338 ( Pt 2)(Pt 2):507-13. PMID: 10024529

Thornton DJ, Khan N, Mehrotra R, Howard M, Veerman E, Packer NH, Sheehan JK. Salivary mucin MG1 is comprised almost entirely of different glycosylated forms of the MUC5B gene product. Glycobiology. 1999 Mar; 9(3):293-302. PMID: 10024667

Devine PL, Quin RJ, Shield PW, Liew YW, Sheehan JK, Thornton DJ. Monoclonal antibody recognizing a core epitope on mucin. Dis Markers. 1998 Oct; 14(2):99-112. PMID: 9868597

Mehrotra R, Thornton DJ, Sheehan JK. Isolation and physical characterization of the MUC7 (MG2) mucin from saliva: evidence for self-association. Biochem J. 1998 Sep 01; 334 ( Pt 2)(Pt 2):415-22. PMID: 9716500

Hanna AN, Waldman WJ, Lott JA, Koesters SC, Hughes AM, Thornton DJ. Increased alkaline phosphatase isoforms in autoimmune diseases. Clin Chem. 1997 Aug; 43(8 Pt 1):1357-64. PMID: 9267314

Thornton DJ, Howard M, Khan N, Sheehan JK. Identification of two glycoforms of the MUC5B mucin in human respiratory mucus. Evidence for a cysteine-rich sequence repeated within the molecule. J Biol Chem. 1997 Apr 04; 272(14):9561-6. PMID: 9083100

Thornton DJ, Carlstedt I, Howard M, Devine PL, Price MR, Sheehan JK. Respiratory mucins: identification of core proteins and glycoforms. Biochem J. 1996 Jun 15; 316 ( Pt 3)(Pt 3):967-75. PMID: 8670177

Sheehan JK, Thornton DJ, Howard M, Carlstedt I, Corfield AP, Paraskeva C. Biosynthesis of the MUC2 mucin: evidence for a slow assembly of fully glycosylated units. Biochem J. 1996 May 01; 315 ( Pt 3)(Pt 3):1055-60. PMID: 8645144

Thornton DJ, Carlstedt I, Sheehan JK. Identification of glycoproteins on nitrocellulose membranes and gels. Mol Biotechnol. 1996 Apr; 5(2):171-6. PMID: 8734429

Sheehan JK, Richardson PS, Fung DC, Howard M, Thornton DJ. Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus. Am J Respir Cell Mol Biol. 1995 Dec; 13(6):748-56. PMID: 7576713

Sheehan JK, Hanski C, Corfield AP, Paraskeva C, Thornton DJ. Mucin biosynthesis and macromolecular assembly. Biochem Soc Trans. 1995 Nov; 23(4):819-21. PMID: 8654845

Thornton DJ, Howard M, Devine PL, Sheehan JK. Methods for separation and deglycosylation of mucin subunits. Anal Biochem. 1995 May 01; 227(1):162-7. PMID: 7668377

Thornton DJ, Devine PL, Hanski C, Howard M, Sheehan JK. Identification of two major populations of mucins in respiratory secretions. Am J Respir Crit Care Med. 1994 Sep; 150(3):823-32. PMID: 8087358

Thornton DJ, Carlstedt I, Sheehan JK. Identification of glycoproteins on nitrocellulose membranes and gels. Methods Mol Biol. 1994; 32:119-28. PMID: 7524938

Lucas JM, Bryans M, Lo K, Wilkie NM, Freshney M, Thornton D, Lang JC. The FGF-4 promoter is required for transformation and is active in both embryonal and somatic cells. Oncol Res. 1994; 6(3):139-49. PMID: 7994085

Hamoudi AC, Singley CT, Teitelbaum DH, Thornton DJ, Broner CW. Intravascular calcium deposits in a critically ill patient. Light- and electron-microscopic findings. Arch Pathol Lab Med. 1993 Dec; 117(12):1257-60. PMID: 8250700

Sheehan JK, Thornton DJ, Somerville M, Carlstedt I. Mucin structure. The structure and heterogeneity of respiratory mucus glycoproteins. Am Rev Respir Dis. 1991 Sep; 144(3 Pt 2):S4-9. PMID: 1892325

Thornton DJ, Sheehan JK, Lindgren H, Carlstedt I. Mucus glycoproteins from cystic fibrotic sputum. Macromolecular properties and structural 'architecture'. Biochem J. 1991 Jun 15; 276 ( Pt 3)(Pt 3):667-75. PMID: 2064605

Thornton DJ, Sheehan JK, Carlstedt I. Heterogeneity of mucus glycoproteins from cystic fibrotic sputum. Are there different families of mucins? Biochem J. 1991 Jun 15; 276 ( Pt 3)(Pt 3):677-82. PMID: 2064606

Sheehan JK, Boot-Handford RP, Chantler E, Carlstedt I, Thornton DJ. Evidence for shared epitopes within the 'naked' protein domains of human mucus glycoproteins. A study performed by using polyclonal antibodies and electron microscopy. Biochem J. 1991 Feb 15; 274 ( Pt 1)(Pt 1):293-6. PMID: 1705799

Cromer BA, Tarnowski KJ, Stein AM, Harton P, Thornton DJ. The school breakfast program and cognition in adolescents. J Dev Behav Pediatr. 1990 Dec; 11(6):295-300. PMID: 2289961

Nelson JW, Tredgett MW, Sheehan JK, Thornton DJ, Notman D, Govan JR. Mucinophilic and chemotactic properties of Pseudomonas aeruginosa in relation to pulmonary colonization in cystic fibrosis. Infect Immun. 1990 Jun; 58(6):1489-95. PMID: 2111280

Sheehan JK, Thornton DJ, Carlstedt I. Histochemical methods used in biochemical approaches to mucus glycoproteins. Acta Histochem Suppl. 1990; 40:133-5. PMID: 2091040

Thornton DJ, Holmes DF, Sheehan JK, Carlstedt I. Quantitation of mucus glycoproteins blotted onto nitrocellulose membranes. Anal Biochem. 1989 Oct; 182(1):160-4. PMID: 2604041

Thornton DJ, Morris HG, Cockin GH, Huckerby TN, Nieduszynski IA, Carlstedt I, Hardingham TE, Ratcliffe A. Structural and immunological studies of keratan sulphates from mature bovine articular cartilage. Biochem J. 1989 May 15; 260(1):277-82. PMID: 2528344

Cromer BA, Steinberg K, Gardner L, Thornton D, Shannon B. Psychosocial determinants of compliance in adolescents with iron deficiency. Am J Dis Child. 1989 Jan; 143(1):55-8. PMID: 2910045

Thornton DJ, Morris HG, Cockin GH, Huckerby TN, Nieduszynski IA. Structural studies of two populations of keratan sulphate chains from mature bovine articular cartilage. Glycoconj J. 1989; 6(2):209-18. PMID: 2535485

Shenep JL, Kalwinsky DK, Hutson PR, George SL, Dodge RK, Blankenship KR, Thornton D. Efficacy of oral sucralfate suspension in prevention and treatment of chemotherapy-induced mucositis. J Pediatr. 1988 Oct; 113(4):758-63. PMID: 3050005

Thornton DJ, Sheehan JK, Nieduszynski IA. A study of the interaction between cartilage proteoglycan and link protein. Biochem J. 1987 Dec 15; 248(3):943-51. PMID: 3435493

Bassett ME, Thornton DJ, Sheehan JK, Nieduszynski IA. An enzyme-linked immunosorbent assay (ELISA) of denatured cartilage link protein. Biochim Biophys Acta. 1987 Sep 11; 925(3):347-55. PMID: 3620506

Thornton DJ, Nieduszynski IA, Oates K, Sheehan JK. Electron-microscopic and electrophoretic studies of bovine femoral-head cartilage proteoglycan fractions. Biochem J. 1986 Nov 15; 240(1):41-8. PMID: 3827853

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 146 publications over 37 distinct years, with a maximum of 10 publications in 2018

Bar chart showing 146 publications over 37 distinct years, with a maximum of 10 publications in 2018

Year	Publications
1986	1
1987	2
1988	1
1989	4
1990	3
1991	4
1993	1
1994	3
1995	3
1996	3
1997	2
1998	2
1999	3
2000	7
2001	1
2002	5
2003	4
2004	5
2006	2
2007	7
2008	5
2009	5
2010	2
2011	4
2012	7
2013	5
2014	7
2015	3
2016	4
2017	3
2018	10
2019	9
2020	4
2021	6
2022	3
2023	2
2024	4

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