Brigitte Ritter | Profiles RNS

Brigitte Ritter, PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Biochemistry & Cell Biology

PhD, University of Cologne

Websites

	Biochemistry Faculty
	ResearchGate
	LinkedIn

ORCID : 0000-0002-0094-0460

Her research interests and expertise is in intracellular receptor sorting controls basic cellular functions such as nutrient uptake and signaling as well as complex behaviors such as migration, differentiation and tissue morphogenesis. Accordingly, the proteins and mechanisms involved in the various sorting pathways are key to normal cell physiology and their misregulation directly contributes to human disease.

Her laboratory focused on clathrin-mediated sorting events and the regulation of these events by the NECAP protein family.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research

Cyclin G-associated kinase as a novel target for Parkinson's disease
01/01/2017 - 12/31/2019 (Co-Investigator)
PI: Richard H. Myers, PhD
Ellison Foundation

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Husein D, Alamoudi A, Ohyama Y, Mochida H, Ritter B, Mochida Y. Identification of the C-terminal region in Amelogenesis Imperfecta causative protein WDR72 required for Golgi localization. Sci Rep. 2022 03 17; 12(1):4640.View Related Profiles.

Ritter, Brigitte
Husein, Dina
Ohyama, Yoshio
Mochida, Yoshiyuki

PMID: 35301423; PMCID: PMC8930991; DOI: 10.1038/s41598-022-08719-7;

Ritter B, Ferguson SM, De Camilli P, McPherson PS. A lentiviral system for efficient knockdown of proteins in neuronal cultures [version 1; referees: 2 approved]. MNI Open Res. 2017; 1(2). PMID: 29355247; PMCID: PMC5771425; DOI: 10.12688/mniopenres.12766.1;

Chamberland JP, Ritter B. Retromer revisited: Evolving roles for retromer in endosomal sorting. J Cell Biol. 2017 11 06; 216(11):3433-3436.View Related Profiles.

Ritter, Brigitte
Chamberland, John

PMID: 29061649; PMCID: PMC5674901; DOI: 10.1083/jcb.201708111;

Chamberland JP, Antonow LT, Dias Santos M, Ritter B. NECAP2 controls clathrin coat recruitment to early endosomes for fast endocytic recycling. J Cell Sci. 2016 Jul 01; 129(13):2625-37.View Related Profiles.

Ritter, Brigitte
Chamberland, John

PMID: 27206861; DOI: 10.1242/jcs.173708;

Rouka E, Simister PC, Janning M, Kumbrink J, Konstantinou T, Muniz JR, Joshi D, O'Reilly N, Volkmer R, Ritter B, Knapp S, von Delft F, Kirsch KH, Feller SM. Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3). J Biol Chem. 2015 Oct 16; 290(42):25275-92.View Related Profiles.

Ritter, Brigitte
Kumbrink, Joerg
Kirsch, Kathrin

PMID: 26296892; PMCID: PMC4646179; DOI: 10.1074/jbc.M115.637207;

Allaire PD, McPherson PS, Ritter B. Analysis of connecdenn 1-3 (DENN1A-C) GEF activity for Rab35. Methods Mol Biol. 2015; 1298:217-31. PMID: 25800846; DOI: 10.1007/978-1-4939-2569-8_19;

Wu Y, O'Toole ET, Girard M, Ritter B, Messa M, Liu X, McPherson PS, Ferguson SM, De Camilli P. A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis. Elife. 2014; 3:e01621. PMID: 24963135; PMCID: PMC4107917; DOI: 10.7554/eLife.01621;

Ritter B, Murphy S, Dokainish H, Girard M, Gudheti MV, Kozlov G, Halin M, Philie J, Jorgensen EM, Gehring K, McPherson PS. NECAP 1 regulates AP-2 interactions to control vesicle size, number, and cargo during clathrin-mediated endocytosis. PLoS Biol. 2013 Oct; 11(10):e1001670. PMID: 24130457; PMCID: PMC3794858; DOI: 10.1371/journal.pbio.1001670;

Allaire PD, Seyed Sadr M, Chaineau M, Seyed Sadr E, Konefal S, Fotouhi M, Maret D, Ritter B, Del Maestro RF, McPherson PS. Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and migration. J Cell Sci. 2013 Feb 1; 126(Pt 3):722-31. PMID: 23264734; DOI: 10.1242/jcs.112375;

Kent CB, Shimada T, Ferraro GB, Ritter B, Yam PT, McPherson PS, Charron F, Kennedy TE, Fournier AE. 14-3-3 proteins regulate protein kinase a activity to modulate growth cone turning responses. J Neurosci. 2010 Oct 20; 30(42):14059-67. PMID: 20962227; PMCID: PMC6634753; DOI: 10.1523/JNEUROSCI.3883-10.2010;

Showing 10 of 28 results. Show More

Ceni C, Kommaddi RP, Thomas R, Vereker E, Liu X, McPherson PS, Ritter B, Barker PA. The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling. J Cell Sci. 2010 Jul 1; 123(Pt 13):2299-307. PMID: 20530577; DOI: 10.1242/jcs.062612;

Allaire PD, Marat AL, Dall'Armi C, Di Paolo G, McPherson PS, Ritter B. The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes. Mol Cell. 2010 Feb 12; 37(3):370-82. PMID: 20159556; PMCID: PMC2825348; DOI: 10.1016/j.molcel.2009.12.037;

Katoh Y, Ritter B, Gaffry T, Blondeau F, Höning S, McPherson PS. The clavesin family, neuron-specific lipid- and clathrin-binding Sec14 proteins regulating lysosomal morphology. J Biol Chem. 2009 Oct 2; 284(40):27646-54. PMID: 19651769; PMCID: PMC2785693; DOI: 10.1074/jbc.M109.034884;

Thomas S, Ritter B, Verbich D, Sanson C, Bourbonnière L, McKinney RA, McPherson PS. Intersectin regulates dendritic spine development and somatodendritic endocytosis but not synaptic vesicle recycling in hippocampal neurons. J Biol Chem. 2009 May 1; 284(18):12410-9. PMID: 19258322; PMCID: PMC2673308; DOI: 10.1074/jbc.M809746200;

Goodman OB, Barwe SP, Ritter B, McPherson PS, Vasko AJ, Keen JH, Nanus DM, Bander NH, Rajasekaran AK. Interaction of prostate specific membrane antigen with clathrin and the adaptor protein complex-2. Int J Oncol. 2007 Nov; 31(5):1199-203. PMID: 17912448

Ritter B, Denisov AY, Philie J, Allaire PD, Legendre-Guillemin V, Zylbergold P, Gehring K, McPherson PS. The NECAP PHear domain increases clathrin accessory protein binding potential. EMBO J. 2007 Sep 19; 26(18):4066-77. PMID: 17762867; PMCID: PMC2230672; DOI: 10.1038/sj.emboj.7601836;

Allaire PD, Ritter B, Thomas S, Burman JL, Denisov AY, Legendre-Guillemin V, Harper SQ, Davidson BL, Gehring K, McPherson PS. Connecdenn, a novel DENN domain-containing protein of neuronal clathrin-coated vesicles functioning in synaptic vesicle endocytosis. J Neurosci. 2006 Dec 20; 26(51):13202-12. PMID: 17182770; PMCID: PMC6674997; DOI: 10.1523/JNEUROSCI.4608-06.2006;

Ritter B, McPherson PS. There's a GAP in the ENTH domain. Proc Natl Acad Sci U S A. 2006 Mar 14; 103(11):3953-4. PMID: 16537466; PMCID: PMC1449625; DOI: 10.1073/pnas.0600658103;

McPherson PS, Ritter B. Peptide motifs: building the clathrin machinery. Mol Neurobiol. 2005 Aug; 32(1):73-87. PMID: 16077185

Burman JL, Wasiak S, Ritter B, de Heuvel E, McPherson PS. Aftiphilin is a component of the clathrin machinery in neurons. FEBS Lett. 2005 Apr 11; 579(10):2177-84. PMID: 15811338

Ritter B, Blondeau F, Denisov AY, Gehring K, McPherson PS. Molecular mechanisms in clathrin-mediated membrane budding revealed through subcellular proteomics. Biochem Soc Trans. 2004 Nov; 32(Pt 5):769-73. PMID: 15494011

Ritter B, Denisov AY, Philie J, Deprez C, Tung EC, Gehring K, McPherson PS. Two WXXF-based motifs in NECAPs define the specificity of accessory protein binding to AP-1 and AP-2. EMBO J. 2004 Oct 1; 23(19):3701-10. PMID: 15359277; PMCID: PMC522786

Denisov AY, Ritter B, McPherson PS, Gehring K. 1H, 15N and 13C resonance assignments and 15N-1H residual dipolar couplings for the alpha-adaptin ear-domain. J Biomol NMR. 2004 Jul; 29(3):441-2. PMID: 15213459

Blondeau F, Ritter B, Allaire PD, Wasiak S, Girard M, Hussain NK, Angers A, Legendre-Guillemin V, Roy L, Boismenu D, Kearney RE, Bell AW, Bergeron JJ, McPherson PS. Tandem MS analysis of brain clathrin-coated vesicles reveals their critical involvement in synaptic vesicle recycling. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3833-8. PMID: 15007177; PMCID: PMC374330

Mattera R, Ritter B, Sidhu SS, McPherson PS, Bonifacino JS. Definition of the consensus motif recognized by gamma-adaptin ear domains. J Biol Chem. 2004 Feb 27; 279(9):8018-28. PMID: 14665628

Ritter B, Philie J, Girard M, Tung EC, Blondeau F, McPherson PS. Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif. EMBO Rep. 2003 Nov; 4(11):1089-95. PMID: 14555962; PMCID: PMC1326374

Modregger J, Schmidt AA, Ritter B, Huttner WB, Plomann M. Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1. J Biol Chem. 2003 Feb 7; 278(6):4160-7. PMID: 12456676

Wasiak S, Quinn CC, Ritter B, de Heuvel E, Baranes D, Plomann M, McPherson PS. The Ras/Rac guanine nucleotide exchange factor mammalian Son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of endocytosis and the actin cytoskeleton. J Biol Chem. 2001 Jul 13; 276(28):26622-8. PMID: 11352907

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 28 publications over 16 distinct years, with a maximum of 4 publications in 2004

Bar chart showing 28 publications over 16 distinct years, with a maximum of 4 publications in 2004

Year	Publications
2001	1
2002	1
2003	2
2004	4
2005	2
2006	2
2007	2
2009	2
2010	3
2012	1
2013	1
2014	1
2015	2
2016	1
2017	2
2022	1

Contact for Mentoring:

72 E. Concord St Instructional Building (L)
Boston MA 02118
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617.358.9547

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