Yoshiyuki Mochida | Profiles RNS

Yoshiyuki Mochida, DDS, PhD

Clinical Professor

Boston University Henry M. Goldman School of Dental Medicine

Molecular & Cell Biology

PhD, Tokyo Medical and Dental University
DDS, Tokyo Medical and Dental University

Websites

	Dental Medicine Periodontology & Oral Biology Faculty
	LinkedIn

ORCID : 0000-0002-2115-4303

Yoshiyuki Mochida, DDS, PhD, is a Clinical Professor of Molecular & Cell Biology at the Boston University Goldman School of Dental Medicine. After earning two degrees in his native Japan, Dr. Mochida began as a Research Associate in Dental Research Center at UNC Chapel Hill. A few years after being promoted he came to Boston University in 2009. Since then he has been active in the dental school by serving on several committees and teaching over 11 classes. For his teaching he won three awards from UNC Chapel Hill and has mentored both Masters and PhD students at BUSM. He holds multiple patents and has given three public hearing testimonies on insurance coverage for craniofacial conditions.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

EVC2: A Novel Modulator in Tooth Development
07/01/2009 - 06/30/2015 (PI)
NIH/National Institute of Dental & Craniofacial Research
5R01DE019527-06

Effect of DSP Fragment on Pulp Stem Cells
12/01/2012 - 11/30/2014 (PI)
American Association of Endodontists Foundation

Title

Yr	Title	Project-Sub Proj	Pubs
2013	EVC2: A novel modulator in tooth development	5R01DE019527-06	11
2012	EVC2: A novel modulator in tooth development	5R01DE019527-05	11
2011	EVC2: A novel modulator in tooth development	5R01DE019527-04	11
2010	Role of Vwc2-assisted activin signaling in bone formation	5R21AR057451-03	3
2010	EVC2: A novel modulator in tooth development	5R01DE019527-03	11
2009	Role of Vwc2-assisted activin signaling in bone formation	7R21AR057451-02	3
2009	Role of Vwc2-assisted activin signaling in bone formation	1R21AR057451-01	3
2009	EVC2: A novel modulator in tooth development	7R01DE019527-02	11
2009	EVC2: A novel modulator in tooth development	1R01DE019527-01A1	11
2005	Roles of Matrix Proteoglycans in Dentin Bonding	5R03DE016116-02	7

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Pitt K, Mochida Y, Senoo M. Greener Grass: The Modern History of Epithelial Stem Cell Innovation. Life (Basel). 2023 Mar 03; 13(3). PMID: 36983843; PMCID: PMC10058258; DOI: 10.3390/life13030688;

Husein D, Alamoudi A, Ohyama Y, Mochida H, Ritter B, Mochida Y. Identification of the C-terminal region in Amelogenesis Imperfecta causative protein WDR72 required for Golgi localization. Sci Rep. 2022 03 17; 12(1):4640.View Related Profiles.

Ritter, Brigitte
Husein, Dina
Ohyama, Yoshio
Mochida, Yoshiyuki

PMID: 35301423; PMCID: PMC8930991; DOI: 10.1038/s41598-022-08719-7;

Govitvattana N, Kaku M, Ohyama Y, Jaha H, Lin IP, Mochida H, Pavasant P, Mochida Y. Molecular Cloning of Mouse Homologue of Enamel Protein C4orf26 and Its Phosphorylation by FAM20C. Calcif Tissue Int. 2021 10; 109(4):445-454.View Related Profiles.

Ohyama, Yoshio
Mochida, Yoshiyuki

PMID: 33884476; PMCID: PMC8429244; DOI: 10.1007/s00223-021-00847-y;

Lin JH, Lin IP, Ohyama Y, Mochida H, Kudo A, Kaku M, Mochida Y. FAM20C directly binds to and phosphorylates Periostin. Sci Rep. 2020 10 13; 10(1):17155.View Related Profiles.

Ohyama, Yoshio
Mochida, Yoshiyuki

PMID: 33051588; PMCID: PMC7555550; DOI: 10.1038/s41598-020-74400-6;

Kulkarni AK, Louie KW, Yatabe M, Ruellas ACO, Mochida Y, Cevidanes LHS, Mishina Y, Zhang H. A Ciliary Protein EVC2/LIMBIN Plays a Critical Role in the Skull Base for Mid-Facial Development. Front Physiol. 2018; 9:1484. PMID: 30410447; PMCID: PMC6210651; DOI: 10.3389/fphys.2018.01484;

Almehmadi A, Ohyama Y, Kaku M, Alamoudi A, Husein D, Katafuchi M, Mishina Y, Mochida Y. VWC2 Increases Bone Formation Through Inhibiting Activin Signaling. Calcif Tissue Int. 2018 12; 103(6):663-674.View Related Profiles.

Husein, Dina
Ohyama, Yoshio
Mochida, Yoshiyuki

PMID: 30074079; PMCID: PMC6549224; DOI: 10.1007/s00223-018-0462-9;

Kwon EK, Louie K, Kulkarni A, Yatabe M, Ruellas ACO, Snider TN, Mochida Y, Cevidanes LHS, Mishina Y, Zhang H. The Role of Ellis-Van Creveld 2(EVC2) in Mice During Cranial Bone Development. Anat Rec (Hoboken). 2018 Jan; 301(1):46-55. PMID: 28950429; PMCID: PMC5729076; DOI: 10.1002/ar.23692;

Zhang H, Takeda H, Tsuji T, Kamiya N, Kunieda T, Mochida Y, Mishina Y. Loss of Function of Evc2 in Dental Mesenchyme Leads to Hypomorphic Enamel. J Dent Res. 2017 Apr; 96(4):421-429. PMID: 28081373; PMCID: PMC5384488; DOI: 10.1177/0022034516683674;

Zhang H, Kamiya N, Tsuji T, Takeda H, Scott G, Rajderkar S, Ray MK, Mochida Y, Allen B, Lefebvre V, Hung IH, Ornitz DM, Kunieda T, Mishina Y. Elevated Fibroblast Growth Factor Signaling Is Critical for the Pathogenesis of the Dwarfism in Evc2/Limbin Mutant Mice. PLoS Genet. 2016 Dec; 12(12):e1006510. PMID: 28027321; PMCID: PMC5189957; DOI: 10.1371/journal.pgen.1006510;

Showing 10 of 46 results. Show More

Ohyama Y, Lin JH, Govitvattana N, Lin IP, Venkitapathi S, Alamoudi A, Husein D, An C, Hotta H, Kaku M, Mochida Y. FAM20A binds to and regulates FAM20C localization. Sci Rep. 2016 06 13; 6:27784.View Related Profiles.

Husein, Dina
Venkitapathi, Sundharamani
Ohyama, Yoshio
Mochida, Yoshiyuki

PMID: 27292199; PMCID: PMC4904241; DOI: 10.1038/srep27784;

Jaha H, Husein D, Ohyama Y, Xu D, Suzuki S, Huang GT, Mochida Y. N-terminal Dentin Sialoprotein fragment induces type I collagen production and upregulates dentinogenesis marker expression in osteoblasts. Biochem Biophys Rep. 2016 Jun; 6:190-196.View Related Profiles.

Husein, Dina
Ohyama, Yoshio
Mochida, Yoshiyuki

PMID: 27158678; PMCID: PMC4857711; DOI: 10.1016/j.bbrep.2016.04.004;

Badri MK, Zhang H, Ohyama Y, Venkitapathi S, Alamoudi A, Kamiya N, Takeda H, Ray M, Scott G, Tsuji T, Kunieda T, Mishina Y, Mochida Y. Expression of Evc2 in craniofacial tissues and craniofacial bone defects in Evc2 knockout mouse. Arch Oral Biol. 2016 Aug; 68:142-52.View Related Profiles.

Venkitapathi, Sundharamani
Ohyama, Yoshio
Mochida, Yoshiyuki

PMID: 27164562; PMCID: PMC4903910; DOI: 10.1016/j.archoralbio.2016.05.002;

Badri MK, Zhang H, Ohyama Y, Venkitapathi S, Kamiya N, Takeda H, Ray M, Scott G, Tsuji T, Kunieda T, Mishina Y, Mochida Y. Ellis Van Creveld2 is Required for Postnatal Craniofacial Bone Development. Anat Rec (Hoboken). 2016 Aug; 299(8):1110-20.View Related Profiles.

Venkitapathi, Sundharamani
Ohyama, Yoshio
Mochida, Yoshiyuki

PMID: 27090777; PMCID: PMC4940231; DOI: 10.1002/ar.23353;

Zhang H, Takeda H, Tsuji T, Kamiya N, Rajderkar S, Louie K, Collier C, Scott G, Ray M, Mochida Y, Kaartinen V, Kunieda T, Mishina Y. Generation of Evc2/Limbin global and conditional KO mice and its roles during mineralized tissue formation. Genesis. 2015 Sep; 53(9):612-626. PMID: 26219237; PMCID: PMC4731321; DOI: 10.1002/dvg.22879;

Kaku M, Komatsu Y, Mochida Y, Yamauchi M, Mishina Y, Ko CC. Identification and characterization of neural crest-derived cells in adult periodontal ligament of mice. Arch Oral Biol. 2012 Dec; 57(12):1668-75. PMID: 22704955; PMCID: PMC3537832; DOI: 10.1016/j.archoralbio.2012.04.022;

Ohyama Y, Katafuchi M, Almehmadi A, Venkitapathi S, Jaha H, Ehrenman J, Morcos J, Aljamaan R, Mochida Y. Modulation of matrix mineralization by Vwc2-like protein and its novel splicing isoforms. Biochem Biophys Res Commun. 2012 Feb 3; 418(1):12-6.View Related Profiles.

Aljamaan, Reem
Venkitapathi, Sundharamani
Ohyama, Yoshio
Mochida, Yoshiyuki

PMID: 22209847; PMCID: PMC3273656; DOI: 10.1016/j.bbrc.2011.12.075;

Boushell LW, Kaku M, Mochida Y, Yamauchi M. Distribution and relative activity of matrix metalloproteinase-2 in human coronal dentin. Int J Oral Sci. 2011 Oct; 3(4):192-9. PMID: 22010577; PMCID: PMC3469976; DOI: 10.4248/IJOS11070;

Mochida Y, Kaku M, Yoshida K, Katafuchi M, Atsawasuwan P, Yamauchi M. Podocan-like protein: a novel small leucine-rich repeat matrix protein in bone. Biochem Biophys Res Commun. 2011 Jul 1; 410(2):333-8.View Related Profiles.

Yoshida, Keiko
Mochida, Yoshiyuki

PMID: 21672516; PMCID: PMC3159388; DOI: 10.1016/j.bbrc.2011.05.150;

Atsawasuwan P, Mochida Y, Katafuchi M, Tokutomi K, Mocanu V, Parker CE, Yamauchi M. A novel proteolytic processing of prolysyl oxidase. Connect Tissue Res. 2011; 52(6):479-86. PMID: 21591931; PMCID: PMC3499975; DOI: 10.3109/03008207.2011.564337;

Miguez PA, Terajima M, Nagaoka H, Mochida Y, Yamauchi M. Role of glycosaminoglycans of biglycan in BMP-2 signaling. Biochem Biophys Res Commun. 2011 Feb 11; 405(2):262-6. PMID: 21219861; PMCID: PMC3057115; DOI: 10.1016/j.bbrc.2011.01.022;

Kamiya N, Kobayashi T, Mochida Y, Yu PB, Yamauchi M, Kronenberg HM, Mishina Y. Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts. J Bone Miner Res. 2010 Feb; 25(2):200-10. PMID: 19874086; PMCID: PMC3153381; DOI: 10.1359/jbmr.090806;

Kamiya N, Ye L, Kobayashi T, Lucas DJ, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ, Mishina Y. Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass. J Bone Miner Res. 2008 Dec; 23(12):2007-17. PMID: 18684091; PMCID: PMC2686924; DOI: 10.1359/jbmr.080809;

Mochida Y, Parisuthiman D, Pornprasertsuk-Damrongsri S, Atsawasuwan P, Sricholpech M, Boskey AL, Yamauchi M. Decorin modulates collagen matrix assembly and mineralization. Matrix Biol. 2009 Jan; 28(1):44-52. PMID: 19049867; PMCID: PMC2650102; DOI: 10.1016/j.matbio.2008.11.003;

Nagaoka H, Mochida Y, Atsawasuwan P, Kaku M, Kondoh T, Yamauchi M. 1,25(OH)2D3 regulates collagen quality in an osteoblastic cell culture system. Biochem Biophys Res Commun. 2008 Dec 12; 377(2):674-8. PMID: 18930711; DOI: 10.1016/j.bbrc.2008.10.036;

Kamiya N, Ye L, Kobayashi T, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ, Mishina Y. BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development. 2008 Nov; 135(22):3801-11. PMID: 18927151; PMCID: PMC2694443; DOI: 10.1242/dev.025825;

Atsawasuwan P, Mochida Y, Katafuchi M, Kaku M, Fong KS, Csiszar K, Yamauchi M. Lysyl oxidase binds transforming growth factor-beta and regulates its signaling via amine oxidase activity. J Biol Chem. 2008 Dec 5; 283(49):34229-40. PMID: 18835815; PMCID: PMC2590693; DOI: 10.1074/jbc.M803142200;

Boushell LW, Kaku M, Mochida Y, Bagnell R, Yamauchi M. Immunohistochemical localization of matrixmetalloproteinase-2 in human coronal dentin. Arch Oral Biol. 2008 Feb; 53(2):109-16. PMID: 18001692; PMCID: PMC2258007; DOI: 10.1016/j.archoralbio.2007.09.012;

Kaku M, Mochida Y, Atsawasuwan P, Parisuthiman D, Yamauchi M. Post-translational modifications of collagen upon BMP-induced osteoblast differentiation. Biochem Biophys Res Commun. 2007 Aug 3; 359(3):463-8. PMID: 17553463; PMCID: PMC1994940; DOI: 10.1016/j.bbrc.2007.05.109;

Mochida Y, Parisuthiman D, Kaku M, Hanai J, Sukhatme VP, Yamauchi M. Nephrocan, a novel member of the small leucine-rich repeat protein family, is an inhibitor of transforming growth factor-beta signaling. J Biol Chem. 2006 Nov 24; 281(47):36044-51. PMID: 16990280

Mochida Y, Parisuthiman D, Yamauchi M. Biglycan is a positive modulator of BMP-2 induced osteoblast differentiation. Adv Exp Med Biol. 2006; 585:101-13. PMID: 17120779

Parisuthiman D, Mochida Y, Duarte WR, Yamauchi M. Biglycan modulates osteoblast differentiation and matrix mineralization. J Bone Miner Res. 2005 Oct; 20(10):1878-86. PMID: 16160746

Atsawasuwan P, Mochida Y, Parisuthiman D, Yamauchi M. Expression of lysyl oxidase isoforms in MC3T3-E1 osteoblastic cells. Biochem Biophys Res Commun. 2005 Feb 25; 327(4):1042-6. PMID: 15652501

Pornprasertsuk S, Duarte WR, Mochida Y, Yamauchi M. Overexpression of lysyl hydroxylase-2b leads to defective collagen fibrillogenesis and matrix mineralization. J Bone Miner Res. 2005 Jan; 20(1):81-7. PMID: 15619673

Endo Y, Uzawa K, Mochida Y, Shiiba M, Bukawa H, Yokoe H, Tanzawa H. Sarcoendoplasmic reticulum Ca(2+) ATPase type 2 downregulated in human oral squamous cell carcinoma. Int J Cancer. 2004 Jun 10; 110(2):225-31. PMID: 15069686

Pornprasertsuk S, Duarte WR, Mochida Y, Yamauchi M. Lysyl hydroxylase-2b directs collagen cross-linking pathways in MC3T3-E1 cells. J Bone Miner Res. 2004 Aug; 19(8):1349-55. PMID: 15231023

Ono K, Uzawa K, Nakatsuru M, Shiiba M, Mochida Y, Tada A, Bukawa H, Miyakawa A, Yokoe H, Tanzawa H. Down-regulation of FEZ1/LZTS1 gene with frequent loss of heterozygosity in oral squamous cell carcinomas. Int J Oncol. 2003 Aug; 23(2):297-302. PMID: 12851677

Uzawa K, Yeowell HN, Yamamoto K, Mochida Y, Tanzawa H, Yamauchi M. Lysine hydroxylation of collagen in a fibroblast cell culture system. Biochem Biophys Res Commun. 2003 Jun 6; 305(3):484-7. PMID: 12763018

Mochida Y, Duarte WR, Tanzawa H, Paschalis EP, Yamauchi M. Decorin modulates matrix mineralization in vitro. Biochem Biophys Res Commun. 2003 May 23; 305(1):6-9. PMID: 12732188

Endo Y, Uzawa K, Mochida Y, Nakatsuru M, Shiiba M, Yokoe H, Yamauchi M, Tanzawa H. Differential distribution of glycosaminoglycans in human cementifying fibroma and fibro-osseous lesions. Oral Dis. 2003 Mar; 9(2):73-6. PMID: 12657032

Yamashita Y, Miyakawa A, Mochida Y, Aisaki K, Yama M, Shiiba M, Watanabe T, Yokoe H, Uzawa K, Imai Y, Tanzawa H. Genetic aberration on chromosome 10 in human oral squamous cell carcinoma. Int J Oncol. 2002 Mar; 20(3):595-8. PMID: 11836574

Mochida Y, Takeda K, Saitoh M, Nishitoh H, Amagasa T, Ninomiya-Tsuji J, Matsumoto K, Ichijo H. ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction. J Biol Chem. 2000 Oct 20; 275(42):32747-52. PMID: 10921914

Hatai T, Matsuzawa A, Inoshita S, Mochida Y, Kuroda T, Sakamaki K, Kuida K, Yonehara S, Ichijo H, Takeda K. Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation. J Biol Chem. 2000 Aug 25; 275(34):26576-81. PMID: 10849426

Mochida Y. [Functional analysis of apoptosis signal-regulating kinase 1 (ASK 1)-binding proteins]. Kokubyo Gakkai Zasshi. 2000 Jun; 67(2):182-92. PMID: 10921242

Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H. ASK1 is essential for JNK/SAPK activation by TRAF2. Mol Cell. 1998 Sep; 2(3):389-95. PMID: 9774977

Takeda K, Ichijo H, Fujii M, Mochida Y, Saitoh M, Nishitoh H, Sampath TK, Miyazono K. Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA. J Biol Chem. 1998 Jul 3; 273(27):17079-85. PMID: 9642273

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 45 publications over 20 distinct years, with a maximum of 5 publications in 2008 and 2011 and 2016

Bar chart showing 45 publications over 20 distinct years, with a maximum of 5 publications in 2008 and 2011 and 2016

Year	Publications
1998	2
2000	3
2002	1
2003	4
2004	3
2005	2
2006	2
2007	2
2008	5
2010	1
2011	5
2012	1
2015	1
2016	5
2017	2
2018	2
2020	1
2021	1
2022	1
2023	1

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617.358.3787

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