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Last Name

Laisheng (Lee) Chou, DMD, PhD

TitleProfessor
InstitutionBoston University Henry M. Goldman School of Dental Medicine
DepartmentRestorative Sciences & Biomaterials
Address801 Albany St Gilmore & Vines (S Bldg)
Boston MA 02118
Phone(617) 638-5598
ORCID ORCID Icon0000-0002-9922-720X
Other Positions
TitleProfessor
InstitutionBoston University Henry M. Goldman School of Dental Medicine
DepartmentGeneral Dentistry

TitleDirector of Oral Medicine
InstitutionBoston University Henry M. Goldman School of Dental Medicine
DepartmentGeneral Dentistry

 Research Expertise & Professional Interests
Expertise in molecular biocompatibility of implant materials. Hydroxyapatite (HA) and bioactive glass materials are commonly used in medical and dental implants. However, the mechanisms by which implant material surface chemistry and topography initiate the biological tissue response, and the molecular nature the tissue response still remain largely unknown. This study aims to establish the in vitro and in vivo molecular profiles of osteogenic activities as a function of biomaterial surface chemistry and topography. The expected profile will be used as a biological guide for: (1) the selection of optimal material surface chemistry and topography for controlled cell attachment and bone formation, and (2) the development of novel osteoinductive coating systems for dental and medical implant devices.

Expertise in engineered bone regeneration with biomimetic scaffolds. Over one million surgical operations annually in this country involve bone repair. An existing challenge in bone tissue engineering is to develop scaffolds which have programmed osteogenic bioactivity and biodegradation. The study has been carried out in this field is based on the hypothesis that the material chemistry and three-dimensional geometry of tissue engineering scaffolds can be manipulated under the guidance of biological parameters, resulting in scaffold-controlled tissue reactions favorable to bone regeneration. The long-term goal is to develop a novel approach to biomimetic scaffolds with ordered microarchitectures and biofunctional ingredients, as well as anatomically accurate macrostructure for clinical treatment of orofacial and orthopedic bone defects.

Expertise in HIV-1 infection in oral mucosal Langerhans cells.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Xu L, Shao A, Zhao Y, Wang Z, Zhang C, Sun Y, Deng J, Chou LL. Neurotoxicity of Silver Nanoparticles in Rat Brain After Intragastric Exposure. J Nanosci Nanotechnol. 2015 Jun; 15(6):4215-23. PMID: 26369032.
    View in: PubMed
  2. Xu L, Shi C, Shao A, Li X, Cheng X, Ding R, Wu G, Chou LL. Toxic responses in rat embryonic cells to silver nanoparticles and released silver ions as analyzed via gene expression profiles and transmission electron microscopy. Nanotoxicology. 2015 May; 9(4):513-22. PMID: 25119417.
    View in: PubMed
  3. Zhang ZC, Giordano R, Shen G, Chou LL, Qian YF. Shear bond strength of an experimental composite bracket. J Orofac Orthop. 2013 Jul; 74(4):319-31. PMID: 23807258.
    View in: PubMed
  4. Xu L, Li X, Takemura T, Hanagata N, Wu G, Chou LL. Genotoxicity and molecular response of silver nanoparticle (NP)-based hydrogel. J Nanobiotechnology. 2012; 10:16. PMID: 22548743.
    View in: PubMed
  5. Ortiz J, Chou LL. Calcium upregulated survivin expression and associated osteogenesis of normal human osteoblasts. J Biomed Mater Res A. 2012 Jul; 100(7):1770-6. PMID: 22488949.
    View in: PubMed
  6. Xu Z, Chou L, Sun J. Effects of SiO2 nanoparticles on HFL-I activating ROS-mediated apoptosis via p53 pathway. J Appl Toxicol. 2012 May; 32(5):358-64. PMID: 21766316.
    View in: PubMed
  7. Zhang C, Hong S, Yang P, Zhong W, Xie S, Chou L. Application of PET in diagnosis and treatment plan of head and neck tumors. Chinese Journal of Oral and Maxillofacial Surgery. 2011; 5(9):430-434.
  8. Huang J, Chou L, Li R. Cellular affinity of inorganic active element bone scaffold materials. Journal of Medical, Aesthetics and Cosmetology. 2011; 1(17):44-47.
  9. Jin H, Zhang W, Jiao Q, Li G, Xie S, Zhong W, Chou L. Technique of cone-beam computed tomography for oral clinic practice. Journal of Dental Materials and Devices. 2011; 3(20):158-161.
  10. Wu L, Guo Z, Meng S, Zhong W, Du Q, Chou LL. Synthesis of a zwitterionic silane and its application in the surface modification of silicon-based material surfaces for improved hemocompatibility. ACS Appl Mater Interfaces. 2010 Oct; 2(10):2781-8. PMID: 20839802.
    View in: PubMed
  11. Tang J, Xiong L, Zhou G, Wang S, Wang J, Liu L, Li J, Yuan F, Lu S, Wan Z, Chou L, Xi T. Silver nanoparticles crossing through and distribution in the blood-brain barrier in vitro. J Nanosci Nanotechnol. 2010 Oct; 10(10):6313-7. PMID: 21137724.
    View in: PubMed
  12. Sun XJ, Xia LG, Chou LL, Zhong W, Zhang XL, Wang SY, Zhao J, Jiang XQ, Zhang ZY. Maxillary sinus floor elevation using a tissue engineered bone complex with BMP-2 gene modified bMSCs and a novel porous ceramic scaffold in rabbits. Arch Oral Biol. 2010 Mar; 55(3):195-202. PMID: 20144455.
    View in: PubMed
  13. Gong F, Chou L, Li R. Bio-inductive effects of the inorganic elements scaffold material on osteogenic cells in postoperative jaw defects. Journal of Oral Science Research. 2010; 2(26):175-179.
  14. Otiz J, Marques M, Chou L. . Expression of survivin gene in normal human osteoblasts. Chinese Journal of Oral and Maxillofacial Surgery. 2010; 3(8):241-249.
  15. Wu L, Guo Z, Meng S, Zhong W, Du Q, Chou L. Synthesis of a novel zwitterionic silane and its application in the surface modification of silicon-based material surface for improved haemocompatibility. ACS Applied Materials & Interfaces: American Chemical Society Publication. 2010; 2(10):2781-2788.
  16. Meng S, Liu Z, Shen L, Guo Z, Chou LL, Zhong W, Du Q, Ge J. The effect of a layer-by-layer chitosan-heparin coating on the endothelialization and coagulation properties of a coronary stent system. Biomaterials. 2009 Apr; 30(12):2276-83. PMID: 19168214.
    View in: PubMed
  17. Guo Z, Meng S, Zhong W, Du Q, Chou L. Self-assembly of silanated poly(ethylene glycol) on silicon and glass surface for improved haemocompatibility. Applied Surface Sciences. 2009; 255(15):6771-6780.
  18. Zhou Y, Ye M, Chou L. Initial report of bony remodeling in treating palindromic trigeminal III with the active element graft after cutting off inferior alveolar nerve. Stomatology. 2009; 29(8):321-324.
  19. Sun XJ, Zhang ZY, Wang SY, Gittens SA, Jiang XQ, Chou LL. Maxillary sinus floor elevation using a tissue-engineered bone complex with OsteoBone and bMSCs in rabbits. Clin Oral Implants Res. 2008 Aug; 19(8):804-13. PMID: 18705812.
    View in: PubMed
  20. Ni S, Lin K, Chang J, Chou L. Beta-CaSiO3/beta-Ca3(PO4)2 composite materials for hard tissue repair: in vitro studies. J Biomed Mater Res A. 2008 Apr; 85(1):72-82. PMID: 17688291.
    View in: PubMed
  21. Gong F, Chou L, Li R. Scanning electron microscope observation of the rehabilitation and reconstruction of mandible defect with inorganic scaffold materials for tissue engineering. Journal of Oral Science Research. 2008; 1(24):12-15.
  22. Ye M, Chou L, Wang R, et al. Evaluation of reconstruction in jaw defects by the mineralized active inducement bone scaffold biomaterials from 69 cases. Journal of Plastic, Reconstructive and Aesthetic Surgery. Chinese Journal of Oral and Maxillofacial Surgery. 2008; (5):117.
  23. Huang J, Chou L, Li R, et al. Hemostatic effect of inorganic active element bone scaffold materials in vivo. Chinese Journal of Oral and Maxillofacial Surgery. 2008; 3(6):205-209.
  24. Huang J, Ye M, Chou L, et al. Post-operation wound healing by inorganic active elements in patients with cancer. Chinese Journal of Geriatric Dentistry. 2008; 1(6):21-23.
  25. Ni S, Chang J, Chou L. In vitro studies of novel CaO-SiO2-MgO system composite bioceramics. J Mater Sci Mater Med. 2008 Jan; 19(1):359-67. PMID: 17607509.
    View in: PubMed
  26. Ni S, Chang J, Chou L. Preparation and characterization of Forsterite (Mg2SiO4) bioceramics. Ceramics International. 2007; 33:83-88.
  27. Ye M, Chou L, et al. Clinical application of mineralized grafts in dental implantation. Chinese Journal of Maxillofacial Surgery. 2007; 5(2):107-109.
  28. Ye M, Chou L, Liu Y, et al. Reconstruction of sheep bone defect with osteogenic biomateirals. Chinese Journal of Tissue Engineering and Reconstruction. 2007; 48(11):9627-9633.
  29. Meng S, Zhong W, Chou L, Wang Q, Liu Z, Du Q. . Phosphorylcholine end-capped poly-E-caprolactone: a novel biodegradable material with improved antiadsorption property. Journal of Applied Polymer Science. 2007; (103):989-997.
  30. Ni S, Chang J, Chou L, Zhai W. Comparison of osteoblast-like cell responses to calcium silicate and tricalcium phosphate ceramics in vitro. J Biomed Mater Res B Appl Biomater. 2007 Jan; 80(1):174-83. PMID: 16767735.
    View in: PubMed
  31. Xi TF, Fan CX, Feng XM, Wan ZY, Wang CR, Chou LL. Cytotoxicity and altered c-myc gene expression by medical polyacrylamide hydrogel. J Biomed Mater Res A. 2006 Aug; 78(2):283-90. PMID: 16637045.
    View in: PubMed
  32. Ni S, Chang J, Chou L. A novel bioactive porous CaSiO3 scaffold for bone tissue engineering. J Biomed Mater Res A. 2006 Jan; 76(1):196-205. PMID: 16265636.
    View in: PubMed
  33. Kang R, Ye M, Wang L, Liu Y, Chou L. Radiographic study of tissue engineered sheep bone with osteogenic scaffolds. Stomatology. 2006; 26(3):211-213.
  34. Wang L, Chou L, Liu Q, et al. In vitro study of osteoinductive scaffolds for its biocompatibility. Journal of Modern Stomatology. 2006; 20(6):601-605.
  35. Zhou LS, Liao ZJ, Zhang Q, Luo M, Lu G, Zhang W. [Bio-inductive effects of inorganic elements on skin wound healing]. Zhonghua Shao Shang Za Zhi. 2005 Oct; 21(5):363-6. PMID: 16383040.
    View in: PubMed
  36. Ye M, Chou L, Chen K, et al. Histological study of repaired defect bone tissue with inorganic osteogenic elements. Chinese Journal of Maxillofacial Surgery. 2005; 15(3):247-251.
  37. Chou L. Biomedical engineering technology in wound healing. Chinese Journal of Burns. 2005; 20:1, 6-8.
  38. Chou L. Frontiers of research in biomaterials and tissue engineering. Scientific Chinese. 2005; (1):26.
  39. Ye M, Chou L, Kang R, et al. Radiological evaluation of reconstructing and repairing jaw defect with bioinductive materials. Chinese Journal of Maxillofacial Surgery. 2005; 15(4):330-334.
  40. Chen M, Ye M, Chou L, et al. . In vitro study on biocompatibility of osteogenic inorganic elements. Dental Research. 2005; 21(5):513-516.
  41. Ye M, Chou L, Li S, et al. Engineered bone with osteogenic scaffolds in dental application. Dental Research. 2005; 21(6):615-617.
  42. Chou L. HIV-associated oral lesions and dental practices – update. Shanghai Journal of Stomatology. 2004; 13:6-7.
  43. He C, Deng L, Chou L, Feng W, Wan C, Yang Q. Reparing of tip bone defect using a combination of autologous osteoblasts and nBGC. Chinese Journal of Plastic Surgery. 2003; 5(11):1047-1049.
  44. He C, Deng L, Chou L, Feng W, Wan C, Yang Q. Co-culture of canine osteoblasts and nBGC. Journal of Shanghai No. 2 Medical University. 2003; 4(23):301-304.
  45. Anhoury P, Nathanson D, Hughes CV, Socransky S, Feres M, Chou LL. Microbial profile on metallic and ceramic bracket materials. Angle Orthod. 2002 Aug; 72(4):338-43. PMID: 12169034.
    View in: PubMed
  46. Chou L. Clinical and research advances in Oral AIDS. Shanghai Journal of Stomatology. 2001; 3(10):193-195.
  47. Chou LL, Epstein J, Cassol SA, West DM, He W, Firth JD. Oral mucosal Langerhans' cells as target, effector and vector in HIV infection. J Oral Pathol Med. 2000 Sep; 29(8):394-402. PMID: 10972348.
    View in: PubMed
  48. Batal H, Chou LL, Cottrell DA. Sarcoidosis: medical and dental implications. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Oct; 88(4):386-90. PMID: 10519742.
    View in: PubMed
  49. Chou L, Marek B, Wagner WR. Effects of hydroxylapatite coating crystallinity on biosolubility, cell attachment efficiency and proliferation in vitro. Biomaterials. 1999 May; 20(10):977-85. PMID: 10353652.
    View in: PubMed
  50. Chou L, Firth JD, Uitto VJ, Brunette DM. Effects of titanium substratum and grooved surface topography on metalloproteinase-2 expression in human fibroblasts. J Biomed Mater Res. 1998 Mar 5; 39(3):437-45. PMID: 9468053.
    View in: PubMed
  51. Al-Bazie S, Cottrell D, Nathanson D, Chou L. In vivo study of the effects of Bioglass and HA synthetic bone grafts materials on the induction of osteocalcin and alkaline phosphatase. The Journal of Oral and Maxillofacial Surgery. 1998; 56(8):91-92.
  52. Chou L, Al-Bazie S, Cottrell D, Giordano R, Nathanson D:. Atomic and molecular mechanisms underlying the osteogenic effects of bioglass materials. Bioceramics. 1998; (11):265-268.
  53. Nathanson D, Lertpitayakun P, Lamkin MS, Edalatpour M, Chou LL. In vitro elution of leachable components from dental sealants. J Am Dent Assoc. 1997 Nov; 128(11):1517-23. PMID: 9368436.
    View in: PubMed
  54. Chou L. Effects of substratum surface chemistry and topography on extracellular matrix gene expression. Doctor of Philosophy Dissertation. 1997.
  55. Chou L, Firth JD, Nathanson D, Uitto VJ, Brunette DM. Effects of titanium on transcriptional and post-transcriptional regulation of fibronectin in human fibroblasts. J Biomed Mater Res. 1996 Jun; 31(2):209-17. PMID: 8731209.
    View in: PubMed
  56. Chou L, Firth JD, Uitto VJ, Brunette DM. Substratum surface topography alters cell shape and regulates fibronectin mRNA level, mRNA stability, secretion and assembly in human fibroblasts. J Cell Sci. 1995 Apr; 108 ( Pt 4):1563-73. PMID: 7615675.
    View in: PubMed
  57. Daniels TE, Chou L, Greenspan JS, Grady DG, Hauck WW, Greene JC, Ernster VL. Reduction of Langerhans cells in smokeless tobacco-associated oral mucosal lesions. J Oral Pathol Med. 1992 Mar; 21(3):100-4. PMID: 1374796.
    View in: PubMed
  58. Chou LS, Hansen LS, Daniels TE. Choristomas of the oral cavity: a review. Oral Surg Oral Med Oral Pathol. 1991 Nov; 72(5):584-93. PMID: 1745517.
    View in: PubMed
  59. Chou L, Ficarra G, Hansen LS. Hyaline ring granuloma: a distinct oral entity. Oral Surg Oral Med Oral Pathol. 1990 Sep; 70(3):318-24. PMID: 1699192.
    View in: PubMed
  60. Ficarra G, Chou L, and Panzon E. . Granular odontogenic cyst (sialo-odontogenic cyst). International Journal of Oral and Maxillofacial Surgery. 1990; 19:331-333.
  61. Kircos LT, Staninec M, Chou L. Comparative evaluation of the sensitometric properties of screen-film systems and conventional dental receptors for intraoral radiography. Oral Surg Oral Med Oral Pathol. 1989 Dec; 68(6):787-92. PMID: 2594331.
    View in: PubMed
  62. Chou LS, Hansen LS. Ganglioneuroma of the mandible. Oral Surg Oral Med Oral Pathol. 1989 Aug; 68(2):201-5. PMID: 2674830.
    View in: PubMed
  63. Kircos LT, Staninec M, Chou LS. Rare earth filters for intraoral radiography: exposure reduction as a function of kV(p) with comparisons of image quality. J Am Dent Assoc. 1989 May; 118(5):605-9. PMID: 2715547.
    View in: PubMed
  64. Kircos LT, Staninec M, Chou LS. Effect of developer temperature changes on the sensitometric properties of direct exposure and screen-film imaging systems. Dentomaxillofac Radiol. 1989 Feb; 18(1):11-4. PMID: 2599232.
    View in: PubMed
  65. Wang X, Chou L, Liang J, and Ni J. The location of the apical foramen of human teeth and its clinical significance. Journal of Stomatology. 1989; 6:243-246.
  66. Steller M, Chou L, Daniels TE. Electrical stimulation of salivary flow in patients with Sjögren's syndrome. J Dent Res. 1988 Oct; 67(10):1334-7. PMID: 3262637.
    View in: PubMed
  67. Chou L and Hansen L. . Oral manifestations of the AIDS - Up date. International Journal of Stomatology. 1988; 12:68-72.
  68. Chou L and Hansen L. . Acquired immunodeficiency syndrome (AIDS) and its oral manifestations. Journal of Stomatology. 1986; (6):57-60.
  69. Chou L. Anhidrotic ectodermal dysplasia syndrome. Journal of Stomatology. 1985; (5):123-125.
  70. Chou L. Anodontia. International Journal of Stomatology. 1980; (4):205-208.
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