Laisheng (Lee) Chou, DMD, PhD
Professor
Boston University Henry M. Goldman School of Dental Medicine
Dept of Restorative Sciences & Biomaterials

DMD, Shanghai Second Medical University
PhD, University of British Columbia



Expertise in molecular biocompatibility of implant materials. Hydroxyapatite (HA) and bioactive glass materials are commonly used in medical and dental implants. However, the mechanisms by which implant material surface chemistry and topography initiate the biological tissue response, and the molecular nature the tissue response still remain largely unknown. This study aims to establish the in vitro and in vivo molecular profiles of osteogenic activities as a function of biomaterial surface chemistry and topography. The expected profile will be used as a biological guide for: (1) the selection of optimal material surface chemistry and topography for controlled cell attachment and bone formation, and (2) the development of novel osteoinductive coating systems for dental and medical implant devices.

Expertise in engineered bone regeneration with biomimetic scaffolds. Over one million surgical operations annually in this country involve bone repair. An existing challenge in bone tissue engineering is to develop scaffolds which have programmed osteogenic bioactivity and biodegradation. The study has been carried out in this field is based on the hypothesis that the material chemistry and three-dimensional geometry of tissue engineering scaffolds can be manipulated under the guidance of biological parameters, resulting in scaffold-controlled tissue reactions favorable to bone regeneration. The long-term goal is to develop a novel approach to biomimetic scaffolds with ordered microarchitectures and biofunctional ingredients, as well as anatomically accurate macrostructure for clinical treatment of orofacial and orthopedic bone defects.

Expertise in HIV-1 infection in oral mucosal Langerhans cells.

Professor
Boston University Henry M. Goldman School of Dental Medicine
General Dentistry


Director of Oral Medicine
Boston University Henry M. Goldman School of Dental Medicine
General Dentistry




AIDS Education and Training Center's Program
09/01/2015 - 06/30/2017 (PI)
University of Massachusetts, Worcester HHS HRSA
6U1OHA29294-02-02

AIDS Education and Training Centers
07/01/2014 - 08/31/2015 (PI)
University of Massachusetts, Worcester HHS HRSA
5H4AHA00050-13-00

AIDS Education and Training Centers
07/01/2012 - 08/30/2014 (PI)
University of Massachusetts, Worcester HHS HRSA
5H4AHA00050-12-00

New England AIDS Education and Training Center
07/01/2011 - 06/30/2012 (PI)
University of Massachusetts, Worcester HHS HRSA
6H4AHA00050-10-01

AIDS Education and Clinical Training
07/01/2002 - 06/30/2007 (PI)
University of Massachusetts, Worcester HHS HRSA

Sol-Gel Animal Study
07/01/2002 - 06/15/2003 (PI)
US Biomaterials Corporation

New England AIDS Education and Training Center
01/01/1998 - 06/30/2002 (PI)
University of Massachusetts NIH BHP




Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Xu L, Shao A, Zhao Y, Wang Z, Zhang C, Sun Y, Deng J, Chou LL. Neurotoxicity of Silver Nanoparticles in Rat Brain After Intragastric Exposure. J Nanosci Nanotechnol. 2015 Jun; 15(6):4215-23. PMID: 26369032.
  2. Xu L, Shi C, Shao A, Li X, Cheng X, Ding R, Wu G, Chou LL. Toxic responses in rat embryonic cells to silver nanoparticles and released silver ions as analyzed via gene expression profiles and transmission electron microscopy. Nanotoxicology. 2015 May; 9(4):513-22. PMID: 25119417; DOI: 10.3109/17435390.2014.948942;.
  3. Zhang ZC, Giordano R, Shen G, Chou LL, Qian YF. Shear bond strength of an experimental composite bracket. J Orofac Orthop. 2013 Jul; 74(4):319-31.View Related Profiles. PMID: 23807258; DOI: 10.1007/s00056-013-0154-z;.
  4. Xu L, Li X, Takemura T, Hanagata N, Wu G, Chou LL. Genotoxicity and molecular response of silver nanoparticle (NP)-based hydrogel. J Nanobiotechnology. 2012; 10:16. PMID: 22548743; PMCID: PMC3430588; DOI: 10.1186/1477-3155-10-16;.
  5. Ortiz J, Chou LL. Calcium upregulated survivin expression and associated osteogenesis of normal human osteoblasts. J Biomed Mater Res A. 2012 Jul; 100(7):1770-6. PMID: 22488949; DOI: 10.1002/jbm.a.34103;.
  6. Xu Z, Chou L, Sun J. Effects of SiO2 nanoparticles on HFL-I activating ROS-mediated apoptosis via p53 pathway. J Appl Toxicol. 2012 May; 32(5):358-64. PMID: 21766316; DOI: 10.1002/jat.1710;.
  7. Zhang C, Hong S, Yang P, Zhong W, Xie S, Chou L. Application of PET in diagnosis and treatment plan of head and neck tumors. Chinese Journal of Oral and Maxillofacial Surgery. 2011; 5(9):430-434.
  8. Jin H, Zhang W, Jiao Q, Li G, Xie S, Zhong W, Chou L. Technique of cone-beam computed tomography for oral clinic practice. Journal of Dental Materials and Devices. 2011; 3(20):158-161.
  9. Huang J, Chou L, Li R. Cellular affinity of inorganic active element bone scaffold materials. Journal of Medical, Aesthetics and Cosmetology. 2011; 1(17):44-47.
  10. Tang J, Xiong L, Zhou G, Wang S, Wang J, Liu L, Li J, Yuan F, Lu S, Wan Z, Chou L, Xi T. Silver nanoparticles crossing through and distribution in the blood-brain barrier in vitro. J Nanosci Nanotechnol. 2010 Oct; 10(10):6313-7. PMID: 21137724.
Showing 10 of 70 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 70 publications over 29 distinct years, with a maximum of 7 publications in 2005

YearPublications
19801
19851
19861
19882
19895
19902
19911
19921
19951
19961
19972
19983
19992
20001
20011
20021
20032
20041
20057
20064
20076
20086
20093
20106
20114
20122
20131
20141
20151
Contact for Mentoring:


650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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