Zhen Jiang | Profiles RNS

Zhen Y. Jiang, MD, PhD

Associate Professor

Boston University Chobanian & Avedisian School of Medicine

Pharmacology, Physiology & Biophysics

MD, Jiangxi University of Traditional Chinese Medicine
PhD, University of London
MSc, China Academy of Chinese Medical Sciences (CACMS)

Websites

	Pharmacology & Experimental Therapeutics Faculty
	Jiang Lab

ORCID : 0000-0001-6520-2226

Experience

Dr. Jiang was trained as a Medical Doctor before earning his M.S. in Pharmacology from Peking Union Medical College, China, and a Ph.D. in Biochemistry from University College, the University of London, UK. He did his postdoctoral research training at the Joslin Diabetes Center, Harvard Medical School in Boston before working as an Instructor/Research Assistant Professor in the Program in Molecular Medicine at the University of Massachusetts Medical School. Dr. Jiang was then recruited to the Diabetes and Obesity Research Center at Sanford-Burnham Medical Research Institute as an Assistant Professor in 2008. Dr. Jiang has been a faculty member in the Department of Pharmacology and Whitaker Cardiovascular Institute at Chobanian and Avedisian School of Medicine since 2013.

Research Interests

Jiang lab is interested in understanding how nutritional factors, obesity and gut microbiota influence myelopoiesis and innate immunity in connection with adipose inflammation, insulin sensitivity, metabolic and vascular functions. Currently, Jiang lab is mainly focused on the following research areas: (1) Understanding how innate immunity regulates metabolic and vascular functions. In particular, we are exploring the role of neutrophils and neutrophil elastase in the development of adipose inflammation, insulin resistance and vascular dysfunction (Mansuy-Aubert V et al, Cell Metabolism 2013). (2) Investigating the role of CDP138, a novel calcium-binding phosphoprotein, in the regulation of glucose and lipid metabolisms, thermogenesis, fat browning, and cardiovascular functions (Xie X et al, Cell Metabolism 2011). Approaches used in the lab include flow cytometry, live cell imaging, bone marrow transplantation, transcriptional regulation, cell differentiation, and genetically modified animal models fed with high-fat diet.

Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Endocrinology, Diabetes, Nutrition & Weight Management

Member
Boston University
Whitaker Cardiovascular Institute

Associate Professor
Boston University Chobanian & Avedisian School of Medicine
Medicine
Cardiovascular Medicine

Graduate Faculty (Primary Mentor of Grad Students)
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences

BU Research
NIH RePORTER Research

Neutrophils play a pivotal role in vascular aging
03/22/2023 - 02/28/2027 (PI)
NIH/National Heart, Lung, and Blood Institute
1R01HL168560-01

Neutrophil elastase in obesity-related fatty liver diseases
09/15/2020 - 08/31/2024 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK126949-03

Neutrophil elastase in obesity-related fatty liver diseases
09/15/2019 - 08/31/2022 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
1R56DK121142-01A1

Regulation of Neutrophil production and phenotypes in diet-induced obesity
01/01/2016 - 06/30/2019 (PI)
American Diabetes Association

Phosphoprotein CDP138 Regulates Glucose Metabolism
12/01/2013 - 05/31/2018 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK094025-06

High-fat diet-induced regulation of gene expression in bone marrow neutrophils and progenitors
01/01/2017 - 12/31/2017 (PI)
American Diabetes Association

Novel Protein PPC2D functions as a converging point for GLUT4 translocation
10/26/2013 - 06/30/2014 (PI)
American Diabetes Association

Role of PPC2D in Exercise-Regulated Glucose Metabolism
10/25/2013 - 06/30/2014 (PI)
American Diabetes Association

Title

Yr	Title	Project-Sub Proj	Pubs
2024	Neutrophils play a pivotal role in vascular aging	5R01HL168560-02
2023	Neutrophils play a pivotal role in vascular aging	1R01HL168560-01
2022	Neutrophil elastase in obesity-related fatty liver diseases	5R01DK126949-03
2021	Neutrophil elastase in obesity-related fatty liver diseases	5R01DK126949-02
2020	Neutrophil elastase in obesity-related fatty liver diseases	1R01DK126949-01
2019	Neutrophil elastase in obesity-related fatty liver diseases	1R56DK121142-01A1
2016	Phosphoprotein CDP138 regulates glucose metabolism	5R01DK094025-06	4
2015	Phosphoprotein CDP138 regulates glucose metabolism	5R01DK094025-05	4
2014	Phosphoprotein CDP138 regulates glucose metabolism	5R01DK094025-04	4
2013	Phosphoprotein CDP138 regulates glucose metabolism	7R01DK094025-03	4

Showing 10 of 13 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Ushakumari CJ, Zhou QL, Wang YH, Na S, Rigor MC, Zhou CY, Kroll MK, Lin BD, Jiang ZY. Neutrophil Elastase Increases Vascular Permeability and Leukocyte Transmigration in Cultured Endothelial Cells and Obese Mice. Cells. 2022 Jul 25; 11(15). PMID: 35892585; PMCID: PMC9332277; DOI: 10.3390/cells11152288;

Zhou QL, Song Y, Huang CH, Huang JY, Gong Z, Liao Z, Sharma AG, Greene L, Deng JZ, Rigor MC, Xie X, Qi S, Ayala JE, Jiang ZY. Membrane Trafficking Protein CDP138 Regulates Fat Browning and Insulin Sensitivity through Controlling Catecholamine Release. Mol Cell Biol. 2018 04 15; 38(8).View Related Profiles.

Zhou, Qiong
Jiang, Zhen

PMID: 29378832; PMCID: PMC5879461; DOI: 10.1128/MCB.00153-17;

Huang JY, Zhou QL, Huang CH, Song Y, Sharma AG, Liao Z, Zhu K, Massidda MW, Jamieson RR, Zhang JY, Tenen DG, Jiang ZY. Neutrophil Elastase Regulates Emergency Myelopoiesis Preceding Systemic Inflammation in Diet-induced Obesity. J Biol Chem. 2017 Mar 24; 292(12):4770-4776.View Related Profiles.

Zhu, Kavin
Zhou, Qiong
Jiang, Zhen

PMID: 28202548; PMCID: PMC5377793; DOI: 10.1074/jbc.C116.758748;

Mansuy-Aubert V, Zhou QL, Xie X, Gong Z, Huang JY, Khan AR, Aubert G, Candelaria K, Thomas S, Shin DJ, Booth S, Baig SM, Bilal A, Hwang D, Zhang H, Lovell-Badge R, Smith SR, Awan FR, Jiang ZY. Imbalance between neutrophil elastase and its inhibitor a1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab. 2013 Apr 2; 17(4):534-48.View Related Profiles.

Zhou, Qiong
Jiang, Zhen

PMID: 23562077; PMCID: PMC3646573; DOI: 10.1016/j.cmet.2013.03.005;

Xie X, Gong Z, Mansuy-Aubert V, Zhou QL, Tatulian SA, Sehrt D, Gnad F, Brill LM, Motamedchaboki K, Chen Y, Czech MP, Mann M, Krüger M, Jiang ZY. C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Cell Metab. 2011 Sep 7; 14(3):378-89.View Related Profiles.

Zhou, Qiong
Jiang, Zhen

PMID: 21907143; PMCID: PMC3172579; DOI: 10.1016/j.cmet.2011.06.015;

Zhou QL, Jiang ZY, Mabardy AS, Del Campo CM, Lambright DG, Holik J, Fogarty KE, Straubhaar J, Nicoloro S, Chawla A, Czech MP. A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes. J Biol Chem. 2010 Sep 3; 285(36):27581-9.View Related Profiles.

Zhou, Qiong
Jiang, Zhen

PMID: 20587420; PMCID: PMC2934625; DOI: 10.1074/jbc.M110.146886;

Zhou QL, Jiang ZY, Holik J, Chawla A, Hagan GN, Leszyk J, Czech MP. Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes. Biochem J. 2008 May 1; 411(3):647-55.View Related Profiles.

Zhou, Qiong
Jiang, Zhen

PMID: 18215134; PMCID: PMC2903061; DOI: 10.1042/BJ20071084;

Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP. Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells. J Biol Chem. 2005 Jun 3; 280(22):21622-8.View Related Profiles.

Zhou, Qiong
Jiang, Zhen

PMID: 15799971; DOI: 10.1074/jbc.M414464200;

Zhou QL, Park JG, Jiang ZY, Holik JJ, Mitra P, Semiz S, Guilherme A, Powelka AM, Tang X, Virbasius J, Czech MP. Analysis of insulin signalling by RNAi-based gene silencing. Biochem Soc Trans. 2004 Nov; 32(Pt 5):817-21.View Related Profiles.

Zhou, Qiong
Jiang, Zhen

PMID: 15494023; DOI: 10.1042/BST0320817;

Zhou QL, Park JG, Jiang ZY, Holik J, Mitra P, Semitz S, Guilherme A, Powelka AM, Tang X, Virbasius J, Czech MP. Analysis of insulin signaling by si RNA-b ased gene silencing. Biochemical Soc. Transactions. 2004; 32:817-21.

Showing 10 of 33 results. Show More

Jiang ZY, Zhou QL, Coleman KA, Chouinard M, Boese Q, Czech MP. Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7569-74.View Related Profiles.

Zhou, Qiong
Jiang, Zhen

PMID: 12808134; PMCID: PMC164627; DOI: 10.1073/pnas.1332633100;

Jiang ZY, He Z, King BL, Kuroki T, Opland DM, Suzuma K, Suzuma I, Ueki K, Kulkarni RN, Kahn CR, King GL. Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J. Biol.Chem. 2003; 278:31964-71.

Bose A, Guilherme A, Robida SI, Nicoloro SM, Zhou QL, Jiang ZY, Pomerleau DP, Czech MP. Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Nature. 2002 Dec 19-26; 420(6917):821-4.View Related Profiles.

Zhou, Qiong
Jiang, Zhen

PMID: 12490950; DOI: 10.1038/nature01246;

Jiang ZY, Chawla A, Bose A, Way M, Czech MP. A PI 3-kinase-independent Insulin Signaling Pathway through N-WASP-Arp2-3/F-Actinin Required for GLUT4 Glucose Transporter Recycling. J. Biol. Chem. 2002; 277:509-515.

Cai W, Rook SL, Jiang ZY, Takahara N, Aiello LP. Mechanisms of hepatocyte growth factor-induced retinal endothelial cell migration and growth. Invest Ophthalmol Vis Sci. 2000 Jun; 41(7):1885-93. PMID: 10845613

Goldfine AB, Patti ME, Zuberi L, Goldstein BJ, LeBlanc R, Landaker EJ, Jiang ZY, Willsky GR, Kahn CR. Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. Metabolism. 2000 Mar; 49(3):400-10. PMID: 10726921

Kuboki K, Jiang ZY, Takahara N, Ha SW, Igarashi M, Yamauchi T, Feener EP, Herbert TP, Rhodes CJ, King GL. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin. Circulation. 2000 Feb 15; 101(6):676-81. PMID: 10673261

Jiang ZY, Zhou QL, Chatterjee A, Feener EP, Myers MG, White MF, King GL. Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. Diabetes. 1999 May; 48(5):1120-30.View Related Profiles.

Zhou, Qiong
Jiang, Zhen

PMID: 10331419

Jiang ZY, Lin YW, Clermont AC, Feener EP, Hein KD, Igarashi M, Yamauchi T, White MF, King GL. Selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J. Clin. Invest. 1999; 104:447-57.

Igarashi M, Wakasaki H, Takahara N, Ishii H, Jiang ZY, Yamauchi T, Kuboki K, Meier M, Rhodes CJ, King GL. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest. 1999 Jan; 103(2):185-95. PMID: 9916130; PMCID: PMC407875; DOI: 10.1172/JCI3326;

Jiang ZY, Zhou QL, Chatterjee A, Feener EP, Myers Jr. MG, White MF, King GL. Endothelin-1 modulates insulin signaling through PI3-kinase pathway in vascular smooth muscle cells. Diabetes. 1999; 48:1120 -30.
Fang C, Jiang Z, Tomlinson. Expression of constitutive cyclo-oxygenase (COX-1) in rats with streptozotocin-induced diabetes; effects of treatment with evening primrose oil or an aldose reductase inhibitor on COX-1 mRNA levels. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 1997; 56:167-63.
Jiang ZY, Towler HMA, Luthert P, Lightman SL. Diabetes Mellitus: A Fundamental and Clnical Text. Eds: LeRoith D, Taylor SI, Olefsky JM. Pathophysiology of diabetic retinopathy. Lippincott-Raven. Philadelphia, PA. 1996; 719-27.
Takagi C, Bussell S-E, Lin Y-W, Takagi H, Duh E, Jiang Z, Clermont AC, King GL. Regulation of retinal hemodynamics in diabetic rats by increased expression and action of ET-1. Investigative Ophthalmology Visual Science. 1996; 37: 2504-18.
Xia P, Aiello, Jiang ZY, Park DJ, Robinson GS, Takagi H, Newsome WP, Jirousek MR, King GL. Characterization of vascular endothelial growth factor’s effect on the activation of protein kinase C, its isoforms and endothelial cell growth. J. Clin. Invest. 1996; 98:2018-2026.
Jiang Z, Xie MZ. The hypoglycemic effect of AH—9. Zhongguo Yi Xue Ke Hue Yuan Xue Bao (Chinese). 1993; 15(4):235-41.
Jiang Z, Xie MZ. The antioxidant action of AH-9. Zhongguo Yi Xue Ke Hue Yuan Xue Bao (Chinese). 1993; 15(4):291-4.

Hunt JV, Jiang ZY, Wolff SP. Formation of hydrogen peroxide by lens proteins: protein-derived hydrogen peroxide as a potential mechanism of oxidative insult to the lens. Free Radic Biol Med. 1992 Oct; 13(4):319-23. PMID: 1398215

Jiang ZY, Hunt JV, Wolff SP. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein. Anal Biochem. 1992 May 1; 202(2):384-9. PMID: 1519766

Jiang ZY, Zhou QL, Eaton JW, Koppenol WH, Hunt JV, Wolff SP. Spirohydantoin inhibitors of aldose reductase inhibit iron- and copper-catalysed ascorbate oxidation in vitro. Biochem Pharmacol. 1991 Aug 22; 42(6):1273-8.View Related Profiles.

Zhou, Qiong
Jiang, Zhen

PMID: 1909528

Wolff SP, Jiang ZY, Hunt JV. Protein glycation and oxidative stress in diabetes mellitus and ageing. Free Radic Biol Med. 1991; 10(5):339-52. PMID: 1855674

Wolff SP, Jiang ZY. In “Eye lens membranes and Aging,” Eds. Vrensen GFJM, Clauweaert J. Eye lens membranes and Aging. Eds. Vrensen GFJM, Clauweaert J,. Free radical and cataract: direct chemical damage or exaggerated physiological response?. Eurage. The Netherlands. 1991; 221-31.

Jiang ZY, Woollard AC, Wolff SP. Hydrogen peroxide production during experimental protein glycation. FEBS Lett. 1990 Jul 30; 268(1):69-71. PMID: 2384174

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 33 publications over 19 distinct years, with a maximum of 4 publications in 1999