Zhen Y. Jiang, MD, PhD
Associate Professor
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

MD, Jiangxi University of Traditional Chinese Medicine
PhD, University of London
MSc, China Academy of Chinese Medical Sciences (CACMS)



Experience

Dr. Jiang was trained as a Medical Doctor before earning his M.S. in Pharmacology from Peking Union Medical College, China, and a Ph.D. in Biochemistry from University College, the University of London, UK. He did his postdoctoral research training at the Joslin Diabetes Center, Harvard Medical School in Boston before working as an Instructor/Research Assistant Professor in the Program in Molecular Medicine at the University of Massachusetts Medical School. Dr. Jiang was then recruited to the Diabetes and Obesity Research Center at Sanford-Burnham Medical Research Institute as an Assistant Professor in 2008. Dr. Jiang has been a faculty member in the Department of Pharmacology and Whitaker Cardiovascular Institute at Boston University School of Medicine since 2013.

Research Interests

Jiang lab is interested in understanding how nutritional factors, obesity and gut microbiota influence myelopoiesis and innate immunity in connection with adipose inflammation, insulin sensitivity, metabolic and vascular functions. Currently, Jiang lab is mainly focused on the following research areas: (1) Understanding how innate immunity regulates metabolic and vascular functions. In particular, we are exploring the role of neutrophils and neutrophil elastase in the development of adipose inflammation, insulin resistance and vascular dysfunction (Mansuy-Aubert V et al, Cell Metabolism 2013). (2) Investigating the role of CDP138, a novel calcium-binding phosphoprotein, in the regulation of glucose and lipid metabolisms, thermogenesis, fat browning, and cardiovascular functions (Xie X et al, Cell Metabolism 2011). Approaches used in the lab include flow cytometry, live cell imaging, bone marrow transplantation, transcriptional regulation, cell differentiation, and genetically modified animal models fed with high-fat diet.

Associate Professor
Boston University School of Medicine
Medicine
Endocrinology, Diabetes & Nutrition

Associate Professor
Boston University School of Medicine
Medicine
Cardiovascular Medicine


2003-2006 American Diabetes Association: Junior Faculty Award
1998-1999 NIH: Training Fellowship
1997-1998 Mary K. Iacocca Research Fellowship
1993-1994 Fight for Sight (UK): Research Fellowship
1989-1993 Research into Aging (UK): Scholarship


REGULATION OF NEUTROPHIL PRODUCTION AND PHENOTYPES IN DIET-INDUCED OBESITY
01/01/2016 - 12/31/2018 (PI)
American Diabetes Association

PHOSPHOPROTEIN CDP138 REGULATES GLUCOSE METABOLISM
12/01/2013 - 05/31/2018 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK094025-06

HIGH-FAT DIET-INDUCED REGULATION OF GENE EXPRESSION IN BONE MARROW NEUTROPHILS AND PROGENITORS
01/01/2017 - 12/31/2017 (PI)
American Diabetes Association

NOVEL PROTEIN PPC2D FUNCTIONS AS A CONVERGING POINT FOR GLUT4 TRANSLOCATION
10/26/2013 - 06/30/2014 (PI)
American Diabetes Association

ROLE OF PPC2D IN EXERCISE-REGULATED GLUCOSE METABOLISM
10/25/2013 - 06/30/2014 (PI)
American Diabetes Association



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Zhou QL, Song Y, Huang CH, Huang JY, Gong Z, Liao Z, Sharma AG, Greene L, Deng JZ, Rigor MC, Xie X, Qi S, Ayala JE, Jiang ZY. Membrane Trafficking Protein CDP138 Regulates Fat Browning and Insulin Sensitivity through Controlling Catecholamine Release. Mol Cell Biol. 2018 Jan 29.View Related Profiles. PMID: 29378832.
     
  2. Huang JY, Zhou QL, Huang CH, Song Y, Sharma AG, Liao Z, Zhu K, Massidda MW, Jamieson RR, Zhang JY, Tenen DG, Jiang ZY. Neutrophil Elastase Regulates Emergency Myelopoiesis Preceding Systemic Inflammation in Diet-induced Obesity. J Biol Chem. 2017 Mar 24; 292(12):4770-4776.View Related Profiles. PMID: 28202548; DOI: 10.1074/jbc.C116.758748;.
     
  3. Mansuy-Aubert V, Zhou QL, Xie X, Gong Z, Huang JY, Khan AR, Aubert G, Candelaria K, Thomas S, Shin DJ, Booth S, Baig SM, Bilal A, Hwang D, Zhang H, Lovell-Badge R, Smith SR, Awan FR, Jiang ZY. Imbalance between neutrophil elastase and its inhibitor a1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab. 2013 Apr 2; 17(4):534-48.View Related Profiles. PMID: 23562077; PMCID: PMC3646573; DOI: 10.1016/j.cmet.2013.03.005;.
     
  4. Xie X, Gong Z, Mansuy-Aubert V, Zhou QL, Tatulian SA, Sehrt D, Gnad F, Brill LM, Motamedchaboki K, Chen Y, Czech MP, Mann M, Krüger M, Jiang ZY. C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Cell Metab. 2011 Sep 7; 14(3):378-89.View Related Profiles. PMID: 21907143; PMCID: PMC3172579; DOI: 10.1016/j.cmet.2011.06.015;.
     
  5. Zhou QL, Jiang ZY, Mabardy AS, Del Campo CM, Lambright DG, Holik J, Fogarty KE, Straubhaar J, Nicoloro S, Chawla A, Czech MP. A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes. J Biol Chem. 2010 Sep 3; 285(36):27581-9.View Related Profiles. PMID: 20587420; PMCID: PMC2934625; DOI: 10.1074/jbc.M110.146886;.
     
  6. Zhou QL, Jiang ZY, Holik J, Chawla A, Hagan GN, Leszyk J, Czech MP. Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes. Biochem J. 2008 May 1; 411(3):647-55.View Related Profiles. PMID: 18215134; PMCID: PMC2903061; DOI: 10.1042/BJ20071084;.
     
  7. Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP. Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells. J Biol Chem. 2005 Jun 3; 280(22):21622-8.View Related Profiles. PMID: 15799971; DOI: 10.1074/jbc.M414464200;.
     
  8. Zhou QL, Park JG, Jiang ZY, Holik JJ, Mitra P, Semiz S, Guilherme A, Powelka AM, Tang X, Virbasius J, Czech MP. Analysis of insulin signalling by RNAi-based gene silencing. Biochem Soc Trans. 2004 Nov; 32(Pt 5):817-21.View Related Profiles. PMID: 15494023; DOI: 10.1042/BST0320817;.
     
  9. Zhou QL, Park JG, Jiang ZY, Holik J, Mitra P, Semitz S, Guilherme A, Powelka AM, Tang X, Virbasius J, Czech MP. Analysis of insulin signaling by si RNA-b ased gene silencing. Biochemical Soc. Transactions. 2004; 32:817-21.
  10. Jiang ZY, Zhou QL, Coleman KA, Chouinard M, Boese Q, Czech MP. Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7569-74.View Related Profiles. PMID: 12808134; PMCID: PMC164627; DOI: 10.1073/pnas.1332633100;.
     
Showing 10 of 32 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 32 publications over 18 distinct years, with a maximum of 4 publications in 1999

YearPublications
19901
19913
19922
19932
19963
19971
19994
20003
20022
20032
20042
20051
20081
20101
20111
20131
20171
20181
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

obesity, insulin resistance, adipose inflammation, myelopoiesis, neutrophil polarization, neutrophil elastase
Contact for Mentoring:


650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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