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Last Name

Qiong L. Zhou, PhD

TitleResearch Assistant Professor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-4842
 Research Expertise & Professional Interests
Dr. Zhou currently works directly with Zhen Y. Jiang, M.D., Ph.D., Director of the Laboratory of Diabetes and Obesity Research, on understanding how insulin signaling networks and innate immunity regulate metabolic functions.

During her research career, Qiong L. Zhou, Ph.D., has contributed significantly to collaborative projects with renowned scientists. In a collaborative study with Dr. Craig Mello’s laboratory while at the University of Massachusetts Medical School, she established microRNA profiles of three sets of samples from: 1. 3T3-L1 preadipocytes, adipocytes and adipocytes treated with insulin; 2. human muscle tissues from non exercised or exercised individuals; and 3. human monocytes before and after lipid perfusion by using deep sequencing technique. She is continuing to analyze these profiles to identify the major microRNAs that target the components of insulin signaling pathways and key molecules involved in diabetes and obesity. She was also part of the team that identified a new Akt substrate, TBC1D1, a RabGAP containing protein. These results were published in a paper suggesting that TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes (Zhou et al, Biochem J. 2008). While at the Sanford-Burnham Medical Research Institute, Qiong has worked on a project dissecting the role of neutrophil elastase in the development of high-fat diet induced obesity and related inflammation, insulin resistance and energy imbalance with different mouse models. This also resulted in a recent publication (Aubert et al, Cell Metabolism 2013).

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Huang JY, Zhou QL, Huang CH, Song Y, Sharma AG, Liao Z, Zhu K, Massidda MW, Jamieson RR, Zhang JY, Tenen DG, Jiang ZY. Neutrophil Elastase Regulates Emergency Myelopoiesis Preceding Systemic Inflammation in Diet-induced Obesity. J Biol Chem. 2017 Mar 24; 292(12):4770-4776. PMID: 28202548.
    View in: PubMed
  2. Mansuy-Aubert V, Zhou QL, Xie X, Gong Z, Huang JY, Khan AR, Aubert G, Candelaria K, Thomas S, Shin DJ, Booth S, Baig SM, Bilal A, Hwang D, Zhang H, Lovell-Badge R, Smith SR, Awan FR, Jiang ZY. Imbalance between neutrophil elastase and its inhibitor a1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab. 2013 Apr 2; 17(4):534-48. PMID: 23562077.
    View in: PubMed
  3. Xie X, Gong Z, Mansuy-Aubert V, Zhou QL, Tatulian SA, Sehrt D, Gnad F, Brill LM, Motamedchaboki K, Chen Y, Czech MP, Mann M, Krüger M, Jiang ZY. C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Cell Metab. 2011 Sep 7; 14(3):378-89. PMID: 21907143.
    View in: PubMed
  4. Zhou QL, Jiang ZY, Mabardy AS, Del Campo CM, Lambright DG, Holik J, Fogarty KE, Straubhaar J, Nicoloro S, Chawla A, Czech MP. A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes. J Biol Chem. 2010 Sep 3; 285(36):27581-9. PMID: 20587420.
    View in: PubMed
  5. Walz HA, Shi X, Chouinard M, Bue CA, Navaroli DM, Hayakawa A, Zhou QL, Nadler J, Leonard DM, Corvera S. Isoform-specific regulation of Akt signaling by the endosomal protein WDFY2. J Biol Chem. 2010 May 7; 285(19):14101-8. PMID: 20189988.
    View in: PubMed
  6. Zhou QL, Jiang ZY, Holik J, Chawla A, Hagan GN, Leszyk J, Czech MP. Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes. Biochem J. 2008 May 1; 411(3):647-55. PMID: 18215134.
    View in: PubMed
  7. Forman SA, Zhou QL, Stewart DS. Photoactivated 3-azioctanol irreversibly desensitizes muscle nicotinic ACh receptors via interactions at alphaE262. Biochemistry. 2007 Oct 23; 46(42):11911-8. PMID: 17910479.
    View in: PubMed
  8. Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP. Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells. J Biol Chem. 2005 Jun 3; 280(22):21622-8. PMID: 15799971.
    View in: PubMed
  9. Zhou QL, Park JG, Jiang ZY, Holik JJ, Mitra P, Semiz S, Guilherme A, Powelka AM, Tang X, Virbasius J, Czech MP. Analysis of insulin signalling by RNAi-based gene silencing. Biochem Soc Trans. 2004 Nov; 32(Pt 5):817-21. PMID: 15494023.
    View in: PubMed
  10. Jiang ZY, Zhou QL, Coleman KA, Chouinard M, Boese Q, Czech MP. Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7569-74. PMID: 12808134.
    View in: PubMed
  11. Bose A, Guilherme A, Robida SI, Nicoloro SM, Zhou QL, Jiang ZY, Pomerleau DP, Czech MP. Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Nature. 2002 Dec 19-26; 420(6917):821-4. PMID: 12490950.
    View in: PubMed
  12. Zhou QL, Strichartz G, Davar G. Endothelin-1 activates ET(A) receptors to increase intracellular calcium in model sensory neurons. Neuroreport. 2001 Dec 4; 12(17):3853-7. PMID: 11726808.
    View in: PubMed
  13. Zhou QL, Zhou Q, Forman SA. The n-alcohol site in the nicotinic receptor pore is a hydrophobic patch. Biochemistry. 2000 Dec 05; 39(48):14920-6. PMID: 11101308.
    View in: PubMed
  14. Jiang ZY, Zhou QL, Chatterjee A, Feener EP, Myers MG, White MF, King GL. Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. Diabetes. 1999 May; 48(5):1120-30. PMID: 10331419.
    View in: PubMed
  15. Jiang ZY, Zhou QL, Eaton JW, Koppenol WH, Hunt JV, Wolff SP. Spirohydantoin inhibitors of aldose reductase inhibit iron- and copper-catalysed ascorbate oxidation in vitro. Biochem Pharmacol. 1991 Aug 22; 42(6):1273-8. PMID: 1909528.
    View in: PubMed
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