Keywords
Last Name

Zhen Y. Jiang, MD, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPharmacology & Experimental Therapeutics
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-4300
Other Positions
TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionEndocrinology, Diabetes & Nutrition

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionCardiovascular Medicine

 Awards and Honors

Start-EndDescription
2003-2006American Diabetes Association: Junior Faculty Award
1998-1999NIH: Training Fellowship
1997-1998Mary K. Iacocca Research Fellowship
1993-1994Fight for Sight (UK): Research Fellowship
1989-1993Research into Aging (UK): Scholarship
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mansuy-Aubert V, Zhou QL, Xie X, Gong Z, Huang JY, Khan AR, Aubert G, Candelaria K, Thomas S, Shin DJ, Booth S, Baig SM, Bilal A, Hwang D, Zhang H, Lovell-Badge R, Smith SR, Awan FR, Jiang ZY. Imbalance between neutrophil elastase and its inhibitor a1-antitrypsin in obesity alters insulin sensitivity, inflammation, and energy expenditure. Cell Metab. 2013 Apr 2; 17(4):534-48. PMID: 23562077.
    View in: PubMed
  2. Xie X, Gong Z, Mansuy-Aubert V, Zhou QL, Tatulian SA, Sehrt D, Gnad F, Brill LM, Motamedchaboki K, Chen Y, Czech MP, Mann M, Krüger M, Jiang ZY. C2 domain-containing phosphoprotein CDP138 regulates GLUT4 insertion into the plasma membrane. Cell Metab. 2011 Sep 7; 14(3):378-89. PMID: 21907143.
    View in: PubMed
  3. Zhou QL, Jiang ZY, Mabardy AS, Del Campo CM, Lambright DG, Holik J, Fogarty KE, Straubhaar J, Nicoloro S, Chawla A, Czech MP. A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes. J Biol Chem. 2010 Sep 3; 285(36):27581-9. PMID: 20587420.
    View in: PubMed
  4. Zhou QL, Jiang ZY, Holik J, Chawla A, Hagan GN, Leszyk J, Czech MP. Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes. Biochem J. 2008 May 1; 411(3):647-55. PMID: 18215134.
    View in: PubMed
  5. Jiang ZY, Zhou QL, Holik J, Patel S, Leszyk J, Coleman K, Chouinard M, Czech MP. Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells. J Biol Chem. 2005 Jun 3; 280(22):21622-8. PMID: 15799971.
    View in: PubMed
  6. Zhou QL, Park JG, Jiang ZY, Holik JJ, Mitra P, Semiz S, Guilherme A, Powelka AM, Tang X, Virbasius J, Czech MP. Analysis of insulin signalling by RNAi-based gene silencing. Biochem Soc Trans. 2004 Nov; 32(Pt 5):817-21. PMID: 15494023.
    View in: PubMed
  7. Zhou QL, Park JG, Jiang ZY, Holik J, Mitra P, Semitz S, Guilherme A, Powelka AM, Tang X, Virbasius J, Czech MP. Analysis of insulin signaling by si RNA-b ased gene silencing. Biochemical Soc. Transactions. 2004; 32:817-21.
  8. Jiang ZY, Zhou QL, Coleman KA, Chouinard M, Boese Q, Czech MP. Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7569-74. PMID: 12808134.
    View in: PubMed
  9. Jiang ZY, He Z, King BL, Kuroki T, Opland DM, Suzuma K, Suzuma I, Ueki K, Kulkarni RN, Kahn CR, King GL. Characterization of multiple signaling pathways of insulin in the regulation of vascular endothelial growth factor expression in vascular cells and angiogenesis. J. Biol.Chem. 2003; 278:31964-71.
  10. Bose A, Guilherme A, Robida SI, Nicoloro SM, Zhou QL, Jiang ZY, Pomerleau DP, Czech MP. Glucose transporter recycling in response to insulin is facilitated by myosin Myo1c. Nature. 2002 Dec 19-26; 420(6917):821-4. PMID: 12490950.
    View in: PubMed
  11. Jiang ZY, Chawla A, Bose A, Way M, Czech MP. A PI 3-kinase-independent Insulin Signaling Pathway through N-WASP-Arp2-3/F-Actinin Required for GLUT4 Glucose Transporter Recycling. J. Biol. Chem. 2002; 277:509-515.
  12. Cai W, Rook SL, Jiang ZY, Takahara N, Aiello LP. Mechanisms of hepatocyte growth factor-induced retinal endothelial cell migration and growth. Invest Ophthalmol Vis Sci. 2000 Jun; 41(7):1885-93. PMID: 10845613.
    View in: PubMed
  13. Goldfine AB, Patti ME, Zuberi L, Goldstein BJ, LeBlanc R, Landaker EJ, Jiang ZY, Willsky GR, Kahn CR. Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. Metabolism. 2000 Mar; 49(3):400-10. PMID: 10726921.
    View in: PubMed
  14. Kuboki K, Jiang ZY, Takahara N, Ha SW, Igarashi M, Yamauchi T, Feener EP, Herbert TP, Rhodes CJ, King GL. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin. Circulation. 2000 Feb 15; 101(6):676-81. PMID: 10673261.
    View in: PubMed
  15. Jiang ZY, Zhou QL, Chatterjee A, Feener EP, Myers MG, White MF, King GL. Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. Diabetes. 1999 May; 48(5):1120-30. PMID: 10331419.
    View in: PubMed
  16. Jiang ZY, Lin YW, Clermont AC, Feener EP, Hein KD, Igarashi M, Yamauchi T, White MF, King GL. Selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J. Clin. Invest. 1999; 104:447-57.
  17. Jiang ZY, Zhou QL, Chatterjee A, Feener EP, Myers Jr. MG, White MF, King GL. Endothelin-1 modulates insulin signaling through PI3-kinase pathway in vascular smooth muscle cells. Diabetes. 1999; 48:1120 -30.
  18. Igarashi M, Wakasaki H, Takahara N, Ishii H, Jiang ZY, Yamauchi T, Kuboki K, Meier M, Rhodes CJ, King GL. Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways. J Clin Invest. 1999 Jan; 103(2):185-95. PMID: 9916130.
    View in: PubMed
  19. Fang C, Jiang Z, Tomlinson. Expression of constitutive cyclo-oxygenase (COX-1) in rats with streptozotocin-induced diabetes; effects of treatment with evening primrose oil or an aldose reductase inhibitor on COX-1 mRNA levels. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 1997; 56:167-63.
  20. Xia P, Aiello, Jiang ZY, Park DJ, Robinson GS, Takagi H, Newsome WP, Jirousek MR, King GL. Characterization of vascular endothelial growth factor’s effect on the activation of protein kinase C, its isoforms and endothelial cell growth. J. Clin. Invest. 1996; 98:2018-2026.
  21. Takagi C, Bussell S-E, Lin Y-W, Takagi H, Duh E, Jiang Z, Clermont AC, King GL. Regulation of retinal hemodynamics in diabetic rats by increased expression and action of ET-1. Investigative Ophthalmology Visual Science. 1996; 37: 2504-18.
  22. Jiang ZY, Towler HMA, Luthert P, Lightman SL. Diabetes Mellitus: A Fundamental and Clnical Text. Eds: LeRoith D, Taylor SI, Olefsky JM. Pathophysiology of diabetic retinopathy. Lippincott-Raven. Philadelphia, PA. 1996; 719-27.
  23. Jiang Z, Xie MZ. The hypoglycemic effect of AH—9. Zhongguo Yi Xue Ke Hue Yuan Xue Bao (Chinese). 1993; 15(4):235-41.
  24. Jiang Z, Xie MZ. The antioxidant action of AH-9. Zhongguo Yi Xue Ke Hue Yuan Xue Bao (Chinese). 1993; 15(4):291-4.
  25. Hunt JV, Jiang ZY, Wolff SP. Formation of hydrogen peroxide by lens proteins: protein-derived hydrogen peroxide as a potential mechanism of oxidative insult to the lens. Free Radic Biol Med. 1992 Oct; 13(4):319-23. PMID: 1398215.
    View in: PubMed
  26. Jiang ZY, Hunt JV, Wolff SP. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein. Anal Biochem. 1992 May 1; 202(2):384-9. PMID: 1519766.
    View in: PubMed
  27. Jiang ZY, Zhou QL, Eaton JW, Koppenol WH, Hunt JV, Wolff SP. Spirohydantoin inhibitors of aldose reductase inhibit iron- and copper-catalysed ascorbate oxidation in vitro. Biochem Pharmacol. 1991 Aug 22; 42(6):1273-8. PMID: 1909528.
    View in: PubMed
  28. Wolff SP, Jiang ZY. In “Eye lens membranes and Aging,” Eds. Vrensen GFJM, Clauweaert J. Eye lens membranes and Aging. Eds. Vrensen GFJM, Clauweaert J,. Free radical and cataract: direct chemical damage or exaggerated physiological response?. Eurage. The Netherlands. 1991; 221-31.
  29. Wolff SP, Jiang ZY, Hunt JV. Protein glycation and oxidative stress in diabetes mellitus and ageing. Free Radic Biol Med. 1991; 10(5):339-52. PMID: 1855674.
    View in: PubMed
  30. Jiang ZY, Woollard AC, Wolff SP. Hydrogen peroxide production during experimental protein glycation. FEBS Lett. 1990 Jul 30; 268(1):69-71. PMID: 2384174.
    View in: PubMed
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