Sema Quadir
Pre-Doctoral Trainee
Boston University School of Medicine, Graduate Medical Sciences
Dept of Pharmacology & Experimental Therapeutics

BUSM Department of Pharmacology:
*Lab of Addictive Disorders (April 2017- present)
–working under Dr. Valentina Sabino to examine the neurobiological underpinnings of alcohol addiction
–gained experience working with mice and rats including running cognitive behavioral tests (differential rates of low responding, attentional set shifting) and anxiety tests (elevated plus maze, defensive withdrawal, open field, novelty suppressed feeding)
–learning immunohistochemistry and stereotaxic surgery

University of California Santa Barbara Department of Psychological and Brain Sciences:
*Behavioral and Neural Genetics Laboratory (April 2013–August 2016)
–worked under Dr. Karen Szumlinksi to examine changes in the brain following exposure to drugs of abuse (alcohol, methamphetamine, heroin) in mice
–trained extensively handling of mice including weighing, scruffing, intraperitoneal injections, subcutaneous injections and brief exposure to intracranial stereotaxic surgery
–performed behavioral tests such as conditioned place preference, loss of righting reflex, Rotorod testing, locomotor testing
–established a model of unpredictable chronic mild stress (UCMS)
–executed experiments involving cross-sensitization, selective breeding, and the use of transgenic mice
–prepared tissue via slicing on the Vibratome followed by cresyl violet staining
–trained new members in the lab on various techniques such as general animal handling, subcutaneous injections, place conditioning procedures and UCMS
–coordinated schedules of ~5 undergraduate assistants to make sure things were being run as efficiently as possible

Investigating the role of the Sigma-1 receptors in alcohol addiction and associated cognitive deficits and pain states
07/21/2020 - 07/20/2022 (PI)
NIH/National Institute on Alcohol Abuse and Alcoholism


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Fultz EK, Quadir SG, Martin D, Flaherty DM, Worley PF, Kippin TE, Szumlinski KK. ERK-Directed Phosphorylation of mGlu5 Gates Methamphetamine Reward and Reinforcement in Mouse. Int J Mol Sci. 2021 Feb 02; 22(3). PMID: 33540617
  2. Quadir SG, Tanino SM, Rohl CD, Sahn JJ, Yao EJ, Cruz LDR, Cottone P, Martin SF, Sabino V. The Sigma-2 receptor / transmembrane protein 97 (s2R/TMEM97) modulator JVW-1034 reduces heavy alcohol drinking and associated pain states in male mice. Neuropharmacology. 2021 02 15; 184:108409.View Related Profiles. PMID: 33221481
  3. Quadir SG, Rohl CD, Zeabi A, Moore CF, Cottone P, Sabino V. Effect of different standard rodent diets on ethanol intake and associated allodynia in male mice. Alcohol. 2020 09; 87:17-23.View Related Profiles. PMID: 32330590
  4. Quadir SG, Cottone P, Sabino V. Role of Sigma Receptors in Alcohol Addiction. Front Pharmacol. 2019; 10:687.View Related Profiles. PMID: 31258483
  5. Campbell RR, Domingo RD, Williams AR, Wroten MG, McGregor HA, Waltermire RS, Greentree DI, Goulding SP, Thompson AB, Lee KM, Quadir SG, Jimenez Chavez CL, Coelho MA, Gould AT, von Jonquieres G, Klugmann M, Worley PF, Kippin TE, Szumlinski KK. Increased Alcohol-Drinking Induced by Manipulations of mGlu5 Phosphorylation within the Bed Nucleus of the Stria Terminalis. J Neurosci. 2019 04 03; 39(14):2745-2761. PMID: 30737312
  6. Quadir SG, Guzelian E, Palmer MA, Martin DL, Kim J, Szumlinski KK. Complex interactions between the subject factors of biological sex and prior histories of binge-drinking and unpredictable stress influence behavioral sensitivity to alcohol and alcohol intake. Physiol Behav. 2019 05 01; 203:100-112. PMID: 28803118
  7. Szumlinski KK, Lominac KD, Campbell RR, Cohen M, Fultz EK, Brown CN, Miller BW, Quadir SG, Martin D, Thompson AB, von Jonquieres G, Klugmann M, Phillips TJ, Kippin TE. Methamphetamine Addiction Vulnerability: The Glutamate, the Bad, and the Ugly. Biol Psychiatry. 2017 Jun 01; 81(11):959-970. PMID: 27890469; DOI: 10.1016/j.biopsych.2016.10.005;
  8. Lominac KD, Quadir SG, Barrett HM, McKenna CL, Schwartz LM, Ruiz PN, Wroten MG, Campbell RR, Miller BW, Holloway JJ, Travis KO, Rajasekar G, Maliniak D, Thompson AB, Urman LE, Kippin TE, Phillips TJ, Szumlinski KK. Prefrontal glutamate correlates of methamphetamine sensitization and preference. Eur J Neurosci. 2016 Mar; 43(5):689-702. PMID: 26742098; PMCID: PMC4783259; DOI: 10.1111/ejn.13159;
  9. Quadir SG, Santos JR, Campbell RR, Wroten MG, Singh N, Holloway JJ, Bal SK, Camarini R, Szumlinski KK. Homer2 regulates alcohol and stress cross-sensitization. Addict Biol. 2016 May; 21(3):613-33. PMID: 25916683; PMCID: PMC4624079; DOI: 10.1111/adb.12252;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 9 publications over 6 distinct years, with a maximum of 2 publications in 2016 and 2019 and 2020


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