Sema Quadir
Predoctoral Trainee
Boston University Chobanian & Avedisian School of Medicine, Graduate Medical Sciences
Pharmacology, Physiology & Biophysics

BUSM Department of Pharmacology:
*Lab of Addictive Disorders (April 2017- present)
–working under Dr. Valentina Sabino to examine the neurobiological underpinnings of alcohol addiction
–gained experience working with mice and rats including running cognitive behavioral tests (differential rates of low responding, attentional set shifting) and anxiety tests (elevated plus maze, defensive withdrawal, open field, novelty suppressed feeding)
–learning immunohistochemistry and stereotaxic surgery

University of California Santa Barbara Department of Psychological and Brain Sciences:
*Behavioral and Neural Genetics Laboratory (April 2013–August 2016)
–worked under Dr. Karen Szumlinksi to examine changes in the brain following exposure to drugs of abuse (alcohol, methamphetamine, heroin) in mice
–trained extensively handling of mice including weighing, scruffing, intraperitoneal injections, subcutaneous injections and brief exposure to intracranial stereotaxic surgery
–performed behavioral tests such as conditioned place preference, loss of righting reflex, Rotorod testing, locomotor testing
–established a model of unpredictable chronic mild stress (UCMS)
–executed experiments involving cross-sensitization, selective breeding, and the use of transgenic mice
–prepared tissue via slicing on the Vibratome followed by cresyl violet staining
–trained new members in the lab on various techniques such as general animal handling, subcutaneous injections, place conditioning procedures and UCMS
–coordinated schedules of ~5 undergraduate assistants to make sure things were being run as efficiently as possible

Investigating the role of the Sigma-1 receptors in alcohol addiction and associated cognitive deficits and pain states
07/21/2020 - 11/13/2020 (PI)
NIH/National Institute on Alcohol Abuse and Alcoholism


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Quadir SG, Arleth GM, Cone MG, High MW, Ramage MC, Effinger DP, Echeveste Sanchez M, Herman MA. Chronic Alcohol Drinking Drives Sex-Specific Differences in Affective Behavior and Medial Prefrontal Cortex Activity in CRF1:Cre:tdTomato Transgenic Rats. eNeuro. 2023 Jul; 10(7). PMID: 37414553; PMCID: PMC10348447; DOI: 10.1523/ENEURO.0055-23.2023;
  2. Valentina S, Blasio A, Ferragud A, Quadir SG, Iyer MR, Rice KC, Cottone P. Characterization of a differential reinforcement of low rates of responding task in non-deprived male and female rats: Role of Sigma-1 receptors. Neuropharmacology. 2021 12 01; 200:108786.View Related Profiles. PMID: 34516984; PMCID: PMC9869339; DOI: 10.1016/j.neuropharm.2021.108786;
  3. Quadir SG, Tanino SM, Sami YN, Minnig MA, Iyer MR, Rice KC, Cottone P, Sabino V. Antagonism of Sigma-1 receptor blocks heavy alcohol drinking and associated hyperalgesia in male mice. Alcohol Clin Exp Res. 2021 07; 45(7):1398-1407.View Related Profiles. PMID: 34060104; PMCID: PMC8295198; DOI: 10.1111/acer.14635;
  4. Agoglia AE, Zhu M, Quadir SG, Bluitt MN, Douglass E, Hanback T, Tella J, Ying R, Hodge CW, Herman MA. Sex-specific plasticity in CRF regulation of inhibitory control in central amygdala CRF1 neurons after chronic voluntary alcohol drinking. Addict Biol. 2022 01; 27(1):e13067. PMID: 34075665; PMCID: PMC8636550; DOI: 10.1111/adb.13067;
  5. Fultz EK, Quadir SG, Martin D, Flaherty DM, Worley PF, Kippin TE, Szumlinski KK. ERK-Directed Phosphorylation of mGlu5 Gates Methamphetamine Reward and Reinforcement in Mouse. Int J Mol Sci. 2021 Feb 02; 22(3). PMID: 33540617; PMCID: PMC7867251; DOI: 10.3390/ijms22031473;
  6. Quadir SG, Tanino SM, Rohl CD, Sahn JJ, Yao EJ, Cruz LDR, Cottone P, Martin SF, Sabino V. The Sigma-2 receptor / transmembrane protein 97 (s2R/TMEM97) modulator JVW-1034 reduces heavy alcohol drinking and associated pain states in male mice. Neuropharmacology. 2021 02 15; 184:108409.View Related Profiles. PMID: 33221481; PMCID: PMC7856185; DOI: 10.1016/j.neuropharm.2020.108409;
  7. Quadir SG, Rohl CD, Zeabi A, Moore CF, Cottone P, Sabino V. Effect of different standard rodent diets on ethanol intake and associated allodynia in male mice. Alcohol. 2020 09; 87:17-23.View Related Profiles. PMID: 32330590; PMCID: PMC7812484; DOI: 10.1016/j.alcohol.2020.04.003;
  8. Quadir SG, Cottone P, Sabino V. Role of Sigma Receptors in Alcohol Addiction. Front Pharmacol. 2019; 10:687.View Related Profiles. PMID: 31258483; PMCID: PMC6586921; DOI: 10.3389/fphar.2019.00687;
  9. Campbell RR, Domingo RD, Williams AR, Wroten MG, McGregor HA, Waltermire RS, Greentree DI, Goulding SP, Thompson AB, Lee KM, Quadir SG, Jimenez Chavez CL, Coelho MA, Gould AT, von Jonquieres G, Klugmann M, Worley PF, Kippin TE, Szumlinski KK. Increased Alcohol-Drinking Induced by Manipulations of mGlu5 Phosphorylation within the Bed Nucleus of the Stria Terminalis. J Neurosci. 2019 04 03; 39(14):2745-2761. PMID: 30737312; PMCID: PMC6445984; DOI: 10.1523/JNEUROSCI.1909-18.2018;
  10. Quadir SG, Guzelian E, Palmer MA, Martin DL, Kim J, Szumlinski KK. Complex interactions between the subject factors of biological sex and prior histories of binge-drinking and unpredictable stress influence behavioral sensitivity to alcohol and alcohol intake. Physiol Behav. 2019 05 01; 203:100-112. PMID: 28803118; PMCID: PMC6401319; DOI: 10.1016/j.physbeh.2017.08.002;
Showing 10 of 13 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 13 publications over 7 distinct years, with a maximum of 4 publications in 2021


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