As the volume of cumulated biological data grows exponentially, its systematic analyses and interpretations become more and more critical. However, the synergy between computational and experimental biology can be challenging due to the difficulty of clear communication between these disciplines. As an interdisciplinary biologist, my overarching career goal is to study crucial biological questions through the combination of Big Data analytics and experimental validations. Specifically, throughout my postdoctoral training and independent career, I have studied mammalian gene regulatory mechanisms at the transcription level. Through integrative and comprehensive Big Data analysis, I discovered that CpG islands (CGIs) direct modes of gene regulation, including 3-D chromatin architectures and transcriptional/epigenetic regulations. This discovery has provided important clues to the mechanism by which changes in chromatin architecture contribute to age-associated physiological deterioration.
Diversity, Equity, Inclusion and Accessibility
2018-2021 Mentored multiple local and national undergraduate students (one underrepresented, two first-generation internationals, and two female students)
Loss of transcriptional homeostasis of genes lacking CpG islands during aging
06/01/2023 - 05/31/2026 (PI)NIH/National Institute on Aging7R01AG068179-03
Hevolution/AFAR New Investigator Award in Biology and Geroscience Research
12/31/2022 - 12/31/2025 (Subcontract PI)American Federation for Aging Research Hevolution Fdn
Publications listed below are automatically derived from MEDLINE/PubMed and other
sources, which might result in incorrect or missing publications. Faculty can
to make corrections and additions.
Showing 10 of 27 results.
Lee J, Beck S. Misexpression of Genes Lacking Cpg Islands is a Hallmark of Aging. Open Access Journal of Gerontology & Geriatric Medicine. 2022; 3(6):OAJGGM.MS.ID.555690.
Lee JY, Davis I, Youth EHH, Kim J, Churchill G, Godwin J, Korstanje R, Beck S. Misexpression of genes lacking CpG islands drives degenerative changes during aging. Sci Adv. 2021 Dec 17; 7(51):eabj9111. PMID: 34910517; PMCID: PMC8673774; DOI: 10.1126/sciadv.abj9111;
Oh SH, Kim SH, Jeon JH, Kim EB, Lee NK, Beck S, Choi YJ, Kang SK. Cytoplasmic expression of a model antigen with M Cell-Targeting moiety in lactic acid bacteria and implication of the mechanism as a mucosal vaccine via oral route. Vaccine. 2021 Jul 05; 39(30):4072-4081. PMID: 34127296; DOI: 10.1016/j.vaccine.2021.06.010;
Lee JY, Song J, LeBlanc L, Davis I, Kim J, Beck S. Conserved dual-mode gene regulation programs in higher eukaryotes. Nucleic Acids Res. 2021 Mar 18; 49(5):2583-2597. PMID: 33621342; PMCID: PMC7969006; DOI: 10.1093/nar/gkab108;
Lee BK, Jang YJ, Kim M, LeBlanc L, Rhee C, Lee J, Beck S, Shen W, Kim J. Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells. Nat Commun. 2019 Oct 18; 10(1):4749. PMID: 31628347; PMCID: PMC6802173; DOI: 10.1038/s41467-019-12720-6;
Wang E, Sorolla A, Cunningham PT, Bogdawa HM, Beck S, Golden E, Dewhurst RE, Florez L, Cruickshank MN, Hoffmann K, Hopkins RM, Kim J, Woo AJ, Watt PM, Blancafort P. Tumor penetrating peptides inhibiting MYC as a potent targeted therapeutic strategy for triple-negative breast cancers. Oncogene. 2019 Jan; 38(1):140-150. PMID: 30076412; PMCID: PMC6318000; DOI: 10.1038/s41388-018-0421-y;
Beck S, Rhee C, Song J, Lee BK, LeBlanc L, Cannon L, Kim J. Implications of CpG islands on chromosomal architectures and modes of global gene regulation. Nucleic Acids Res. 2018 May 18; 46(9):4382-4391. PMID: 29529258; PMCID: PMC5961348; DOI: 10.1093/nar/gky147;
Lee BK, Uprety N, Jang YJ, Tucker SK, Rhee C, LeBlanc L, Beck S, Kim J. Fosl1 overexpression directly activates trophoblast-specific gene expression programs in embryonic stem cells. Stem Cell Res. 2018 Jan; 26:95-102. PMID: 29272857; PMCID: PMC5899959; DOI: 10.1016/j.scr.2017.12.004;
Rhee C, Lee BK, Beck S, LeBlanc L, Tucker HO, Kim J. Mechanisms of transcription factor-mediated direct reprogramming of mouse embryonic stem cells to trophoblast stem-like cells. Nucleic Acids Res. 2017 Sep 29; 45(17):10103-10114. PMID: 28973471; PMCID: PMC5737334; DOI: 10.1093/nar/gkx692;
Skamagki M, Correia C, Yeung P, Baslan T, Beck S, Zhang C, Ross CA, Dang L, Liu Z, Giunta S, Chang TP, Wang J, Ananthanarayanan A, Bohndorf M, Bosbach B, Adjaye J, Funabiki H, Kim J, Lowe S, Collins JJ, Lu CW, Li H, Zhao R, Kim K. ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. Nat Cell Biol. 2017 Sep; 19(9):1037-1048. PMID: 28846095; PMCID: PMC5843481; DOI: 10.1038/ncb3598;
This graph shows the total number of publications by year, by first, middle/unknown,
or last author.
Rom Rhome International Professional Development Award
2016 Department of Molecular Biosciences Retreat, UT-Austin:
Best Poster Award
2015 KSEA West Gulf Coast Regional Conference / KoreanAmerican Biomedical Scientists Symposium:
Best Talk/Poster Award
2015 Scientist and Engineers Early-career Development (SEED) Workshop:
Travel Award for Outstanding Early Career Professionals