Ricardo da Costa e Sousa, DVM, MSC, PhD
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Dept of Medicine
Endocrinology, Diabetes, Nutrition & Weight Management

PhD, Federal University of Rio De Janeiro
DVM, Federal University of Rio De Janeiro
MSc, Federal University of Rio De Janeiro



Dr. Ricardo da Costa e Sousa has a broad background in Physiology and Basic Medical Research, with special expertise in Neuroendocrinology. During his Doctorate he has studied how the hypothalamus controls TSH secretion and thyroid activity, focusing on the role of NPY receptors. He further deepened his research on the hypothalamic-pituitary-axis during his postdoc, studying thyroid hormones action in the pituitary and the regulation of TRH neurons. His research has contributed to our current understanding of how the brain controls the thyroid as well as how thyroid hormones acts in different tissues.

In 2019, he joined the Division of Endocrinology, Diabetes and Metabolism at Weill Cornell Medicine to study how specific subpopulations of hypothalamic neurons control the HPT axis, as well as how thyroid hormones act in the hypothalamus. Recent data his team generated is promising and has the potential to change paradigms in the field. He became an Assistant Professor at Boston University in 2022. Currently, his research interest is focused on the neuroendocrine control of thyroid hormones and metabolism.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Calvino C, Império GE, Wilieman M, Costa-E-Sousa RH, Souza LL, Trevenzoli IH, Pazos-Moura CC. Hypothyroidism Induces Hypophagia Associated with Alterations in Protein Expression of Neuropeptide Y and Proopiomelanocortin in the Arcuate Nucleus, Independently of Hypothalamic Nuclei-Specific Changes in Leptin Signaling. Thyroid. 2016 Jan; 26(1):134-43. PMID: 26538454; DOI: 10.1089/thy.2015.0384;
     
  2. Astapova I, Ramadoss P, Costa-e-Sousa RH, Ye F, Holtz KA, Li Y, Niepel MW, Cohen DE, Hollenberg AN. Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRß1-governed pathway. J Clin Invest. 2014 May; 124(5):1976-86.View Related Profiles. PMID: 24713658; PMCID: PMC4001554; DOI: 10.1172/JCI73419;
     
  3. Vella KR, Ramadoss P, Costa-E-Sousa RH, Astapova I, Ye FD, Holtz KA, Harris JC, Hollenberg AN. Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors. Mol Cell Biol. 2014 May; 34(9):1564-75.View Related Profiles. PMID: 24550004; PMCID: PMC3993596; DOI: 10.1128/MCB.00129-14;
     
  4. Ramadoss P, Abraham BJ, Tsai L, Zhou Y, Costa-e-Sousa RH, Ye F, Bilban M, Zhao K, Hollenberg AN. Novel mechanism of positive versus negative regulation by thyroid hormone receptor ß1 (TRß1) identified by genome-wide profiling of binding sites in mouse liver. J Biol Chem. 2014 Jan 17; 289(3):1313-28.View Related Profiles. PMID: 24288132; PMCID: PMC3894317; DOI: 10.1074/jbc.M113.521450;
     
  5. Costa-e-Sousa RH, Astapova I, Ye F, Wondisford FE, Hollenberg AN. The thyroid axis is regulated by NCoR1 via its actions in the pituitary. Endocrinology. 2012 Oct; 153(10):5049-57.View Related Profiles. PMID: 22878400; PMCID: PMC3512014; DOI: 10.1210/en.2012-1504;
     
  6. Calvino C, Souza LL, Costa-e-Sousa RH, Almeida NA, Trevenzoli IH, Pazos-Moura CC. Hypothyroidism reduces ObRb-STAT3 leptin signalling in the hypothalamus and pituitary of rats associated with resistance to leptin acute anorectic action. J Endocrinol. 2012 Oct; 215(1):129-35. PMID: 22875962; DOI: 10.1530/JOE-11-0476;
     
  7. Costa-e-Sousa RH, Hollenberg AN. Minireview: The neural regulation of the hypothalamic-pituitary-thyroid axis. Endocrinology. 2012 Sep; 153(9):4128-35.View Related Profiles. PMID: 22759379; PMCID: PMC3423621; DOI: 10.1210/en.2012-1467;
     
  8. Costa-e-Sousa RH, Souza LL, Calviño C, Cabanelas A, Almeida NA, Oliveira KJ, Pazos-Moura CC. Central NPY-Y5 receptors activation plays a major role in fasting-induced pituitary-thyroid axis suppression in adult rat. Regul Pept. 2011 Nov 10; 171(1-3):43-7. PMID: 21771616; DOI: 10.1016/j.regpep.2011.07.001;
     
  9. Araujo IG, Trindade DC, Mecawi AS, Sonoda-Côrtes R, Werneck-de-Castro JP, Costa-E-Sousa RH, Reis LC, Olivares EL. Inhibition of brain renin-angiotensin system improves diastolic cardiac function following myocardial infarction in rats. Clin Exp Pharmacol Physiol. 2009 Aug; 36(8):803-9. PMID: 19215232; DOI: 10.1111/j.1440-1681.2009.05159.x;
     
  10. da Veiga MA, Fonseca Bloise F, Costa-E-Sousa RH, Souza LL, Almeida NA, Oliveira KJ, Pazos-Moura CC. Acute effects of endocannabinoid anandamide and CB1 receptor antagonist, AM251 in the regulation of thyrotropin secretion. J Endocrinol. 2008 Nov; 199(2):235-42. PMID: 18755884; DOI: 10.1677/JOE-08-0380;
     
Showing 10 of 29 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 29 publications over 12 distinct years, with a maximum of 7 publications in 2007

YearPublications
20031
20041
20056
20064
20077
20081
20091
20111
20123
20131
20142
20151


2011 The Endocrine Society: Outstanding Abstract Award
2011 CAPES, Ministry of Education: International Post Doctoral Fellowship
Contact for Mentoring:

700 Albany St
Boston MA 02118
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