Marek Orzechowski, PhD
Senior Computational Scientist
Broad Institute of MIT and Harvard

Postdoctoral Fellow (Previously held)
Boston University Chobanian & Avedisian School of Medicine

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Farman GP, Rynkiewicz MJ, Orzechowski M, Lehman W, Moore JR. HCM and DCM cardiomyopathy-linked a-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments. Arch Biochem Biophys. 2018 06 01; 647:84-92.View Related Profiles. PMID: 29626422; PMCID: PMC5958618; DOI: 10.1016/;
  2. Rynkiewicz MJ, Schott V, Orzechowski M, Lehman W, Fischer S. Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin. J Muscle Res Cell Motil. 2015 Dec; 36(6):525-33.View Related Profiles. PMID: 26286845; PMCID: PMC4760918; DOI: 10.1007/s10974-015-9419-z;
  3. Orzechowski M, Fischer S, Moore JR, Lehman W, Farman GP. Energy landscapes reveal the myopathic effects of tropomyosin mutations. Arch Biochem Biophys. 2014 Dec 15; 564:89-99.View Related Profiles. PMID: 25241052; PMCID: PMC4258436; DOI: 10.1016/;
  4. Orzechowski M, Li XE, Fischer S, Lehman W. An atomic model of the tropomyosin cable on F-actin. Biophys J. 2014 Aug 5; 107(3):694-9.View Related Profiles. PMID: 25099808; PMCID: PMC4129500; DOI: 10.1016/j.bpj.2014.06.034;
  5. Li XE, Orzechowski M, Lehman W, Fischer S. Structure and flexibility of the tropomyosin overlap junction. Biochem Biophys Res Commun. 2014 Mar 28; 446(1):304-8.View Related Profiles. PMID: 24607906; PMCID: PMC4003899; DOI: 10.1016/j.bbrc.2014.02.097;
  6. Yang S, Barbu-Tudoran L, Orzechowski M, Craig R, Trinick J, White H, Lehman W. Three-dimensional organization of troponin on cardiac muscle thin filaments in the relaxed state. Biophys J. 2014 Feb 18; 106(4):855-64.View Related Profiles. PMID: 24559988; PMCID: PMC3944806; DOI: 10.1016/j.bpj.2014.01.007;
  7. Orzechowski M, Moore JR, Fischer S, Lehman W. Tropomyosin movement on F-actin during muscle activation explained by energy landscapes. Arch Biochem Biophys. 2014 Mar 1; 545:63-8.View Related Profiles. PMID: 24412204; PMCID: PMC3943668; DOI: 10.1016/;
  8. Lehman W, Li XE, Orzechowski M, Fischer S. The structural dynamics of a-tropomyosin on F-actin shape the overlap complex between adjacent tropomyosin molecules. Arch Biochem Biophys. 2014 Jun 15; 552-553:68-73.View Related Profiles. PMID: 24071513; PMCID: PMC3962804; DOI: 10.1016/;
  9. Lehman W, Orzechowski M, Li XE, Fischer S, Raunser S. Gestalt-binding of tropomyosin on actin during thin filament activation. J Muscle Res Cell Motil. 2013 Aug; 34(3-4):155-63.View Related Profiles. PMID: 23666668; PMCID: PMC3773262; DOI: 10.1007/s10974-013-9342-0;
  10. White KH, Orzechowski M, Fourmy D, Visscher K. Mechanical unfolding of the beet western yellow virus -1 frameshift signal. J Am Chem Soc. 2011 Jun 29; 133(25):9775-82. PMID: 21598975
Showing 10 of 15 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 15 publications over 10 distinct years, with a maximum of 5 publications in 2014


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72 E. Concord St Instructional (L)
Boston MA 02118
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