Lucia Rameh Plant, PhD
Research Associate Professor
Boston University School of Medicine
Dept of Medicine
Endocrinology, Diabetes & Nutrition

PhD, Universidade de São Paulo

Studies in the Rameh Lab ( are aimed at understanding how phosphoinositide lipids affect different aspects of the diabetes/obesity cycle. As regulator of many cellular processes, such as vesicle trafficking and hormone signaling, phosphoinositide kinases are promising targets in the treatment of these diseases. The Rameh Lab is particularly interested in determining the role of the phosphoinositide PtdIns-5-P in pancreatic beta cell function. Recent data from the Lab show that PtdIns-5-P 4-kinases can regulate nutrient-independent TORC1 signaling that activates basal protein translation. They are currently investigating how these can impact basal insulin production and secretion in the pre-diabetic state. The Rameh Lab uses state-of-the art high performance liquid chromatography (HPLC) coupled to flow scintillation analysis to measure cellular phosphoinositides in cultured cells. They have recently developed a unique method for PtdIns-5-P detection that will aid future research on the cellular function of this lipid.

The Role of Ptdins-5-P in Cell Function & Signaling
03/01/2013 - 08/31/2014 (PI)

Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Ando K, Shah AK, Sachdev V, Kleinstiver BP, Taylor-Parker J, Welch MM, Hu Y, Salgia R, White FM, Parvin JD, Ozonoff A, Rameh LE, Joung JK, Bharti AK. Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway. Oncotarget. 2017 Jul 04; 8(27):43733-43751.View Related Profiles. PMID: 28415827; DOI: 10.18632/oncotarget.16376;.
  2. Rameh LE, Mackey AM. IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3. Nat Cell Biol. 2016 Nov 29; 18(12):1263-1265. PMID: 27897158; DOI: 10.1038/ncb3440;.
  3. Rameh LE, Deeney JT. Phosphoinositide signalling in type 2 diabetes: a ß-cell perspective. Biochem Soc Trans. 2016 Feb; 44(1):293-8.View Related Profiles. PMID: 26862218; DOI: 10.1042/BST20150229;.
  4. Sarkes DA, Rameh LE. Analysis of the Phosphoinositide Composition of Subcellular Membrane Fractions. Methods Mol Biol. 2016; 1376:213-27. PMID: 26552687; DOI: 10.1007/978-1-4939-3170-5_18;.
  5. Toker A, Rameh L. PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K? Cancer Cell. 2015 Aug 10; 28(2):143-5. PMID: 26267528; DOI: 10.1016/j.ccell.2015.07.010;.
  6. Mackey AM, Sarkes DA, Bettencourt I, Asara JM, Rameh LE. PIP4k? is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation. Sci Signal. 2014 Nov 04; 7(350):ra104. PMID: 25372051; PMCID: PMC4579097; DOI: 10.1126/scisignal.2005191;.
  7. McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Nagle A, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman AM, Dechering KJ, Kumar TR, Henrich PP, Gagaring K, Ibanez M, Kato N, Kuhen KL, Fischli C, Rottmann M, Plouffe DM, Bursulaya B, Meister S, Rameh L, Trappe J, Haasen D, Timmerman M, Sauerwein RW, Suwanarusk R, Russell B, Renia L, Nosten F, Tully DC, Kocken CH, Glynne RJ, Bodenreider C, Fidock DA, Diagana TT, Winzeler EA. Targeting Plasmodium PI(4)K to eliminate malaria. Nature. 2013 Dec 12; 504(7479):248-53. PMID: 24284631; PMCID: PMC3940870; DOI: 10.1038/nature12782;.
  8. Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC. Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 2013 Nov 7; 155(4):844-57. PMID: 24209622; PMCID: PMC4070383; DOI: 10.1016/j.cell.2013.09.057;.
  9. Er EE, Mendoza MC, Mackey AM, Rameh LE, Blenis J. AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve. Sci Signal. 2013 Jun 11; 6(279):ra45. PMID: 23757022; PMCID: PMC4041878; DOI: 10.1126/scisignal.2004015;.
  10. Oppelt A, Lobert VH, Haglund K, Mackey AM, Rameh LE, Liestøl K, Schink KO, Pedersen NM, Wenzel EM, Haugsten EM, Brech A, Rusten TE, Stenmark H, Wesche J. Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. EMBO Rep. 2013 Jan; 14(1):57-64. PMID: 23154468; PMCID: PMC3537138; DOI: 10.1038/embor.2012.183;.
Showing 10 of 43 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 43 publications over 23 distinct years, with a maximum of 4 publications in 2010

Contact for Mentoring:

650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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