Krista Huybrechts, PhD
Adjunct Assistant Professor
Boston University School of Public Health
Epidemiology

PhD, Boston University School of Public Health
MS, University of Antwerp
BS, University of Antwerp



Krista F. Huybrechts, M.S., Ph.D. is an Associate Professor of Medicine at Harvard Medical School and an epidemiologist in the Division of Pharmacoepidemiology and Pharmacoeconomics at the Brigham and Women’s Hospital. She also holds an appointment as adjunct Assistant Professor of Epidemiology at Boston University School of Public Health. Her research centers on the utilization, comparative safety and effectiveness of prescription medications in pregnant women and their offspring, and on studying the outcomes of medications for mental health disorders in vulnerable populations. She also has a special interest in research methodology and innovative research applications in relation to both these fields of study. She currently serves on the Board of Directors of the International Society of Pharmacoepidemiology and Therapeutic Risk Management and is a member of FDA’s Drug Safety and Risk Management Advisory Committee.

Her research centers on the utilization, comparative safety and effectiveness of prescription medications in pregnant women and their offspring (www.harvardpreg.org), and on studying the outcomes of medications for mental health disorders in vulnerable populations. She also has a special interest in research methodology and innovative research applications in relation to both these fields of study.

Dr. Huybrechts graduated magna cum laude with a Master of Science degree in Economics from the University of Antwerp, Belgium where she also worked as a researcher in health economics. Prior to completing a doctoral degree in epidemiology at Boston University School of Public Health, Dr. Huybrechts held several positions in pharmacoeconomics and outcomes research, both in Europe and the US. Her research projects focused primarily on psychiatry and neurology, and covered a broad spectrum of research designs, including clinical trials, naturalistic studies, retrospective data analyses, and decision-analytic simulation models.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Sarpatwari A, Mahesri M, Lii J, Lee SB, Zakoul H, Toyserkani GA, Zhou EH, Lacivita C, Dal Pan GJ, Bykov K, Moran L, Avorn J, Kesselheim AS, Huybrechts KF. Risk of neutropenia-related hospitalisation among clozapine initiators. BMJ Ment Health. 2026 Feb 06; 29(1). PMID: 41651559; PMCID: PMC12887490; DOI: 10.1136/bmjment-2025-302122;
     
  2. Leonard SA, Main EK, Hlatky MA, Huybrechts KF, Bateman BT. Reply: Targeted Therapy for Hypertension in Pregnancy: Hemodynamics as a Therapeutic Compass. JACC Adv. 2026 Feb; 5(2):102521. PMID: 41558365; PMCID: PMC12856592; DOI: 10.1016/j.jacadv.2025.102521;
     
  3. Bea S, Basham CA, Edrees HH, Huybrechts KF, Vine SM, Glynn RJ, Bateman BT, Bykov K. Risk of opioid overdose associated with concurrent use of hydrocodone and CYP3A4-inhibiting calcium channel blockers: a population-based cohort study. Am J Epidemiol. 2025 Dec 02; 194(12):3609-3619. PMID: 40908920; PMCID: PMC12700321; DOI: 10.1093/aje/kwaf198;
     
  4. Bea S, Huybrechts KF, Glynn RJ, Vine SM, Belitkar S, Bateman BT, Bykov K. Opioid overdose associated with concomitant use of hydrocodone and selective serotonin reuptake inhibitors. BMC Med. 2025 Nov 28; 23(1):666. PMID: 41316177; PMCID: PMC12664141; DOI: 10.1186/s12916-025-04475-3;
     
  5. Huybrechts KF, Hernández-Díaz S, Bateman BT. Untangling the Risks of Antidepressants in Pregnancy. N Engl J Med. 2025 Nov 27; 393(21):2073-2075. PMID: 41283218
     
  6. Brown JP, Huybrechts KF, Straub L, Heider D, Bateman BT, Hernández-Díaz S. Associations of maternal and paternal characteristics with cardiac malformations using real-world data and machine learning. Commun Med (Lond). 2025 Oct 15; 5(1):423. PMID: 41094179; PMCID: PMC12528688; DOI: 10.1038/s43856-025-01139-4;
     
  7. Zhu Y, Anand P, Sarpatwari A, Hernández-Díaz S, Bykov K, Kesselheim AS, Avorn J, Vine SM, Adomi M, DiCesare EC, Mahesri M, Zakoul H, Mogun H, Toyserkani GA, LaCivita C, Zhou EH, Dal Pan GJ, Huybrechts KF. Isotretinoin Risk Evaluation and Mitigation Strategy and Pregnancy Incidence. JAMA Intern Med. 2025 Oct 01; 185(10):1289-1291. PMID: 40690251; PMCID: PMC12281394; DOI: 10.1001/jamainternmed.2025.3168;
     
  8. Bykov K, Basham CA, Khan NF, Glynn RJ, Belitkar S, Vine SM, Bea S, Bateman BT, Huybrechts KF. Comparative Risks of Opioid Overdose in Patients on Oxycodone Initiating Selective Serotonin Reuptake Inhibitors. Epidemiology. 2026 Jan 01; 37(1):132-140. PMID: 40951958; PMCID: PMC12697926; DOI: 10.1097/EDE.0000000000001914;
     
  9. Damkier P, Huybrechts KF, Nordeng H. Big Data in the Assessment of Medication Safety in Pregnancy: Opportunities and Challenges. Paediatr Drugs. 2025 Nov; 27(6):673-677. PMID: 40906238
     
  10. Ng S, Brown JP, Straub L, Bateman B, Gray KJ, Huybrechts KF, Hernández-Díaz S. Leveraging Health Insurance Claims Data to Complement the Centers for Disease Control and Prevention Surveillance System for Birth Defects. Birth Defects Res. 2025 Sep; 117(9):e2523. PMID: 40892020; PMCID: PMC13014526; DOI: 10.1002/bdr2.2523;
     
Showing 10 of 255 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 255 publications over 28 distinct years, with a maximum of 30 publications in 2024

YearPublications
19991
20002
20012
20024
20031
20041
20053
20062
20071
20082
20091
20101
20115
20126
20139
201411
201512
20167
201722
201819
201914
202026
202118
202216
202315
202430
202522
20262


2018 American Psychiatric Association, American Journal of Psychiatry: Invited to APA press briefing
2017 Annals of Internal Medicine: Reviewer Recognition
2016 Journal of Pharmacoepidemiology & Drug Safety: Best Reviewer designation
2016 Department of Medicine, Brigham and Women’s Hospital: 2016 DOM Early Career Faculty Mentoring Award
2015 Clinical Research Forum: “Top 10 Clinical Research Achievement Award”
2014 Canadian Medical Association Journal: Reviewer Recognition
2013 Journal of Clinical Psychopharmacology: 2012 Mitchell B. Balter Award
2013 Journal of Clinical Psychopharmacology: Journal of Clinical Psychopharmacology
2013 Journal of Clinical Epidemiology: JCE Reviewer Award
2013 Journal of Pharmacoepidemiology & Drug Safety: Best Reviewer
2011 Honorary Society in Public Health: Induction in Delta Omega (Alpha Beta chapter)
2010 Boston University School of Public Health: School of Public Health Dean’s Award
2010 International Society for Pharmacoepidemiology: Best Student Drug Utilization Abstract
1990 Belgian Association of Health Economists: Dr. Paul Janssen Health Economics Prize
Contact for Mentoring:

715 Albany Street
Boston MA 02118
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