Krista Huybrechts, PhD
Adjunct Assistant Professor
Boston University School of Public Health
Epidemiology

PhD, Boston University School of Public Health
MS, University of Antwerp
BS, University of Antwerp



Krista F. Huybrechts, M.S., Ph.D. is an Associate Professor of Medicine at Harvard Medical School and an epidemiologist in the Division of Pharmacoepidemiology and Pharmacoeconomics at the Brigham and Women’s Hospital. She also holds an appointment as adjunct Assistant Professor of Epidemiology at Boston University School of Public Health. Her research centers on the utilization, comparative safety and effectiveness of prescription medications in pregnant women and their offspring, and on studying the outcomes of medications for mental health disorders in vulnerable populations. She also has a special interest in research methodology and innovative research applications in relation to both these fields of study. She currently serves on the Board of Directors of the International Society of Pharmacoepidemiology and Therapeutic Risk Management and is a member of FDA’s Drug Safety and Risk Management Advisory Committee.

Her research centers on the utilization, comparative safety and effectiveness of prescription medications in pregnant women and their offspring (www.harvardpreg.org), and on studying the outcomes of medications for mental health disorders in vulnerable populations. She also has a special interest in research methodology and innovative research applications in relation to both these fields of study.

Dr. Huybrechts graduated magna cum laude with a Master of Science degree in Economics from the University of Antwerp, Belgium where she also worked as a researcher in health economics. Prior to completing a doctoral degree in epidemiology at Boston University School of Public Health, Dr. Huybrechts held several positions in pharmacoeconomics and outcomes research, both in Europe and the US. Her research projects focused primarily on psychiatry and neurology, and covered a broad spectrum of research designs, including clinical trials, naturalistic studies, retrospective data analyses, and decision-analytic simulation models.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Shupler M, Huybrechts K, Leung M, Wei Y, Schwartz J, Hernandez-Diaz S, Papatheodorou S. The association of short-term increases in ambient PM2.5 and temperature exposures with stillbirth: racial/ethnic disparities among Medicaid recipients. Am J Epidemiol. 2024 Oct 07; 193(10):1372-1383.View Related Profiles. PMID: 38770979
     
  2. Thai TN, Smolinski NE, Nduaguba S, Bird S, Straub L, Bateman BT, Hernandez-Diaz S, Huybrechts KF, Rasmussen SA, Winterstein AG. Development and Validation of an Algorithm to Predict Stillbirth Gestational Age in Medicaid Billing Records. Am J Epidemiol. 2024 Sep 20.View Related Profiles. PMID: 39307537
     
  3. Nopsopon T, Brown A, Hahn G, Rank M, Huybrechts KF, Akenroye A. Temporal variation in the effectiveness of biologics in asthma: Effect modification by changing patient characteristics. Respir Med. 2024 Sep 10; 234:107802. PMID: 39260678
     
  4. Straub L, Bateman BT, Hernández-Díaz S, Zhu Y, Suarez EA, Vine SM, Jones HE, Connery HS, Davis JM, Gray KJ, Lester B, Terplan M, Zakoul H, Mogun H, Huybrechts KF. Comparative Safety of In Utero Exposure to Buprenorphine Combined With Naloxone vs Buprenorphine Alone. JAMA. 2024 Sep 10; 332(10):805-816. PMID: 39133511; PMCID: PMC11320336; DOI: 10.1001/jama.2024.11501;
     
  5. Yland JJ, Huybrechts KF, Wesselink AK, Straub L, Chiu YH, Seely EW, Patorno E, Bateman BT, Mogun H, Wise LA, Hernández-Díaz S. Perinatal Outcomes Associated With Metformin Use During Pregnancy in Women With Pregestational Type 2 Diabetes Mellitus. Diabetes Care. 2024 Sep 01; 47(9):1688-1695.View Related Profiles. PMID: 39042587; PMCID: PMC11362109; DOI: 10.2337/dc23-2056;
     
  6. Straub L, Wang SV, Hernandez-Diaz S, Gray KJ, Vine SM, Russo M, Mittal L, Bateman BT, Zhu Y, Huybrechts KF. Hierarchical Clustering Analysis to Inform Classification of Congenital Malformations for Surveillance of Medication Safety in Pregnancy. Am J Epidemiol. 2024 Aug 09.View Related Profiles. PMID: 39123096
     
  7. Chiu YH, Huybrechts KF, Zhu Y, Straub L, Bateman BT, Logan R, Hernández-Díaz S. Internal validation of gestational age estimation algorithms in health-care databases using pregnancies conceived through fertility procedures. Am J Epidemiol. 2024 Aug 05; 193(8):1168-1175. PMID: 38583933; PMCID: PMC11299027; DOI: 10.1093/aje/kwae045;
     
  8. Feldman WB, Mahesri M, Sarpatwari A, Huybrechts KF, Zhu Y, Hwang CS, Lii J, Lee SB, Kattinakere Sreedhara S, Toyserkani GA, Zhou EH, Zendel L, LaCivita C, Manzo C, Dal Pan GJ, Kesselheim AS, Bykov K. Removing the FDA's Boxed Hepatotoxicity Warning and Liver Function Testing Requirement for Ambrisentan. JAMA Netw Open. 2024 Jul 01; 7(7):e2419873. PMID: 39023895; PMCID: PMC11258588; DOI: 10.1001/jamanetworkopen.2024.19873;
     
  9. McEwen I, Huybrechts KF, Straub L, Hernández-Díaz S. Patterns of paternal medication dispensation around the time of conception. Paediatr Perinat Epidemiol. 2024 Aug; 38(6):461-466. PMID: 38949455; PMCID: PMC11365770; DOI: 10.1111/ppe.13098;
     
  10. Chiu YH, Huybrechts KF, Patorno E, Yland JJ, Cesta CE, Bateman BT, Seely EW, Hernán MA, Hernández-Díaz S. Metformin Use in the First Trimester of Pregnancy and Risk for Nonlive Birth and Congenital Malformations: Emulating a Target Trial Using Real-World Data. Ann Intern Med. 2024 Jul; 177(7):862-870. PMID: 38885505
     
Showing 10 of 228 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 227 publications over 26 distinct years, with a maximum of 26 publications in 2020 and 2024

YearPublications
19991
20002
20012
20024
20031
20041
20053
20062
20071
20082
20091
20101
20115
20126
20139
201411
201512
20167
201722
201819
201914
202026
202118
202216
202315
202426


2018 American Psychiatric Association, American Journal of Psychiatry: Invited to APA press briefing
2017 Annals of Internal Medicine: Reviewer Recognition
2016 Journal of Pharmacoepidemiology & Drug Safety: Best Reviewer designation
2016 Department of Medicine, Brigham and Women’s Hospital: 2016 DOM Early Career Faculty Mentoring Award
2015 Clinical Research Forum: “Top 10 Clinical Research Achievement Award”
2014 Canadian Medical Association Journal: Reviewer Recognition
2013 Journal of Clinical Psychopharmacology: 2012 Mitchell B. Balter Award
2013 Journal of Clinical Psychopharmacology: Journal of Clinical Psychopharmacology
2013 Journal of Clinical Epidemiology: JCE Reviewer Award
2013 Journal of Pharmacoepidemiology & Drug Safety: Best Reviewer
2011 Honorary Society in Public Health: Induction in Delta Omega (Alpha Beta chapter)
2010 Boston University School of Public Health: School of Public Health Dean’s Award
2010 International Society for Pharmacoepidemiology: Best Student Drug Utilization Abstract
1990 Belgian Association of Health Economists: Dr. Paul Janssen Health Economics Prize
Contact for Mentoring:

715 Albany Street
Boston MA 02118
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