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Lutchen KR, Paré PD, Seow CY. Hyperresponsiveness: Relating the Intact Airway to the Whole Lung. Physiology (Bethesda). 2017 07; 32(4):322-331. PMID: 28615315; DOI: 10.1152/physiol.00008.2017;
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Harvey BC, Lutchen KR, Barbone PE. Spatial distribution of airway wall displacements during breathing and bronchoconstriction measured by ultrasound elastography using finite element image registration. Ultrasonics. 2017 03; 75:174-184. PMID: 27988462; PMCID: PMC5228632; DOI: 10.1016/j.ultras.2016.11.023;
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Lutchen KR. Invited Editorial on "Measurement of intraindividual airway tone heterogeneity and its importance in asthma": How does an airway and subsequently the lung become hyperresponsive? J Appl Physiol (1985). 2016 07 01; 121(1):221-2. PMID: 27197858; DOI: 10.1152/japplphysiol.00444.2016;
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Harvey BC, Parameswaran H, Lutchen KR. Can breathing-like pressure oscillations reverse or prevent narrowing of small intact airways? J Appl Physiol (1985). 2015 Jul 01; 119(1):47-54. PMID: 25953836; PMCID: PMC4491531; DOI: 10.1152/japplphysiol.01100.2014;
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Lutchen KR. Airway smooth muscle stretch and airway hyperresponsiveness in asthma: have we chased the wrong horse? J Appl Physiol (1985). 2014 Apr 15; 116(8):1113-5. PMID: 24265278; DOI: 10.1152/japplphysiol.00968.2013;
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Harvey BC, Parameswaran H, Lutchen KR. Can tidal breathing with deep inspirations of intact airways create sustained bronchoprotection or bronchodilation? J Appl Physiol (1985). 2013 Aug 15; 115(4):436-45. PMID: 23722710; PMCID: PMC3742943; DOI: 10.1152/japplphysiol.00009.2013;
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Lui JK, LaPrad AS, Parameswaran H, Sun Y, Albert MS, Lutchen KR. Semiautomatic segmentation of ventilated airspaces in healthy and asthmatic subjects using hyperpolarized 3He MRI. Comput Math Methods Med. 2013; 2013:624683.View Related Profiles. PMID: 23606904; PMCID: PMC3626384; DOI: 10.1155/2013/624683;
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Harvey BC, Lutchen KR. Factors determining airway caliber in asthma. Crit Rev Biomed Eng. 2013; 41(6):515-32. PMID: 24940663
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Lutchen K, Ayers J, Gallagher S, Abu-Taleb L. Engineering efficient technology transfer. Sci Transl Med. 2011 Nov 23; 3(110):110cm32. PMID: 22116931; DOI: 10.1126/scitranslmed.3003004;
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Laprad AS, Lutchen KR. The dissolution of intact airway responsiveness from breathing fluctuations: what went wrong? J Appl Physiol (1985). 2011 Jun; 110(6):1506-7. PMID: 21454749; DOI: 10.1152/japplphysiol.00356.2011;
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Kaczka DW, Lutchen KR, Hantos Z. Emergent behavior of regional heterogeneity in the lung and its effects on respiratory impedance. J Appl Physiol (1985). 2011 May; 110(5):1473-81. PMID: 21292840; PMCID: PMC3098668; DOI: 10.1152/japplphysiol.01287.2010;
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Laprad AS, Szabo TL, Suki B, Lutchen K. Reply to Noble, Hernandez, Mitchell, and Janssen. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 2010; 109(3). View Publication
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Mulally W, Milutinovic A, Albert M, Betke M, Lutchen K. Personalized Airway Trees from a Generative Model, Lung Atlas, and Hyperpolarized Helium MRI. 2010.
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Campana L, Kenyon J, Zhalehdoust-Sani S, Tzeng YS, Sun Y, Albert M, Lutchen KR. Probing airway conditions governing ventilation defects in asthma via hyperpolarized MRI image functional modeling. J Appl Physiol (1985). 2009 Apr; 106(4):1293-300. PMID: 19213937; PMCID: PMC2698646; DOI: 10.1152/japplphysiol.91428.2008;
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Ma B, Lutchen KR. CFD simulation of aerosol deposition in an anatomically based human large-medium airway model. Ann Biomed Eng. 2009 Feb; 37(2):271-85. PMID: 19082892; DOI: 10.1007/s10439-008-9620-y;
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Mullally W, Betke M, Albert M, Lutchen K. Explaining clustered ventilation defects via a minimal number of airway closure locations. Ann Biomed Eng. 2009 Feb; 37(2):286-300. PMID: 19082726; PMCID: PMC2934853; DOI: 10.1007/s10439-008-9603-z;
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Tzeng YS, Lutchen K, Albert M. The difference in ventilation heterogeneity between asthmatic and healthy subjects quantified using hyperpolarized 3He MRI. J Appl Physiol (1985). 2009 Mar; 106(3):813-22. PMID: 19023025; DOI: 10.1152/japplphysiol.01133.2007;
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LaPrad AS, West AR, Noble PB, Lutchen KR, Mitchell HW. Maintenance of airway caliber in isolated airways by deep inspiration and tidal strains. J Appl Physiol (1985). 2008 Aug; 105(2):479-85. PMID: 18556436; DOI: 10.1152/japplphysiol.01220.2007;
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Tzeng YS, Hoffman E, Cook-Granroth J, Gereige J, Mansour J, Washko G, Cho M, Stepp E, Lutchen K, Albert M. Investigation of hyperpolarized 3He magnetic resonance imaging utility in examining human airway diameter behavior in asthma through comparison with high-resolution computed tomography. Acad Radiol. 2008 Jun; 15(6):799-808. PMID: 18486015; PMCID: PMC2587251; DOI: 10.1016/j.acra.2008.02.003;
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LaPrad AS, Lutchen KR. Respiratory impedance measurements for assessment of lung mechanics: focus on asthma. Respir Physiol Neurobiol. 2008 Nov 30; 163(1-3):64-73. PMID: 18579455; PMCID: PMC2637462; DOI: 10.1016/j.resp.2008.04.015;
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Bellardine Black CL, Hoffman AM, Tsai LW, Ingenito EP, Suki B, Kaczka DW, Simon BA, Lutchen KR. Impact of positive end-expiratory pressure during heterogeneous lung injury: insights from computed tomographic image functional modeling. Ann Biomed Eng. 2008 Jun; 36(6):980-91.View Related Profiles. PMID: 18340535; DOI: 10.1007/s10439-008-9451-x;
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Lutchen K. Rebuttal from Dr. Mitzner. Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology. 2007; 103(5):1907.
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Bellardine Black CL, Hoffman A, Tsai LW, Ingenito EP, Suki B, Kaczka DW, Simon BA, Lutchen K. Dynamic respiratory mechanics measurements for optimization of ventilator settings in acute lung injury. Critical Care Medicine. 2007; 35(7):1807-1808. View Publication
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An SS, Bai TR, Bates JH, Black JL, Brown RH, Brusasco V, Chitano P, Deng L, Dowell M, Eidelman DH, Fabry B, Fairbank NJ, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gosens R, Gunst SJ, Halayko AJ, Ingram RH, Irvin CG, James AL, Janssen LJ, King GG, Knight DA, Lauzon AM, Lakser OJ, Ludwig MS, Lutchen KR, Maksym GN, Martin JG, Mauad T, McParland BE, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Paré PD, Pellegrino R, Sanderson MJ, Schellenberg RR, Seow CY, Silveira PS, Smith PG, Solway J, Stephens NL, Sterk PJ, Stewart AG, Tang DD, Tepper RS, Tran T, Wang L. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur Respir J. 2007 May; 29(5):834-60. PMID: 17470619
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Tgavalekos NT, Musch G, Harris RS, Vidal Melo MF, Winkler T, Schroeder T, Callahan R, Lutchen KR, Venegas JG. Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics. Eur Respir J. 2007 Jun; 29(6):1174-81. PMID: 17360726; DOI: 10.1183/09031936.00113606;
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Affonce D, Lutchen K. Erratum: New perspectives on the mechanical basis for airway hyperreactivity and airway hypersensitivity in asthma. Journal of Applied Physiology. 2006; 101:1710-1719. View Publication
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Ma B, Lutchen KR. An anatomically based hybrid computational model of the human lung and its application to low frequency oscillatory mechanics. Ann Biomed Eng. 2006 Nov; 34(11):1691-704. PMID: 17019619; DOI: 10.1007/s10439-006-9184-7;
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Affonce DA, Lutchen KR. New perspectives on the mechanical basis for airway hyperreactivity and airway hypersensitivity in asthma. J Appl Physiol (1985). 2006 Dec; 101(6):1710-9. PMID: 16902064; DOI: 10.1152/japplphysiol.00344.2006;
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Henderson AC, Ingenito EP, Salcedo ES, Moy ML, Reilly JJ, Lutchen KR. Dynamic lung mechanics in late-stage emphysema before and after lung volume reduction surgery. Respir Physiol Neurobiol. 2007 Mar 15; 155(3):234-42.View Related Profiles. PMID: 16870511
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Suki B, Lutchen K. Wiley Encyclopedia of Biomedical Engineering. Lung Tissue Viscoelasticity. 2006. View Publication
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Lutchen KR, Berbari EJ. White paper: Rationale, goals, and approach for education of biosystems and biosignals in undergraduate biomedical engineering degree programs. Ann Biomed Eng. 2006 Feb; 34(2):248-52. PMID: 16450197; DOI: 10.1007/s10439-005-9018-z;
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Ito S, Majumdar A, Kume H, Shimokata K, Naruse K, Lutchen KR, Stamenovic D, Suki B. Viscoelastic and dynamic nonlinear properties of airway smooth muscle tissue: roles of mechanical force and the cytoskeleton. Am J Physiol Lung Cell Mol Physiol. 2006 Jun; 290(6):L1227-37.View Related Profiles. PMID: 16414980; DOI: 10.1152/ajplung.00299.2005;
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Majumdar A, Alencar AM, Buldyrev SV, Hantos Z, Lutchen KR, Stanley HE, Suki B. Relating airway diameter distributions to regular branching asymmetry in the lung. Phys Rev Lett. 2005 Oct 14; 95(16):168101.View Related Profiles. PMID: 16241843
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Bates JH, Lutchen KR. The interface between measurement and modeling of peripheral lung mechanics. Respir Physiol Neurobiol. 2005 Aug 25; 148(1-2):153-64. PMID: 15950552; DOI: 10.1016/j.resp.2005.04.021;
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Tgavalekos NT, Tawhai M, Harris RS, Musch G, Mush G, Vidal-Melo M, Venegas JG, Lutchen KR. Identifying airways responsible for heterogeneous ventilation and mechanical dysfunction in asthma: an image functional modeling approach. J Appl Physiol (1985). 2005 Dec; 99(6):2388-97. PMID: 16081622; DOI: 10.1152/japplphysiol.00391.2005;
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Ingenito EP, Tsai LW, Mentzer SJ, Jaklitsch MT, Reilly JJ, Lutchen K, Mazan M, Hoffman A. Respiratory impedance following bronchoscopic or surgical lung volume reduction for emphysema. Respiration. 2005 Jul-Aug; 72(4):406-17. PMID: 16088285; DOI: 10.1159/000086256;
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Hoffman A, Tsai L, Mazan M, Bellardine C, Bell A, Lutchen K, Ingenito E. Pulmonary function tests versus computed tomography in sheep with experimental emphysema. Exp Lung Res. 2005 Jun; 31(5):497-512. PMID: 16019984
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Bellardine CL, Ingenito EP, Hoffman A, Lopez F, Sanborn W, Suki B, Lutchen KR. Heterogeneous airway versus tissue mechanics and their relation to gas exchange function during mechanical ventilation. Ann Biomed Eng. 2005 May; 33(5):626-41.View Related Profiles. PMID: 15981863; DOI: 10.1007/s10439-005-1540-5;
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Bai TR, Bates JH, Brusasco V, Camoretti-Mercado B, Chitano P, Deng LH, Dowell M, Fabry B, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gunst SJ, Hai CM, Halayko AJ, Hirst SJ, James AL, Janssen LJ, Jones KA, King GG, Lakser OJ, Lambert RK, Lauzon AM, Lutchen KR, Maksym GN, Meiss RA, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Paré PD, Schellenberg RR, Seow CY, Sieck GC, Smith PG, Smolensky AV, Solway J, Stephens NL, Stewart AG, Tang DD, Wang L. On the terminology for describing the length-force relationship and its changes in airway smooth muscle. J Appl Physiol (1985). 2004 Dec; 97(6):2029-34. PMID: 15531570; DOI: 10.1152/japplphysiol.00884.2004;
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Ito S, Ingenito EP, Brewer KK, Black LD, Parameswaran H, Lutchen KR, Suki B. Mechanics, nonlinearity, and failure strength of lung tissue in a mouse model of emphysema: possible role of collagen remodeling. J Appl Physiol (1985). 2005 Feb; 98(2):503-11.View Related Profiles. PMID: 15465889; DOI: 10.1152/japplphysiol.00590.2004;
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Bates J, Irvin C, Brusasco V, Drazen J, Fredberg J, Loring S, Eidelman D, Ludwig M, Macklem P, Martin J, Milic-Emili J, Hantos Z, Hyatt R, Lai-Fook S, Leff A, Solway J, Lutchen K, Suki B, Mitzner W, Paré P, Pride N, Sly P. The use and misuse of Penh in animal models of lung disease. Am J Respir Cell Mol Biol. 2004 Sep; 31(3):373-4.View Related Profiles. PMID: 15317683
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Kaczka DW, Lutchen KR. Servo-controlled pneumatic pressure oscillator for respiratory impedance measurements and high-frequency ventilation. Ann Biomed Eng. 2004 Apr; 32(4):596-608. PMID: 15117033; DOI: 10.1023/b:abme.0000019179.87974.7d;
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Dellacà RL, Black LD, Atileh H, Pedotti A, Lutchen KR. Effects of posture and bronchoconstriction on low-frequency input and transfer impedances in humans. J Appl Physiol (1985). 2004 Jul; 97(1):109-18. PMID: 14966017; DOI: 10.1152/japplphysiol.00721.2003;
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Black LD, Henderson AC, Atileh H, Israel E, Ingenito EP, Lutchen KR. Relating maximum airway dilation and subsequent reconstriction to reactivity in human lungs. J Appl Physiol (1985). 2004 May; 96(5):1808-14. PMID: 14766781; DOI: 10.1152/japplphysiol.01170.2003;
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Polak AG, Lutchen KR. Computational model for forced expiration from asymmetric normal lungs. Ann Biomed Eng. 2003 Sep; 31(8):891-907. PMID: 12918904; DOI: 10.1114/1.1588651;
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Brewer KK, Sakai H, Alencar AM, Majumdar A, Arold SP, Lutchen KR, Ingenito EP, Suki B. Lung and alveolar wall elastic and hysteretic behavior in rats: effects of in vivo elastase treatment. J Appl Physiol (1985). 2003 Nov; 95(5):1926-36.View Related Profiles. PMID: 12871961; DOI: 10.1152/japplphysiol.00102.2003;
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Suki B, Arold S, Alencar A, Lutchen K, Ingenito EP. Noisy Ventilation Improves Lung Function. 2003. View Publication
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Henderson AC, Ingenito EP, Atileh H, Israel E, Suki B, Lutchen KR. How does airway inflammation modulate asthmatic airway constriction? An antigen challenge study. J Appl Physiol (1985). 2003 Aug; 95(2):873-82; discussion 863.View Related Profiles. PMID: 12704089; DOI: 10.1152/japplphysiol.00075.2003;
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Black LD, Dellaca R, Jung K, Atileh H, Israel E, Ingenito EP, Lutchen KR. Tracking variations in airway caliber by using total respiratory vs. airway resistance in healthy and asthmatic subjects. J Appl Physiol (1985). 2003 Aug; 95(2):511-8. PMID: 12692146
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Tgavalekos NT, Venegas JG, Suki B, Lutchen KR. Relation between structure, function, and imaging in a three-dimensional model of the lung. Ann Biomed Eng. 2003 Apr; 31(4):363-73.View Related Profiles. PMID: 12723678; DOI: 10.1114/1.1557972;
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Dellacà RL, Aliverti A, Lutchen KR, Pedotti A. Spatial distribution of human respiratory system transfer impedance. Ann Biomed Eng. 2003 Feb; 31(2):121-31. PMID: 12627819
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Arold SP, Mora R, Lutchen KR, Ingenito EP, Suki B. Variable tidal volume ventilation improves lung mechanics and gas exchange in a rodent model of acute lung injury. Am J Respir Crit Care Med. 2002 Feb 01; 165(3):366-71.View Related Profiles. PMID: 11818322; DOI: 10.1164/ajrccm.165.3.2010155;
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Bellardine CL, Ingenito EP, Hoffman A, Lopez F, Sanborn W, Lutchen K. Tracking severity and distribution of lung disease during mechanical ventilation: Applications to bronchoconstriction and respiratory distress syndrome. 2002. View Publication
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Latourelle JC, Gillis HL, Lutchen KR. Exact morphometric modeling of rat lungs for predicting mechanical impedance. Respir Physiol. 2001 Aug; 127(1):75-85.View Related Profiles. PMID: 11445202
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Sakai H, Ingenito EP, Mora R, Abbay S, Cavalcante FS, Lutchen KR, Suki B. Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities. J Appl Physiol (1985). 2001 Aug; 91(2):737-47.View Related Profiles. PMID: 11457789; DOI: 10.1152/jappl.2001.91.2.737;
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Lutchen KR, Jensen A, Atileh H, Kaczka DW, Israel E, Suki B, Ingenito EP. Airway constriction pattern is a central component of asthma severity: the role of deep inspirations. Am J Respir Crit Care Med. 2001 Jul 15; 164(2):207-15.View Related Profiles. PMID: 11463589; DOI: 10.1164/ajrccm.164.2.2008119;
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Jensen A, Atileh H, Suki B, Ingenito EP, Lutchen KR. Selected contribution: airway caliber in healthy and asthmatic subjects: effects of bronchial challenge and deep inspirations. J Appl Physiol (1985). 2001 Jul; 91(1):506-15; discussion 504-5.View Related Profiles. PMID: 11408470; DOI: 10.1152/jappl.2001.91.1.506;
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Kaczka DW, Ingenito EP, Body SC, Duffy SE, Mentzer SJ, DeCamp MM, Lutchen KR. Inspiratory lung impedance in COPD: effects of PEEP and immediate impact of lung volume reduction surgery. J Appl Physiol (1985). 2001 May; 90(5):1833-41.View Related Profiles. PMID: 11299274
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Westwick DT, Lutchen KR. Fast, robust identification of nonlinear physiological systems using an implicit basis expansion. Ann Biomed Eng. 2000 Sep; 28(9):1116-25. PMID: 11132195
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Henderson C, Salcedo ES, Ingenito EP, Loring S, Moy M, Atileh H, Lutchen K. Probing dynamic lung mechanical properties in emphysema patients. 2000.
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Sakai H, Ingenito EP, Lutchen K, Suki B. Effects of lung configurational changes on airway and tissue mechanics in elastase-induced emphysematous rats. 2000.
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Arold S, Mora R, Lutchen K, Ingenito EP, Suki B. Variable peak pressure ventilation improves lung mechanics and gas exchange during long term mechanical ventilation in a Rodent model of ARDS. 2000.
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Jensen A, Atileh H, Ingenito EP, Lutchen K. Dynamics of airway dilation during and after a deep inspiration (DI) in asthmatics. 2000.
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Tgavalekos N, Tepper R, Bates J, Lutchen K. Computational model to predict the impact of airway wall morphometry on lung function in mature and immature lungs. 2000.
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Yuan H, Westwick DT, Ingenito EP, Lutchen KR, Suki B. Parametric and nonparametric nonlinear system identification of lung tissue strip mechanics. Ann Biomed Eng. 1999 Jul-Aug; 27(4):548-62.View Related Profiles. PMID: 10468239; DOI: 10.1114/1.217;
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Gillis HL, Lutchen KR. Airway remodeling in asthma amplifies heterogeneities in smooth muscle shortening causing hyperresponsiveness. J Appl Physiol (1985). 1999 Jun; 86(6):2001-12. PMID: 10368367; DOI: 10.1152/jappl.1999.86.6.2001;
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Kaczka DW, Ingenito EP, Lutchen KR. Technique to determine inspiratory impedance during mechanical ventilation: implications for flow limited patients. Ann Biomed Eng. 1999 May-Jun; 27(3):340-55. PMID: 10374726; DOI: 10.1114/1.146;
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Suki B, Arold S, Mora R, Lutchen K, Ingenito EP. American Journal of Respiratory and Critical Care Medicine. Comparison of conventional and noisy mechanical ventilation. 1999; 159(3):A49.
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Gillis HL, Lutchen KR. How heterogeneous bronchoconstriction affects ventilation distribution in human lungs: a morphometric model. Ann Biomed Eng. 1999 Jan-Feb; 27(1):14-22. PMID: 9916756; DOI: 10.1114/1.161;
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Zhang Q, Lutchen KR, Suki B. A frequency domain approach to nonlinear and structure identification for long memory systems: application to lung mechanics. Ann Biomed Eng. 1999 Jan-Feb; 27(1):1-13.View Related Profiles. PMID: 9916755; DOI: 10.1114/1.186;
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Kaczka DW, Ingenito EP, Israel E, Lutchen KR. Airway and lung tissue mechanics in asthma. Effects of albuterol. Am J Respir Crit Care Med. 1999 Jan; 159(1):169-78. PMID: 9872836; DOI: 10.1164/ajrccm.159.1.9709109;
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Arold S, Groark M, Hohman R, Mora R, Ingenito EP, Lutchen K, Suki B. Noise added to mechanical ventilation improves gas exchange in acute lung injury. 1999. View Publication
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Jensen A, Lutchen K, Kaczka DW, Sanborn W, Isaza F. Estimation of respiratory dynamic mechanical properties during clinically used mechanical ventilation. 1999. View Publication
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Lutchen K, Jensen A, Salcedo ES, Hoffman A, Reilly J, Swanson S, Mentzer S, Ingenito EP. Potential tracking of mechanical consequences of induced emphysema and lung volume reduction in sheep. 1999. View Publication
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Suki B, Alencar AM, Sujeer MK, Lutchen KR, Collins JJ, Andrade JS, Ingenito EP, Zapperi S, Stanley HE. Life-support system benefits from noise. Nature. 1998 May 14; 393(6681):127-8.View Related Profiles. PMID: 9603516
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Westwick DT, Suki B, Lutchen KR. Sensitivity analysis of kernel estimates: implications in nonlinear physiological system identification. Ann Biomed Eng. 1998 May-Jun; 26(3):488-501.View Related Profiles. PMID: 9570231; DOI: 10.1114/1.40;
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Lutchen KR, Sullivan A, Arbogast FT, Celli BR, Jackson AC. Use of transfer impedance measurements for clinical assessment of lung mechanics. Am J Respir Crit Care Med. 1998 Feb; 157(2):435-46. PMID: 9476855; DOI: 10.1164/ajrccm.157.2.9508067;
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Zhang Q, Suki B, Westwick DT, Lutchen KR. Factors affecting Volterra kernel estimation: emphasis on lung tissue viscoelasticity. Ann Biomed Eng. 1998 Jan-Feb; 26(1):103-16.View Related Profiles. PMID: 10355555; DOI: 10.1114/1.82;
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Lutchen KR, Gillis H. Relationship between heterogeneous changes in airway morphometry and lung resistance and elastance. J Appl Physiol (1985). 1997 Oct; 83(4):1192-201. PMID: 9338428; DOI: 10.1152/jappl.1997.83.4.1192;
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Cooper JD, Patterson GS, Sundaresan RS, Trulock EP, Yusen RD, Kaczka DW, Ingenito EP, Lutchen K, Pohl MS, Lefrak SS. Results of 150 consecutive bilateral lung volume tory impedance during mechanical ventilation: Implications for flow reduction procedures in patients with severe emphysema. The Journal of thoracic and cardiovascular surgery. 1996; 112:1319-1329.
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Lutchen K, Suki B, Khoo MCK. Bioengineering Approaches to Pulmonary Physiology and Medicine. Understanding Pulmonary Mechanics Using The Forced Oscillations Technique. 1996; 227-253. View Publication
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Zhang Q, Suki B, Lutchen KR. Harmonic distortion from nonlinear systems with broadband inputs: applications to lung mechanics. Ann Biomed Eng. 1995 Sep-Oct; 23(5):672-81.View Related Profiles. PMID: 7503467; DOI: 10.1007/BF02584464;
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Christini DJ, Bennett FM, Lutchen KR, Ahmed HM, Hausdorff JM, Oriol N. Application of linear and nonlinear time series modeling to heart rate dynamics analysis. IEEE Trans Biomed Eng. 1995 Apr; 42(4):411-5. PMID: 7729840; DOI: 10.1109/10.376135;
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Kaczka DW, Barnas GM, Suki B, Lutchen KR. Assessment of time-domain analyses for estimation of low-frequency respiratory mechanical properties and impedance spectra. Ann Biomed Eng. 1995 Mar-Apr; 23(2):135-51.View Related Profiles. PMID: 7605051; DOI: 10.1007/BF02368321;
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Christini DJ, Kulkarni A, Rao S, Stutman ER, Bennett FM, Hausdorff JM, Oriol N, Lutchen KR. Influence of autoregressive model parameter uncertainty on spectral estimates of heart rate dynamics. Ann Biomed Eng. 1995 Mar-Apr; 23(2):127-34. PMID: 7605050; DOI: 10.1007/BF02368320;
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Barnas GM, Harinath P, Green MD, Suki B, Kaczka DW, Lutchen KR. Influence of waveform and analysis technique on lung and chest wall properties. Respir Physiol. 1994 May; 96(2-3):331-44.View Related Profiles. PMID: 8059094
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Barbini P, Cevenini G, Lutchen KR, Ursino M. Estimating respiratory mechanical parameters of ventilated patients: a critical study in the routine intensive-care unit. Med Biol Eng Comput. 1994 Mar; 32(2):153-60. PMID: 8022211
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Lutchen K, Suki B, Zhang Q. Optimal Design of Inputs for Identifying Linear and Nonlinear Pulmonary Mechanical Properties. IFAC Proceedings Volumes (IFAC Papers-OnLine). 1994; 27(1):541-546. View Publication
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Lutchen K, Suki B, Kaczka DW, Zhang Q, Hantos Z, Daroczy B, Petak F. Direct use of mechanical ventilation to measure respiratory mechanics associated with physiological breathing. European Respiratory Review. 1994; 19:198-202.
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Lutchen KR, Everett JR, Jackson AC. Impact of frequency range and input impedance on airway-tissue separation implied from transfer impedance. J Appl Physiol (1985). 1993 Mar; 74(3):1089-99. PMID: 8482647; DOI: 10.1152/jappl.1993.74.3.1089;
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Suki B, Lutchen KR. Pseudorandom signals to estimate apparent transfer and coherence functions of nonlinear systems: applications to respiratory mechanics. IEEE Trans Biomed Eng. 1992 Nov; 39(11):1142-51.View Related Profiles. PMID: 1487277; DOI: 10.1109/10.168693;
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Barnas GM, Stamenovic D, Lutchen KR. Lung and chest wall impedances in the dog in normal range of breathing: effects of pulmonary edema. J Appl Physiol (1985). 1992 Sep; 73(3):1040-6.View Related Profiles. PMID: 1400015
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Lutchen KR, Jackson AC. Confidence bounds on respiratory mechanical properties estimated from transfer versus input impedance in humans versus dogs. IEEE Trans Biomed Eng. 1992 Jun; 39(6):644-51. PMID: 1601446; DOI: 10.1109/10.141203;
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Barnas GM, Stamenovic D, Lutchen KR, Mackenzie CF. Lung and chest wall impedances in the dog: effects of frequency and tidal volume. J Appl Physiol (1985). 1992 Jan; 72(1):87-93.View Related Profiles. PMID: 1537748
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Habib RH, Lutchen KR. Moment analysis of a multibreath nitrogen washout based on an alveolar gas dilution number. Am Rev Respir Dis. 1991 Sep; 144(3 Pt 1):513-9. PMID: 1892289; DOI: 10.1164/ajrccm/144.3_Pt_1.513;
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Jackson AC, Lutchen KR. Physiological basis for resonant frequencies in respiratory system impedances in dogs. J Appl Physiol (1985). 1991 Mar; 70(3):1051-8. PMID: 2032970; DOI: 10.1152/jappl.1991.70.3.1051;
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Davis KA, Lutchen KR. Time series versus Fourier transform methods for estimation of respiratory impedance spectra. Int J Biomed Comput. 1991 Mar-Apr; 27(3-4):261-76. PMID: 2050434; DOI: 10.1016/0020-7101(91)90067-o;
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Kaczka DW, Yang K, Barnas GM, Lutchen K. Identification of human respiratory mechanics using ventilator driven forced oscillations at low frequencies. 1991.
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Davis KA, Lutchen KR. Respiratory impedance spectral estimation for digitally created random noise. Ann Biomed Eng. 1991; 19(2):179-95. PMID: 2048776; DOI: 10.1007/BF02368468;
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Lutchen KR, Costa KD. Physiological interpretations based on lumped element models fit to respiratory impedance data: use of forward-inverse modeling. IEEE Trans Biomed Eng. 1990 Nov; 37(11):1076-86. PMID: 2276755; DOI: 10.1109/10.61033;
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Lutchen KR. Sensitivity analysis of respiratory parameter uncertainties: impact of criterion function form and constraints. J Appl Physiol (1985). 1990 Aug; 69(2):766-75. PMID: 2228887; DOI: 10.1152/jappl.1990.69.2.766;
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Lutchen KR, Giurdanella CA, Jackson AC. Inability to separate airway from tissue properties by use of human respiratory input impedance. J Appl Physiol (1985). 1990 Jun; 68(6):2403-12. PMID: 2384422; DOI: 10.1152/jappl.1990.68.6.2403;
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Lutchen KR, Habib RH, Dorkin HL, Wall MA. Respiratory impedance and multibreath N2 washout in healthy, asthmatic, and cystic fibrosis subjects. J Appl Physiol (1985). 1990 May; 68(5):2139-49. PMID: 2361915; DOI: 10.1152/jappl.1990.68.5.2139;
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Lutchen KR, Jackson AC. Effects of tidal volume and methacholine on low-frequency total respiratory impedance in dogs. J Appl Physiol (1985). 1990 May; 68(5):2128-38. PMID: 2193908; DOI: 10.1152/jappl.1990.68.5.2128;
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Lutchen KR. Optimal selection of frequencies for estimating parameters from respiratory impedance data. IEEE Trans Biomed Eng. 1988 Aug; 35(8):607-17. PMID: 3169811
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Lutchen KR, Hantos Z, Jackson AC. Importance of low-frequency impedance data for reliably quantifying parallel inhomogeneities of respiratory mechanics. IEEE Trans Biomed Eng. 1988 Jun; 35(6):472-81. PMID: 3397101
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Dorkin HL, Lutchen KR, Jackson AC. Human respiratory input impedance from 4 to 200 Hz: physiological and modeling considerations. J Appl Physiol (1985). 1988 Feb; 64(2):823-31. PMID: 3372439
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Lutchen K. Use of Sensitivity Analysis and Optimal Experiment Design for Estimating Mechanical Parameters in Respiratory System Models. IFAC Proceedings Volumes (IFAC Papers-OnLine). 1988; 21(1):473-478. View Publication
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Jackson AC, Lutchen KR, Dorkin HL. Inverse modeling of dog airway and respiratory system impedances. J Appl Physiol (1985). 1987 Jun; 62(6):2273-82. PMID: 3610923
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Jackson AC, Lutchen KR. Modeling of respiratory system impedances in dogs. J Appl Physiol (1985). 1987 Feb; 62(2):414-20. PMID: 3558201
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Lutchen KR, Jackson AC. Reliability of parameter estimates from models applied to respiratory impedance data. J Appl Physiol (1985). 1987 Feb; 62(2):403-13. PMID: 3558200
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Lutchen KR, Jackson AC. Statistical measures of parameter estimates from models fit to respiratory impedance data: emphasis on joint variabilities. IEEE Trans Biomed Eng. 1986 Nov; 33(11):1000-9. PMID: 3793121
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Lutchen KR, Saidel GM. Estimation of mechanical parameters in multicompartment models applied to normal and obstructed lungs during tidal breathing. IEEE Trans Biomed Eng. 1986 Sep; 33(9):878-87. PMID: 3759120
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Swidwa DM, Montenegro HD, Goldman MD, Lutchen KR, Saidel GM. Helium-oxygen breathing in severe chronic obstructive pulmonary disease. Chest. 1985 Jun; 87(6):790-5. PMID: 3996069
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Lutchen KR, Saidel GM, Primiano FP, Horowitz JG, Deal EC. Mechanics and gas distribution in normal and obstructed lungs during tidal breathing. Am Rev Respir Dis. 1984 Dec; 130(6):974-9. PMID: 6508018
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Lutchen KR, Saidel GM. Sensitivity analysis and experimental design techniques: application to nonlinear, dynamic lung models. Comput Biomed Res. 1982 Oct; 15(5):434-54. PMID: 7140244
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Lutchen KR, Primiano FP, Saidel GM. Nonlinear model combining pulmonary mechanics and gas concentration dynamics. IEEE Trans Biomed Eng. 1982 Sep; 29(9):629-41. PMID: 7129468
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Lutchen K. 01/01/2000. Computational challenges to probing structure-function in lung disease.
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Rodeski V, Mullally W, Bellardine C, Lutchen K, Betke M. Computing a uniform scaling parameter for 3D registration of lung surfaces.
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Kenyon J, Tzeng YS, Zender JB, Campana L, Washko GR, Israel E, Albert M, Lutchen K. Image Functional Modeling (IFM) using Hyperpolarized Helium MRI.