Karl J. Karlson, MD
Assistant Professor
Boston University School of Medicine
Dept of Surgery
Cardiothoracic Surgery

MD, Brown University School of Medicine
MMS, Brown University



As a clinical cardiac surgeon, I am frequently confronted with the problems of revascularization of the ischemic heart. Coronary artery bypass grafting is often employed to deliver new blood supply to the myocardium, but occasionally the anastomoses fail because of the development of neointimal hyperplasia and fibrosis where vessel connections are constructed. Using nanotechnology to deliver agents to the site of the anastomoses could be a game changer in terms of graft patency.

Transmyocardial laser revascularization of the heart has been shown to trigger neovascularization in underperfused regions of the myocardium not amenable to standard revascularization. The prospect of using nanotechnology to deliver growth factor or other agents in a targeted fashion to the area of the laser channels may help to achieve a quantum increase in the benefit realized from the laser surgery.

Boston Medical Center




Flipped Biomedical Grand Rounds: Creating a Clinical Immersion Classroom
06/04/2018 - 03/31/2023 (Co-PI)
NIH/National Institute of Biomedical Imaging & Bioengineering
1R25EB025788-01




Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Lazar HL, Ketchedjian A, Haime M, Karlson K, Cabral H. Topical vancomycin in combination with perioperative antibiotics and tight glycemic control helps to eliminate sternal wound infections. J Thorac Cardiovasc Surg. 2014 Sep; 148(3):1035-8; 1038-40.View Related Profiles. PMID: 25129595; DOI: 10.1016/j.jtcvs.2014.06.045;.
     
  2. Dunton RF, Karlson KJ, Leonardi HK, Jenkins RL, Berger RL. Coronary artery bypass grafting in patients with transplanted livers. Ann Thorac Surg. 1994 Oct; 58(4):1054-8. PMID: 7944749.
     
  3. Staples MH, Dunton RF, Karlson KJ, Leonardi HK, Berger RL. Heparin resistance after preoperative heparin therapy or intraaortic balloon pumping. Ann Thorac Surg. 1994 May; 57(5):1211-6. PMID: 8179387.
     
  4. Berger RL, Dunton RF, Leonardi HK, Karlson KJ. Pack and close approach to persistent postcardiopulmonary bypass bleeding. J Am Coll Surg. 1994 Apr; 178(4):353-6. PMID: 8149034.
     
  5. Dzik WH, Fleisher AG, Ciavarella D, Karlson KJ, Reed GE, Berger RL. Safety and efficacy of autologous blood donation before elective aortic valve operation. Ann Thorac Surg. 1992 Dec; 54(6):1177-80; discussion 1180-1. PMID: 1449306.
     
  6. Berger RL, Karlson KJ, Dunton RF, Leonardi HK. Replacement of the thoracic aorta with intraluminal sutureless prosthesis. Ann Thorac Surg. 1992 May; 53(5):920-7. PMID: 1571002.
     
  7. Berger RL, Dunton RF, Ashraf MM, Leonardi HK, Karlson KJ, Neptune WB. Thoracic surgery and the war against smoking: Richard H. Overholt, MD. Ann Thorac Surg. 1992 Apr; 53(4):719-25. PMID: 1554293.
     
  8. Streitz JM, Karlson KJ. Complications of percutaneous dart therapy in management of pneumothorax. Chest. 1991 Jun; 99(6):1549-50. PMID: 2036856.
     
  9. Karlson KJ, Ashraf MM, Berger RL. Rupture of left ventricle following mitral valve replacement. Ann Thorac Surg. 1988 Nov; 46(5):590-7. PMID: 3190341.
     
  10. Karlson KJ, Brescia R, Najafi H. The healing characteristics of autogenous saphenous vein used in the reconstruction of previously implanted arterial saphenous vein grafts. Ann Thorac Surg. 1987 Jun; 43(6):648-52. PMID: 3592836.
     
Showing 10 of 11 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 11 publications over 7 distinct years, with a maximum of 3 publications in 1992 and 1994

YearPublications
19851
19871
19881
19911
19923
19943
20141

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