Karl J. Karlson, MD
Emeritus Assistant Professor
Boston University School of Medicine
Dept of Surgery
Cardiothoracic Surgery

MD, Brown University School of Medicine
MMS/MMSc, Brown University

As a clinical cardiac surgeon, I am frequently confronted with the problems of revascularization of the ischemic heart. Coronary artery bypass grafting is often employed to deliver new blood supply to the myocardium, but occasionally the anastomoses fail because of the development of neointimal hyperplasia and fibrosis where vessel connections are constructed. Using nanotechnology to deliver agents to the site of the anastomoses could be a game changer in terms of graft patency.

Transmyocardial laser revascularization of the heart has been shown to trigger neovascularization in underperfused regions of the myocardium not amenable to standard revascularization. The prospect of using nanotechnology to deliver growth factor or other agents in a targeted fashion to the area of the laser channels may help to achieve a quantum increase in the benefit realized from the laser surgery.

Boston University
Evans Center for Interdisciplinary Biomedical Research

Boston Medical Center
Cardiac Surgery

Flipped Biomedical Grand Rounds: Creating a Clinical Immersion Classroom
06/04/2018 - 03/31/2023 (Multi-PI)
PI: Karl J. Karlson, MD
NIH/National Institute of Biomedical Imaging & Bioengineering


Yr Title Project-Sub Proj Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Brydges H, Yin K, Balasubramaniyan R, Lawrence KW, Luo R, Karlson KJ, McAneny DB, Edwards NM, Reardon MJ, Dobrilovic N. Primary Pericardial Mesothelioma: A Population-Based Propensity Score-Matched Analysis. Semin Thorac Cardiovasc Surg. 2021 Jul 25.View Related Profiles. PMID: 34320396
  2. Yin K, March RJ, Hoopes CW, Balk RA, Raman J, Lateef OB, Tiwari A, Bak E, Karlson KJ, Edwards NM, Dobrilovic N. Extracorporeal membrane oxygenation in the management of granulomatosis with polyangiitis. J Card Surg. 2021 Feb; 36(2):743-747.View Related Profiles. PMID: 33350513
  3. Yin K, Brydges H, Lawrence KW, Wei Y, Karlson KJ, McAneny DB, Edwards NM, Reardon MJ, Dobrilovic N. Primary cardiac lymphoma. J Thorac Cardiovasc Surg. 2020 Oct 07.View Related Profiles. PMID: 33158567
  4. Yin K, Luo R, Wei Y, Wang F, Zhang Y, Karlson KJ, Zhang Z, Reardon MJ, Dobrilovic N. Survival outcomes in patients with primary cardiac sarcoma in the United States. J Thorac Cardiovasc Surg. 2021 07; 162(1):107-115.e2.View Related Profiles. PMID: 32111430
  5. Lazar HL, Ketchedjian A, Haime M, Karlson K, Cabral H. Topical vancomycin in combination with perioperative antibiotics and tight glycemic control helps to eliminate sternal wound infections. J Thorac Cardiovasc Surg. 2014 Sep; 148(3):1035-8; 1038-40.View Related Profiles. PMID: 25129595; DOI: 10.1016/j.jtcvs.2014.06.045;
  6. Dunton RF, Karlson KJ, Leonardi HK, Jenkins RL, Berger RL. Coronary artery bypass grafting in patients with transplanted livers. Ann Thorac Surg. 1994 Oct; 58(4):1054-8. PMID: 7944749
  7. Staples MH, Dunton RF, Karlson KJ, Leonardi HK, Berger RL. Heparin resistance after preoperative heparin therapy or intraaortic balloon pumping. Ann Thorac Surg. 1994 May; 57(5):1211-6. PMID: 8179387
  8. Berger RL, Dunton RF, Leonardi HK, Karlson KJ. Pack and close approach to persistent postcardiopulmonary bypass bleeding. J Am Coll Surg. 1994 Apr; 178(4):353-6. PMID: 8149034
  9. Dzik WH, Fleisher AG, Ciavarella D, Karlson KJ, Reed GE, Berger RL. Safety and efficacy of autologous blood donation before elective aortic valve operation. Ann Thorac Surg. 1992 Dec; 54(6):1177-80; discussion 1180-1. PMID: 1449306
  10. Berger RL, Karlson KJ, Dunton RF, Leonardi HK. Replacement of the thoracic aorta with intraluminal sutureless prosthesis. Ann Thorac Surg. 1992 May; 53(5):920-7. PMID: 1571002
Showing 10 of 15 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 15 publications over 9 distinct years, with a maximum of 3 publications in 1992 and 1994 and 2020


Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Project Mentor
Contact for Mentoring:

88 E. Newton St Newton Pavilion
Boston MA 02118
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