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Novikova G, Kapoor M, Tcw J, Abud EM, Efthymiou AG, Chen SX, Cheng H, Fullard JF, Bendl J, Liu Y, Roussos P, Björkegren JL, Liu Y, Poon WW, Hao K, Marcora E, Goate AM. Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes. Nat Commun. 2021 03 12; 12(1):1610. PMID: 33712570; PMCID: PMC7955030; DOI: 10.1038/s41467-021-21823-y;
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Qian L, Tcw J. Human iPSC-Based Modeling of Central Nerve System Disorders for Drug Discovery. Int J Mol Sci. 2021 Jan 26; 22(3). PMID: 33530458; PMCID: PMC7865494; DOI: 10.3390/ijms22031203;
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Neff RA, Wang M, Vatansever S, Guo L, Ming C, Wang Q, Wang E, Horgusluoglu-Moloch E, Song WM, Li A, Castranio EL, Tcw J, Ho L, Goate A, Fossati V, Noggle S, Gandy S, Ehrlich ME, Katsel P, Schadt E, Cai D, Brennand KJ, Haroutunian V, Zhang B. Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets. Sci Adv. 2021 01; 7(2). PMID: 33523961; PMCID: PMC7787497; DOI: 10.1126/sciadv.abb5398;
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TCW J*, Preman P*, Snellinx A, Calafate S, Alfonso-Triguero M, Corthout N, Munck S, Rudolf Thal D, Goate AM, De Strooper B, Arranz AM. . Human iPSC-derived astrocytes transplanted into the mouse brain display three morphological responses to amyloid-ß plaques. bioRxiv. 2020; https://doi.org/10.1101/2020.1.
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Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM. The innate immunity protein IFITM3 modulates ?-secretase in Alzheimer's disease. Nature. 2020 10; 586(7831):735-740. PMID: 32879487; PMCID: PMC7919141; DOI: 10.1038/s41586-020-2681-2;
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Cao J, Huang M, Guo L, Zhu L, Hou J, Zhang L, Pero A, Ng S, El Gaamouch F, Elder G, Sano M, Goate A, Tcw J, Haroutunian V, Zhang B, Cai D. MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis. Mol Psychiatry. 2021 09; 26(9):4687-4701. PMID: 32632205; PMCID: PMC7785685; DOI: 10.1038/s41380-020-0824-3;
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Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D'Orazio LM, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Reiman EM, Caselli RJ, Chui HC, Tcw J, Chen Y, Pa J, Conti PS, Law M, Toga AW, Zlokovic BV. APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. Nature. 2020 05; 581(7806):71-76. PMID: 32376954; PMCID: PMC7250000; DOI: 10.1038/s41586-020-2247-3;
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TCW J, Preman P, Snellinx A, Calafate S, Alfonso-Triguero M, Corthout N, Munck S, Rudolf Thal D, Goate AM, De Strooper B, Arranz AM. Human iPSC-derived astrocytes transplanted into the mouse brain display three morphological responses to amyloid-ß plaques. bioRxiv. 2020. View Publication
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TCW J, Liang SA, Qian L, Pipalia NH, Chao MJ, Shi Y, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Holtzman DM, Maxfield FR, Zhang B, Wang M, Poon WW, Goate AM. . Cholesterol and matrisome pathways dysregulated in human APOE e4 glia. SSRN. 2019; http://dx.doi.org/10.2139/ssrn.
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Bowles KR, Tcw J, Qian L, Jadow BM, Goate AM. Reduced variability of neural progenitor cells and improved purity of neuronal cultures using magnetic activated cell sorting. PLoS One. 2019; 14(3):e0213374. PMID: 30917153; PMCID: PMC6436701; DOI: 10.1371/journal.pone.0213374;
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Tcw J. Human iPSC application in Alzheimer's disease and Tau-related neurodegenerative diseases. Neurosci Lett. 2019 04 23; 699:31-40. PMID: 30685408
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Bowles KR, Pugh DA, Farrell K, Han N, TCW J, Liu Y, Liang SA, Qian L, Bendl J, Fullard JF, Renton AE, Casella A, Iida MA, Bandres-Ciga S, Gan-Or Z, Heutink P, Siitonen A, Bertelsen S, Karch CM, Frucht SJ, Kopell BH, Peter I, Park YJ, Crane PK, Kauwe JSK, Boehme KL, Höglinger GU, PART working group, International Parkinson’s Disease Genomics Consortium (IPDGC), Progressive Supranuclear Palsy Genetics Consortium, A Charney, P Roussos, Wang JC, Poon WW, Raj T, Crary JF, Goate AM. . 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease and progressive supranuclear palsy converge on altered glial regulation. bioRxiv. 2019. View Publication
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TCW J, Liang SA, Qian L, Pipalia NH, Chao MJ, Shi Y, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Holtzman DM, Maxfield FR, Zhang B, Wang M, Poon WW, Goate AM. . Cholesterol and matrisome pathways dysregulated in human APOE e4 glia. bioRxiv. 2019; https://doi.org/10.1101/713362.
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Novikova G, Kapoor M, TCW J, Abud EM, Efthymiou AG, Cheng H, Fullard JF, Bendl J, Roussos P, Poon WW, Hao K, Marcora E, Goate AM. . Integration of Alzheimer's disease genetics and myeloid genomics reveals novel disease risk mechanisms. bioRxiv. 2019; https://doi.org/10.1101/694281.
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Grochowski CM, Gu S, Yuan B, Tcw J, Brennand KJ, Sebat J, Malhotra D, McCarthy S, Rudolph U, Lindstrand A, Chong Z, Levy DL, Lupski JR, Carvalho CMB. Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes. Hum Mutat. 2018 07; 39(7):939-946. PMID: 29696747; PMCID: PMC5995661; DOI: 10.1002/humu.23537;
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Tcw J, Wang M, Pimenova AA, Bowles KR, Hartley BJ, Lacin E, Machlovi SI, Abdelaal R, Karch CM, Phatnani H, Slesinger PA, Zhang B, Goate AM, Brennand KJ. An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 08 08; 9(2):600-614. PMID: 28757165; PMCID: PMC5550034; DOI: 10.1016/j.stemcr.2017.06.018;
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Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C, Jacob F, Nguyen HN, Itkin M, Hanna C, Shinn P, Allen C, Michael SG, Simeonov A, Huang W, Christian KM, Goate A, Brennand KJ, Huang R, Xia M, Ming GL, Zheng W, Song H, Tang H. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nat Med. 2016 10; 22(10):1101-1107. PMID: 27571349
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