Julia TCW
Assistant Professor
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics


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Dr. Julia TCW received Ph.D. and A.M. in Molecular and Cellular Biology from Harvard University with research studies in induced pluripotent stem cell (iPSC) reprogramming in the Department of Stem Cell and Regenerative Biology. She then perused her postdoctoral research in the Department of Neuroscience, Ronald M. Loeb Center for Alzheimer’s Disease, Department of Genetics and Genomic Sciences at Icahn School of Medicine at Mount Sinai, New York with a research focus of the development of iPSC models and study Alzheimer’s disease (AD) genetics. She achieved Druckenmiller Fellowship award from New York Stem Cell Foundation and K, U and R awards from NIH-NIA.

Our research laboratory is aiming at human induced pluripotent stem cell therapeutics. There are two main goals; 1) Deciphering functional mechanisms of Alzheimer’s disease (AD) genetics using in vitro iPSCs and in vivo iPSC/mouse Chimera models and 2) Developing in vitro model systems of human brain for drug screen.

1. Much of our research focuses on the effects of AD genetic risks, especially Apolipoprotein E4 (APOE4), the most significant risk factor for late-onset AD on human brain cell types. Our lab uses the forward genetic, unbiased multi-Omics computational (bioinformatics) approach to uncover pathways and network defects of AD genetic risks and demonstrate molecular mechanisms of the risk factors in CNS cell types derived from CRISPR/Cas9 genome-edited isogenic and population iPSCs. We develop novel computational pipelines to identify molecular and network drivers and integrate genetics and transcriptomics/proteomics for a functional genomic study. In vitro and in vivo work have been focused on efferocytosis, lipid metabolism, matrisome and inflammation in pure human microglia, astrocytes and organoids (multiple brain cell types as a whole) associated with AD genetic risks. Further, our lab is also collaborating with the industry to find a drug target for AD therapeutics.

2. We have developed multiple novel CNS cell type protocols including astrocytes, microglia, pericytes, neural progenitors and glutamatergic neurons and continuously put our effort to advance the 2D models to 3D human brain model to establish efficient platforms for drug screen.

Director of the Laboratory of Human Induced Pluripotent Stem Cell Therapeutics
Boston University School of Medicine


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. Preman P, Tcw J, Calafate S, Snellinx A, Alfonso-Triguero M, Corthout N, Munck S, Thal DR, Goate AM, De Strooper B, Arranz AM. Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-ß plaques. Mol Neurodegener. 2021 Sep 25; 16(1):68. PMID: 34563212; PMCID: PMC8467145; DOI: 10.1186/s13024-021-00487-8;
     
  2. Cao J, Huang M, Guo L, Zhu L, Hou J, Zhang L, Pero A, Ng S, Gaamouch FE, Elder G, Sano M, Goate A, Tcw J, Haroutunian V, Zhang B, Cai D. MicroRNA-195 rescues AD-associated lysosomal defects. Mol Psychiatry. 2021 Sep; 26(9):4563. PMID: 34773105
     
  3. Novikova G, Kapoor M, Tcw J, Abud EM, Efthymiou AG, Chen SX, Cheng H, Fullard JF, Bendl J, Liu Y, Roussos P, Björkegren JL, Liu Y, Poon WW, Hao K, Marcora E, Goate AM. Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes. Nat Commun. 2021 03 12; 12(1):1610. PMID: 33712570; PMCID: PMC7955030; DOI: 10.1038/s41467-021-21823-y;
     
  4. Qian L, Tcw J. Human iPSC-Based Modeling of Central Nerve System Disorders for Drug Discovery. Int J Mol Sci. 2021 Jan 26; 22(3). PMID: 33530458; PMCID: PMC7865494; DOI: 10.3390/ijms22031203;
     
  5. Neff RA, Wang M, Vatansever S, Guo L, Ming C, Wang Q, Wang E, Horgusluoglu-Moloch E, Song WM, Li A, Castranio EL, Tcw J, Ho L, Goate A, Fossati V, Noggle S, Gandy S, Ehrlich ME, Katsel P, Schadt E, Cai D, Brennand KJ, Haroutunian V, Zhang B. Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets. Sci Adv. 2021 Jan; 7(2). PMID: 33523961; PMCID: PMC7787497; DOI: 10.1126/sciadv.abb5398;
     
  6. Saroja SR, Gorbachev K, TCW J, Goate AM, Pereira AC. Astrocyte-secreted glypican-4 drives APOE4-dependent tau pathology. PNAS. 2021.
  7. Neff R, Wang M, Vatansever S, Guo L, Ming C, Wang Q, Wang E, Horgusluoglu-Moloch E, Song W, Li A, Castranio E, TCW J, Ho L, Goate A, Fossati V, Noggle S, Gandy S, Ehrlich ME, Katsel P, Schadt E, Cai D, Brennand KJ, Haroutunian V, Zhang B. Systematic Identification and Characterization of Molecular Subtypes of Alzheimer’s Disease. Scientific Advances. 2021.
  8. Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM. The innate immunity protein IFITM3 modulates ?-secretase in Alzheimer's disease. Nature. 2020 10; 586(7831):735-740. PMID: 32879487; PMCID: PMC7919141; DOI: 10.1038/s41586-020-2681-2;
     
  9. Cao J, Huang M, Guo L, Zhu L, Hou J, Zhang L, Pero A, Ng S, El Gaamouch F, Elder G, Sano M, Goate A, Tcw J, Haroutunian V, Zhang B, Cai D. MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis. Mol Psychiatry. 2021 Sep; 26(9):4687-4701. PMID: 32632205; PMCID: PMC7785685; DOI: 10.1038/s41380-020-0824-3;
     
  10. Cao J, Zhu L, Huang M, Hou J, Zhang L, Pero A, Ng S, Gaamouch FE, Elder G, Sano M, Goate AM, TCW J, Haroutunian V, Cai D. MicroRNA-195 rescues ApoE4-induced brain phospholipid dysregulation and cognitive deficits in Alzheimer’s Disease. Molecular Psychiatry. 2020.
Showing 10 of 27 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 27 publications over 10 distinct years, with a maximum of 7 publications in 2020 and 2021

YearPublications
20071
20091
20141
20151
20161
20174
20181
20193
20207
20217

Contact for Mentoring:

700 Albany St
Boston MA 02118
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