-
Saha O, Melo de Farias AR, Pelletier A, Siedlecki-Wullich D, Landeira BS, Gadaut J, Carrier A, Vreulx AC, Guyot K, Shen Y, Bonnefond A, Amouyel P, Tcw J, Kilinc D, Queiroz CM, Delahaye F, Lambert JC, Costa MR. The Alzheimer's disease risk gene BIN1 regulates activity-dependent gene expression in human-induced glutamatergic neurons. Mol Psychiatry. 2024 Sep; 29(9):2634-2646. PMID: 38514804; PMCID: PMC11420064; DOI: 10.1038/s41380-024-02502-y;
-
Vance JM, Farrer LA, Huang Y, Cruchaga C, Hyman BT, Pericak-Vance MA, Goate AM, Greicius MD, Griswold AJ, Haines JL, Tcw J, Schellenberg GD, Tsai LH, Herz J, Holtzman DM. Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease. Ann Neurol. 2024 Apr; 95(4):625-634.View Related Profiles. PMID: 38180638
-
Kloske CM, Barnum CJ, Batista AF, Bradshaw EM, Brickman AM, Bu G, Dennison J, Gearon MD, Goate AM, Haass C, Heneka MT, Hu WT, Huggins LKL, Jones NS, Koldamova R, Lemere CA, Liddelow SA, Marcora E, Marsh SE, Nielsen HM, Petersen KK, Petersen M, Piña-Escudero SD, Qiu WQ, Quiroz YT, Reiman E, Sexton C, Tansey MG, Tcw J, Teunissen CE, Tijms BM, van der Kant R, Wallings R, Weninger SC, Wharton W, Wilcock DM, Wishard TJ, Worley SL, Zetterberg H, Carrillo MC. APOE and immunity: Research highlights. Alzheimers Dement. 2023 Jun; 19(6):2677-2696.View Related Profiles. PMID: 36975090
-
Tcw J, Arranz AM. hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer's disease and potential therapeutics. Mol Neurodegener. 2023 Mar 25; 18(1):19. PMID: 36966344; PMCID: PMC10039591; DOI: 10.1186/s13024-023-00612-9;
-
Lee S, Williams HC, Gorman AA, Devanney NA, Harrison DA, Walsh AE, Goulding DS, Tuck T, Schwartz JL, Zajac DJ, Macauley SL, Estus S, Julia T, Johnson LA, Morganti JM. APOE4 drives transcriptional heterogeneity and maladaptive immunometabolic responses of astrocytes. bioRxiv. 2023 Feb 06. PMID: 36798317; PMCID: PMC9934552; DOI: 10.1101/2023.02.06.527204;
-
Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, Tcw J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M. CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states. Nat Neurosci. 2022 Nov; 25(11):1528-1542. PMID: 36303069; PMCID: PMC9633461; DOI: 10.1038/s41593-022-01180-9;
-
Saroja SR, Gorbachev K, Julia T, Goate AM, Pereira AC. Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation. Proc Natl Acad Sci U S A. 2022 Aug 23; 119(34):e2108870119. PMID: 35969759; PMCID: PMC9407658; DOI: 10.1073/pnas.2108870119;
-
Tcw J, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, Jain BR, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Andrews EJ, Martini AC, Karch CM, Head E, Holtzman DM, Zhang B, Wang M, Maxfield FR, Poon WW, Goate AM. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell. 2022 Jun 23; 185(13):2213-2233.e25.View Related Profiles. PMID: 35750033; PMCID: PMC9340815; DOI: 10.1016/j.cell.2022.05.017;
-
Preman P, Tcw J, Calafate S, Snellinx A, Alfonso-Triguero M, Corthout N, Munck S, Thal DR, Goate AM, De Strooper B, Arranz AM. Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-ß plaques. Mol Neurodegener. 2021 09 25; 16(1):68. PMID: 34563212; PMCID: PMC8467145; DOI: 10.1186/s13024-021-00487-8;
-
Cao J, Huang M, Guo L, Zhu L, Hou J, Zhang L, Pero A, Ng S, Gaamouch FE, Elder G, Sano M, Goate A, Tcw J, Haroutunian V, Zhang B, Cai D. MicroRNA-195 rescues AD-associated lysosomal defects. Mol Psychiatry. 2021 Sep; 26(9):4563. PMID: 34773105
-
Novikova G, Kapoor M, Tcw J, Abud EM, Efthymiou AG, Chen SX, Cheng H, Fullard JF, Bendl J, Liu Y, Roussos P, Björkegren JL, Liu Y, Poon WW, Hao K, Marcora E, Goate AM. Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes. Nat Commun. 2021 03 12; 12(1):1610. PMID: 33712570; PMCID: PMC7955030; DOI: 10.1038/s41467-021-21823-y;
-
Qian L, Tcw J. Human iPSC-Based Modeling of Central Nerve System Disorders for Drug Discovery. Int J Mol Sci. 2021 Jan 26; 22(3). PMID: 33530458; PMCID: PMC7865494; DOI: 10.3390/ijms22031203;
-
Neff RA, Wang M, Vatansever S, Guo L, Ming C, Wang Q, Wang E, Horgusluoglu-Moloch E, Song WM, Li A, Castranio EL, Tcw J, Ho L, Goate A, Fossati V, Noggle S, Gandy S, Ehrlich ME, Katsel P, Schadt E, Cai D, Brennand KJ, Haroutunian V, Zhang B. Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets. Sci Adv. 2021 01; 7(2). PMID: 33523961; PMCID: PMC7787497; DOI: 10.1126/sciadv.abb5398;
-
Saroja SR, Gorbachev K, TCW J, Goate AM, Pereira AC. Astrocyte-secreted glypican-4 drives APOE4-dependent tau pathology. PNAS. 2021.
-
Neff R, Wang M, Vatansever S, Guo L, Ming C, Wang Q, Wang E, Horgusluoglu-Moloch E, Song W, Li A, Castranio E, TCW J, Ho L, Goate A, Fossati V, Noggle S, Gandy S, Ehrlich ME, Katsel P, Schadt E, Cai D, Brennand KJ, Haroutunian V, Zhang B. Systematic Identification and Characterization of Molecular Subtypes of Alzheimer’s Disease. Scientific Advances. 2021.
-
TCW J*, Preman P*, Snellinx A, Calafate S, Alfonso-Triguero M, Corthout N, Munck S, Rudolf Thal D, Goate AM, De Strooper B, Arranz AM. . Human iPSC-derived astrocytes transplanted into the mouse brain display three morphological responses to amyloid-ß plaques. bioRxiv. 2020; https://doi.org/10.1101/2020.1.
-
Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Renton AE, Esposito BT, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate A, Li YM. The innate immunity protein IFITM3 modulates ?-secretase in Alzheimer's disease. Nature. 2020 10; 586(7831):735-740. PMID: 32879487; PMCID: PMC7919141; DOI: 10.1038/s41586-020-2681-2;
-
Cao J, Huang M, Guo L, Zhu L, Hou J, Zhang L, Pero A, Ng S, El Gaamouch F, Elder G, Sano M, Goate A, Tcw J, Haroutunian V, Zhang B, Cai D. MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis. Mol Psychiatry. 2021 09; 26(9):4687-4701. PMID: 32632205; PMCID: PMC7785685; DOI: 10.1038/s41380-020-0824-3;
-
-
Levy D, Morgan C, Bodkin J.A., Coleman M, Godfrey L, Carvalho C, Grochowski C, Kaufman M, Jensen J.E., TCW J, Brennand K, McCarthy S, Malhotra D, Sebat J, Goff D, Lupski J, Coyle J, Rudolph U. Partial pharmacological “Rescue” and MRS spectroscopy in two carriers of a rare marker chromosome containing extra copies of the GLDC gene encoding a glycine-degrading enzyme implicate NMDA Receptor hypofunction in psychosis. Biological Psychiatry. 2020.
-
Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D'Orazio LM, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Reiman EM, Caselli RJ, Chui HC, Tcw J, Chen Y, Pa J, Conti PS, Law M, Toga AW, Zlokovic BV. APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. Nature. 2020 05; 581(7806):71-76. PMID: 32376954; PMCID: PMC7250000; DOI: 10.1038/s41586-020-2247-3;
-
TCW J, Preman P, Snellinx A, Calafate S, Alfonso-Triguero M, Corthout N, Munck S, Rudolf Thal D, Goate AM, De Strooper B, Arranz AM. Human iPSC-derived astrocytes transplanted into the mouse brain display three morphological responses to amyloid-ß plaques. bioRxiv. 2020. View Publication
-
TCW J, Liang SA, Qian L, Pipalia NH, Chao MJ, Shi Y, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Holtzman DM, Maxfield FR, Zhang B, Wang M, Poon WW, Goate AM. . Cholesterol and matrisome pathways dysregulated in human APOE e4 glia. SSRN. 2019; http://dx.doi.org/10.2139/ssrn.
-
Bowles KR, Tcw J, Qian L, Jadow BM, Goate AM. Reduced variability of neural progenitor cells and improved purity of neuronal cultures using magnetic activated cell sorting. PLoS One. 2019; 14(3):e0213374. PMID: 30917153; PMCID: PMC6436701; DOI: 10.1371/journal.pone.0213374;
-
Tcw J. Human iPSC application in Alzheimer's disease and Tau-related neurodegenerative diseases. Neurosci Lett. 2019 04 23; 699:31-40. PMID: 30685408
-
Bowles KR, Pugh DA, Farrell K, Han N, TCW J, Liu Y, Liang SA, Qian L, Bendl J, Fullard JF, Renton AE, Casella A, Iida MA, Bandres-Ciga S, Gan-Or Z, Heutink P, Siitonen A, Bertelsen S, Karch CM, Frucht SJ, Kopell BH, Peter I, Park YJ, Crane PK, Kauwe JSK, Boehme KL, Höglinger GU, PART working group, International Parkinson’s Disease Genomics Consortium (IPDGC), Progressive Supranuclear Palsy Genetics Consortium, A Charney, P Roussos, Wang JC, Poon WW, Raj T, Crary JF, Goate AM. . 17q21.31 sub-haplotypes underlying H1-associated risk for Parkinson’s disease and progressive supranuclear palsy converge on altered glial regulation. bioRxiv. 2019. View Publication
-
TCW J, Liang SA, Qian L, Pipalia NH, Chao MJ, Shi Y, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Holtzman DM, Maxfield FR, Zhang B, Wang M, Poon WW, Goate AM. . Cholesterol and matrisome pathways dysregulated in human APOE e4 glia. bioRxiv. 2019; https://doi.org/10.1101/713362.
-
Novikova G, Kapoor M, TCW J, Abud EM, Efthymiou AG, Cheng H, Fullard JF, Bendl J, Roussos P, Poon WW, Hao K, Marcora E, Goate AM. . Integration of Alzheimer's disease genetics and myeloid genomics reveals novel disease risk mechanisms. bioRxiv. 2019; https://doi.org/10.1101/694281.
-
Grochowski CM, Gu S, Yuan B, Tcw J, Brennand KJ, Sebat J, Malhotra D, McCarthy S, Rudolph U, Lindstrand A, Chong Z, Levy DL, Lupski JR, Carvalho CMB. Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes. Hum Mutat. 2018 07; 39(7):939-946. PMID: 29696747; PMCID: PMC5995661; DOI: 10.1002/humu.23537;
-
Jiang Y, Loh E, Rajarajan P, Hirayama T, Will Liao, Kassim B, Javidfar B, Fullard J, Hartley BJ, Giakoumaki SG, Egli T, Hatzimanolis A, Kleofas L, Pothula V, Park R, Labonte B, Ho SM, Chandrasekaran S, Do C, Brianna Ramirez, Peter C, TCW J, Brain Safaie, Smyrnis N, fanis NC, Avramopoulos D, de Quervain D J-F, Papassotiropoulos A, Bitsios P, Goate AM, Tycko B, Morishita H, Schaefer A, Nestler EJ, Roussos P, Brennand K, Yagi T, Shen L, Akbarian S. The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain. Nature Genetics. 2017.
-
Tcw J, Wang M, Pimenova AA, Bowles KR, Hartley BJ, Lacin E, Machlovi SI, Abdelaal R, Karch CM, Phatnani H, Slesinger PA, Zhang B, Goate AM, Brennand KJ. An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 08 08; 9(2):600-614. PMID: 28757165; PMCID: PMC5550034; DOI: 10.1016/j.stemcr.2017.06.018;
-
-
Tcw J, Carvalho CMB, Yuan B, Gu S, Altheimer AN, McCarthy S, Malhotra D, Sebat J, Siegel AJ, Rudolph U, Lupski JR, Levy DL, Brennand KJ. Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis. Stem Cell Reports. 2017 03 14; 8(3):519-528. PMID: 28216146; PMCID: PMC5355568; DOI: 10.1016/j.stemcr.2017.01.010;
-
Xu M, Lee EM, Wen Z, Cheng Y, Huang WK, Qian X, Tcw J, Kouznetsova J, Ogden SC, Hammack C, Jacob F, Nguyen HN, Itkin M, Hanna C, Shinn P, Allen C, Michael SG, Simeonov A, Huang W, Christian KM, Goate A, Brennand KJ, Huang R, Xia M, Ming GL, Zheng W, Song H, Tang H. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nat Med. 2016 10; 22(10):1101-1107. PMID: 27571349
-
Ho SM, Hartley BJ, Tcw J, Beaumont M, Stafford K, Slesinger PA, Brennand KJ. Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells. Methods. 2016 05 15; 101:113-24. PMID: 26626326
-
Ichida JK, Tcw J, Williams LA, Carter AC, Shi Y, Moura MT, Ziller M, Singh S, Amabile G, Bock C, Umezawa A, Rubin LL, Bradner JE, Akutsu H, Meissner A, Eggan K. Notch inhibition allows oncogene-independent generation of iPS cells. Nat Chem Biol. 2014 Aug; 10(8):632-639. PMID: 24952596
-
Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, Huangfu D, Akutsu H, Liu DR, Rubin LL, Eggan K. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell. 2009 Nov 06; 5(5):491-503. PMID: 19818703; PMCID: PMC3335195; DOI: 10.1016/j.stem.2009.09.012;
-
Yang HY, Kang KJ, Chung JE, Shim H. Construction of a large synthetic human scFv library with six diversified CDRs and high functional diversity. Mol Cells. 2009 Feb 28; 27(2):225-35. PMID: 19277506; DOI: 10.1007/s10059-009-0028-9;
-
Chung EY, Shin SY, Lee YH. Amitriptyline induces early growth response-1 gene expression via ERK and JNK mitogen-activated protein kinase pathways in rat C6 glial cells. Neurosci Lett. 2007 Jul 05; 422(1):43-8. PMID: 17590509; DOI: 10.1016/j.neulet.2007.05.057;