Jonathan Williams | Profiles RNS

Jonathan S. Williams, MD

Adjunct Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Medicine

Endocrinology, Diabetes, Nutrition & Weight Management

MD, Hahnemann University
MMS/MMSc, Harvard University
BS, Brigham Young University

Websites

	Brigham and Women's Hospital
	ResearchGate
	Partners Healthcare
	LinkedIn
	Harvard Catalyst

Dr. Williams is Associate Professor of Medicine at Harvard Medical School and practicing endocrinologist at Brigham and Women's Hospital and the Boston VA Healthcare System. He directs the Cardiometabolic Human Genetics Research Program, which houses the HyperPath and HyperPath2 cohorts established over 20 years ago as a multinational program to decipher the genetic and mechanistic underpinnings of complex heritable diseases. His administrative roles include IRB Chair (MassGeneral Brigham), Co-Director Clinical and Translational Research Academy (Harvard Medical School), and Lead Medical Research Officer, Center for Clinical Investigations (Brigham and Women's Hospital).

Associate Professor
Harvard Medical School

VA Boston Healthcare System

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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Aljaibeji H, Heydarpour M, Stanton AM, Williams JS, Pojoga LH, Romero JR, Williams GH. Role of Raptor Gene Variants in Hypertension: Influence on Blood Pressure Independent of Salt Intake in White Population. Hypertension. 2024 Mar 18. PMID: 38497230

Heydarpour M, Parksook WW, Pojoga LH, Williams GH, Williams JS. Mineralocorticoid receptor and aldosterone: Interaction between NR3C2 genetic variants, sex and age in a mixed cohort. J Clin Endocrinol Metab. 2024 Mar 04. PMID: 38437868

Gholami SK, Heydarpour M, Williams JS, Pojoga LH, Adler GK, Williams GH, Romero JR. Striatin Gene Variants Are Associated With Salt Sensitivity of Blood Pressure by Mechanisms That Differ in Women and Men. Hypertension. 2024 Feb; 81(2):330-339. PMID: 38018471; PMCID: PMC10843568; DOI: 10.1161/HYPERTENSIONAHA.123.21955;

Stanton AM, Heydarpour M, Williams JS, Williams GH, Adler GK. CACNA1D Gene Polymorphisms Associate With Increased Blood Pressure and Salt Sensitivity of Blood Pressure in White Individuals. Hypertension. 2023 Dec; 80(12):2665-2673. PMID: 37846579; PMCID: PMC10843263; DOI: 10.1161/HYPERTENSIONAHA.123.21229;

Zitting KM, Isherwood CM, Yuan RK, Wang W, Vujovic N, Münch M, Cain SW, Williams JS, Buxton OM, Czeisler CA, Duffy JF. Eating during the biological night is associated with nausea. Sleep Health. 2023 Sep 18. PMID: 37730474; PMCID: PMC10947563; DOI: 10.1016/j.sleh.2023.08.004;

Burton Murray H, Ljótsson B, Healy B, Van Oudenhove L, Williams JS, Keefer L, Lawson EA, Kuo B, Thomas JJ. Brief cognitive-behavioral treatment for avoidant/restrictive food intake disorder in the context of functional dyspepsia: Study protocol for a feasibility randomized controlled trial. Contemp Clin Trials. 2023 Nov; 134:107336. PMID: 37722485

Heydarpour M, Parksook WW, Hopkins PN, Pojoga LH, Williams GH, Williams JS. A candidate locus in the renalase gene and susceptibility to blood pressure responses to the dietary salt. J Hypertens. 2023 May 01; 41(5):723-732. PMID: 36789764; PMCID: PMC10079562; DOI: 10.1097/HJH.0000000000003391;

Katayama IA, Huang Y, Garza AE, Brooks DL, Williams JS, Nascimento MM, Heimann JC, Pojoga LH. Longitudinal changes in blood pressure are preceded by changes in albuminuria and accelerated by increasing dietary sodium intake. Exp Gerontol. 2023 Mar; 173:112114. PMID: 36738979

Tan YJD, Brooks DL, Wong KYH, Huang Y, Romero JR, Williams JS, Pojoga LH. Lysine-specific demethylase 1 deficiency modifies aldosterone synthesis in a sex-specific manner. J Endocrinol. 2023 Jan 01; 256(1). PMID: 36327153; PMCID: PMC9855026; DOI: 10.1530/JOE-22-0141;

Xin Q, Yuan RK, Zitting KM, Wang W, Purcell SM, Vujovic N, Ronda JM, Quan SF, Williams JS, Buxton OM, Duffy JF, Czeisler CA. Impact of chronic sleep restriction on sleep continuity, sleep structure, and neurobehavioral performance. Sleep. 2022 Jul 11; 45(7). PMID: 35218665; PMCID: PMC9272266; DOI: 10.1093/sleep/zsac046;

Showing 10 of 89 results. Show More

Parksook WW, Heydarpour M, Gholami SK, Luther JM, Hopkins PN, Pojoga LH, Williams JS. Salt Sensitivity of Blood Pressure and Aldosterone: Interaction Between the Lysine-specific Demethylase 1 Gene, Sex, and Age. J Clin Endocrinol Metab. 2022 Apr 19; 107(5):1294-1302. PMID: 35022775; PMCID: PMC9016472; DOI: 10.1210/clinem/dgac011;

Zitting KM, Vetrivelan R, Yuan RK, Vujovic N, Wang W, Bandaru SS, Quan SF, Klerman EB, Scheer FAJL, Buxton OM, Williams JS, Duffy JF, Saper CB, Czeisler CA. Chronic circadian disruption on a high-fat diet impairs glucose tolerance. Metabolism. 2022 05; 130:155158. PMID: 35150732

Haas AV, En Yee L, Yuan YE, Wong YH, Hopkins PN, Jeunemaitre X, Lasky-Su J, Williams JS, Adler GK, Williams GH. Genetic Predictors of Salt Sensitivity of Blood Pressure: The Additive Impact of 2 Hits in the Same Biological Pathway. Hypertension. 2021 12; 78(6):1809-1817. PMID: 34757767; PMCID: PMC8589116; DOI: 10.1161/HYPERTENSIONAHA.121.18033;

Yuan RK, Zitting KM, Duffy JF, Vujovic N, Wang W, Quan SF, Klerman EB, Scheer FAJL, Buxton OM, Williams JS, Czeisler CA. Chronic Sleep Restriction While Minimizing Circadian Disruption Does Not Adversely Affect Glucose Tolerance. Front Physiol. 2021; 12:764737. PMID: 34744800; PMCID: PMC8564292; DOI: 10.3389/fphys.2021.764737;

Stone IB, Green JAEM, Koefoed AW, Hornik ES, Williams JS, Adler GK, Williams GH. Striatin genotype-based, mineralocorticoid receptor antagonist-driven clinical trial: study rationale and design. Pharmacogenet Genomics. 2021 06 01; 31(4):83-88. PMID: 33904521; PMCID: PMC10352129; DOI: 10.1097/FPC.0000000000000425;

Haas AV, Baudrand R, Easly RM, Murray GR, Touyz RM, Pojoga LH, Jeunemaitre X, Hopkins PN, Rosner B, Williams JS, Williams GH, Adler GK. Interplay Between Statins, Cav1 (Caveolin-1), and Aldosterone. Hypertension. 2020 09; 76(3):962-967. PMID: 32755411; PMCID: PMC7418929; DOI: 10.1161/HYPERTENSIONAHA.120.14777;

Hornik ES, Altman-Merino AE, Koefoed AW, Meyer KM, Stone IB, Green JA, Williams GH, Adler GK, Williams JS. A clinical trial to evaluate the effect of statin use on lowering aldosterone levels. BMC Endocr Disord. 2020 Jul 14; 20(1):105. PMID: 32664962; PMCID: PMC7362429; DOI: 10.1186/s12902-020-00587-4;

Maris SA, Meyer KM, Murray G, Williams JS. Physical Activity and the Acute Hemodynamic Response to ACE Inhibition in Hypertension. Am J Lifestyle Med. 2022 Jul-Aug; 16(4):538-545. PMID: 35860373; PMCID: PMC9290176; DOI: 10.1177/1559827620935367;

Yuan RK, Zitting KM, Wang W, Buxton OM, Williams JS, Duffy JF, Czeisler CA. Fasting blood triglycerides vary with circadian phase in both young and older people. Physiol Rep. 2020 06; 8(11):e14453. PMID: 32519460; PMCID: PMC7283043; DOI: 10.14814/phy2.14453;

Bayomy O, Zaheer S, Williams JS, Curhan G, Vaidya A. Disentangling the Relationships Between the Renin-Angiotensin-Aldosterone System, Calcium Physiology, and Risk for Kidney Stones. J Clin Endocrinol Metab. 2020 06 01; 105(6). PMID: 32163150; PMCID: PMC7185954; DOI: 10.1210/clinem/dgaa123;

Treesaranuwattana T, Wong KYH, Brooks DL, Tay CS, Williams GH, Williams JS, Pojoga LH. Lysine-Specific Demethylase-1 Deficiency Increases Agonist Signaling Via the Mineralocorticoid Receptor. Hypertension. 2020 04; 75(4):1045-1053. PMID: 32160100; PMCID: PMC8160386; DOI: 10.1161/HYPERTENSIONAHA.119.13821;

Carmichael CY, Kuwabara JT, Pascale CL, Moreira JD, Mahne SE, Kapusta DR, Rosene DL, Williams JS, Cunningham JT, Wainford RD. Hypothalamic Paraventricular Nucleus Gai2 (Guanine Nucleotide-Binding Protein Alpha Inhibiting Activity Polypeptide 2) Protein-Mediated Neural Control of the Kidney and the Salt Sensitivity of Blood Pressure. Hypertension. 2020 04; 75(4):1002-1011.View Related Profiles.

Carmichael, Casey
Rosene, Douglas
Moreira, Jesse
Williams, Jonathan
Wainford, Richard
Mahne, Sarah

PMID: 32148128; PMCID: PMC7329357; DOI: 10.1161/HYPERTENSIONAHA.119.13777;

Roumie CL, Hung AM, Russell GB, Basile J, Kreider KE, Nord J, Ramsey TM, Rastogi A, Sweeney ME, Tamariz L, Kostis WJ, Williams JS, Zias A, Cushman WC. Blood Pressure Control and the Association With Diabetes Mellitus Incidence: Results From SPRINT Randomized Trial. Hypertension. 2020 02; 75(2):331-338. PMID: 31865790; PMCID: PMC7015147; DOI: 10.1161/HYPERTENSIONAHA.118.12572;

Ranjit S, Wong JY, Tan JW, Sin Tay C, Lee JM, Yin Han Wong K, Pojoga LH, Brooks DL, Garza AE, Maris SA, Katayama IA, Williams JS, Rivera A, Adler GK, Williams GH, Romero JR. Sex-specific differences in endoplasmic reticulum aminopeptidase 1 modulation influence blood pressure and renin-angiotensin system responses. JCI Insight. 2019 11 01; 4(21). PMID: 31672933; PMCID: PMC6948756; DOI: 10.1172/jci.insight.129615;

Chellappa SL, Vujovic N, Williams JS, Scheer FAJL. Impact of Circadian Disruption on Cardiovascular Function and Disease. Trends Endocrinol Metab. 2019 10; 30(10):767-779. PMID: 31427142; PMCID: PMC6779516; DOI: 10.1016/j.tem.2019.07.008;

Maris SA, Williams JS, Sun B, Brown S, Mitchell GF, Conlin PR. Interactions of the DASH Diet with the Renin-Angiotensin-Aldosterone System. Curr Dev Nutr. 2019 Sep; 3(9):nzz091.View Related Profiles.

Williams, Jonathan
Conlin, Paul

PMID: 31528838; PMCID: PMC6735835; DOI: 10.1093/cdn/nzz091;

Haas AV, Hopkins PN, Brown NJ, Pojoga LH, Williams JS, Adler GK, Williams GH. Higher urinary cortisol levels associate with increased cardiovascular risk. Endocr Connect. 2019 Jun 01; 8(6):634-640. PMID: 31018177; PMCID: PMC6528405; DOI: 10.1530/EC-19-0182;

Huang Y, Ting PY, Yao TM, Homma T, Brooks D, Katayama Rangel I, Adler GK, Romero JR, Williams JS, Pojoga LH, Williams GH. Histone demethylase LSD1 deficiency and biological sex: impact on blood pressure and aldosterone production. J Endocrinol. 2019 02 01; 240(2):111-122. PMID: 30400034; PMCID: PMC6824586; DOI: 10.1530/JOE-18-0247;

Zitting KM, Vujovic N, Yuan RK, Isherwood CM, Medina JE, Wang W, Buxton OM, Williams JS, Czeisler CA, Duffy JF. Human Resting Energy Expenditure Varies with Circadian Phase. Curr Biol. 2018 11 19; 28(22):3685-3690.e3. PMID: 30416064; PMCID: PMC6300153; DOI: 10.1016/j.cub.2018.10.005;

Zhang X, Frame AA, Williams JS, Wainford RD. GNAI2 polymorphic variance associates with salt sensitivity of blood pressure in the Genetic Epidemiology Network of Salt Sensitivity study. Physiol Genomics. 2018 09 01; 50(9):724-725.View Related Profiles.

Frame, Alissa
Williams, Jonathan
Wainford, Richard
Zhang, Xiaoling

PMID: 29906209; PMCID: PMC6172609; DOI: 10.1152/physiolgenomics.00141.2017;

Shukri MZ, Tan JW, Manosroi W, Pojoga LH, Rivera A, Williams JS, Seely EW, Adler GK, Jaffe IZ, Karas RH, Williams GH, Romero JR. Biological Sex Modulates the Adrenal and Blood Pressure Responses to Angiotensin II. Hypertension. 2018 06; 71(6):1083-1090. PMID: 29686001; PMCID: PMC6086591; DOI: 10.1161/HYPERTENSIONAHA.117.11087;

Williams JS, Autori PJ, Kidd SK, Piazza G, Connors MC, Czeisler CA, Scheuermaier KD, Duffy J, Klerman EB, Scheer FA, Kozak M, Driscoll SM, Goldhaber SZ. Heparin-Induced Thrombocytopenia in Healthy Individuals with Continuous Heparin Infusion. TH Open. 2018 Jan; 2(1):e49-e53. PMID: 31249929; PMCID: PMC6524859; DOI: 10.1055/s-0038-1624565;

Zaheer S, Taquechel K, Brown JM, Adler GK, Williams JS, Vaidya A. A randomized intervention study to evaluate the effect of calcitriol therapy on the renin-angiotensin system in diabetes. J Renin Angiotensin Aldosterone Syst. 2018 Jan-Mar; 19(1):1470320317754178. PMID: 29562806; PMCID: PMC5896865; DOI: 10.1177/1470320317754178;

Gupta T, Connors M, Tan JW, Manosroi W, Ahmed N, Ting PY, Garza AE, Romero JR, Hopkins PN, Williams JS, Williams GH. Striatin Gene Polymorphic Variants Are Associated With Salt Sensitive Blood Pressure in Normotensives and Hypertensives. Am J Hypertens. 2017 Dec 08; 31(1):124-131. PMID: 28985281; PMCID: PMC5861567; DOI: 10.1093/ajh/hpx146;

Tan JW, Gupta T, Manosroi W, Yao TM, Hopkins PN, Williams JS, Adler GK, Romero JR, Williams GH. Dysregulated aldosterone secretion in persons of African descent with endothelin-1 gene variants. JCI Insight. 2017 12 07; 2(23). PMID: 29212952; PMCID: PMC5752283; DOI: 10.1172/jci.insight.95992;

Manosroi W, Tan JW, Rariy CM, Sun B, Goodarzi MO, Saxena AR, Williams JS, Pojoga LH, Lasky-Su J, Cui J, Guo X, Taylor KD, Chen YI, Xiang AH, Hsueh WA, Raffel LJ, Buchanan TA, Rotter JI, Williams GH, Seely EW. The Association of Estrogen Receptor-ß Gene Variation With Salt-Sensitive Blood Pressure. J Clin Endocrinol Metab. 2017 11 01; 102(11):4124-4135. PMID: 28938457; PMCID: PMC5673274; DOI: 10.1210/jc.2017-00957;

Bress AP, King JB, Kreider KE, Beddhu S, Simmons DL, Cheung AK, Zhang Y, Doumas M, Nord J, Sweeney ME, Taylor AA, Herring C, Kostis WJ, Powell J, Rastogi A, Roumie CL, Wiggers A, Williams JS, Yunis R, Zias A, Evans GW, Greene T, Rocco MV, Cushman WC, Reboussin DM, Feinglos MN, Papademetriou V. Effect of Intensive Versus Standard Blood Pressure Treatment According to Baseline Prediabetes Status: A Post Hoc Analysis of a Randomized Trial. Diabetes Care. 2017 Aug 09; 40(10):1401-8. PMID: 28793997

Zaheer S, Brown JM, Connors M, Williams JS, Adler GK, Vaidya A. Angiotensin-Converting Enzyme Inhibition and Parathyroid Hormone Secretion. Int J Endocrinol. 2017; 2017:4138783. PMID: 28808443; PMCID: PMC5541811; DOI: 10.1155/2017/4138783;

Leonardi GC, Oxnard GR, Haas A, Lang JP, Williams JS, Awad MM. Diabetic Ketoacidosis as an Immune-related Adverse Event from Pembrolizumab in Non-Small Cell Lung Cancer. J Immunother. 2017 Jul/Aug; 40(6):249-251.View Related Profiles.

Oxnard, Geoffrey
Williams, Jonathan

PMID: 28557813

Baudrand R, Gupta N, Garza AE, Vaidya A, Leopold JA, Hopkins PN, Jeunemaitre X, Ferri C, Romero JR, Williams J, Loscalzo J, Adler GK, Williams GH, Pojoga LH. Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis. J Am Heart Assoc. 2016 Sep 28; 5(10). PMID: 27680666; DOI: 10.1161/JAHA.116.003845;

Baudrand R, Pojoga L, Vaidya A, Garza A, Vöhringer P, Jeunemaitre X, Hopkins P, Yao T, Williams J, Adler G, Williams G. Response to Letter Regarding Article, "Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects". Circulation. 2016 Apr 19; 133(16):e606. PMID: 27142613; PMCID: PMC4862598; DOI: 10.1161/CIRCULATIONAHA.116.021486;

Baudrand R, Pojoga LH, Vaidya A, Garza AE, Vöhringer PA, Jeunemaitre X, Hopkins PN, Yao TM, Williams J, Adler GK, Williams GH. Statin Use and Adrenal Aldosterone Production in Hypertensive and Diabetic Subjects. Circulation. 2015 Nov 10; 132(19):1825-33. PMID: 26432671; PMCID: PMC4641753; DOI: 10.1161/CIRCULATIONAHA.115.016759;

Baudrand R, Goodarzi MO, Vaidya A, Underwood PC, Williams JS, Jeunemaitre X, Hopkins PN, Brown N, Raby BA, Lasky-Su J, Adler GK, Cui J, Guo X, Taylor KD, Chen YD, Xiang A, Raffel LJ, Buchanan TA, Rotter JI, Williams GH, Pojoga LH. A prevalent caveolin-1 gene variant is associated with the metabolic syndrome in Caucasians and Hispanics. Metabolism. 2015 Dec; 64(12):1674-81. PMID: 26475177; PMCID: PMC4641791; DOI: 10.1016/j.metabol.2015.09.005;

Vaidya A, Brown JM, Williams JS. The renin-angiotensin-aldosterone system and calcium-regulatory hormones. J Hum Hypertens. 2015 Sep; 29(9):515-21. PMID: 25631218; PMCID: PMC4769794; DOI: 10.1038/jhh.2014.125;

Arora P, Reingold J, Baggish A, Guanaga DP, Wu C, Ghorbani A, Song Y, Chen-Tournaux A, Khan AM, Tainsh LT, Buys ES, Williams JS, Heublein DM, Burnett JC, Semigran MJ, Bloch KD, Scherrer-Crosbie M, Newton-Cheh C, Kaplan LM, Wang TJ. Weight loss, saline loading, and the natriuretic peptide system. J Am Heart Assoc. 2015 Jan 16; 4(1):e001265. PMID: 25595796

Garza AE, Rariy CM, Sun B, Williams JS, Lasky-Su J, Baudrand R, Yao T, Moize B, Hafiz WM, Romero JR, Adler GK, Ferri C, Hopkins PN, Pojoga LH, Williams GH. Variants in striatin gene are associated with salt-sensitive blood pressure in mice and humans. Hypertension. 2015 Jan; 65(1):211-7. PMID: 25368024; PMCID: PMC4617687; DOI: 10.1161/HYPERTENSIONAHA.114.04233;

Hamnvik OP, Choueiri TK, Turchin A, McKay RR, Goyal L, Davis M, Kaymakcalan MD, Williams JS. Clinical risk factors for the development of hypertension in patients treated with inhibitors of the VEGF signaling pathway. Cancer. 2015 Jan 15; 121(2):311-9. PMID: 25236375; PMCID: PMC4293233; DOI: 10.1002/cncr.28972;

Coutinho P, Vega C, Pojoga LH, Rivera A, Prado GN, Yao TM, Adler G, Torres-Grajales M, Maldonado ER, Ramos-Rivera A, Williams JS, Williams G, Romero JR. Aldosterone's rapid, nongenomic effects are mediated by striatin: a modulator of aldosterone's effect on estrogen action. Endocrinology. 2014 Jun; 155(6):2233-43. PMID: 24654783; PMCID: PMC4020933; DOI: 10.1210/en.2013-1834;

Seth B, Williams JS. Recent AHA/ACC cholesterol guidelines: vice or virtue? Metabolism. 2014 May; 63(5):605-6. PMID: 24560624

Brown JM, Williams JS, Luther JM, Garg R, Garza AE, Pojoga LH, Ruan DT, Williams GH, Adler GK, Vaidya A. Human interventions to characterize novel relationships between the renin-angiotensin-aldosterone system and parathyroid hormone. Hypertension. 2014 Feb; 63(2):273-80. PMID: 24191286; PMCID: PMC3898197; DOI: 10.1161/HYPERTENSIONAHA.113.01910;

Brown JM, Secinaro K, Williams JS, Vaidya A. Evaluating hormonal mechanisms of vitamin D receptor agonist therapy in diabetic kidney disease: the VALIDATE-D study. BMC Endocr Disord. 2013 Aug 23; 13:33. PMID: 23971740; PMCID: PMC3765219; DOI: 10.1186/1472-6823-13-33;

Williams JS. Evolving research in nongenomic actions of aldosterone. Curr Opin Endocrinol Diabetes Obes. 2013 Jun; 20(3):198-203. PMID: 23519092

Vaidya A, Underwood PC, Annes JP, Sun B, Williams GH, Forman JP, Williams JS. The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes. Metabolism. 2013 Apr; 62(4):539-47.View Related Profiles.

Forman, John
Williams, Jonathan

PMID: 23142162; PMCID: PMC3572332; DOI: 10.1016/j.metabol.2012.10.001;

Krug AW, Tille E, Sun B, Pojoga L, Williams J, Chamarthi B, Lichtman AH, Hopkins PN, Adler GK, Williams GH. Lysine-specific demethylase-1 modifies the age effect on blood pressure sensitivity to dietary salt intake. Age (Dordr). 2013 Oct; 35(5):1809-20. PMID: 23054827; PMCID: PMC3776098; DOI: 10.1007/s11357-012-9480-0;

Underwood PC, Chamarthi B, Williams JS, Vaidya A, Garg R, Adler GK, Grotzke MP, Staskus G, Wadwekar D, Hopkins PN, Ferri C, McCall A, McClain D, Williams GH. Nonmodulation as the mechanism for salt sensitivity of blood pressure in individuals with hypertension and type 2 diabetes mellitus. J Clin Endocrinol Metab. 2012 Oct; 97(10):3775-82. PMID: 22865897; PMCID: PMC3462947; DOI: 10.1210/jc.2012-2127;

Sun B, Chamarthi B, Williams JS, Krug AW, Lasky-Su J, Raby BA, Hopkins PN, Jeunemaitre X, Ferri C, Williams GH. Different polymorphisms of the mineralocorticoid receptor gene are associated with either glucocorticoid or mineralocorticoid levels in hypertension. J Clin Endocrinol Metab. 2012 Sep; 97(9):E1825-9. PMID: 22723323; PMCID: PMC3431565; DOI: 10.1210/jc.2012-1486;

Williams JS. The early-stage patient-oriented researcher in 2012: challenges and strategies. Clin Transl Sci. 2012 Jun; 5(3):221-2. PMID: 22686197; PMCID: PMC5439880; DOI: 10.1111/j.1752-8062.2012.00415.x;

Vaidya A, Sun B, Larson C, Forman JP, Williams JS. Vitamin D3 therapy corrects the tissue sensitivity to angiotensin ii akin to the action of a converting enzyme inhibitor in obese hypertensives: an interventional study. J Clin Endocrinol Metab. 2012 Jul; 97(7):2456-65.View Related Profiles.

Forman, John
Williams, Jonathan

PMID: 22539586; PMCID: PMC3387405; DOI: 10.1210/jc.2012-1156;

Williams JS, Chamarthi B, Goodarzi MO, Pojoga LH, Sun B, Garza AE, Raby BA, Adler GK, Hopkins PN, Brown NJ, Jeunemaitre X, Ferri C, Fang R, Leonor T, Cui J, Guo X, Taylor KD, Ida Chen YD, Xiang A, Raffel LJ, Buchanan TA, Rotter JI, Williams GH, Shi Y. Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension. Am J Hypertens. 2012 Jul; 25(7):812-7. PMID: 22534796; PMCID: PMC3721725; DOI: 10.1038/ajh.2012.43;

Vaidya A, Williams JS. Vitamin D and insulin sensitivity: can gene association and pharmacogenetic studies of the vitamin D receptor provide clarity? Metabolism. 2012 Jun; 61(6):759-61. PMID: 22304841; PMCID: PMC4277866; DOI: 10.1016/j.metabol.2011.12.009;

Larson C, Vaidya A, Sun B, Williams JS. Influence of dietary sodium modulation on electrocardiographic voltage criteria for left ventricular hypertrophy in normotensive individuals. J Investig Med. 2012 Jan; 60(1):39-43. PMID: 22089249; PMCID: PMC3246128; DOI: 10.231/JIM.0b013e31823d05ab;

Pojoga LH, Coutinho P, Rivera A, Yao TM, Maldonado ER, Youte R, Adler GK, Williams J, Turchin A, Williams GH, Romero JR. Activation of the mineralocorticoid receptor increases striatin levels. Am J Hypertens. 2012 Feb; 25(2):243-9. PMID: 22089104; PMCID: PMC3773217; DOI: 10.1038/ajh.2011.197;

Vaidya A, Williams JS. The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes. Metabolism. 2012 Apr; 61(4):450-8. PMID: 22075270; PMCID: PMC3290690; DOI: 10.1016/j.metabol.2011.09.007;

Underwood PC, Chamarthi B, Williams JS, Sun B, Vaidya A, Raby BA, Lasky-Su J, Hopkins PN, Adler GK, Williams GH. Replication and meta-analysis of the gene-environment interaction between body mass index and the interleukin-6 promoter polymorphism with higher insulin resistance. Metabolism. 2012 May; 61(5):667-71. PMID: 22075267; PMCID: PMC3461261; DOI: 10.1016/j.metabol.2011.09.018;

Williams JS, Hopkins PN, Jeunemaitre X, Brown NJ. CYP4A11 T8590C polymorphism, salt-sensitive hypertension, and renal blood flow. J Hypertens. 2011 Oct; 29(10):1913-8. PMID: 21873888; PMCID: PMC3309034; DOI: 10.1097/HJH.0b013e32834aa786;

Pojoga LH, Williams JS, Yao TM, Kumar A, Raffetto JD, do Nascimento GR, Reslan OM, Adler GK, Williams GH, Shi Y, Khalil RA. Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension. Am J Physiol Heart Circ Physiol. 2011 Nov; 301(5):H1862-71.View Related Profiles.

Williams, Jonathan
Raffetto, Joseph

PMID: 21873498; PMCID: PMC3213961; DOI: 10.1152/ajpheart.00513.2011;

Vaidya A, Williams JS, Forman JP. The independent association between 25-hydroxyvitamin D and adiponectin and its relation with BMI in two large cohorts: the NHS and the HPFS. Obesity (Silver Spring). 2012 Jan; 20(1):186-91.View Related Profiles.

Forman, John
Williams, Jonathan

PMID: 21760630; PMCID: PMC3461263; DOI: 10.1038/oby.2011.210;

Vaidya A, Sun B, Forman JP, Hopkins PN, Brown NJ, Kolatkar NS, Williams GH, Williams JS. The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians. Clin Endocrinol (Oxf). 2011 Jun; 74(6):783-90.View Related Profiles.

Forman, John
Williams, Jonathan

PMID: 21521263; PMCID: PMC3089671; DOI: 10.1111/j.1365-2265.2011.03991.x;

Pojoga LH, Underwood PC, Goodarzi MO, Williams JS, Adler GK, Jeunemaitre X, Hopkins PN, Raby BA, Lasky-Su J, Sun B, Cui J, Guo X, Taylor KD, Chen YD, Xiang A, Raffel LJ, Buchanan TA, Rotter JI, Williams GH. Variants of the caveolin-1 gene: a translational investigation linking insulin resistance and hypertension. J Clin Endocrinol Metab. 2011 Aug; 96(8):E1288-92. PMID: 21613355; PMCID: PMC3146791; DOI: 10.1210/jc.2010-2738;

Sun B, Williams JS, Pojoga L, Chamarthi B, Lasky-Su J, Raby BA, Hopkins PN, Jeunemaitre X, Brown NJ, Ferri C, Williams GH. Renin gene polymorphism: its relationship to hypertension, renin levels and vascular responses. J Renin Angiotensin Aldosterone Syst. 2011 Dec; 12(4):564-71. PMID: 21490026; PMCID: PMC3444254; DOI: 10.1177/1470320311405873;

Vaidya A, Forman JP, Underwood PC, Hopkins PN, Williams GH, Pojoga LH, Williams JS. The influence of body mass index and renin-angiotensin-aldosterone system activity on the relationship between 25-hydroxyvitamin D and adiponectin in Caucasian men. Eur J Endocrinol. 2011 Jun; 164(6):995-1002.View Related Profiles.

Forman, John
Williams, Jonathan

PMID: 21402748; PMCID: PMC3104074; DOI: 10.1530/EJE-11-0025;

Vaidya A, Pojoga L, Underwood PC, Forman JP, Hopkins PN, Williams GH, Williams JS. The association of plasma resistin with dietary sodium manipulation, the renin-angiotensin-aldosterone system, and 25-hydroxyvitamin D3 in human hypertension. Clin Endocrinol (Oxf). 2011 Mar; 74(3):294-9.View Related Profiles.

Forman, John
Williams, Jonathan

PMID: 21050256; PMCID: PMC3059847; DOI: 10.1111/j.1365-2265.2010.03922.x;

Vaidya A, Forman JP, Hopkins PN, Seely EW, Williams JS. 25-Hydroxyvitamin D is associated with plasma renin activity and the pressor response to dietary sodium intake in Caucasians. J Renin Angiotensin Aldosterone Syst. 2011 Sep; 12(3):311-9.View Related Profiles.

Forman, John
Williams, Jonathan

PMID: 21330422; PMCID: PMC3146958; DOI: 10.1177/1470320310391922;

Underwood PC, Sun B, Williams JS, Pojoga LH, Raby B, Lasky-Su J, Hunt S, Hopkins PN, Jeunemaitre X, Adler GK, Williams GH. The association of the angiotensinogen gene with insulin sensitivity in humans: a tagging single nucleotide polymorphism and haplotype approach. Metabolism. 2011 Aug; 60(8):1150-7. PMID: 21306748; PMCID: PMC3115454; DOI: 10.1016/j.metabol.2010.12.009;

Vaidya A, Forman JP, Williams JS. Vitamin D and the vascular sensitivity to angiotensin II in obese Caucasians with hypertension. J Hum Hypertens. 2011 Nov; 25(11):672-8.View Related Profiles.

Forman, John
Williams, Jonathan

PMID: 21124341; PMCID: PMC3146961; DOI: 10.1038/jhh.2010.110;

Underwood PC, Sun B, Williams JS, Pojoga LH, Chamarthi B, Lasky-Su J, Raby BA, Hopkins PN, Jeunemaitre X, Brown NJ, Adler GK, Williams GH. The relationship between peroxisome proliferator-activated receptor-gamma and renin: a human genetics study. J Clin Endocrinol Metab. 2010 Sep; 95(9):E75-9. PMID: 20631015; PMCID: PMC2936061; DOI: 10.1210/jc.2010-0270;

Sun B, Williams JS, Svetkey LP, Kolatkar NS, Conlin PR. Beta2-adrenergic receptor genotype affects the renin-angiotensin-aldosterone system response to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern. Am J Clin Nutr. 2010 Aug; 92(2):444-9.View Related Profiles.

Williams, Jonathan
Conlin, Paul

PMID: 20519561; PMCID: PMC2904038; DOI: 10.3945/ajcn.2009.28924;

Chamarthi B, Williams JS, Williams GH. A mechanism for salt-sensitive hypertension: abnormal dietary sodium-mediated vascular response to angiotensin-II. J Hypertens. 2010 May; 28(5):1020-6. PMID: 20216091; PMCID: PMC2945810; DOI: 10.1097/HJH.0b013e3283375974;

Forman JP, Williams JS, Fisher ND. Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system in humans. Hypertension. 2010 May; 55(5):1283-8.View Related Profiles.

Forman, John
Williams, Jonathan

PMID: 20351344; PMCID: PMC3023301; DOI: 10.1161/HYPERTENSIONAHA.109.148619;

Vaidya A, Bentley-Lewis R, Jeunemaitre X, Adler GK, Williams JS. Dietary sodium alters the prevalence of electrocardiogram determined left ventricular hypertrophy in hypertension. Am J Hypertens. 2009 Jun; 22(6):669-73. PMID: 19265788; PMCID: PMC2892415; DOI: 10.1038/ajh.2009.45;

Williams JS, Brown SM, Conlin PR. Videos in clinical medicine. Blood-pressure measurement. N Engl J Med. 2009 Jan 29; 360(5):e6.View Related Profiles.

Williams, Jonathan
Conlin, Paul

PMID: 19179309; PMCID: PMC2825670; DOI: 10.1056/NEJMvcm0800157;

Chamarthi B, Kolatkar NS, Hunt SC, Williams JS, Seely EW, Brown NJ, Murphey LJ, Jeunemaitre X, Williams GH. Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension. J Clin Endocrinol Metab. 2007 Apr; 92(4):1340-6. PMID: 17264181

Gumieniak O, Perlstein TS, Williams JS, Hopkins PN, Brown NJ, Raby BA, Williams GH. Ala92 type 2 deiodinase allele increases risk for the development of hypertension. Hypertension. 2007 Mar; 49(3):461-6. PMID: 17224473

Raji A, Williams JS, Hopkins PN, Simonson DC, Williams GH. Familial aggregation of insulin resistance and cardiovascular risk factors in hypertension. J Clin Hypertens (Greenwich). 2006 Nov; 8(11):791-6. PMID: 17086019

Pojoga L, Kolatkar NS, Williams JS, Perlstein TS, Jeunemaitre X, Brown NJ, Hopkins PN, Raby BA, Williams GH. Beta-2 adrenergic receptor diplotype defines a subset of salt-sensitive hypertension. Hypertension. 2006 Nov; 48(5):892-900. PMID: 17015767

Williams JS, Solomon SD, Crivaro M, Conlin PR. Dietary sodium intake modulates myocardial relaxation responsiveness to angiotensin II. Transl Res. 2006 Aug; 148(2):49-54.View Related Profiles.

Williams, Jonathan
Conlin, Paul

PMID: 16890144

Szmuilowicz ED, Adler GK, Williams JS, Green DE, Yao TM, Hopkins PN, Seely EW. Relationship between aldosterone and progesterone in the human menstrual cycle. J Clin Endocrinol Metab. 2006 Oct; 91(10):3981-7. PMID: 16868049

Williams JR. Depression as a mediator between spousal bereavement and mortality from cardiovascular disease: appreciating and managing the adverse health consequences of depression in an elderly surviving spouse. South Med J. 2005 Jan; 98(1):90-5. PMID: 15678641

Williams JS, Williams GH. 50th anniversary of aldosterone. J Clin Endocrinol Metab. 2003 Jun; 88(6):2364-72. PMID: 12788829

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 89 publications over 20 distinct years, with a maximum of 13 publications in 2011

Bar chart showing 89 publications over 20 distinct years, with a maximum of 13 publications in 2011

Year	Publications
2003	1
2005	1
2006	4
2007	2
2009	2
2010	5
2011	13
2012	9
2013	3
2014	4
2015	4
2016	2
2017	6
2018	5
2019	6
2020	7
2021	3
2022	4
2023	6
2024	2

1998 Hahnemann/Drexel University: Alpha Omega Alpha, Medical Honor Society

Contact for Mentoring:

75 E. Newton St

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