John Caradonna, PhD
Associate Professor
Boston University College of Arts and Sciences

PhD, Columbia University
MPhil, Columbia University
MA, Columbia University
MA, Johns Hopkins University
BA, Johns Hopkins University

The Caradonna research group is interested in understanding the mechanism of action of non-heme iron metalloproteins, with a focus on the chemistry of metalloenzyme active sites involved in biological oxidation reactions. Our efforts span the continuum from the investigation of small molecule synthetic complexes that catalyze oxygen atom transfer reactions, to the characterization of an interesting class of iron/pterin-dependent aromatic amino acid hydroxylases (phenylalanine, tyrosine, and tryptophan hydroxylases), to the computational design of functional metalloproteins (iron-sulfur-based electron transfer clusters, Fe and Mn superoxide dismutanse). A broad-based approach, including chemical, molecular biological, and biophysical (spectroscopic) techniques, is used to develop a global understanding of the intrinsic characteristics of the active site metal centers and the role played by the protein matrix in regulating, modulating, and tuning these properties.

Boston University
Evans Center for Interdisciplinary Biomedical Research

SusCheM: Utilizing Iron-Coenzyme Oxygen Activation in Catalysis
07/01/2013 - 05/31/2017 (PI)
National Science Foundation


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

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  1. McCracken J, Cappillino PJ, McNally JS, Krzyaniak MD, Howart M, Tarves PC, Caradonna JP. Characterization of Water Coordination to Ferrous Nitrosyl Complexes with fac-N2O, cis-N2O2, and N2O3 Donor Ligands. Inorg Chem. 2015 Jul 6; 54(13):6486-97. PMID: 26090963; DOI: 10.1021/acs.inorgchem.5b00788;
  2. Cappillino PJ, Miecznikowski JR, Tyler LA, Tarves PC, McNally JS, Lo W, Kasibhatla BS, Krzyaniak MD, McCracken J, Wang F, Armstrong WH, Caradonna JP. Studies of iron(II) and iron(III) complexes with fac-N2O, cis-N2O2 and N2O3 donor ligands: models for the 2-His 1-carboxylate motif of non-heme iron monooxygenases. Dalton Trans. 2012 May 14; 41(18):5662-77. PMID: 22434362; DOI: 10.1039/c2dt11096b;
  3. Gregor LC, Rowe GT, Rybak-Akimova E, Caradonna JP. Mechanistic investigation of cyclohexane oxidation by a non-heme iron complex: evidence of product inhibition by UV/vis stopped-flow studies. Dalton Trans. 2012 Jan 21; 41(3):777-82. PMID: 22109726; DOI: 10.1039/c1dt11841b;
  4. Cappillino PJ, McNally JS, Wang F, Caradonna JP. The effect of varying carboxylate ligation on the electronic environment of N2O(x) (x = 1-3) nonheme iron: a DFT analysis. Dalton Trans. 2012 Jan 14; 41(2):474-83. PMID: 22042235; DOI: 10.1039/c1dt11199j;
  5. Cong H, Ledbetter D, Rowe GT, Caradonna JP, Porco JA. Electron transfer-initiated Diels-Alder cycloadditions of 2'-hydroxychalcones. J Am Chem Soc. 2008 Jul 23; 130(29):9214-5.View Related Profiles. PMID: 18576647; PMCID: PMC2635952; DOI: 10.1021/ja803094u;
  6. Rowe GT, Rybak-Akimova EV, Caradonna JP. Heterolytic cleavage of peroxide by a diferrous compound generates metal-based intermediates identical to those observed with reactions utilizing oxygen-atom-donor molecules. Chemistry. 2008; 14(27):8303-11. PMID: 18680115; DOI: 10.1002/chem.200800283;
  7. Rowe GT, Rybak-Akimova EV, Caradonna JP. Unraveling the reactive species of a functional non-heme iron monooxygenase model using stopped-flow UV-vis spectroscopy. Inorg Chem. 2007 Dec 10; 46(25):10594-606. PMID: 17988120
  8. Kemsley JN, Wasinger EC, Datta S, Mitic N, Acharya T, Hedman B, Caradonna JP, Hodgson KO, Solomon EI. Spectroscopic and kinetic studies of PKU-inducing mutants of phenylalanine hydroxylase: Arg158Gln and Glu280Lys. J Am Chem Soc. 2003 May 14; 125(19):5677-86. PMID: 12733906
  9. Foster TL, Caradonna JP. Fe2+-catalyzed heterolytic RO-OH bond cleavage and substrate oxidation: a functional synthetic non-heme iron monooxygenase system. J Am Chem Soc. 2003 Apr 2; 125(13):3678-9. PMID: 12656580
  10. Wasinger EC, Mitic N, Hedman B, Caradonna J, Solomon EI, Hodgson KO. X-ray absorption spectroscopic investigation of the resting ferrous and cosubstrate-bound active sites of phenylalanine hydroxylase. Biochemistry. 2002 May 21; 41(20):6211-7. PMID: 12009881
Showing 10 of 20 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 20 publications over 15 distinct years, with a maximum of 3 publications in 1997


Contact for Mentoring:

24 Cummington Mall
Boston MA 02215
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(617) 353-6466 (fax)

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