Deborah Lang, PhD
Associate Professor
Boston University School of Medicine
Dept of Dermatology

PhD, Drexel University College of Medicine



Dr. Lang, appointed as an Associate Professor of Dermatology, was recruited from the University of Chicago. Here at BU, she will continue her basic science research mission focusing on the molecular and cellular biology of melanoma. The lab’s research is centered on studying processes that occur during pigment cell development of the embryo and applying these findings toward melanoma. The premise is that pathways that are essential for development (such as growth, survival, and migration) are also important for melanoma progression (over-growth, inappropriate survival, and metastasis). She has mentored over twenty students and has served as an elected council member and plenary speaker of the Pan American Society for Pigment Cell Research.


PAX3 PATHWAYS IN MELANOMA
10/01/2016 - 07/31/2020 (PI)
NIH/National Cancer Institute
5R01CA184001-04

Daneen & Charles Stifel Investigative Scientist Award
05/01/2018 - 04/30/2019 (PI)
American Skin Association



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Little EC, Kubic JD, Salgia R, Grippo PJ, Lang D. Canonical and alternative transcript expression of PAX6 and CXCR4 in pancreatic cancer. Oncol Lett. 2017 Jun; 13(6):4027-4034. PMID: 28588695.
     
  2. Kubic JD, Little EC, Kaiser RS, Young KP, Lang D. FOXD3 Promotes PAX3 Expression in Melanoma Cells. J Cell Biochem. 2016 Feb; 117(2):533-41. PMID: 26252164; DOI: 10.1002/jcb.25306;.
     
  3. Kubic JD, Lui JW, Little EC, Ludvik AE, Konda S, Salgia R, Aplin AE, Lang D. PAX3 and FOXD3 Promote CXCR4 Expression in Melanoma. J Biol Chem. 2015 Sep 04; 290(36):21901-14. PMID: 26205821; DOI: 10.1074/jbc.M115.670976;.
     
  4. Kubic JD, Little EC, Lui JW, Iizuka T, Lang D. PAX3 and ETS1 synergistically activate MET expression in melanoma cells. Oncogene. 2015 Sep 17; 34(38):4964-74. PMID: 25531327; DOI: 10.1038/onc.2014.420;.
     
  5. Lang D, Mascarenhas JB, Shea CR. Melanocytes, melanocyte stem cells, and melanoma stem cells. Clin Dermatol. 2013 Mar-Apr; 31(2):166-78. PMID: 23438380; PMCID: PMC3582991.
     
  6. Kubic JD, Mascarenhas JB, Iizuka T, Wolfgeher D, Lang D. GSK-3 promotes cell survival, growth, and PAX3 levels in human melanoma cells. Mol Cancer Res. 2012 Aug; 10(8):1065-76. PMID: 22679108; DOI: 10.1158/1541-7786.MCR-11-0387;.
     
  7. Mascarenhas JB, Littlejohn EL, Wolsky RJ, Young KP, Nelson M, Salgia R, Lang D. PAX3 and SOX10 activate MET receptor expression in melanoma. Pigment Cell Melanoma Res. 2010 Apr; 23(2):225-37. PMID: 20067553; DOI: 10.1111/j.1755-148X.2010.00667.x;.
     
  8. Degenhardt KR, Milewski RC, Padmanabhan A, Miller M, Singh MK, Lang D, Engleka KA, Wu M, Li J, Zhou D, Antonucci N, Li L, Epstein JA. Distinct enhancers at the Pax3 locus can function redundantly to regulate neural tube and neural crest expressions. Dev Biol. 2010 Mar 15; 339(2):519-27. PMID: 20045680; PMCID: PMC2830354.
     
  9. Levin MD, Lu MM, Petrenko NB, Hawkins BJ, Gupta TH, Lang D, Buckley PT, Jochems J, Liu F, Spurney CF, Yuan LJ, Jacobson JT, Brown CB, Huang L, Beermann F, Margulies KB, Madesh M, Eberwine JH, Epstein JA, Patel VV. Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. J Clin Invest. 2009 Nov; 119(11):3420-36. PMID: 19855129; DOI: 10.1172/JCI39109;.
     
  10. Chen B, Yates E, Huang Y, Kogut P, Ma L, Turner JR, Tao Y, Camoretti-Mercado B, Lang D, Svensson EC, Garcia JG, Gruber PJ, Morrisey EE, Solway J. Alternative promoter and GATA5 transcripts in mouse. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297(6):G1214-22. PMID: 19779014.
     
Showing 10 of 26 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 26 publications over 17 distinct years, with a maximum of 4 publications in 2009

YearPublications
19951
19961
19981
19991
20002
20032
20051
20061
20071
20083
20094
20102
20121
20131
20141
20152
20171
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Melanoma
melanocytes
molecular biology
gene transcription
transcription factors
Contact for Mentoring:


609 Albany Street
Boston MA 02115
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