Clarissa Valim | Profiles RNS

Clarissa Valim, MD, SM, ScD

Research Associate Professor

Boston University School of Public Health

Global Health

MD, University of Estado Do Rio De Jarviro
ScD, Harvard School of Public Health

Websites

	Harvard T. H. Chan School of Public Health
	LinkedIn
	ResearchGate
	Harvard Catalyst

ORCID : 0000-0001-9621-203X

Dr. Clarissa Valim received her MD from the University of the State of Rio de Janeiro, Brazil in 1988 and her ScD in Immunology and Infectious Diseases (Epidemiology of Infectious Diseases) at the Harvard School of Public Health (HSPH), in 2003. She also has an MSc in Public Health (Epidemiology) from the National School of Public Health / Oswaldo Cruz Foundation, Rio de Janeiro, Brazil and an SM in Biostatistics from the HSPH. She worked as a Biostatistician in the Division of Clinical Research of Children’s Hospital and an Instructor in Surgery, Harvard Medical School until 2011, and then as a Research Scientist at the HSPH.
Clarissa’s research focuses on the epidemiology and immunology of malaria and malaria vaccine trials, novel biomarkers to detect microcephaly and other serious complications of the zika virus during pregnancy and inflammatory response patterns to determine the etiology of fever in young children. Her work on malaria takes her to Malawi, the work on Zika takes her to Brazil and the work on childhood fever and pneumonia takes her to the Gambia.

BU Research

COVID Transmission and Morbidity in Malawi (COVID-TMM)
04/01/2022 - 03/31/2027 (Multi-PI)
PI: Clarissa Valim, MD, SM, ScD
NIH/National Institute of Allergy & Infectious Diseases
5R01AI164686-03

Systems biological assessment of vaccination-induced protective immunity in African children
02/01/2022 - 01/31/2027 (Subcontract PI)
Stanford University NIH NIAID
5U01AI165527-03

Clinical Trial to Evaluate Intermittent Screening and Treatment with High Sensitivity Rapid Diagnostic Tests and Intermittent Preventive Treatment of Malaria in Asymptomatic Schoolchildren to Decrease
07/01/2022 - 06/30/2024 (Subcontract PI)
University of Maryland College Park Doris Duke Fdn

The Intransigence of Malaria in Malawi: Understanding Hidden Reservoirs, Successful Vectors and Prevention Failures
04/01/2023 - 03/31/2024 (Subcontract PI)
Michigan State University NIH NIAID
5U19AI089683-14

The Intransigence of Malaria in Malawi: Understanding Hidden Reservoirs, Successful Vectors and Prevention Failures
01/01/2019 - 03/31/2024 (Subcontract PI)
Michigan State University NIH NIAID
5U19AI089683-13

Longitudinal Antibody Profiles Correlated with Protection from Malaria in Malawi
01/08/2021 - 12/31/2023 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5R21AI151459-02

A Point-of-Care Test to Diagnose Bacterial Infection in Children with Clinical Pneumonia
04/01/2022 - 07/31/2023 (PI)
Hansjorg Wyss Institute for Biologically Inspired Engineering at Harvard

Diagnostic and Prognostic Biomarkers for Childhood Bacterial Pneumonia in Sub-Saharan Africa
03/01/2019 - 05/31/2022 (Multi-PI)
PI: Clarissa Valim, MD, SM, ScD
NIH/National Institute of Allergy & Infectious Diseases
5R21AI140258-03

The Intransigence of Malaria in Malawi: Understanding Hidden Reservoirs, Successful Vectors and Prevention Failures- Administrative Supplement
07/24/2019 - 03/31/2021 (Subcontract PI)
Michigan State University NIH NIAID
5U19AI089683-11

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Dobbs KR, Atieli HE, Valim C, Beeson JG. Previous Malaria Exposures and Immune Dysregulation: Developing Strategies To Improve Malaria Vaccine Efficacy in Young Children. Am J Trop Med Hyg. 2024 Apr 03; 110(4):627-630. PMID: 38442424; PMCID: PMC10993830; DOI: 10.4269/ajtmh.23-0696;

Mbewe RB, Keven JB, Mangani C, Wilson ML, Mzilahowa T, Mathanga DP, Valim C, Laufer MK, Walker ED, Cohee LM. Genotyping of Anopheles mosquito blood meals reveals nonrandom human host selection: implications for human-to-mosquito Plasmodium falciparum transmission. Malar J. 2023 Apr 07; 22(1):115. PMID: 37029433; PMCID: PMC10080529; DOI: 10.1186/s12936-023-04541-2;

Bressan CDS, Teixeira MLB, Gouvêa MIFDS, de Pina-Costa A, Santos HFP, Calvet GA, Lupi O, Siqueira AM, Valls-de-Souza R, Valim C, Brasil P. Challenges of acute febrile illness diagnosis in a national infectious diseases center in Rio de Janeiro: 16-year experience of syndromic surveillance. PLoS Negl Trop Dis. 2023 Apr; 17(4):e0011232. PMID: 37011087; PMCID: PMC10101631; DOI: 10.1371/journal.pntd.0011232;

Beeson JG, Kurtovic L, Valim C, Asante KP, Boyle MJ, Mathanga D, Dobano C, Moncunill G. The RTS,S malaria vaccine: Current impact and foundation for the future. Sci Transl Med. 2022 Nov 16; 14(671):eabo6646. PMID: 36383682; DOI: 10.1126/scitranslmed.abo6646;

Mangani C, Mzilahowa T, Cohee L, Kayange M, Ntenda P, Sixpence A, Gumbo A, Lankhulani S, Goupeyou-Youmsi J, Walker E, Laufer M, Valim C, Seydel K, Wilson ML, Taylor T, Mathanga DP. Malawi ICEMR Malaria Research: Interactions and Results Influencing Health Policies and Practices. Am J Trop Med Hyg. 2022 Oct 11; 107(4_Suppl):49-54. PMID: 36228911; PMCID: PMC9662217; DOI: 10.4269/ajtmh.21-1265;

Cohee LM, Goupeyou-Youmsi J, Seydel KB, Mangani C, Ntenda P, Sixpence A, Mbewe RB, Matengeni A, Takala-Harrison S, Walker ED, Wilson ML, Mzilahowa T, Laufer MK, Valim C, Taylor TE, Mathanga DP. Understanding the Intransigence of Malaria in Malawi. Am J Trop Med Hyg. 2022 Oct 11; 107(4_Suppl):40-48. PMID: 36228915; PMCID: PMC9662216; DOI: 10.4269/ajtmh.21-1263;

Cohee LM, Peterson I, Buchwald AG, Coalson JE, Valim C, Chilombe M, Ngwira A, Bauleni A, Schaffer-DeRoo S, Seydel KB, Wilson ML, Taylor TE, Mathanga DP, Laufer MK. School-Based Malaria Screening and Treatment Reduces Plasmodium falciparum Infection and Anemia Prevalence in Two Transmission Settings in Malawi. J Infect Dis. 2022 Aug 12; 226(1):138-146. PMID: 35290461; PMCID: PMC9373151; DOI: 10.1093/infdis/jiac097;

Macià D, Campo JJ, Moncunill G, Jairoce C, Nhabomba AJ, Mpina M, Sorgho H, Dosoo D, Traore O, Kusi KA, Williams NA, Oberai A, Randall A, Sanz H, Valim C, Asante KP, Owusu-Agyei S, Tinto H, Agnandji ST, Kariuki S, Gyan B, Daubenberger C, Mordmüller B, Petrone P, Dobaño C. Strong off-target antibody reactivity to malarial antigens induced by RTS,S/AS01E vaccination is associated with protection. JCI Insight. 2022 May 23; 7(10). PMID: 35446785; PMCID: PMC9220828; DOI: 10.1172/jci.insight.158030;

Moncunill G, Carnes J, Chad Young W, Carpp L, De Rosa S, Campo JJ, Nhabomba A, Mpina M, Jairoce C, Finak G, Haas P, Muriel C, Van P, Sanz H, Dutta S, Mordmüller B, Agnandji ST, Díez-Padrisa N, Williams NA, Aponte JJ, Valim C, Neafsey DE, Daubenberger C, McElrath MJ, Dobaño C, Stuart K, Gottardo R. Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case-control study. Elife. 2022 01 21; 11. PMID: 35060479; PMCID: PMC8782572; DOI: 10.7554/eLife.70393;

Gillette MA, Mani DR, Uschnig C, Pellé KG, Madrid L, Acácio S, Lanaspa M, Alonso P, Valim C, Carr SA, Schaffner SF, MacInnis B, Milner DA, Bassat Q, Wirth DF. Biomarkers to Distinguish Bacterial From Viral Pediatric Clinical Pneumonia in a Malaria-Endemic Setting. Clin Infect Dis. 2021 12 06; 73(11):e3939-e3948. PMID: 33534888; PMCID: PMC8653634; DOI: 10.1093/cid/ciaa1843;

Showing 10 of 92 results. Show More

Valim C, Olatunji YA, Isa YS, Salaudeen R, Golam S, Knol EF, Kanyi S, Jammeh A, Bassat Q, de Jager W, Diaz AA, Wiegand RC, Ramirez J, Moses MA, D'Alessandro U, Hibberd PL, Mackenzie GA. Seeking diagnostic and prognostic biomarkers for childhood bacterial pneumonia in sub-Saharan Africa: study protocol for an observational study. BMJ Open. 2021 09 30; 11(9):e046590.View Related Profiles.

Valim, Clarissa
Hibberd, Patricia

PMID: 34593486; PMCID: PMC8487183; DOI: 10.1136/bmjopen-2020-046590;

Peterson I, Kapito-Tembo A, Bauleni A, Nyirenda O, Pensulo P, Still W, Valim C, Cohee L, Taylor T, Mathanga DP, Laufer MK. Overdiagnosis of Malaria Illness in an Endemic Setting: A Facility-Based Surveillance Study in Malawi. Am J Trop Med Hyg. 2021 05 03; 104(6):2123-2130. PMID: 33939628; PMCID: PMC8176516; DOI: 10.4269/ajtmh.20-1209;

Cohee LM, Valim C, Coalson JE, Nyambalo A, Chilombe M, Ngwira A, Bauleni A, Seydel KB, Wilson ML, Taylor TE, Mathanga DP, Laufer MK. School-based screening and treatment may reduce P. falciparum transmission. Sci Rep. 2021 03 25; 11(1):6905. PMID: 33767384; PMCID: PMC7994823; DOI: 10.1038/s41598-021-86450-5;

Ackerman H, Olola CHO, Krishna S, Roberts DJ, Kremsner PG, Newton CR, Taylor T, Valim C, Casals-Pascual C. Time-to-death is a potential confounder in observational studies of blood transfusion in severe malaria - Authors' reply. Lancet Haematol. 2021 01; 8(1):e12-e13. PMID: 33357473; PMCID: PMC7613501; DOI: 10.1016/S2352-3026(20)30412-9;

Ackerman H, Ayestaran A, Olola CHO, Jallow M, Agbenyega T, Bojang K, Roberts DJ, Krishna S, Kremsner PG, Newton CR, Taylor T, Valim C, Casals-Pascual C. The effect of blood transfusion on outcomes among African children admitted to hospital with Plasmodium falciparum malaria: a prospective, multicentre observational study. Lancet Haematol. 2020 Nov; 7(11):e789-e797. PMID: 33091354; PMCID: PMC7611367; DOI: 10.1016/S2352-3026(20)30288-X;

Sanz H, Reverter F, Valim C. Correction to: Enhancing SVM for survival data using local invariances and weighting. BMC Bioinformatics. 2020 Aug 27; 21(1):371. PMID: 32854611; PMCID: PMC7450564; DOI: 10.1186/s12859-020-03558-7;

Kapito-Tembo A, Mathanga D, Bauleni A, Nyirenda O, Pensulo P, Ali D, Valim C, Taylor TE, Laufer MK. Prevalence and Clinical Management of Non-malarial Febrile Illnesses among Outpatients in the Era of Universal Malaria Testing in Malawi. Am J Trop Med Hyg. 2020 08; 103(2):887-893. PMID: 32588795; PMCID: PMC7410417; DOI: 10.4269/ajtmh.18-0800;

Sanz H, Reverter F, Valim C. Enhancing SVM for survival data using local invariances and weighting. BMC Bioinformatics. 2020 May 19; 21(1):193. PMID: 32429884; PMCID: PMC7236493; DOI: 10.1186/s12859-020-3481-2;

Fernandes FF, Pitangui NS, Peron G, Valim CXR, Mazucato VM, Oliveira AF, Silva TAD, Roque-Barreira MC, Panunto-Castelo A. Expression of Hsp60 and its cell location in Paracoccidioides brasiliensis. Rev Inst Med Trop Sao Paulo. 2020; 62:e29. PMID: 32401956; PMCID: PMC7232959; DOI: 10.1590/S1678-9946202062029;

Dobaño C, Ubillos I, Jairoce C, Gyan B, Vidal M, Jiménez A, Santano R, Dosoo D, Nhabomba AJ, Ayestaran A, Aguilar R, Williams NA, Díez-Padrisa N, Lanar D, Chauhan V, Chitnis C, Dutta S, Gaur D, Angov E, Asante KP, Owusu-Agyei S, Valim C, Gamain B, Coppel RL, Cavanagh D, Beeson JG, Campo JJ, Moncunill G. RTS,S/AS01E immunization increases antibody responses to vaccine-unrelated Plasmodium falciparum antigens associated with protection against clinical malaria in African children: a case-control study. BMC Med. 2019 08 14; 17(1):157. PMID: 31409398; PMCID: PMC6693200; DOI: 10.1186/s12916-019-1378-6;

Dobaño C, Sanz H, Sorgho H, Dosoo D, Mpina M, Ubillos I, Aguilar R, Ford T, Díez-Padrisa N, Williams NA, Ayestaran A, Traore O, Nhabomba AJ, Jairoce C, Waitumbi J, Agnandji ST, Kariuki S, Abdulla S, Aponte JJ, Mordmüller B, Asante KP, Owusu-Agyei S, Tinto H, Campo JJ, Moncunill G, Gyan B, Valim C, Daubenberger C. Concentration and avidity of antibodies to different circumsporozoite epitopes correlate with RTS,S/AS01E malaria vaccine efficacy. Nat Commun. 2019 05 15; 10(1):2174. PMID: 31092823; PMCID: PMC6520358; DOI: 10.1038/s41467-019-10195-z;

Dobaño C, Santano R, Vidal M, Jiménez A, Jairoce C, Ubillos I, Dosoo D, Aguilar R, Williams NA, Díez-Padrisa N, Ayestaran A, Valim C, Asante KP, Owusu-Agyei S, Lanar D, Chauhan V, Chitnis C, Dutta S, Angov E, Gamain B, Coppel RL, Beeson JG, Reiling L, Gaur D, Cavanagh D, Gyan B, Nhabomba AJ, Campo JJ, Moncunill G. Differential Patterns of IgG Subclass Responses to Plasmodium falciparum Antigens in Relation to Malaria Protection and RTS,S Vaccination. Front Immunol. 2019; 10:439. PMID: 30930896; PMCID: PMC6428712; DOI: 10.3389/fimmu.2019.00439;

Sanz H, Valim C, Vegas E, Oller JM, Reverter F. SVM-RFE: selection and visualization of the most relevant features through non-linear kernels. BMC Bioinformatics. 2018 Nov 19; 19(1):432. PMID: 30453885; PMCID: PMC6245920; DOI: 10.1186/s12859-018-2451-4;

Shaffer JG, Doumbia SO, Ndiaye D, Diarra A, Gomis JF, Nwakanma D, Abubakar I, Ahmad A, Affara M, Lukowski M, Valim C, Welty JC, Mather FJ, Keating J, Krogstad DJ. Development of a data collection and management system in West Africa: challenges and sustainability. Infect Dis Poverty. 2018 Nov 16; 7(1):125. PMID: 30541626; PMCID: PMC6292095; DOI: 10.1186/s40249-018-0494-4;

Ubillos I, Ayestaran A, Nhabomba AJ, Dosoo D, Vidal M, Jiménez A, Jairoce C, Sanz H, Aguilar R, Williams NA, Díez-Padrisa N, Mpina M, Sorgho H, Agnandji ST, Kariuki S, Mordmüller B, Daubenberger C, Asante KP, Owusu-Agyei S, Sacarlal J, Aide P, Aponte JJ, Dutta S, Gyan B, Campo JJ, Valim C, Moncunill G, Dobaño C. Baseline exposure, antibody subclass, and hepatitis B response differentially affect malaria protective immunity following RTS,S/AS01E vaccination in African children. BMC Med. 2018 10 31; 16(1):197. PMID: 30376866; PMCID: PMC6208122; DOI: 10.1186/s12916-018-1186-4;

Ubillos I, Aguilar R, Sanz H, Jiménez A, Vidal M, Valmaseda A, Dong Y, Gaur D, Chitnis CE, Dutta S, Angov E, Aponte JJ, Campo JJ, Valim C, Harezlak J, Dobaño C. Analysis of factors affecting the variability of a quantitative suspension bead array assay measuring IgG to multiple Plasmodium antigens. PLoS One. 2018; 13(7):e0199278. PMID: 29966018; PMCID: PMC6028107; DOI: 10.1371/journal.pone.0199278;

Sanz H, Aponte JJ, Harezlak J, Dong Y, Ayestaran A, Nhabomba A, Mpina M, Maurin OR, Díez-Padrisa N, Aguilar R, Moncunill G, Selidji Todagbe A, Daubenberger C, Dobaño C, Valim C. drLumi: An open-source package to manage data, calibrate, and conduct quality control of multiplex bead-based immunoassays data analysis. PLoS One. 2017; 12(11):e0187901. PMID: 29136653; PMCID: PMC5685631; DOI: 10.1371/journal.pone.0187901;

Moncunill G, Mpina M, Nhabomba AJ, Aguilar R, Ayestaran A, Sanz H, Campo JJ, Jairoce C, Barrios D, Dong Y, Díez-Padrisa N, Fernandes JF, Abdulla S, Sacarlal J, Williams NA, Harezlak J, Mordmüller B, Agnandji ST, Aponte JJ, Daubenberger C, Valim C, Dobaño C. Distinct Helper T Cell Type 1 and 2 Responses Associated With Malaria Protection and Risk in RTS,S/AS01E Vaccinees. Clin Infect Dis. 2017 Sep 01; 65(5):746-755. PMID: 28505356; PMCID: PMC5850568; DOI: 10.1093/cid/cix429;

Moncunill G, De Rosa SC, Ayestaran A, Nhabomba AJ, Mpina M, Cohen KW, Jairoce C, Rutishauser T, Campo JJ, Harezlak J, Sanz H, Díez-Padrisa N, Williams NA, Morris D, Aponte JJ, Valim C, Daubenberger C, Dobaño C, McElrath MJ. RTS,S/AS01E Malaria Vaccine Induces Memory and Polyfunctional T Cell Responses in a Pediatric African Phase III Trial. Front Immunol. 2017; 8:1008. PMID: 28878775; PMCID: PMC5572329; DOI: 10.3389/fimmu.2017.01008;

Bae DS, Valim C, Connell P, Brustowicz KA, Waters PM. Bivalved Versus Circumferential Cast Immobilization for Displaced Forearm Fractures: A Randomized Clinical Trial to Assess Efficacy and Safety. J Pediatr Orthop. 2017 Jun; 37(4):239-246. PMID: 26422394; DOI: 10.1097/BPO.0000000000000655;

Metsky HC, Matranga CB, Wohl S, Schaffner SF, Freije CA, Winnicki SM, West K, Qu J, Baniecki ML, Gladden-Young A, Lin AE, Tomkins-Tinch CH, Ye SH, Park DJ, Luo CY, Barnes KG, Shah RR, Chak B, Barbosa-Lima G, Delatorre E, Vieira YR, Paul LM, Tan AL, Barcellona CM, Porcelli MC, Vasquez C, Cannons AC, Cone MR, Hogan KN, Kopp EW, Anzinger JJ, Garcia KF, Parham LA, Ramírez RMG, Montoya MCM, Rojas DP, Brown CM, Hennigan S, Sabina B, Scotland S, Gangavarapu K, Grubaugh ND, Oliveira G, Robles-Sikisaka R, Rambaut A, Gehrke L, Smole S, Halloran ME, Villar L, Mattar S, Lorenzana I, Cerbino-Neto J, Valim C, Degrave W, Bozza PT, Gnirke A, Andersen KG, Isern S, Michael SF, Bozza FA, Souza TML, Bosch I, Yozwiak NL, MacInnis BL, Sabeti PC. Zika virus evolution and spread in the Americas. Nature. 2017 06 15; 546(7658):411-415. PMID: 28538734; PMCID: PMC5563848; DOI: 10.1038/nature22402;

Tang V, Valim C, Moman R, Richman A, Zhou J, Ramgopal V, Albert R, Boone JH, Rufo PA. Assessment of Fecal ASCA Measurement as a Biomarker of Crohn Disease in Pediatric Patients. J Pediatr Gastroenterol Nutr. 2017 Feb; 64(2):248-253.View Related Profiles.

Valim, Clarissa
Rufo, Paul

PMID: 27111346; DOI: 10.1097/MPG.0000000000001244;

Silterra J, Gillette MA, Lanaspa M, Pellé KG, Valim C, Ahmad R, Acácio S, Almendinger KD, Tan Y, Madrid L, Alonso PL, Carr SA, Wiegand RC, Bassat Q, Mesirov JP, Milner DA, Wirth DF. Transcriptional Categorization of the Etiology of Pneumonia Syndrome in Pediatric Patients in Malaria-Endemic Areas. J Infect Dis. 2017 01 15; 215(2):312-320. PMID: 27837008; PMCID: PMC6392473; DOI: 10.1093/infdis/jiw531;

Mathanga DP, Tembo AK, Mzilahowa T, Bauleni A, Mtimaukenena K, Taylor TE, Valim C, Walker ED, Wilson ML. Patterns and determinants of malaria risk in urban and peri-urban areas of Blantyre, Malawi. Malar J. 2016 Dec 08; 15(1):590. PMID: 27931234; PMCID: PMC5146950; DOI: 10.1186/s12936-016-1623-9;

Valim C, Ahmad R, Lanaspa M, Tan Y, Acácio S, Gillette MA, Almendinger KD, Milner DA, Madrid L, Pellé K, Harezlak J, Silterra J, Alonso PL, Carr SA, Mesirov JP, Wirth DF, Wiegand RC, Bassat Q. Responses to Bacteria, Virus, and Malaria Distinguish the Etiology of Pediatric Clinical Pneumonia. Am J Respir Crit Care Med. 2016 Feb 15; 193(4):448-59. PMID: 26469764; PMCID: PMC5440057; DOI: 10.1164/rccm.201506-1100OC;

Neafsey DE, Juraska M, Bedford T, Benkeser D, Valim C, Griggs A, Lievens M, Abdulla S, Adjei S, Agbenyega T, Agnandji ST, Aide P, Anderson S, Ansong D, Aponte JJ, Asante KP, Bejon P, Birkett AJ, Bruls M, Connolly KM, D'Alessandro U, Dobaño C, Gesase S, Greenwood B, Grimsby J, Tinto H, Hamel MJ, Hoffman I, Kamthunzi P, Kariuki S, Kremsner PG, Leach A, Lell B, Lennon NJ, Lusingu J, Marsh K, Martinson F, Molel JT, Moss EL, Njuguna P, Ockenhouse CF, Ogutu BR, Otieno W, Otieno L, Otieno K, Owusu-Agyei S, Park DJ, Pellé K, Robbins D, Russ C, Ryan EM, Sacarlal J, Sogoloff B, Sorgho H, Tanner M, Theander T, Valea I, Volkman SK, Yu Q, Lapierre D, Birren BW, Gilbert PB, Wirth DF. Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine. N Engl J Med. 2015 Nov 19; 373(21):2025-2037. PMID: 26488565; PMCID: PMC4762279; DOI: 10.1056/NEJMoa1505819;

Walldorf JA, Cohee LM, Coalson JE, Bauleni A, Nkanaunena K, Kapito-Tembo A, Seydel KB, Ali D, Mathanga D, Taylor TE, Valim C, Laufer MK. School-Age Children Are a Reservoir of Malaria Infection in Malawi. PLoS One. 2015; 10(7):e0134061. PMID: 26207758; PMCID: PMC4514805; DOI: 10.1371/journal.pone.0134061;

Seydel KB, Kampondeni SD, Valim C, Potchen MJ, Milner DA, Muwalo FW, Birbeck GL, Bradley WG, Fox LL, Glover SJ, Hammond CA, Heyderman RS, Chilingulo CA, Molyneux ME, Taylor TE. Brain swelling and death in children with cerebral malaria. N Engl J Med. 2015 Mar 19; 372(12):1126-37. PMID: 25785970; PMCID: PMC4450675; DOI: 10.1056/NEJMoa1400116;

Galinsky K, Valim C, Salmier A, de Thoisy B, Musset L, Legrand E, Faust A, Baniecki ML, Ndiaye D, Daniels RF, Hartl DL, Sabeti PC, Wirth DF, Volkman SK, Neafsey DE. COIL: a methodology for evaluating malarial complexity of infection using likelihood from single nucleotide polymorphism data. Malar J. 2015 Jan 19; 14:4. PMID: 25599890; PMCID: PMC4417311; DOI: 10.1186/1475-2875-14-4;

Zimmerman LA, Shamberger RC, Valim C, Bousvaros A. The effect of immunomodulators and biologics on indication for surgical bowel resection in children with Crohn's disease. Inflamm Bowel Dis. 2014 Jun; 20(6):1015-20. PMID: 24788215; DOI: 10.1097/MIB.0000000000000042;

Van Tyne D, Dieye B, Valim C, Daniels RF, Sène PD, Lukens AK, Ndiaye M, Bei AK, Ndiaye YD, Hamilton EJ, Ndir O, Mboup S, Volkman SK, Wirth DF, Ndiaye D. Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal. Malar J. 2013 Dec 06; 12:441. PMID: 24314037; PMCID: PMC3924193; DOI: 10.1186/1475-2875-12-441;

Baldini F, Gabrieli P, South A, Valim C, Mancini F, Catteruccia F. The interaction between a sexually transferred steroid hormone and a female protein regulates oogenesis in the malaria mosquito Anopheles gambiae. PLoS Biol. 2013 Oct; 11(10):e1001695. PMID: 24204210; PMCID: PMC3812110; DOI: 10.1371/journal.pbio.1001695;

Lanaspa M, Valim C, Acacio S, Almendinger K, Ahmad R, Wiegand R, Bassat Q. High reliability in respiratory rate assessment in children with respiratory symptomatology in a rural area in Mozambique. J Trop Pediatr. 2014 Apr; 60(2):93-8. PMID: 24072556; DOI: 10.1093/tropej/fmt081;

Bopp SE, Rodrigo E, González-Páez GE, Frazer M, Barnes SW, Valim C, Watson J, Walker JR, Schmedt C, Winzeler EA. Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9. Malar J. 2013 Sep 11; 12:316. PMID: 24025732; PMCID: PMC3848760; DOI: 10.1186/1475-2875-12-316;

Ndiaye D, Dieye B, Ndiaye YD, Van Tyne D, Daniels R, Bei AK, Mbaye A, Valim C, Lukens A, Mboup S, Ndir O, Wirth DF, Volkman S. Polymorphism in dhfr/dhps genes, parasite density and ex vivo response to pyrimethamine in Plasmodium falciparum malaria parasites in Thies, Senegal. Int J Parasitol Drugs Drug Resist. 2013 Dec; 3:135-42. PMID: 24533303; PMCID: PMC3862402; DOI: 10.1016/j.ijpddr.2013.07.001;

Rovira-Vallbona E, Monteiro I, Bardají A, Serra-Casas E, Neafsey DE, Quelhas D, Valim C, Alonso P, Dobaño C, Ordi J, Menéndez C, Mayor A. VAR2CSA signatures of high Plasmodium falciparum parasitemia in the placenta. PLoS One. 2013; 8(7):e69753. PMID: 23936092; PMCID: PMC3723727; DOI: 10.1371/journal.pone.0069753;

Nehra D, Fallon EM, Potemkin AK, Voss SD, Mitchell PD, Valim C, Belfort MB, Bellinger DC, Duggan C, Gura KM, Puder M. A comparison of 2 intravenous lipid emulsions: interim analysis of a randomized controlled trial. JPEN J Parenter Enteral Nutr. 2014 Aug; 38(6):693-701. PMID: 23770843; PMCID: PMC4635445; DOI: 10.1177/0148607113492549;

Milner DA, Valim C, Carr RA, Chandak PB, Fosiko NG, Whitten R, Playforth KB, Seydel KB, Kamiza S, Molyneux ME, Taylor TE. A histological method for quantifying Plasmodium falciparum in the brain in fatal paediatric cerebral malaria. Malar J. 2013 Jun 07; 12:191. PMID: 23758807; PMCID: PMC3701562; DOI: 10.1186/1475-2875-12-191;

Postels DG, Birbeck GL, Valim C, Mannor KM, Taylor TE. Seasonal differences in retinopathy-negative versus retinopathy-positive cerebral malaria. Am J Trop Med Hyg. 2013 Feb; 88(2):315-8. PMID: 23166194; PMCID: PMC3583323; DOI: 10.4269/ajtmh.2012.12-0415;

Park DJ, Lukens AK, Neafsey DE, Schaffner SF, Chang HH, Valim C, Ribacke U, Van Tyne D, Galinsky K, Galligan M, Becker JS, Ndiaye D, Mboup S, Wiegand RC, Hartl DL, Sabeti PC, Wirth DF, Volkman SK. Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite. Proc Natl Acad Sci U S A. 2012 Aug 07; 109(32):13052-7. PMID: 22826220; PMCID: PMC3420184; DOI: 10.1073/pnas.1210585109;

Milner DA, Vareta J, Valim C, Montgomery J, Daniels RF, Volkman SK, Neafsey DE, Park DJ, Schaffner SF, Mahesh NC, Barnes KG, Rosen DM, Lukens AK, Van Tyne D, Wiegand RC, Sabeti PC, Seydel KB, Glover SJ, Kamiza S, Molyneux ME, Taylor TE, Wirth DF. Human cerebral malaria and Plasmodium falciparum genotypes in Malawi. Malar J. 2012 Feb 07; 11:35. PMID: 22314206; PMCID: PMC3295736; DOI: 10.1186/1475-2875-11-35;

O'Brien LC, Valim C, Neault M, Kammerer B, Clark T, Johnston J, Culver S, Zhou J, Kenna MA, Licameli GR. Prognosis tool based on a modified children's implant profile for use in pediatric cochlear implant candidacy evaluation. Ann Otol Rhinol Laryngol. 2012 Feb; 121(2):73-84. PMID: 22397214; DOI: 10.1177/000348941212100201;

Milner DA, Valim C, Luo R, Playforth KB, Kamiza S, Molyneux ME, Seydel KB, Taylor TE. Supraorbital postmortem brain sampling for definitive quantitative confirmation of cerebral sequestration of Plasmodium falciparum parasites. J Infect Dis. 2012 May 15; 205(10):1601-6. PMID: 22291197; PMCID: PMC3415818; DOI: 10.1093/infdis/jis001;

Doumbia SO, Ndiaye D, Koita OA, Diakité M, Nwakanma D, Coulibaly M, Traoré SF, Keating J, Milner DA, Ndiaye JL, Sene PD, Ahouidi A, Dieye TN, Gaye O, Okebe J, Ceesay SJ, Ngwa A, Oriero EC, Konaté L, Sy N, Jawara M, Faye O, Kéita M, Cissé M, Sogoba N, Poudiougou B, Diawara S, Sangaré L, Coulibaly T, Seck I, Abubakar I, Gomis J, Mather FJ, Sissako A, Diarra A, Kandeh B, Whalen C, Moyer B, Nnedu O, Thiero O, Bei AK, Daniels R, Miura K, Long CA, Fairhurst RM, Duraisingh M, Muskavitch MA, D'Alessandro U, Conway DJ, Volkman SK, Valim C, Wirth DF, Krogstad DJ. Improving malaria control in West Africa: interruption of transmission as a paradigm shift. Acta Trop. 2012 Mar; 121(3):175-83. PMID: 22142790; PMCID: PMC3294075; DOI: 10.1016/j.actatropica.2011.11.009;

Ceesay SJ, Bojang KA, Nwakanma D, Conway DJ, Koita OA, Doumbia SO, Ndiaye D, Coulibaly TF, Diakité M, Traoré SF, Coulibaly M, Ndiaye JL, Sarr O, Gaye O, Konaté L, Sy N, Faye B, Faye O, Sogoba N, Jawara M, Dao A, Poudiougou B, Diawara S, Okebe J, Sangaré L, Abubakar I, Sissako A, Diarra A, Kéita M, Kandeh B, Long CA, Fairhurst RM, Duraisingh M, Perry R, Muskavitch MA, Valim C, Volkman SK, Wirth DF, Krogstad DJ. Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes. Acta Trop. 2012 Mar; 121(3):166-74. PMID: 22119584; PMCID: PMC3294051; DOI: 10.1016/j.actatropica.2011.11.005;

Zhang JJ, Senaratne TN, Daniels R, Valim C, Alifrangis M, Amerasinghe P, Konradsen F, Rajakaruna R, Wirth DF, Karunaweera ND. Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006. Am J Trop Med Hyg. 2011 Nov; 85(5):811-4. PMID: 22049031; PMCID: PMC3205623; DOI: 10.4269/ajtmh.2011.11-0167;

Delgado-Borrego A, Kamegaya Y, Jordan SH, Agrawal S, Valim C, Chung RT. HCV synergizes with body weight in the promotion of insulin resistance. J Viral Hepat. 2011 Feb; 18(2):135-41. PMID: 20497310; PMCID: PMC3806633; DOI: 10.1111/j.1365-2893.2010.01291.x;

Brunoni AR, Valim C, Fregni F. Combination of noninvasive brain stimulation with pharmacotherapy. Expert Rev Med Devices. 2011 Jan; 8(1):31-9. PMID: 21158538; DOI: 10.1586/erd.10.62;

Duro D, Fitzgibbons S, Valim C, Yang CF, Zurakowski D, Dolan M, Bechard L, Yu YM, Duggan C, Jaksic T. [13C]Methionine breath test to assess intestinal failure-associated liver disease. Pediatr Res. 2010 Oct; 68(4):349-54. PMID: 20581744; PMCID: PMC3721749; DOI: 10.1203/PDR.0b013e3181ed15e5;

Bourgeois FT, Shannon MW, Valim C, Mandl KD. Adverse drug events in the outpatient setting: an 11-year national analysis. Pharmacoepidemiol Drug Saf. 2010 Sep; 19(9):901-10. PMID: 20623513; PMCID: PMC2932855; DOI: 10.1002/pds.1984;

Diaz AA, Valim C, Yamashiro T, Estépar RS, Ross JC, Matsuoka S, Bartholmai B, Hatabu H, Silverman EK, Washko GR. Airway count and emphysema assessed by chest CT imaging predicts clinical outcome in smokers. Chest. 2010 Oct; 138(4):880-7. PMID: 20558554; PMCID: PMC2951760; DOI: 10.1378/chest.10-0542;

Tracy S, Estroff J, Valim C, Friedman S, Chen C. Abnormal neuroimaging and neurodevelopmental findings in a cohort of antenatally diagnosed congenital diaphragmatic hernia survivors. J Pediatr Surg. 2010 May; 45(5):958-65. PMID: 20438935; DOI: 10.1016/j.jpedsurg.2010.02.015;

Nicksa GA, Yu DC, Curatolo AS, McNeish BL, Barnewolt CE, Valim C, Buchmiller TL, Moses MA, Fauza DO. Prenatal urinary matrix metalloproteinase profiling as a potential diagnostic tool in fetal obstructive uropathy. J Pediatr Surg. 2010 Jan; 45(1):70-3.View Related Profiles.

Valim, Clarissa
Nicksa, Grace

PMID: 20105582

Lee SI, Valim C, Johnston P, Le HD, Meisel J, Arsenault DA, Gura KM, Puder M. Impact of fish oil-based lipid emulsion on serum triglyceride, bilirubin, and albumin levels in children with parenteral nutrition-associated liver disease. Pediatr Res. 2009 Dec; 66(6):698-703. PMID: 19687773; PMCID: PMC3377973; DOI: 10.1203/PDR.0b013e3181bbdf2b;

Bourgeois FT, Valim C, McAdam AJ, Mandl KD. Relative impact of influenza and respiratory syncytial virus in young children. Pediatrics. 2009 Dec; 124(6):e1072-80. PMID: 19933730; PMCID: PMC3374864; DOI: 10.1542/peds.2008-3074;

Weir DC, Glickman JN, Roiff T, Valim C, Leichtner AM. Variability of histopathological changes in childhood celiac disease. Am J Gastroenterol. 2010 Jan; 105(1):207-12. PMID: 19809405; DOI: 10.1038/ajg.2009.557;

Lightdale JR, Mahoney LB, Fredette ME, Valim C, Wong S, DiNardo JA. Nurse reports of adverse events during sedation procedures at a pediatric hospital. J Perianesth Nurs. 2009 Oct; 24(5):300-6. PMID: 19853814; DOI: 10.1016/j.jopan.2009.07.004;

Bourgeois FT, Mandl KD, Valim C, Shannon MW. Pediatric adverse drug events in the outpatient setting: an 11-year national analysis. Pediatrics. 2009 Oct; 124(4):e744-50. PMID: 19786435; PMCID: PMC2975566; DOI: 10.1542/peds.2008-3505;

Lightdale JR, Valim C, Mahoney LB, Sharon Wong, DiNardo J, Goldmann DA. Agitation during procedural sedation and analgesia in children. Clin Pediatr (Phila). 2010 Jan; 49(1):35-42. PMID: 19738182; DOI: 10.1177/0009922809344425;

Puder M, Valim C, Meisel JA, Le HD, de Meijer VE, Robinson EM, Zhou J, Duggan C, Gura KM. Parenteral fish oil improves outcomes in patients with parenteral nutrition-associated liver injury. Ann Surg. 2009 Sep; 250(3):395-402. PMID: 19661785; PMCID: PMC3366279; DOI: 10.1097/SLA.0b013e3181b36657;

Fitzgibbons SC, Ching Y, Yu D, Carpenter J, Kenny M, Weldon C, Lillehei C, Valim C, Horbar JD, Jaksic T. Mortality of necrotizing enterocolitis expressed by birth weight categories. J Pediatr Surg. 2009 Jun; 44(6):1072-5; discussion 1075-6. PMID: 19524719; DOI: 10.1016/j.jpedsurg.2009.02.013;

Steigman SA, Ahmed A, Shanti RM, Tuan RS, Valim C, Fauza DO. Sternal repair with bone grafts engineered from amniotic mesenchymal stem cells. J Pediatr Surg. 2009 Jun; 44(6):1120-6; discussion 1126. PMID: 19524727; PMCID: PMC3556735; DOI: 10.1016/j.jpedsurg.2009.02.038;

Misra MV, Gutweiler JR, Suh MY, Twark CM, Valim C, Perez-Atayde A, Kim HB. A murine model of graft-vs-host disease after in utero hematopoietic cell transplantation. J Pediatr Surg. 2009 Jun; 44(6):1102-7; discussion 1107. PMID: 19524724; DOI: 10.1016/j.jpedsurg.2009.02.033;

Yang CF, Lee M, Valim C, Hull MA, Zhou J, Jones BA, Gura K, Collier S, Lo C, Duggan C, Jaksic T. Persistent alanine aminotransferase elevations in children with parenteral nutrition-associated liver disease. J Pediatr Surg. 2009 Jun; 44(6):1084-7; discussion 1087-8. PMID: 19524721; PMCID: PMC4547788; DOI: 10.1016/j.jpedsurg.2009.02.011;

Ching YA, Fitzgibbons S, Valim C, Zhou J, Duggan C, Jaksic T, Kim HB. Long-term nutritional and clinical outcomes after serial transverse enteroplasty at a single institution. J Pediatr Surg. 2009 May; 44(5):939-43. PMID: 19433174; PMCID: PMC3217836; DOI: 10.1016/j.jpedsurg.2009.01.070;

Fitzgibbons S, Ching YA, Valim C, Zhou J, Iglesias J, Duggan C, Jaksic T. Relationship between serum citrulline levels and progression to parenteral nutrition independence in children with short bowel syndrome. J Pediatr Surg. 2009 May; 44(5):928-32. PMID: 19433172; PMCID: PMC3217826; DOI: 10.1016/j.jpedsurg.2009.01.034;

Kremsner PG, Valim C, Missinou MA, Olola C, Krishna S, Issifou S, Kombila M, Bwanaisa L, Mithwani S, Newton CR, Agbenyega T, Pinder M, Bojang K, Wypij D, Taylor T. Prognostic value of circulating pigmented cells in African children with malaria. J Infect Dis. 2009 Jan 01; 199(1):142-50. PMID: 19086817; PMCID: PMC3755538; DOI: 10.1086/595295;

Duro D, Duggan C, Valim C, Bechard L, Fitzgibbons S, Jaksic T, Yu YM. Novel intravenous (13)C-methionine breath test as a measure of liver function in children with short bowel syndrome. J Pediatr Surg. 2009 Jan; 44(1):236-40; discussion 240. PMID: 19159749; PMCID: PMC3253360; DOI: 10.1016/j.jpedsurg.2008.10.046;

Steigman SA, Nemes L, Barnewolt CE, Estroff JA, Valim C, Jennings RW, Fauza DO. Differential risk for neonatal surgical airway intervention in prenatally diagnosed neck masses. J Pediatr Surg. 2009 Jan; 44(1):76-9. PMID: 19159721; DOI: 10.1016/j.jpedsurg.2008.10.014;

Hait EJ, Barendse RM, Arnold JH, Valim C, Sands BE, Korzenik JR, Fishman LN. Transition of adolescents with inflammatory bowel disease from pediatric to adult care: a survey of adult gastroenterologists. J Pediatr Gastroenterol Nutr. 2009 Jan; 48(1):61-5. PMID: 19172125; DOI: 10.1097/MPG.0b013e31816d71d8;

Valim C, Mezzetti M, Maguire J, Urdaneta M, Wypij D. Estimation of vaccine efficacy in a repeated measures study under heterogeneity of exposure or susceptibility to infection. Philos Trans A Math Phys Eng Sci. 2008 Jul 13; 366(1874):2347-60. PMID: 18407892; PMCID: PMC3227149; DOI: 10.1098/rsta.2008.0044;

Lightdale JR, Valim C, Newburg AR, Mahoney LB, Zgleszewski S, Fox VL. Efficiency of propofol versus midazolam and fentanyl sedation at a pediatric teaching hospital: a prospective study. Gastrointest Endosc. 2008 Jun; 67(7):1067-75. PMID: 18367187; DOI: 10.1016/j.gie.2007.11.038;

Gura KM, Lee S, Valim C, Zhou J, Kim S, Modi BP, Arsenault DA, Strijbosch RA, Lopes S, Duggan C, Puder M. Safety and efficacy of a fish-oil-based fat emulsion in the treatment of parenteral nutrition-associated liver disease. Pediatrics. 2008 Mar; 121(3):e678-86. PMID: 18310188; DOI: 10.1542/peds.2007-2248;

Sawicki GS, Lu FL, Valim C, Cleveland RH, Colin AA. Necrotising pneumonia is an increasingly detected complication of pneumonia in children. Eur Respir J. 2008 Jun; 31(6):1285-91. PMID: 18216055; DOI: 10.1183/09031936.00099807;

Modi BP, Langer M, Ching YA, Valim C, Waterford SD, Iglesias J, Duro D, Lo C, Jaksic T, Duggan C. Improved survival in a multidisciplinary short bowel syndrome program. J Pediatr Surg. 2008 Jan; 43(1):20-4. PMID: 18206449; PMCID: PMC3253359; DOI: 10.1016/j.jpedsurg.2007.09.014;

Bourgeois FT, Porter SC, Valim C, Jackson T, Cook EF, Mandl KD. The value of patient self-report for disease surveillance. J Am Med Inform Assoc. 2007 Nov-Dec; 14(6):765-71. PMID: 17712092; PMCID: PMC2213481; DOI: 10.1197/jamia.M2134;

Banerjee S, Bishop W, Valim C, Mahoney LB, Lightdale JR. Percutaneous liver biopsy practice patterns among pediatric gastroenterologists in North America. J Pediatr Gastroenterol Nutr. 2007 Jul; 45(1):84-9. PMID: 17592369; DOI: 10.1097/MPG.0b013e318053eab4;

Duggan C, Piper H, Javid PJ, Valim C, Collier S, Kim HB, Jaksic T. Growth and nutritional status in infants with short-bowel syndrome after the serial transverse enteroplasty procedure. Clin Gastroenterol Hepatol. 2006 Oct; 4(10):1237-41. PMID: 16904948; DOI: 10.1016/j.cgh.2006.06.006;

Bourgeois FT, Valim C, Wei JC, McAdam AJ, Mandl KD. Influenza and other respiratory virus-related emergency department visits among young children. Pediatrics. 2006 Jul; 118(1):e1-8. PMID: 16818524; DOI: 10.1542/peds.2005-2248;

Taylor T, Olola C, Valim C, Agbenyega T, Kremsner P, Krishna S, Kwiatkowski D, Newton C, Missinou M, Pinder M, Wypij D. Standardized data collection for multi-center clinical studies of severe malaria in African children: establishing the SMAC network. Trans R Soc Trop Med Hyg. 2006 Jul; 100(7):615-22. PMID: 16551469; PMCID: PMC1459261; DOI: 10.1016/j.trstmh.2005.09.021;

Newton CR, Valim C, Krishna S, Wypij D, Olola C, Agbenyega T, Taylor TE. The prognostic value of measures of acid/base balance in pediatric falciparum malaria, compared with other clinical and laboratory parameters. Clin Infect Dis. 2005 Oct 01; 41(7):948-57. PMID: 16142658; PMCID: PMC1388262; DOI: 10.1086/432941;

Vasconcelos IA, Vasconcelos AW, Fe Filho NM, Queiroz RG, Santana EW, Bozza M, Sallenave SM, Valim C, David JR, Lopes UG. The identity of Leishmania isolated from sand flies and vertebrate hosts in a major focus of cutaneous leishmaniasis in Baturite, northeastern Brazil. Am J Trop Med Hyg. 1994 Feb; 50(2):158-64. PMID: 8116807; DOI: 10.4269/ajtmh.1994.50.158;

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 92 publications over 21 distinct years, with a maximum of 17 publications in 2009

Bar chart showing 92 publications over 21 distinct years, with a maximum of 17 publications in 2009

Year	Publications
1994	1
2005	1
2006	3
2007	2
2008	5
2009	17
2010	5
2011	5
2012	5
2013	8
2014	1
2015	4
2016	2
2017	7
2018	4
2019	3
2020	6
2021	4
2022	6
2023	2
2024	1

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